Patricia Chévez-Barrios, MD

Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Full Clinical Member, Research Institute
Program Director, Ophthalmic Pathology Residency, Department of Pathology & Genomic Medicine
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

After finishing all seven of her postdoctoral training programs, Dr. Chévez-Barrios joined the faculty of the Baylor College of Medicine in 1996 as an Assistant Professor in the Department of Pathology, with a secondary appointment in the Department of Ophthalmology. She became a Clinical Assistant Professor in the Department of Ophthalmology there in 2004, and received the Fulbright & Jaworski LLP Award for Faculty Excellence in Teaching and Evaluation and became Associate Member of the Cell and Gene Therapy Center that same year. She has current appointments of adjunct professor in the Department of Pathology at The University of Texas MD Anderson Cancer Center and Department of Ophthalmology at the Baylor College of Medicine. Dr. Chévez- Barrios assumed her current positions at Methodist in 2004.

Description of Research

The main research interest of Dr. Chévez-Barrios and her laboratory is the study of retinoblastoma, including cancer stem cells, suicide gene therapy for retinoblastoma, the study of metastatic properties of retinoblastoma and preclinical models of the tumor. Other topics of interest are ocular gene therapy, cataractogenesis, vascular proliferation in hypoxic ocular diseases and corneal diseases. Dr. Chevez-Barrios’ laboratory is currently participating in the project of gene therapy for Retinoblastomas in collaboration with the Texas Children’s Cancer Center and the Center for Gene Therapy of Texas Children's Hospital, and Baylor College of Medicine. Pre-clinical studies and a phase 1 clinical trial of vitreous seed of retinoblastoma have been completed. The phase II clinical trial is in preparation. Dr. Chevez-Barrios is a committee member responsible of evaluating all enucleated eyes from the prospective multicenter study of the ARET0332 Children’s Oncology Group protocol on “A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy. Dr. Chevez-Barrios is also interested in the biological differences between retinoblastoma cell lines that have the capability of producing metastasis, and those that behave less aggressively and remain as intraocular tumors.

Areas Of Expertise

Retinoblastoma Metastasis Gene therapy Neovascularization
Education & Training

Residency , Baylor College of Medicine
Clinical Fellowship , Baylor College of Medicine
MD , Universidad Nacional Autonoma
Publications

Nothing to Spit At
Hashemi, N, Billah, S, Conderman, CP, Alava, I, Supsupin, EP, Chevez-Barrios, P & Adesina, OOO 2017, Journal of Neuro-Ophthalmology. DOI:

Histopathologic Analysis of Transvitreal Fine Needle Aspiration Biopsy Needle Tracts for Uveal Melanoma
Kim, RS, Chevez-Barrios, P, Bretana, ME, Wong, TP, Teh, BS & Schefler, AC 2017, American Journal of Ophthalmology, vol 174, pp. 9-16. DOI:

Vitreous Seeds in Retinoblastoma. Clinicopathologic Classification and Correlation
Amram, AL, Rico, G, Kim, JW, Chintagumpala, M, Herzog, CE, Gombos, DS & Chévez-Barrios, P 2017, Ophthalmology. DOI:

Early outcomes of uveal melanoma treated with intraoperative ultrasound guided brachytherapy using custom built plaques
Tann, AW, Teh, BS, Scarboro, SB, Lewis, GD, Bretana, ME, Croft, PC, Raizen, Y, Butler, EB, Kim, RS, Chevez-Barrios, P & Schefler, AC 2017, Practical Radiation Oncology. DOI:

RecutClub.com: An Open Source, Whole Slide Image-based Pathology Education System
Christensen, PA, Lee, NE, Thrall, MJ, Powell, SZ, Chevez-Barrios, P & Long, SW 2017, Journal of Pathology Informatics, vol 8, no. 10, pp. 10. DOI:

Microsporidial Stromal Keratitis: Successful Treatment with Topical Voriconazole and Oral Itraconazole
Coca, M, Kim, J, Shenoy, S, Chévez-Barrios, P & Kapur, M 2016, Cureus, vol 8, no. 12, pp. e934. DOI:

