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Weidong Le, MD, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Le received his Bachelor’s degree from Suzhou Medical College in 1978, and his doctoral degree from Shanghai 2nd Medical University in 1988. He did postdoctoral training at Baylor College of Medicine starting in 1989. He was promoted to Assistant Professor in 1993, Associate Professor in 2000 and Professor in 2005 at Baylor College of Medicine. He has published over 185 SCI papers in peer review journals and 7 scientific books. He has been awarded 26 research grants including 3 NIH R0-1 awards, grants from Michael Fox Foundation, APDA, PDF and NPA. Recently, he received two grant awards from the Helis Foundation to support Parkinson’s disease research. He is a reviewer committee member of NIH, VA, INSERM, Singapore Academy of Science, and the Chinese Nature Science Foundation. He is an editorial board member of six international journals including Autophagy, Neurodegenerative Disease, and is the Academic Editor of Plos One and J Alzheimer’s Disease.

Description of Research

Dr. Le is a neurologist/neuroscientist with research interest in the cellular and molecular basis of neuronal injury in these neurodegenerative diseases. Dr. Le’s research program focuses on defining the molecular mechanisms and pathological pathways of three major neurodegenerative diseases (Parkinson’s disease [PD], Alzheimers’s disease, and ALS). Recently he pioneered a linkage study of transcription factors regulating CNS development and neurodegenerative disorders.

Areas Of Expertise

Neurodegenerative diseases Parkinson’s Disease Alzheimer ALS
Education & Training

, Baylor College of Medicine
, Shanghai 2nd Medical University
Publications

Protective microglia and their regulation in Parkinson’s disease
Le, W, Wu, J & Tang, Y 2016, Frontiers in Molecular Neuroscience, vol 9, no. SEP2016, 89. DOI:

Therapies for Parkinson’s diseases: alternatives to current pharmacological interventions
Li, S, Dong, J, Cheng, C & Le, W 2016, Journal of Neural Transmission, pp. 1-21. DOI:

The recommendations of Chinese Parkinson's disease and movement disorder society consensus on therapeutic management of Parkinson's disease
Chen, S, Chan, P, Sun, S, Chen, H, Zhang, B, Le, W, Liu, C, Peng, G, Tang, B, Wang, L, Cheng, Y, Shao, M, Liu, Z, Wang, Z, Chen, X, Wang, M, Wan, X, Shang, H, Liu, Y, Xu, P, Wang, J, Feng, T, Chen, X, Hu, X, Xie, A & Xiao, Q 2016, Translational Neurodegeneration, vol 5, no. 1, 12. DOI:

Nanomaterial-modulated autophagy: Underlying mechanisms and functional consequences
Zheng, W, Wei, M, Li, S & Le, W 2016, Nanomedicine, vol 11, no. 11, pp. 1417-1430. DOI:

Induced pluripotent stem cells in Alzheimer's disease: Applications for disease modeling and cell-replacement therapy
Yang, J, Li, S, He, XB, Cheng, C & Le, W 2016, Molecular Neurodegeneration, vol 11, no. 1, 39. DOI:

Current pharmaceutical treatments and alternative therapies of parkinson’s disease
Dong, J, Cui, Y, Li, S & Le, W 2016, Current Neuropharmacology, vol 14, no. 4, pp. 339-355.

Current therapy of drugs in amyotrophic lateral sclerosis
Lu, H, Le, WD, Xie, YY & Wang, XP 2016, Current Neuropharmacology, vol 14, no. 4, pp. 314-321.

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
Tang, Y & Le, W 2016, Molecular Neurobiology, vol 53, no. 2, pp. 1181-1194. DOI:

Chronic Sleep Deprivation Exacerbates Learning-Memory Disability and Alzheimer's Disease-Like Pathologies in AßPPswe/PS1Delta;E9 Mice
Qiu, H, Zhong, R, Liu, H, Zhang, F, Li, S & Le, W 2016, Journal of Alzheimers Disease, vol 50, no. 3, pp. 669-685. DOI:

Chronic hypoxia facilitates Alzheimer's disease through demethylation of ?-secretase by downregulating DNA methyltransferase 3b
Liu, H, Qiu, H, Yang, J, Ni, J & Le, W 2016, Alzheimers and Dementia, vol 12, no. 2, pp. 130-143. DOI:

Corrigendum to "A quantitative approach to developing Parkinsonian monkeys (Macaca fascicularis) with intracerebroventricular 1-methyl-4-phenylpyridinium injections" [J. Neurosci. Methods 251 (2015) 99-107]
Li, H, Lei, X, Huang, B, Rizak, JD, Yang, L, Yang, S, Wu, J, Lü, L, Wang, J, Yan, T, Li, H, Wang, Z, Hu, Y, Le, W, Deng, X, Huang, T, Li, J, Xu, L, Zhang, B & Hu, X 2016, Journal of Neuroscience Methods, vol 258, pp. 135. DOI:

Erratum: 1-methyl-4-phenylpyridinium stereotactic infusion completely and specifically ablated the nigrostriatal dopaminergic pathway in Rhesus Macaque (PLoS ONE (2016) 11:1 (e0147094)
Lei, X, Li, H, Huang, B, Rizak, J, Li, L, Xu, L, Liu, L, Wu, J, Lü, L, Wang, Z, Hu, Y, Le, W, Deng, X, Li, J, Yao, Y, Xu, L, Hu, X & Zhang, B 2016, PLoS ONE, vol 11, no. 1, e0147094. DOI:

Nurr1-Based Therapies for Parkinson's Disease
Dong, J, Li, S, Mo, JL, Cai, HB & Le, WD 2016, CNS Neuroscience and Therapeutics. DOI:

Double-Edged Roles of Nitric Oxide Signaling on APP Processing and Amyloid-ß Production In Vitro: Preliminary Evidence from Sodium Nitroprusside
Cai, ZX, Guo, HS, Wang, C, Wei, M, Cheng, C, Yang, ZF, Chen, YW, Le, WD & Li, S 2016, Neurotoxicity Research, vol 29, no. 1, pp. 21-34. DOI:

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
Klionsky, DJ, Abeliovich, H, Agostinis, P, Agrawal, DK, Aliev, G, Askew, DS, Baba, M, Baehrecke, EH, Bahr, BA, Ballabio, A, Bamber, BA, Bassham, DC, Bergamini, E, Bi, X, Biard-Piechaczyk, M, Blum, JS, Bredesen, DE, Brodsky, JL, Brumell, JH, Brunk, UT, Bursch, W, Camougrand, N, Cebollero, E, Cecconi, F, Chen, Y, Chin, LS, Choi, A, Chu, CT, Chung, J, Clarke, PGH, Clark, RSB, Clarke, SG, Clavé, C, Cleveland, JL, Codogno, P, Colombo, MI, Cotomontes, A, Cregg, JM, Cuervo, AM, Debnath, J, Demarchi, F, Dennis, PB, Dennis, PA, Deretic, V, Devenish, RJ, Di Sano, F, Dice, JF, DiFiglia, M, Dinesh-Kumar, S, Distelhorst, CW, Djavaheri-Mergny, M, Dorsey, FC, Dröge, W, Dron, M, Dunn, WA, Duszenko, M, Eissa, NT, Elazar, Z, Esclatine, A, Eskelinen, EL, Fésüs, L, Finley, KD, Fuentes, JM, Fueyo, J, Fujisaki, K, Galliot, B, Gao, FB, Gewirtz, DA, Gibson, SB, Gohla, A, Goldberg, AL, Gonzalez, R, González-Estévez, C, Gorski, S, Gottlieb, RA, Häussinger, D, He, YW, Heidenreich, K, Hill, JA, Høyer-Hansen, M, Hu, X, Huang, WP, Iwasaki, A, Jäättelä, M, Jackson, WT, Jiang, X, Jin, S, Johansen, T, Jung, JU, Kadowaki, M, Kang, C, Kelekar, A, Kessel, DH, Kiel, JAKW, Hong, PK, Kimchi, A, Kinsella, TJ, Kiselyov, K, Kitamoto, K, Knecht, E, Komatsu, M, Kominami, E, Kondo, S, Kovács, AL, Kroemer, G, Kuan, CY, Kumar, R, Kundu, M, Landry, J, Laporte, M, Le, W, Lei, HY, Lenardo, MJ, Levine, B, Lieberman, A, Lim, KL, Lin, FC, Liou, W, Liu, LF, Lopez-Berestein, G, López-Otín, C, Lu, B, Macleod, KF, Malorni, W, Martinet, W, Matsuoka, K, Mautner, J, Meijer, AJ, Meléndez, A, Michels, P, Miotto, G, Mistiaen, WP, Mizushima, N, Mograbi, B, Monastyrska, I, Moore, MN, Moreira, PI, Moriyasu, Y, Motyl, T, Münz, C, Murphy, LO, Naqvi, NI, Neufeld, TP, Nishino, I, Nixon, RA, Noda, T, Nürnberg, B, Ogawa, M, Oleinick, NL, Olsen, LJ, Ozpolat, B, Paglin, S, Palmer, GE, Papassideri, I, Parkes, M, Perlmutter, DH, Perry, G, Piacentini, M, Pinkas-Kramarski, R, Prescott, M, Proikascezanne, T, Raben, N, Rami, A, Reggiori, F, Rohrer, B, Rubinsztein, DC, Ryan, KM, Sadoshima, J, Sakagami, H, Sakai, Y, Sandri, M, Sasakawa, C, Sass, M, Schneider, C, Seglen, PO, Seleverstov, O, Settleman, J, Shacka, JJ, Shapiro, IM, Sibirny, A, Silva-Zacarin, ECM, Simon, HU, Simone, C, Simonsen, A, Smith, MA, Spanel-Borowski, K, Srinivas, V, Steeves, M, Stenmark, H, Stromhaug, PE, Subauste, CS, Sugimoto, S, Sulzer, D, Suzuki, T, Swanson, MS, Tabas, I, Takeshita, F, Talbot, NJ, Tallóczy, Z, Tanaka, K, Tanaka, K, Tanida, I, Taylor, GS, Taylor, JP, Terman, A, Tettamanti, G, Thompson, CB, Thumm, M, Tolkovsky, AM, Tooze, SA, Truant, R, Tumanovska, LV, Uchiyama, Y, Ueno, T, Uzcátegui, NL, Van Der Klei, I, Vaquero, EC, Vellai, T, Vogel, MW, Wang, HG, Webster, P, Wiley, JW, Xi, Z, Xiao, G, Yahalom, J, Yang, JM, Yap, G, Yin, XM, Yoshimori, T, Yu, L, Yue, Z, Yuzaki, M, Zabirnyk, O, Zheng, X, Zhu, X & Deter, RL 2016, Autophagy, vol 12, no. 2, pp. 443. DOI:

Ropinirole alters gene expression profiles in SH-SY5Y cells: A whole genome microarray study
Zhu, MZ, Le, WD & Jin, G 2016, Brazilian Journal of Medical and Biological Research, vol 49, no. 2, e4857. DOI:

miR-29 regulates Tet1 expression and contributes to early differentiation of mouse ESCs
Cui, Y, Li, T, Yang, D, Li, S & Le, W 2016, Oncotarget, vol 7, no. 40, pp. 64932-64941. DOI:

G2019S LRRK2 and aging confer susceptibility to proteasome inhibitor-induced neurotoxicity in nigrostriatal dopaminergic system
Xiao, Q, Yang, S & Le, W 2015, Journal of Neural Transmission, vol 122, no. 12, pp. 1645-1657. DOI:

Pitx3 deficiency produces decreased dopamine signaling and induces motor deficits in Pitx3(-/-) mice
Le, W, Zhang, L, Xie, W, Li, S & Dani, JA 2015, Neurobiology of Aging, vol 36, no. 12, pp. 3314-3320. DOI:

Chronic hypoxia-induced autophagy aggravates the neuropathology of Alzheimer's disease through AMPK-mTOR signaling in the APPSwe/PS1dE9 mouse model
Liu, H, Qiu, H, Xiao, Q & Le, W 2015, Journal of Alzheimers Disease, vol 48, no. 4, pp. 1019-1032. DOI: