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Weidong Le, MD, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Dr. Le received his Bachelor’s degree from Suzhou Medical College in 1978, and his doctoral degree from Shanghai 2nd Medical University in 1988. He did postdoctoral training at Baylor College of Medicine starting in 1989. He was promoted to Assistant Professor in 1993, Associate Professor in 2000 and Professor in 2005 at Baylor College of Medicine. He has published over 185 SCI papers in peer review journals and 7 scientific books. He has been awarded 26 research grants including 3 NIH R0-1 awards, grants from Michael Fox Foundation, APDA, PDF and NPA. Recently, he received two grant awards from the Helis Foundation to support Parkinson’s disease research. He is a reviewer committee member of NIH, VA, INSERM, Singapore Academy of Science, and the Chinese Nature Science Foundation. He is an editorial board member of six international journals including Autophagy, Neurodegenerative Disease, and is the Academic Editor of Plos One and J Alzheimer’s Disease.

Description of Research

Dr. Le is a neurologist/neuroscientist with research interest in the cellular and molecular basis of neuronal injury in these neurodegenerative diseases. Dr. Le’s research program focuses on defining the molecular mechanisms and pathological pathways of three major neurodegenerative diseases (Parkinson’s disease [PD], Alzheimers’s disease, and ALS). Recently he pioneered a linkage study of transcription factors regulating CNS development and neurodegenerative disorders.

Areas Of Expertise

Neurodegenerative diseases Parkinson’s Disease Alzheimer ALS
Education & Training

Postdoctoral Fellowship , Baylor College of Medicine
MS , Shanghai 2nd Medical University
PhD , Shanghai 2nd Medical University

Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death
Leng, ZG, Lin, SJ, Wu, ZR, Guo, YH, Cai, L, Shang, HB, Tang, H, Xue, YJ, Lou, MQ, Zhao, W, Le, WD, Zhao, WG, Zhang, X & Wu, ZB 2017, Autophagy, pp. 1-16. DOI:

Tiny But Mighty: Promising Roles of MicroRNAs in the Diagnosis and Treatment of Parkinson’s Disease
Wang, Y, Yang, Z & Le, W 2017, Neuroscience Bulletin, pp. 1-9. DOI:

Diagnostic accuracy of tablet-based software for the detection of concussion
Yang, S, Flores, B, Magal, R, Harris, K, Gross, J, Ewbank, A, Davenport, S, Ormachea, P, Nasser, W, Le, W, Peacock, WF, Katz, Y & Eagleman, DM 2017, PLoS ONE, vol 12, no. 7, e0179352. DOI:

Gold nanoparticles enhance the differentiation of embryonic stem cells into dopaminergic neurons via mTOR/p70S6K pathway
Wei, M, Li, S, Yang, Z, Zheng, W & Le, W 2017, Nanomedicine, vol 12, no. 11, pp. 1305-1317. DOI:

Gold nanoparticles enhance the differentiation of embryonic stem cells into dopaminergic neurons via mTOR/p70S6K pathway
Wei, M, Li, S, Yang, Z, Zheng, W & Le, W 2017, Nanomedicine, vol 12, no. 11, pp. 1305-1317. DOI:

The missing link between sleep disorders and age-related dementia: recent evidence and plausible mechanisms
Zhang, F, Zhong, R, Li, S, Chang, RCC & Le, W 2017, Journal of Neural Transmission, pp. 1-10. DOI:

Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations
Yang, J, Zhao, H, Ma, Y, Shi, G, Song, J, Tang, Y, Li, S, Li, T, Liu, N, Tang, F, Gu, J, Zhang, L, Zhang, Z, Zhang, X, Jin, Y & Le, W 2017, Oncotarget, vol 8, no. 5, pp. 7900-7913. DOI:

n-butylidenephthalide treatment prolongs life span and attenuates motor neuron loss in SOD1G93A mouse model of amyotrophic lateral sclerosis
Zhou, QM, Zhang, JJ, Li, S, Chen, S & Le, WD 2017, CNS Neuroscience and Therapeutics. DOI:

Autophagy in neurodegenerative diseases: Pathogenesis and therapy
Guo, F, Liu, X, Cai, H & Le, W 2017, Brain Pathology. DOI:

A Central Role for Phosphorylated p38a in Linking Proteasome Inhibition-Induced Apoptosis and Autophagy
Guo, F, He, XB, Li, S & Le, W 2016, Molecular Neurobiology, pp. 1-13. DOI:

Protective microglia and their regulation in Parkinson’s disease
Le, W, Wu, J & Tang, Y 2016, Frontiers in Molecular Neuroscience, vol 9, no. SEP2016, 89. DOI:

Therapies for Parkinson’s diseases: alternatives to current pharmacological interventions
Li, S, Dong, J, Cheng, C & Le, W 2016, Journal of Neural Transmission, pp. 1-21. DOI:

The recommendations of Chinese Parkinson's disease and movement disorder society consensus on therapeutic management of Parkinson's disease
Chen, S, Chan, P, Sun, S, Chen, H, Zhang, B, Le, W, Liu, C, Peng, G, Tang, B, Wang, L, Cheng, Y, Shao, M, Liu, Z, Wang, Z, Chen, X, Wang, M, Wan, X, Shang, H, Liu, Y, Xu, P, Wang, J, Feng, T, Chen, X, Hu, X, Xie, A & Xiao, Q 2016, Translational Neurodegeneration, vol 5, no. 1, 12. DOI:

Nanomaterial-modulated autophagy: Underlying mechanisms and functional consequences
Zheng, W, Wei, M, Li, S & Le, W 2016, Nanomedicine, vol 11, no. 11, pp. 1417-1430. DOI:

Induced pluripotent stem cells in Alzheimer's disease: Applications for disease modeling and cell-replacement therapy
Yang, J, Li, S, He, XB, Cheng, C & Le, W 2016, Molecular Neurodegeneration, vol 11, no. 1, 39. DOI:

Current therapy of drugs in amyotrophic lateral sclerosis
Lu, H, Le, WD, Xie, YY & Wang, XP 2016, Current Neuropharmacology, vol 14, no. 4, pp. 314-321.

Current pharmaceutical treatments and alternative therapies of parkinson’s disease
Dong, J, Cui, Y, Li, S & Le, W 2016, Current Neuropharmacology, vol 14, no. 4, pp. 339-355.

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
Tang, Y & Le, W 2016, Molecular Neurobiology, vol 53, no. 2, pp. 1181-1194. DOI:

Chronic Sleep Deprivation Exacerbates Learning-Memory Disability and Alzheimer's Disease-Like Pathologies in AßPPswe/PS1Delta;E9 Mice
Qiu, H, Zhong, R, Liu, H, Zhang, F, Li, S & Le, W 2016, Journal of Alzheimers Disease, vol 50, no. 3, pp. 669-685. DOI:

Chronic hypoxia facilitates Alzheimer's disease through demethylation of ?-secretase by downregulating DNA methyltransferase 3b
Liu, H, Qiu, H, Yang, J, Ni, J & Le, W 2016, Alzheimers and Dementia, vol 12, no. 2, pp. 130-143. DOI: