Neal Kleiman, MD

Professor of Cardiology, Institute for Academic Medicine
Full Clinical Member, Research Institute
Program Director, Interventional Cardiology Residency, Department of Cardiology
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

Dr. Neal S. Kleiman is the medical director of the cardiac catheterization laboratories at the Houston Methodist DeBakey Heart & Vascular Center at Houston Methodist Hospital and a professor at Weill Cornell Medical College. He has special interests in angioplasty, stenting, coronary artery diseases and interventional cardiology.

His research lies in the relationship between angioplasty, stenting and clotting. His laboratory, recognized nationally as a select site for platelet research, examines the effects of antiplatelet therapy, the use of medications to prevent platelets from clumping and blood from clotting in patients with coronary artery disease who undergo angioplasty procedures. Kleiman has been the principal investigator and/or collaborating investigator in more than 100 studies and multi-center trials related to arterial thrombosis, the formation of blood clots in the arteries, clotting and angioplasty, which have altered the management of patients with chest pain undergoing catheterization.

After receiving his medical degree from Columbia University in New York, Kleiman completed an internship and residency in internal medicine at Baylor College of Medicine, as well as a fellowship in cardiology.

Kleiman has published over 150 manuscripts, book chapters and abstracts. His work has appeared in such publications as the Journal of the American College of Cardiology, Annals of Thoracic Surgery, Journal of Cardiovascular Pharmacology, Circulation, The American College of Cardiology and The European Heart Journal. He is on the editorial board of The Journal of Interventional Cardiology, Circulation, The American Heart Journal and The Journal of Thrombosis and Thrombolysis.

Kleiman is a member of numerous professional organizations including The American Heart Association Council on Clinical Cardiology and Council on Thrombosis, and he is a fellow of The American College of Cardiology and the Society for Coronary Angiography and Interventions.

Description of Research

Dr. Kleiman’s research effort since joining the faculty at Baylor College of Medicine and subsequently at the Houston Methodist DeBakey Heart and Vascular Center has been focused on acute coronary syndromes and coronary interventions. The bulk of this effort has been in the design, management, and execution phases of clinical trials in these two fields, on both the single center (at Houston Methodist Hospital and Ben Taub General Hospital) and multicenter levels. As part of this effort, he has dedicated considerable time to serving on the steering committees of several dozen multicenter trials. Dr. Kleiman established the Applied Platelet Physiology Laboratory at Baylor, now at the Houston Methodist DeBakey Heart and Vascular Center. Work in that laboratory has centered on two areas: providing supporting work in a large number of clinical trials that were complemented by nested mechanistic and pathophysiologic studies, and carrying out independent physiologic studies examining such issues as aspirin dosing, platelet activation during coronary interventions, individual responses to the activity of thienopyridines, and the relation of platelet turnover and COX-2 expression to aspirin sensitivity. The laboratory has also collaborated with other laboratories in the Texas Medical Center including Rice University’s Department of Bioengineering, Baylor’s Leukocyte Biology Laboratory, and most recently, the Molecular Genetics of Cardiovascular Diseases laboratory at Baylor and the stem cell group at MD Anderson Cancer Center. These collaborations have allowed the laboratory to expand its foci to include such investigations as the effects of P2Y12 inhibition and GP IIb/IIIa ligation on leukocyte rolling, leukocyte activation following GP IIb/IIIa administration, the role of platelet P-selectin on leukocyte membrane changes, and most recently the relation circulating endothelial precursor cells and coronary collateral vessels in patients with acute coronary syndromes.

Areas Of Expertise

Acute coronary syndromes Coronary intervention
Education & Training

Clinical Fellowship , Baylor College of Medicine
Residency , Baylor College of Medicine
MD , Columbia University College of Surgeons and Physicians
Publications

Platelet pathophysiology, pharmacology, and function in coronary artery disease
Ibrahim, H & Kleiman, NS 2017, Coronary Artery Disease. DOI: 10.1097/MCA.0000000000000519

Transcatheter Aortic Valve Replacement for Perceval Sutureless Aortic Valve Failure
Kalra, A, Reyes, M, Yang, EY, Little, SH, Nabi, F, Barker, CM, Ramchandani, M, Reul, RM, Reardon, MJ & Kleiman, NS 2017, Journal of Invasive Cardiology, vol 29, no. 6, pp. E65-E66.

At Arm's Length: Radiation Safety During Radial Percutaneous Coronary Intervention
Kleiman, NS & Kleiman, NJ 2017, Journal of the American College of Cardiology, vol 69, no. 20, pp. 2538-2541. DOI: 10.1016/j.jacc.2017.03.016

1-Year Results in Patients Undergoing Transcatheter Aortic Valve Replacement With Failed Surgical Bioprostheses
Deeb, GM, Chetcuti, SJ, Reardon, MJ, Patel, HJ, Grossman, PM, Schreiber, T, Forrest, JK, Bajwa, TK, OHair, DP, Petrossian, G, Robinson, N, Katz, S, Hartman, A, Dauerman, HL, Schmoker, J, Khabbaz, K, Watson, DR, Yakubov, SJ, Oh, JK, Li, S, Kleiman, NS, Adams, DH & Popma, JJ 2017, JACC: Cardiovascular Interventions, vol 10, no. 10, pp. 1034-1044. DOI: 10.1016/j.jcin.2017.03.018

Bioresorbable scaffold: The emerging reality and future directions
Sotomi, Y, Onuma, Y, Collet, C, Tenekecioglu, E, Virmani, R, Kleiman, NS & Serruys, PW 2017, Circulation Research, vol 120, no. 8, pp. 1341-1352. DOI: 10.1161/CIRCRESAHA.117.310275

Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients
Reardon, MJ, Van Mieghem, NM, Popma, JJ, Kleiman, NS, Søndergaard, L, Mumtaz, M, Adams, DH, Deeb, GM, Maini, B, Gada, H, Chetcuti, SJ, Gleason, TG, Heiser, J, Lange, R, Merhi, W, Oh, JK, Olsen, PS, Piazza, N, Williams, M, Windecker, S, Yakubov, SJ, Grube, E, Makkar, RR, Lee, JS, Conte, J, Vang, E, Nguyen, H, Chang, Y, Mugglin, AS, Serruys, PWJC, Kappetein, AP & SURTAVI Investigators 2017, The New England journal of medicine, vol 376, no. 14, pp. 1321-1331. DOI: 10.1056/NEJMoa1700456

New-Generation Coronary Stents: Current Data and Future Directions
Kalra, A, Rehman, H, Khera, S, Thyagarajan, B, Bhatt, DL, Kleiman, NS & Yeh, RW 2017, Current Atherosclerosis Reports, vol 19, no. 3, 14. DOI: 10.1007/s11883-017-0654-1

A 24-Month Interventional Cardiology Fellowship: Learning Motor Skills Through Blocked Repetition
Kalra, A, Bhatt, DL & Kleiman, NS 2017, JACC: Cardiovascular Interventions, vol 10, no. 2, pp. 210-211. DOI: 10.1016/j.jcin.2016.11.017

Early Trifecta valve failure: Report of a cluster of cases from a tertiary care referral center
Kalra, A, Rehman, H, Ramchandani, M, Barker, CM, Lawrie, GM, Reul, RM, Reardon, MJ & Kleiman, NS 2017, Journal of Thoracic and Cardiovascular Surgery. DOI: 10.1016/j.jtcvs.2017.05.044

Optimizing Management of Patients With Atrial Fibrillation Following Transcatheter Aortic Valve Replacement: The Importance of Distinguishing Pre-Existing From New Onset Atrial Fibrillation
Kalra, A, Reardon, MJ & Kleiman, NS 2017, JACC: Cardiovascular Interventions, vol 10, no. 1, pp. 101-103. DOI: 10.1016/j.jcin.2016.10.039

One-Year Outcomes of Transcatheter Aortic Valve Replacement in Patients With End-Stage Renal Disease
OHair, DP, Bajwa, TK, Chetcuti, SJ, Deeb, GM, Stoler, RC, Hebeler, RF, Maini, B, Mumtaz, M, Kleiman, NS, Reardon, MJ, Li, S, Adams, DH, Watson, DR, Yakubov, SJ, Popma, JJ & Petrossian, G 2017, Annals of Thoracic Surgery. DOI: 10.1016/j.athoracsur.2016.11.061

Structural Heart Interventional Training: The Next Steps
Kalra, A, Kleiman, NS & Bhatt, DL 2016, JACC: Cardiovascular Interventions, vol 9, no. 24, pp. 2581-2582. DOI: 10.1016/j.jcin.2016.10.006

Combining clinical and angiographic variables for estimating risk of target lesion revascularization after drug eluting stent placement
Stolker, JM, Cohen, DJ, Kennedy, KF, Pencina, MJ, Arnold, SV, Kleiman, NS & Spertus, JA 2016, Cardiovascular Revascularization Medicine. DOI: 10.1016/j.carrev.2016.12.014

Neurological Events Following Transcatheter Aortic Valve Replacement and Their Predictors: A Report from the CoreValve Trials
Kleiman, NS, Maini, BJ, Reardon, MJ, Conte, J, Katz, S, Rajagopal, V, Kauten, J, Hartman, A, McKay, R, Hagberg, R, Huang, J & Popma, J 2016, Circulation: Cardiovascular Interventions, vol 9, no. 9, e003551. DOI: 10.1161/CIRCINTERVENTIONS.115.003551

The Last Detail: Platelets, Glycoprotein IIb/IIIa Antagonists, and Excipients*
Kleiman, NS 2016, JACC: Cardiovascular Interventions, vol 9, no. 16, pp. 1677-1679. DOI: 10.1016/j.jcin.2016.07.009

Outcomes in the Randomized CoreValve US Pivotal High-risk Trial in Patients With a Society of Thoracic Surgeons Risk Score of 7% or Less
Reardon, MJ , Kleiman, NS, Adams, DH, Yakubov, SJ, Coselli, JS, Deeb, GM, OHair, D, Gleason, TG, Lee, JS, Hermiller, JB, Chetcuti, S, Heiser, J, Merhi, W, Zorn, GL, Tadros, P, Robinson, N, Petrossian, G, Hughes, GC, Harrison, JK, Maini, B, Mumtaz, M, Conte, JV, Resar, JR, Aharonian, V, Pfeffer, T, Oh, JK, Huang, J & Popma, JJ 2016, JAMA Cardiology. DOI: 10.1001/jamacardio.2016.2257

Transcatheter Aortic Valve Replacement Versus Surgery in Women at High Risk for Surgical Aortic Valve Replacement (from the CoreValve US High Risk Pivotal Trial)
Skelding, KA, Yakubov, SJ, Kleiman, NS, Reardon, MJ, Adams, DH, Huang, J, Forrest, JK & Popma, JJ 2016, American Journal of Cardiology, vol 118, no. 4, pp. 560-566. DOI: 10.1016/j.amjcard.2016.05.051

Highway to the heart or one more for the road?: The continued life of direct aortic access for transcatheter aortic valve replacement
Reardon, MJ & Kleiman, NS 2016, Journal of Thoracic and Cardiovascular Surgery. DOI: 10.1016/j.jtcvs.2016.07.038

Are Immature Platelets Growing Up?: Toward a New Marker of Antiplatelet Drug Resistance
Kleiman, NS 2016, Journal of the American College of Cardiology, vol 68, no. 3, pp. 294-296. DOI: 10.1016/j.jacc.2016.04.055

Vascular complication can be minimized with a balloon-expandable, re-collapsible sheath in TAVR with a self-expanding bioprosthesis
Abu Saleh, WK, Tang, GHL, Ahmad, H, Cohen, M, Undemir, C, Lansman, SL, Reyes, M, Barker, CM, Kleiman, NS, Reardon, MJ & Ramlawi, B 2016, Catheterization and Cardiovascular Interventions, vol 88, no. 1, pp. 135-143. DOI: 10.1002/ccd.26336