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Sankar Mitra, PhD

Professor of Radiation Oncology, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

Dr. Mitra had a brillient academic career at Calcutta University, India from which he received MS in Biochemitry in 1959.After earning a Ph.D. from the University of Wisconsin in 1964, Dr. Mitra did postdoctoral research in Arthur Kornberg’s laboratory at Stanford Medical School. He then returned to India to join Bose Institute, Calcutta, as an assistant professor in 1966, and became an associate professor in 1971. He came back to the U.S. in 1971 to join the Biology Division of Oak Ridge National Laboratory as a senior research investigator and subsequently became leader of the Nucleic Acid Enzymology Group. He also served as an adjunct professor of the University of Tennessee Graduate School of Biomedical Sciences. Dr. Mitra moved to the newly created Sealy Center for Molecular Science at the University of Texas Medical Branch (UTMB), Galveston, TX in 1992 as professor of Biochemistry & Molecular Biology, and later as senior scientist in the Sealy Center for Molecular Medicine. After his retirement from UTMB in 2013, he joined Houston Methodist Research Institute as a full member in Radiation Oncology. He was elected a fellow of AAAS in 1989 and as a fellow of the Japan Society for Promotion of Science, participating in lecture tours in Japan in 1991, 1999, and 2008.He was awarded Mark Brothers of Indiana Prize in 2009. Dr. Mitra has been continuously funded by NIH since 1982 and has been serving on various NIH and other  review panels.

Description of Research

Working in the broad area of genome damage, its repair, and its influence in carcinogenesis and cancer therapy, Dr. Mitra has made several seminal discoveries during his tenure at Oak Ridge National Laboratory, including the characterization of the E. coli repair protein for the mutagenic DNA base O-6 methylguanine produced by mutagens and anticancer alkylating agents, the naming of the repair protein MGMT, and the cloning of human MGMT. More recently, Dr. Mitra’s group characterized a new family of DNA repair proteins that they named NEILs for oxidative genome damage. The recent research focus of Dr. Mitra’s group is enhancement of chemo/radiation sensitivity of tumor cells using targeted DNA repair inhibitors. After the early studies on MGMT inhibition, his current research aims to identify inhibitors for repair pathways for oxidative/radiation damage.

Areas Of Expertise

Genome damage Repair Cancer mechanisms Cancer therapy
Education & Training

Postdoctoral Fellowship , Stanford University Medical School
Research Doctorate , Department of Biochemistry University of Wisconsin Madison 6
MS , University of Calcutta
Research Fellowship , Department of Biochemistry, University of Calcutta
University Fellow , Department of Biochemistry, University of Wisconsin, Madison,WI
PhD , University of Wisconsin-Madison
Publications

Chromatin-Bound Oxidized a-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease
Vasquez, V, Mitra, J, Hegde, PM, Pandey, A, Sengupta, S, Mitra, S, Rao, SK & Hegde, ML 2017, Journal of Alzheimers Disease, vol 60, no. s1, pp. S133-S150. DOI: 10.3233/JAD-170342

Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase
Rangaswamy, S, Pandey, A, Mitra, S & Hegde, ML 2017, Genes, vol 8, no. 7. DOI: 10.3390/genes8070175

Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis
Wang, H, Peng, B, Pandita, RK, Engler, DA, Matsunami, RK, Xu, X, Hegde, PM, Butler, EB, Pandita, TK, Mitra, S, Xu, B & Hegde, ML 2017, Oncotarget, vol 8, no. 30, pp. 48671-48687. DOI: 10.18632/oncotarget.16225

DNA damage responses in central nervous system and age-associated neurodegeneration
Hegde, ML, Bohr, VA & Mitra, S 2017, Mechanisms of Ageing and Development, vol 161, pp. 1-3. DOI: 10.1016/j.mad.2017.01.010

Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis
Wang, H, Peng, B, Pandita, RK, Engler, DA, Matsunami, RK, Xu, X, Hegde, PM, Butler, BE, Pandita, TK, Mitra, S, Xu, B & Hegde, ML 2017, Oncotarget, vol 8, no. 30, pp. 48671-48687. DOI: 10.18632/oncotarget.16225

Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex
Dutta, A, Eckelmann, B, Adhikari, S, Ahmed, KM, Sengupta, S, Pandey, A, Hegde, PM, Tsai, M-S, Tainer, JA, Weinfeld, M, Hegde, ML & Mitra, S 2016, Nucleic acids research, vol 45, no. 5, pp. 2585-2599. DOI: 10.1093/nar/gkw1262

Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A
Yang, C , Sengupta, S, Hegde, PM, Mitra, J, Jiang, S, Holey, B, Sarker, AH, Tsai, M-S, Hegde, ML & Mitra, S 2016, Nucleic acids research, vol 45, no. 2, pp. 739-748. DOI: 10.1093/nar/gkw1024

Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing
Kont, YS, Dutta, A, Mallisetty, A, Mathew, J, Minas, T, Kraus, C, Dhopeshwarkar, P, Kallakury, B, Mitra, S, Üren, A & Adhikari, S 2016, DNA Repair, vol 43, pp. 38-47. DOI: 10.1016/j.dnarep.2016.04.009

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
Hegde, ML, Dutta, A, Yang, C, Mantha, AK, Hegde, PM, Pandey, A, Sengupta, S, Yu, Y, Calsou, P, Chen, D, Lees-Miller, SP & Mitra, S 2016, Oncotarget. DOI: 10.18632/oncotarget.9914

Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?
Wang, H, Dharmalingam, P, Vasquez, V, Mitra, J, Boldogh, I, Rao, KS, Kent, TA, Mitra, S & Hegde, ML 2016, Mechanisms of Ageing and Development. DOI: 10.1016/j.mad.2016.09.005

8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging
German, P, Saenz, D, Szaniszlo, P, Aguilera-Aguirre, L, Pan, L, Hegde, ML, Bacsi, A, Hajas, G, Radak, Z, Ba, X, Mitra, S, Papaconstantinou, J & Boldogh, I 2016, Mechanisms of Ageing and Development. DOI: 10.1016/j.mad.2016.06.009

Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice
Sanchez, JR, Reddick, TL, Perez, M, Centonze, VE, Mitra, S, Izumi, T, McMahan, CA & Walter, CA 2015, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol 779, pp. 124-133. DOI: 10.1016/j.mrfmmm.2015.06.008

The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: Dominant negative function of the CTD
Hegde, PM, Dutta, A, Sengupta, S, Mitra, J, Adhikari, S, Tomkinson, AE, Li, GM, Boldogh, I, Hazra, TK, Mitra, S & Hegde, ML 2015, Journal of Biological Chemistry, vol 290, no. 34, pp. 20919-20933. DOI: 10.1074/jbc.M115.642918

Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells
Patel, PR, Hegde, ML, Theruvathu, J, Mitra, SA, Boldogh, I & Sowers, L 2015, Journal of Bioanalysis & Biomedicine, vol 7, no. 3, pp. 75-80. DOI: 10.4172/1948-593X.1000127

New paradigms in the repair of oxidative damage in human genome: Mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins
Dutta, A, Yang, C, Sengupta, S, Mitra, S & Hegde, ML 2015, Cellular and Molecular Life Sciences, vol 72, no. 9, pp. 1679-1698. DOI: 10.1007/s00018-014-1820-z

Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential
Mitra, J, Vasquez, V, Hegde, PM, Boldogh, I, Mitra, S, Kent, TA, Rao, KS & Hegde, ML 2015, Neurological Research and Therapy, vol 1, no. 2. DOI: 10.14437/NRTOA-1-107

A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells
Wang, H, Adhikari, S, Butler, EB, Pandita, TK, Mitra, S & Hegde, ML 2015, Jacobs Journal of Radiation Oncology, vol 1, no. 1:003..

Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: Implications for the regulation of mitochondrial function
Szczesny, B, Brunyanszki, A, Olah, G, Mitra, S & Szabo, C 2014, Nucleic Acids Research, vol 42, no. 21, pp. 13161-13173. DOI: 10.1093/nar/gku1089

New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases
Mitra, J, Guerrero, EN, Hegde, PM, Wang, H, Boldogh, I, Rao, KSH, Mitra, S & Hegde, ML 2014, Biomolecules, vol 4, no. 3, pp. 678-703. DOI: 10.3390/biom4030678

Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-?B pathway
Aguilera-Aguirre, L, Bacsi, A, Radak, Z, Hazra, TK, Mitra, S, Sur, S, Brasier, AR, Ba, X & Boldogh, I 2014, Journal of Immunology, vol 193, no. 9, pp. 4643-4653. DOI: 10.4049/jimmunol.1401625