Orbital metastasis mimicking internuclear ophthalmoplegia: A case report and review
Lin, WV, Chévez-Barrios, P, Sadaka, A & Lee, AG 2016, Canadian Journal of Ophthalmology. DOI:

Necrotizing Fasciitis of the Periorbital Region Complicated by Combined Central Retinal Artery Occlusion, Central Retinal Vein Occlusion, and Posterior Ciliary Occlusion
Sultan, H, Malik, A, Li, HK, Chévez-Barrios, P & Lee, AG 2016, Ophthalmic Plastic and Reconstructive Surgery. DOI:

Late Presentation of Retinoblastoma in a Teen with Aicardi Syndrome
Akinfenwa, PY, Chévez-Barrios, P, Harper, CA & Gombos, DS 2016, Ocular Oncology and Pathology, vol 2, no. 3, pp. 181-4. DOI:

Anterior chamber cholesterolosis in a patient with retinoblastoma
Hong, BK, Say, EAT, Chévez-Barrios, P, Lee, TC & Kim, JW 2016, Digital journal of ophthalmology : DJO, vol 22, no. 1, pp. 35-37. DOI:

Acute and late toxicity of bilateral orbital irradiation in the management of primary intraocular lymphoma
Milgrom, SA, Cheah, CY, Pinnix, CC, Smith, GL, Dabaja, BS, Horace, P, Chevez-Barrios, P, Fowler, NH & Gombos, DS 2016, Leukemia and Lymphoma, pp. 1-7. DOI:

Idiopathic Orbital Inflammation Associated with Relapsing Polychondritis
Mariani, AF, Malik, AI, Chevez-Barrios, P, Smith, SV & Lee, AG 2016, Ophthalmic Plastic and Reconstructive Surgery. DOI:

Apical orbital aspergillosis complicating giant cell arteritis
Zhou, Y, Morgan, ML, Almarzouqi, SJ, Chevez-Barrios, P & Lee, AG 2016, Journal of Neuro-Ophthalmology, vol 36, no. 2, pp. 159-163. DOI:

Correlation of Insurance, Race, and Ethnicity with Pathologic Risk in a Controlled Retinoblastoma Cohort. A Children's Oncology Group Study
Green, AL, Chintagumpala, M, Krailo, M, Langholz, B, Albert, D, Eagle, R, Cockburn, M, Chevez-Barrios, P & Rodriguez-Galindo, C 2015, Ophthalmology. DOI:

Expression of angiogenic factors in invasive retinoblastoma tumors is associated with increase in tumor cells expressing stem cell marker sox2
Garcia, JR, Gombos, DS, Prospero, CM, Ganapathy, A, Penland, RL & Chévez-Barrios, P 2015, Archives of Pathology and Laboratory Medicine, vol 139, no. 12, pp. 1531-1538. DOI:

Levamisole-induced vasculitis: A characteristic cutaneous vasculitis associated with levamisole-adulterated cocaine
Roberts, JA & Chevez-Barrios, P 2015, Archives of Pathology and Laboratory Medicine, vol 139, no. 8, pp. 1058-1061. DOI:

Transarterial Onyx Embolization of an Orbital Solitary Fibrous Tumor
Hashemi, N, Ling, JD, Soparkar, C, Sami, M, Ellezam, B, Klucznik, R, Lee, AG & Chévez-Barrios, P 2015, Ocular Oncology and Pathology, vol 1, no. 2, pp. 98-102. DOI:

Neuro-ophthalmologic features of chordoid glioma
Al-Zubidi, N, McGlynn, MM, Chévez-Barrios, P, Yalamanchili, S & Lee, AG 2014, Journal of Neuro-Ophthalmology, vol 34, no. 1, pp. 47-49. DOI:

Survival outcomes of primary intraocular lymphoma: A single-institution experience
Kim, MM, Dabaja, BS, Medeiros, J, Kim, S, Allen, P, Chevez-Barrios, P, Gombos, DS & Fowler, N 2014, American Journal of Clinical Oncology: Cancer Clinical Trials. DOI:

Varicella-zoster virus detection in varicella-associated stromal keratitis
Matoba, AY, Meghpara, B & Chevez-Barrios, P 2014, JAMA ophthalmology, vol 132, no. 4, pp. 505-506. DOI: