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Muralidhar Hegde,

Houston Methodist
Weill Cornell Medical College


Areas Of Expertise

Genome damage response DNA repair Neurodegenerative diseases Alzheimer’s disease Parkinson’s disease Amyotrophic Lateral Sclerosis (ALS Stroke
Publications

Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A
Yang, C , Sengupta, S, Hegde, PM, Mitra, J, Jiang, S, Holey, B, Sarker, AH, Tsai, M-S, Hegde, ML & Mitra, S 2016, Nucleic acids research. DOI:

Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase1-Mediated Epigenetic Regulation of Nuclear Factor kappaB-Driven Gene Expression
Pan, L, Zhu, B, Hao, W, Zeng, X, Vlahopoulos, SA, Hazra, TK, Hegde, ML, Radak, Z, Bacsi, A, Brasier, AR, Ba, X & Boldogh, I 2016, The Journal of biological chemistry. DOI:

TDP-43/FUS in motor neuron disease: Complexity and challenges
Guerrero, EN, Wang, H, Mitra, J, Hegde, PM, Stowell, SE, Liachko, NF, Kraemer, BC, Garruto, RM, Rao, KS & Hegde, ML 2016, Progress in Neurobiology, vol 145-146, pp. 78-97. DOI:

TDP-43/FUS in motor neuron disease: Complexity and challenges
Guerrero, EN, Wang, H, Mitra, J, Hegde, PM, Stowell, SE, Liachko, NF, Kraemer, BC, Garruto, RM, Rao, KS & Hegde, ML 2016, Progress in Neurobiology, vol 145-146, pp. 78-97. DOI:

Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?
Wang, H, Dharmalingam, P, Vasquez, V, Mitra, J, Boldogh, I, Rao, KS, Kent, TA, Mitra, S & Hegde, ML 2016, Mechanisms of Ageing and Development. DOI:

8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging
German, P, Saenz, D, Szaniszlo, P, Aguilera-Aguirre, L, Pan, L, Hegde, ML, Bacsi, A, Hajas, G, Radak, Z, Ba, X, Mitra, S, Papaconstantinou, J & Boldogh, I 2016, Mechanisms of Ageing and Development. DOI:

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
Hegde, ML, Dutta, A, Yang, C, Mantha, AK, Hegde, PM, Pandey, A, Sengupta, S, Yu, Y, Calsou, P, Chen, D, Lees-Miller, SP & Mitra, S 2016, Oncotarget. DOI:

8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging
German, P, Saenz, D, Szaniszlo, P, Aguilera-Aguirre, L, Pan, L, Hegde, ML, Bacsi, A, Hajas, G, Radak, Z, Ba, X, Mitra, S, Papaconstantinou, J & Boldogh, I 2016, Mechanisms of Ageing and Development. DOI:

Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling
Aguilera-Aguirre, L, Hosoki, K, Bacsi, A, Radák, Z, Sur, S, Hegde, ML, Tian, B, Saavedra-Molina, A, Brasier, AR, Ba, X & Boldogh, I 2015, Free Radical Biology and Medicine, vol 89, pp. 20-33. DOI:

The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: Dominant negative function of the CTD
Hegde, PM, Dutta, A, Sengupta, S, Mitra, J, Adhikari, S, Tomkinson, AE, Li, GM, Boldogh, I, Hazra, TK, Mitra, S & Hegde, ML 2015, Journal of Biological Chemistry, vol 290, no. 34, pp. 20919-20933. DOI:

Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells
Patel, PR, Hegde, ML, Theruvathu, J, Mitra, SA, Boldogh, I & Sowers, L 2015, Journal of Bioanalysis & Biomedicine, vol 7, no. 3, pp. 75-80. DOI:

New paradigms in the repair of oxidative damage in human genome: Mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins
Dutta, A, Yang, C, Sengupta, S, Mitra, S & Hegde, ML 2015, Cellular and Molecular Life Sciences, vol 72, no. 9, pp. 1679-1698. DOI:

Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential
Mitra, J, Vasquez, V, Hegde, PM, Boldogh, I, Mitra, S, Kent, TA, Rao, KS & Hegde, ML 2015, Neurological Research and Therapy, vol 1, no. 2. DOI:

A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells
Wang, H, Adhikari, S, Butler, EB, Pandita, TK, Mitra, S & Hegde, ML 2015, Jacobs Journal of Radiation Oncology, vol 1, no. 1:003..

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis
Chatterjee, A, Saha, S, Chakraborty, A, Silva-Fernandes, A, Mandal, SM, Neves-Carvalho, A, Liu, Y, Pandita, RK, Hegde, ML, Hegde, PM, Boldogh, I, Ashizawa, T, Koeppen, AH, Pandita, TK, Maciel, P, Sarkar, PS & Hazra, TK 2015, PLoS Genetics, vol 11, no. 1, e1004749. DOI:

The role of 8-oxoguanine DNA glycosylase-1 in inflammation
Ba, X, Aguilera-Aguirre, L, Rashid, QTAN, Bacsi, A, Radak, Z, Sur, S, Hosoki, K, Hegde, ML & Boldogh, I 2014, International Journal of Molecular Sciences, vol 15, no. 9, pp. 16975-16997. DOI:

MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice
Gupta, A, Hunt, CR, Hegde, ML, Chakraborty, S, Udayakumar, D, Horikoshi, N, Singh, M, Ramnarain, DB, Hittelman, WN, Namjoshi, S, Asaithamby, A, Hazra, TK, Ludwig, T, Pandita, RK, Tyler, JK & Pandita, TK 2014, Cell Reports, vol 8, no. 1. DOI:

MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice
Gupta, A, Hunt, CR, Hegde, ML, Chakraborty, S, Udayakumar, D, Horikoshi, N, Singh, M, Ramnarain, DB, Hittelman, WN, Namjoshi, S, Asaithamby, A, Hazra, TK, Ludwig, T, Pandita, RK, Tyler, JK & Pandita, TK 2014, Cell Reports, vol 8, no. 1, pp. 177-189. DOI:

New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases
Mitra, J, Guerrero, EN, Hegde, PM, Wang, H, Boldogh, I, Rao, KSH, Mitra, S & Hegde, ML 2014, Biomolecules, vol 4, no. 3, pp. 678-703. DOI:

8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and a-smooth muscle actin polymerization
Luo, J, Hosoki, K, Bacsi, A, Radak, Z, Hegde, ML, Sur, S, Hazra, TK, Brasier, AR, Ba, X & Boldogh, I 2014, Free Radical Biology and Medicine, vol 73, pp. 430-438. DOI: