Steven Shen, MD, PhD

Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Shen is a general surgical pathologist with subspecialty interest in genitourinary pathology. After completing his residency training in Anatomical and Clinical Pathology and fellowship training in Surgical Pathology, Dr. Shen became an assistant professor at Baylor College of Medicine (2002-2003) before joining the Department of Pathology and Genomic Medicine at Houston Methodist Hospital in 2004. In 2005 he joined the Weill Medical College faculty and is a Full Member of the Research Institute.

Dr. Shen is a general surgical pathologist with strong subspecialty expertise in genitourinary cancers. He is currently the Medical Director of the Immunohistochemistry Lab and Associate Director of Surgical Pathology at the Houston Methodist Hospital. He is co-editor of three books and has authored nearly 100 peer reviewed articles, primarily in the areas of diagnostic pathology and genitourinary tumors.

Description of Research

Dr. Shen’s research involves identifying morphologic and molecular abnormalities of neoplasm and correlating these with diagnosis, prognosis, and in some instances, future treatment. He is involved in independent and collaborative studies using conventional histomorphologic techniques, immunohistochemical methods, tissue microarray, and new molecular methods to study cancers of the kidney, urinary bladder, and prostate.

Areas Of Expertise

Cancer Metastasis
Education & Training

, The University of Texas MD Anderson Cancer Center
, Penn State Milton S. Hershey Medical Center
, Tongji University
, Tongji Medical College, Huazhong University of Science and Technology
, 1515 Holcombe Blvd.
, National Institutes of Health
, The University of Texas Houston Health Science Center
, The University of Texas-Houston Health Science Center
Publications

Transurethral biopsy of the prostatic urethra is associated with final apical margin status at radical cystoprostatectomy
von Rundstedt, FC, Mata, DA, Shen, S, Li, Y, Godoy, G & Lerner, SP 2016, Journal of Clinical Urology, vol 9, no. 6, pp. 404-408. DOI:

Neoadjuvant dasatinib for muscle-invasive bladder cancer with tissue analysis of biologic activity
Hahn, NM, Knudsen, BS, Daneshmand, S, Koch, MO, Bihrle, R, Foster, RS, Gardner, TA, Cheng, L, Liu, Z, Breen, T, Fleming, MT, Lance, R, Corless, CL, Alva, AS, Shen, SS, Huang, F, Gertych, A, Gallick, GE, Mallick, J, Ryan, C, Galsky, MD, Lerner, SP, Posadas, EM & Sonpavde, G 2016, Urologic Oncology: Seminars and Original Investigations, vol 34, no. 1, pp. 4.e11-4.e17. DOI:

Neoadjuvant dasatinib for muscle-invasive bladder cancer with tissue analysis of biologic activity
Hahn, NM, Knudsen, BS, Daneshmand, S, Koch, MO, Bihrle, R, Foster, RS, Gardner, TA, Cheng, L, Liu, Z, Breen, T, Fleming, MT, Lance, R, Corless, CL, Alva, AS, Shen, SS, Huang, F, Gertych, A, Gallick, GE, Mallick, J, Ryan, C, Galsky, MD, Lerner, SP, Posadas, EM & Sonpavde, G 2016, Urologic Oncology: Seminars and Original Investigations, vol 34, no. 1. DOI:

Diagnosis of "poorly formed glands" Gleason pattern 4 prostatic adenocarcinoma on needle biopsy: An interobserver reproducibility study among urologic pathologists with recommendations
Zhou, M, Li, J, Cheng, L, Egevad, L, Deng, FM, Kunju, LP, Magi-Galluzzi, C, Melamed, J, Mehra, R, Mendrinos, S, Osunkoya, AO, Paner, G, Shen, SS, Tsuzuki, T, Trpkov, K, Tian, W, Yang, X & Shah, RB 2015, American Journal of Surgical Pathology, vol 39, no. 10, pp. 1331-1339.

Diagnosis of gleason pattern 5 prostate adenocarcinoma on core needle biopsy: An interobserver reproducibility study among urologic pathologists
Shah, RB, Li, J, Cheng, L, Egevad, L, Deng, FM, Fine, SW, Kunju, LP, Melamed, J, Mehra, R, Osunkoya, AO, Paner, GP, Shen, SS, Tsuzuki, T, Trpkov, K, Tian, W, Yang, XJ & Zhou, M 2015, American Journal of Surgical Pathology, vol 39, no. 9, pp. 1242-1249.

Collagenous micronodules in prostate cancer revisited: Are they solely associated with Gleason pattern 3 adenocarcinomas?
Kim, MJ, Divatia, MK, Lee, JH, Shen, S, Miles, BJ, Hwang, JH, Ayala, AG & Ro, JY 2015, International Journal of Clinical and Experimental Pathology, vol 8, no. 4, pp. 3469-3476.

Principles of analytic validation of immunohistochemical assays: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center
Patrick, LF, Linda, AB, Lisa, AF, Alsabeh, R, Regan, SF, Jeffrey, DG, Thomas, SH, Karabakhtsian, RG, Patti, AL, Marolt, MJ, Steven, SS, Anthony, TS & Swanson, PE 2014, Archives of Pathology and Laboratory Medicine, vol 138, no. 11, pp. 1432-1443. DOI:

Seminal vesicle intraepithelial involvement by prostate cancer: putative mechanism and clinicopathological significance
Miyai, K, Kristiansen, A, Egevad, L, Pina-Oviedo, S, Divatia, MK, Shen, SS, Miles, BJ, Ayala, AG, Park, YW & Ro, JY 2014, Human Pathology. DOI:

Influence of histologic criteria and confounding factors in staging equivocal cases for microscopic perivesical tissue invasion (pT3a): An interobserver study among genitourinary pathologists
Ananthanarayanan, V, Pan, Y, Tretiakova, M, Amin, MB, Cheng, L, Epstein, JI, Grignon, DJ, Hansel, DE, Jimenez, RE, McKenney, JK, Montironi, R, Oliva, E, Osunkoya, AO, Rao, P, Reuter, VE, Ro, JY, Shen, SS, Srigley, JR, Tsuzuki, T, Yao, JL, Antic, T, Haber, M, Taxy, JB & Paner, GP 2014, American Journal of Surgical Pathology, vol 38, no. 2, pp. 167-175. DOI:

Intraoperative frozen section evaluation of ureteral and urethral margins: studies of 203 consecutive radical cystoprostatectomy for men with bladder urothelial carcinoma
Zhou, H, Ro, JY, Truong, LD, Ayala, AG & Shen, SS 2014, American Journal of Clinical and Experimental Urology, vol 2, no. 2, pp. 156-60.

Les tumeurs rénales: Recommandations de la conférence de consensus de I'International Society of Urologic Pathology (ISUP) 2012
Rioux-Leclercq, N, Ferran, A, Mahul, A, Argani, P, Billis, A, Bonsib, S, Cheng, L, Cheville, J, Eble, J, Egevad, L, Epstein, J, Grignon, D, Hes, O, Humphrey, P, Magi-Galluzzi, C, Martignoni, G, McKenney, J, Merino, M, Moch, H, Montironi, R, Netto, G, Reuter, V, Samaratunga, H, Shen, S, Srigley, J, Tamboli, P, Tan, PH, Tickoo, S, Trpkov, K, Zhou, M, Delahunt, B & Comperat, E 2014, Annales de Pathologie, vol 34, no. 6, pp. 448-461. DOI:

Intraductal carcinoma of the prostate: Interobserver reproducibility survey of 39 urologic pathologists
Iczkowski, KA, Egevad, L, Ma, J, Harding-Jackson, N, Algaba, F, Billis, A, Camparo, P, Cheng, L, Clouston, D, Comperat, EM, Datta, MW, Evans, AG, Griffiths, DF, Guo, CC, Hailemariam, S, Huang, W, Humphrey, PA, Jiang, Z, Kahane, H, Kristiansen, G, La Rosa, FG, Lopez-Beltran, A, MacLennan, GT, Magi-Galluzzi, C, Merrimen, J, Montironi, R, Osunkoya, AO, Picken, MM, Rao, N, Shah, RB, Shanks, JH, Shen, SS, Tawfik, OW, True, LD, Van Der Kwast, T, Varma, M, Wheeler, TM, Zynger, DL, Sahr, N & Bostwick, DG 2014, Annals of Diagnostic Pathology, vol 18, no. 6, pp. 333-342. DOI:

Haemangiomas in kidneys with end-stage renal disease: A novel clinicopathological association
Kryvenko, ON, Haley, SL, Smith, SC, Shen, SS, Paluru, S, Gupta, NS, Jorda, M, Epstein, JI, Amin, MB & Truong, LD 2014, Histopathology, vol 65, no. 3, pp. 309-318. DOI:

Renal tumors: The International Society of Urologic Pathology (ISUP) 2012 consensus conference recommendations
Rioux-Leclercq, N, Ferran, A, Mahul, A, Argani, P, Billis, A, Bonsib, S, Cheng, L, Cheville, J, Eble, J, Egevad, L, Epstein, J, Grignon, D, Hes, O, Humphrey, P, Magi-Galluzzi, C, Martignoni, G, McKenney, J, Merino, M, Moch, H, Montironi, R, Netto, G, Reuter, V, Samaratunga, H, Shen, S, Srigley, J, Tamboli, P, Tan, PH, Tickoo, S, Trpkov, K, Zhou, M, Delahunt, B & Comperat, E 2014, Annales de Pathologie. DOI:

Tuberous sclerosis-associated renal cell carcinoma: A clinicopathologic study of 57 separate carcinomas in 18 patients
Guo, J, Tretiakova, MS, Troxell, ML, Osunkoya, AO, Fadare, O, Sangoi, AR, Shen, SS, Lopez-Beltran, A, Mehra, R, Heider, A, Higgins, JP, Harik, LR, Leroy, X, Gill, AJ, Trpkov, K, Campbell, SC, Przybycin, C, Magi-Galluzzi, C & McKenney, JK 2014, American Journal of Surgical Pathology, vol 38, no. 11, pp. 1457-1467. DOI:

Heterogeneous clinicopathological features of intraductal carcinoma of the prostate: A comparison between 'precursor-like' and 'regular type' lesions
Miyai, K, Divatia, MK, Shen, SS, Miles, BJ, Ayala, AG & Ro, JY 2014, International Journal of Clinical and Experimental Pathology, vol 7, no. 5, pp. 2518-2526.

Clear cell papillary renal cell carcinoma is the fourth most common histologic type of renal cell carcinoma in 290 consecutive nephrectomies for renal cell carcinoma
Zhou, H, Zheng, S, Truong, LD, Ro, JY, Ayala, AG & Shen, SS 2014, Human Pathology, vol 45, no. 1, pp. 59-64. DOI:

Immunohistochemical evaluation of novel and traditional markers associated with urothelial differentiation in a spectrum of variants of urothelial carcinoma of the urinary bladder
Paner, GP, Annaiah, C, Gulmann, C, Rao, P, Ro, JY, Hansel, DE, Shen, SS, Lopez-Beltran, A, Aron, M, Luthringer, DJ, De Peralta-Venturina, M, Cho, Y & Amin, MB 2014, Human Pathology, vol 45, no. 7, pp. 1473-1482. DOI:

Renal sclerosing perivascular epithelioid cell tumor (PEComa)/angiomyolipoma with extensive rhabdoid cell features
Miyai, K, Mullick, SS, Divatia, MK, Shen, SS, Ayala, AG & Ro, JY 2014, Pathology International, vol 64, no. 5, pp. 247-250. DOI:

Clinicopathological analysis of intraductal proliferative lesions of prostate: Intraductal carcinoma of prostate, high-grade prostatic intraepithelial neoplasia, and atypical cribriform lesion
Miyai, K, Divatia, MK, Shen, SS, Miles, BJ, Ayala, AG & Ro, JY 2014, Human Pathology, vol 45, no. 8, pp. 1572-1581. DOI: