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Xiang Xiao, PhD

Associate Research Professor of Transplant Immunology in Surgery, Academic Institute
Associate Research Member, Research Institute
Houston Methodist


XXIAO@HoustonMethodist.org
Biography

Dr. Xiang Xiao earned his Ph.D. in cell biology from University of Science and Technology of China in Heifei, China in 2005. He completed his postdoctoral fellowship training at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston in 2013. After that, he joined Houston Methodist Research Institute as a research scientist. Dr. Xiao is now an assistant research professor of transplant immunology in surgery. Dr. Xiao studies the cellular and molecular mechanisms T cell functions relevant to transplant tolerance. He has published more than 20 original papers and review articles in high-impact scientific journals.

Description of Research

Dr. Xiao’s research interests are related to how the immune system responds to allotransplants, with specific emphasis on the fundamental mechanisms that control various T cell programs involved in transplant rejection and tolerance. One of the key aspects of his recent research focuses on the role of costimulatory molecules in T helper cells differentiation, functions, and fate decisions.

Education & Training

PhD, University of Science and Technology of China
Postdoctoral Fellowship, Harvard University
Postdoctoral Fellowship, Beth Israel Deaconess Medical Center
Publications

CD4+ T cell immunity is dependent on an intrinsic stem-like program
Zou, D, Yin, Z, Yi, SG, Wang, G, Guo, Y, Xiao, X, Li, S, Zhang, X, Gonzalez, NM, Minze, LJ, Wang, L, Wong, STC, Osama Gaber, A, Ghobrial, RM, Li, XC & Chen, W 2024, , Nature immunology, vol. 25, no. 1, pp. 66-76. https://doi.org/10.1038/s41590-023-01682-z

The transcription factor IRF4 determines the anti-tumor immunity of CD8+ T cells
Yan, H, Dai, Y, Zhang, X, Zhang, H, Xiao, X, Fu, J, Zou, D, Yu, A, Jiang, T, Li, XC, Zhao, Z & Chen, W 2023, , iScience, vol. 26, no. 11, 108087. https://doi.org/10.1016/j.isci.2023.108087

Continuous Expression of Interferon Regulatory Factor 4 Sustains CD8+ T Cell Immunity against Tumor
Yu, A, Fu, J, Yin, Z, Yan, H, Xiao, X, Zou, D, Zhang, X, Zu, X, Li, XC & Chen, W 2023, , Research, vol. 6, 0271. https://doi.org/10.34133/research.0271

Gasdermin D-mediated pyroptosis is regulated by AMPK-mediated phosphorylation in tumor cells
Chu, X, Xiao, X, Wang, G, Uosef, A, Lou, X, Arnold, P, Wang, Y, Kong, G, Wen, M, Minze, LJ & Li, XC 2023, , Cell Death and Disease, vol. 14, no. 7, 469. https://doi.org/10.1038/s41419-023-06013-6

TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions
Lou, X, Ma, B, Zhuang, Y, Xiao, X, Minze, LJ, Xing, J, Zhang, Z & Li, XC 2023, , Computational and Structural Biotechnology Journal, vol. 21, pp. 2801-2808. https://doi.org/10.1016/j.csbj.2023.04.022

Ox40-Cre-mediated deletion of BRD4 reveals an unexpected phenotype of hair follicle stem cells in alopecia
Wen, M, Ying, Y, Xiao, X, Arnold, PR, Wang, G, Chu, X, Ghobrial, RM & Li, XC 2022, , JCI insight, vol. 7, no. 23, e164534. https://doi.org/10.1172/jci.insight.164534

Structural studies of the coiled-coil domain of TRIM75 reveal a tetramer architecture facilitating its E3 ligase complex
Lou, X, Ma, B, Zhuang, Y, Xiao, X, Minze, LJ, Xing, J, Zhang, Z & Li, XC 2022, , Computational and Structural Biotechnology Journal, vol. 20, pp. 4921-4929. https://doi.org/10.1016/j.csbj.2022.08.069, https://doi.org/10.1016/j.csbj.2022.08.069

Suppression of FOXP3 expression by the AP-1 family transcription factor BATF3 requires partnering with IRF4
Arnold, PR, Wen, M, Zhang, L, Ying, Y, Xiao, X, Chu, X, Wang, G, Zhang, X, Mao, Z, Zhang, A, Hamilton, DJ, Chen, W & Li, XC 2022, , Frontiers in immunology, vol. 13, 966364, pp. 966364. https://doi.org/10.3389/fimmu.2022.966364, https://doi.org/10.3389/fimmu.2022.966364

Suppression of FOXP3 expression by the AP-1 family transcription factor BATF3 requires partnering with IRF4
Arnold, PR, Wen, M, Zhang, L, Ying, Y, Xiao, X, Chu, X, Wang, G, Zhang, X, Mao, Z, Zhang, A, Hamilton, DJ, Chen, W & Li, XC 2022, , Frontiers in immunology, vol. 13, 966364. https://doi.org/10.3389/fimmu.2022.966364

The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions
Wang, G, Xiao, X, Wang, Y, Chu, X, Dou, Y, Minze, LJ, Ghobrial, RM, Zhang, Z & Li, XC 2022, , Cellular and Molecular Immunology, vol. 19, no. 6, pp. 687-701. https://doi.org/10.1038/s41423-022-00852-7

Structural studies of the coiled-coil domain of TRIM75 reveal a tetramer architecture facilitating its E3 ligase complex
Lou, X, Ma, B, Zhuang, Y, Xiao, J, Minze, LJ, Zhang, Z & Li, XC 2022, , Computational and Structural Biotechnology Journal.

Transgenic Expression of a Mutant Ribonuclease Regnase-1 in T Cells Disturbs T Cell Development and Functions
Kong, G, Dou, Y, Xiao, X, Wang, Y, Ming, Y & Li, XC 2021, , Frontiers in immunology, vol. 12, 682220. https://doi.org/10.3389/fimmu.2021.682220

Genetically targeting the BATF family transcription factors BATF and BATF3 in the mouse abrogates effector T cell activities and enables long-term heart allograft survival
Wang, Y, Xiao, X, Kong, G, Wen, M, Wang, G, Ghobrial, RM, Dong, N, Chen, W & Li, XC 2022, , American Journal of Transplantation, vol. 22, no. 2, pp. 414-426. https://doi.org/10.1111/ajt.16861

Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics
Chen, S, Zhang, L, Ying, Y, Wang, Y, Arnold, PR, Wang, G, Li, J, Ghobrial, RM, Chen, W, Xiao, X & Li, XC 2020, , American Journal of Transplantation, vol. 20, no. 9, pp. 2366-2379. https://doi.org/10.1111/ajt.15845

T cell exhaustion is associated with antigen abundance and promotes transplant acceptance
Zou, D, Dai, Y, Zhang, X, Wang, G, Xiao, X, Jia, P, Li, XC, Guo, Z & Chen, W 2020, , American Journal of Transplantation, vol. 20, no. 9, pp. 2540-2550. https://doi.org/10.1111/ajt.15870

T follicular helper and memory cell responses and the mTOR pathway in murine heart transplantation
Xie, A, Yan, H, Fu, J, He, A, Xiao, X, Li, XC & Chen, W 2020, , Journal of Heart and Lung Transplantation, vol. 39, no. 2, pp. 134-144. https://doi.org/10.1016/j.healun.2019.11.017

The transcription factor RelB restrains group 2 innate lymphoid cells and type 2 immune pathology in vivo
Zhang, L, Ying, Y, Chen, S, Arnold, PR, Tian, F, Minze, LJ, Xiao, X & Li, XC 2021, , Cellular and Molecular Immunology, vol. 18, no. 1, pp. 230-242. https://doi.org/10.1038/s41423-020-0404-0

Identification of the E3 ligase TRIM29 as a critical checkpoint regulator of NK cell functions
Dou, Y, Xing, J, Kong, G, Wang, G, Lou, X, Xiao, X, Vivier, E, Li, XC & Zhang, Z 2019, , Journal of immunology (Baltimore, Md. : 1950), vol. 203, no. 4, pp. 873-880. https://doi.org/10.4049/jimmunol.1900171

Transcriptional and epigenetic regulation of immune tolerance: roles of the NF-?B family members
Zhang, L, Xiao, X, Arnold, PR & Li, XC 2019, , Cellular and Molecular Immunology, vol. 16, no. 4, pp. 315-323. https://doi.org/10.1038/s41423-019-0202-8

OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms
Zhang, X, Xiao, X, Lan, P, Li, J, Dou, Y, Chen, W, Ishii, N, Chen, S, Xia, B, Chen, K, Taparowsky, E & Li, XC 2018, , Cell Reports, vol. 24, no. 3, pp. 607-618. https://doi.org/10.1016/j.celrep.2018.06.052

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