Not found

Muralidhar Hegde, PhD

Assistant Professor of Radiation Oncology, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Hegde Lab

Dr. Hegde earned his Ph.D. in Biochemistry and Neurosciences from the University of Mysore, India in 2006. He performed his graduate research at the Max-Planck Institute of Biophysical Chemistry, Gottingen, Germany as a DST-DAAD visiting fellow, and at the Indian Institute of Science (IISc), Bangalore, India. He held an Assistant Professor appointment at the University of Texas Medical Branch at Galveston, Texas, USA before becoming a member of the Houston Methodist Research Institute in 2013. As a member of the Research Institute cancer and neuroscience research programs, he directs a research program focusing on understanding the role of genome damage repair in cell death (neurodegenerative diseases) and cell proliferation (cancer) and its potential exploitation in therapeutics. Dr. Hegde has also been a member of grant review boards for the Alzheimer’s Association, USA, Netherlands Organization for Scientific Research, French Scientific Grants (FMRM) and the Motor Neuron Disease Association, UK. He is an Associate Editor for the Journal of Alzheimer’s Disease and serves on the editorial boards of the American Journal of Neurodegenerative Diseases, Jacobs Journal of Radiation Oncology and Research, Journal Neuroscience Research and Therapeutics, the Chinese Journal of Biology, and a peer-reviewer for more than 30 international journals.

Dr. Hegde has published over 50 peer-reviewed publications including more than a dozen as senior author. He has also published five book chapters and fundamental review articles which have received nearly 1500 citations. He has received several awards including gold medals in Masters, New Investigator awards from the Alzheimer’s Association, the Environmental Mutagenesis Society, Researcher of the Month (May 2011) at UTMB and prestigious Gopal Krishna Memorial Young Scientist award from ASIOA. He has recently been awarded the Career Cornerstone award from Houston Methodist for outstanding contribution to translational research.

Description of Research

Dr. Hegde’s research program focuses on delineating the molecular mechanisms underlying neurodegenerative diseases with a primary emphasis on genome damage and their repair inhibitions/deficiencies in neurons. His laboratory is interested in Amyotrophic Lateral Sclerosis (ALS), Parkinson’s Disease (PD) and Stroke. He showed that DNA repair inhibitions/deficiencies play a key role in the etiology of neurodegenerative diseases. He demonstrated that transition metals, iron and copper, act as a ‘double whammy’ by both inducing DNA damage and by inhibiting their repair via direct binding and oxidation of NEIL enzymes involved in oxidized DNA base repair. These studies were funded by American Parkinson’s Disease Association. His current studies focus on characterizing the role of ALS-linked RNA binding protein TDP-43 in DNA double-strand break repair and testing the hypothesis that TDP-43’s nuclear clearance and aggregation in ALS (and other neurodegenerative diseases) cause deficient DNA double-strand repair and contributes significantly to cell death. In another project funded by Alzheimer’s Association’s New Investigator grant, he is delineating the mechanism of genotoxicity of amyloid proteins and exploring its prevention by natural compounds. In collaboration with Dr. Sankar Mitra, he is also exploring the potential of genome repair inhibitions in cancer therapeutics. Dr. Hegde’s research program is supported by NIH/NINDS R01, Muscular Dystrophy Association, ALS Association, Alzheimer’s Association and Melo Foundation.

Areas Of Expertise

Genome damage response DNA repair Neurodegenerative diseases Alzheimer’s disease Parkinson’s disease Amyotrophic Lateral Sclerosis (ALS Stroke
Education & Training

, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston
, Karnataka University
, University of Mysore, Karnataka

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
Hegde, ML, Dutta, A, Yang, C, Mantha, AK, Hegde, PM, Pandey, A, Sengupta, S, Yu, Y, Calsou, P, Chen, D, Lees-Miller, SP & Mitra, S 2016, Oncotarget. DOI:

8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging
German, P, Saenz, D, Szaniszlo, P, Aguilera-Aguirre, L, Pan, L, Hegde, ML, Bacsi, A, Hajas, G, Radak, Z, Ba, X, Mitra, S, Papaconstantinou, J & Boldogh, I 2016, Mechanisms of Ageing and Development. DOI:

Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling
Aguilera-Aguirre, L, Hosoki, K, Bacsi, A, Radák, Z, Sur, S, Hegde, ML, Tian, B, Saavedra-Molina, A, Brasier, AR, Ba, X & Boldogh, I 2015, Free Radical Biology and Medicine, vol 89, pp. 20-33. DOI:

The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: Dominant negative function of the CTD
Hegde, PM, Dutta, A, Sengupta, S, Mitra, J, Adhikari, S, Tomkinson, AE, Li, GM, Boldogh, I, Hazra, TK, Mitra, S & Hegde, ML 2015, Journal of Biological Chemistry, vol 290, no. 34, pp. 20919-20933. DOI:

Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells
Patel, PR, Hegde, ML, Theruvathu, J, Mitra, SA, Boldogh, I & Sowers, L 2015, Journal of Bioanalysis & Biomedicine, vol 7, no. 3, pp. 75-80. DOI:

New paradigms in the repair of oxidative damage in human genome: Mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins
Dutta, A, Yang, C, Sengupta, S, Mitra, S & Hegde, ML 2015, Cellular and Molecular Life Sciences, vol 72, no. 9, pp. 1679-1698. DOI:

Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential
Mitra, J, Vasquez, V, Hegde, PM, Boldogh, I, Mitra, S, Kent, TA, Rao, KS & Hegde, ML 2015, Neurological Research and Therapy, vol 1, no. 2. DOI:

A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells
Wang, H, Adhikari, S, Butler, EB, Pandita, TK, Mitra, S & Hegde, ML 2015, Jacobs Journal of Radiation Oncology, vol 1, no. 1:003..

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis
Chatterjee, A, Saha, S, Chakraborty, A, Silva-Fernandes, A, Mandal, SM, Neves-Carvalho, A, Liu, Y, Pandita, RK, Hegde, ML, Hegde, PM, Boldogh, I, Ashizawa, T, Koeppen, AH, Pandita, TK, Maciel, P, Sarkar, PS & Hazra, TK 2015, PLoS Genetics, vol 11, no. 1, e1004749. DOI:

The role of 8-oxoguanine DNA glycosylase-1 in inflammation
Ba, X, Aguilera-Aguirre, L, Rashid, QTAN, Bacsi, A, Radak, Z, Sur, S, Hosoki, K, Hegde, ML & Boldogh, I 2014, International Journal of Molecular Sciences, vol 15, no. 9, pp. 16975-16997. DOI:

MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice
Gupta, A, Hunt, CR, Hegde, ML, Chakraborty, S, Udayakumar, D, Horikoshi, N, Singh, M, Ramnarain, DB, Hittelman, WN, Namjoshi, S, Asaithamby, A, Hazra, TK, Ludwig, T, Pandita, RK, Tyler, JK & Pandita, TK 2014, Cell Reports, vol 8, no. 1. DOI:

MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice
Gupta, A, Hunt, CR, Hegde, ML, Chakraborty, S, Udayakumar, D, Horikoshi, N, Singh, M, Ramnarain, DB, Hittelman, WN, Namjoshi, S, Asaithamby, A, Hazra, TK, Ludwig, T, Pandita, RK, Tyler, JK & Pandita, TK 2014, Cell Reports, vol 8, no. 1, pp. 177-189. DOI:

New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases
Mitra, J, Guerrero, EN, Hegde, PM, Wang, H, Boldogh, I, Rao, KSH, Mitra, S & Hegde, ML 2014, Biomolecules, vol 4, no. 3, pp. 678-703. DOI:

8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and a-smooth muscle actin polymerization
Luo, J, Hosoki, K, Bacsi, A, Radak, Z, Hegde, ML, Sur, S, Hazra, TK, Brasier, AR, Ba, X & Boldogh, I 2014, Free Radical Biology and Medicine, vol 73, pp. 430-438. DOI:

Identification and characterization of a basic thaumatin-like protein (TLP 2) as an allergen in sapodilla plum (Manilkara zapota)
Hegde, VL, Ashok Kumar, HG, Sreenath, K, Hegde, ML & Venkatesh, YP 2014, Molecular Nutrition and Food Research, vol 58, no. 4, pp. 894-902. DOI:

Molecular characterization of neuroprotective activities of plant based products could revive their utilization and lead discovery of new drug candidates for brain diseases
Hegde, ML 2014, Journal of Pharmacy and Bioallied Sciences, vol 6, no. 2, pp. 63-64.

Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair
German, P, Szaniszlo, P, Hajas, G, Radak, Z, Bacsi, A, Hazra, TK, Hegde, ML, Ba, X & Boldogh, I 2013, DNA Repair, vol 12, no. 10, pp. 856-863. DOI:

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins
Hegde, ML, Hegde, PM, Bellot, LJ, Mandal, SM, Hazra, TK, Li, GM, Boldogh, I, Tomkinson, AE & Mitra, S 2013, Proceedings of the National Academy of Sciences of the United States of America, vol 110, no. 33. DOI:

The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions
Hegde, ML, Tsutakawa, SE, Hegde, PM, Holthauzen, LMF, Li, J, Oezguen, N, Hilser, VJ, Tainer, JA & Mitra, S 2013, Journal of Molecular Biology, vol 425, no. 13, pp. 2359-2371. DOI:

8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1
Hajas, G, Bacsi, A, Aguilera-Aguirre, L, Hegde, ML, Tapas, KH, Sur, S, Radak, Z, Ba, X & Boldogh, I 2013, Free Radical Biology and Medicine, vol 61, pp. 384-394. DOI: