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Kyuson Yun, PhD

Assistant Professor of Neurosurgery, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Yun Lab

Areas Of Expertise

Signaling pathways Targeted therapy Brain cancer Medulloblastoma Glioblastoma Cancer stem cells Diagnostic device
Education & Training

Postdoctoral Associate, Dartmouth-Hitchcock Medical Center
Postdoctoral Fellowship, Dartmouth-Hitchcock Medical Center
PhD, California Institute of Technology
BS, California Institute of Technology

S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in Glioblastoma
Chow, K-H, Park, HJ, George, J, Yamamoto, K, Gallup, AD, Graber, JH, Chen, Y, Jiang, W, Steindler, DA, Neilson, EG, Kim, BYS & Yun, K 2017, Cancer Research. DOI: 10.1158/0008-5472.CAN-17-1294

Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy
Yuan, H, Jiang, W, von Roemeling, CA, Qie, Y, Liu, X, Chen, Y, Wang, Y, Wharen, RE, Yun, K, Bu, G, Knutson, KL & Kim, BYS 2017, Nature Nanotechnology. DOI: 10.1038/nnano.2017.69

Expression and function of ABCG2 and XIAP in glioblastomas
Emery, IF, Gopalan, A, Wood, S, Chow, KH, Battelli, C, George, J, Blaszyk, H, Florman, J & Yun, K 2017, Journal of Neuro-Oncology, pp. 1-11. DOI: 10.1007/s11060-017-2422-z

High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients
Cho, S-Y, Park, C, Na, D, Han, JY, Lee, J, Park, O-K, Zhang, C, Sung, CO, Moon, HE, Kim, Y, Kim, JH, Kim, JJ, Khang, SK, Nam, D-H, Choi, JW, Suh, Y-L, Kim, DG, Park, SH, Youn, H, Yun, K, Kim, J-I, Lee, C, Paek, SH & Park, H 2017, Experimental & Molecular Medicine , vol 49, no. 4, pp. e317. DOI: 10.1038/emm.2017.9

High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients
Cho, SY, Park, C, Na, D, Han, JY, Lee, J, Park, OK, Zhang, C, Sung, CO, Moon, HE, Kim, Y, Kim, JH, Kim, JJ, Khang, SK, Nam, DH, Choi, JW, Suh, YL, Kim, DG, Park, SH, Youn, H, Yun, K, Kim, JI, Lee, C, Paek, SH & Park, H 2017, Experimental and Molecular Medicine, vol 49, no. 4, e317. DOI: 10.1038/emm.2017.9

S100a4 is a novel biomarker and regulator of glioma stem cells that is critical for mesenchymal transition in glioblastomas
Yun, K 2017, Cancer Research.

Addressing intra-tumoral heterogeneity and therapy resistance
Rybinski, B & Yun, K 2016, Oncotarget, vol 7, no. 44, pp. 72322-72342. DOI: 10.18632/oncotarget.11875

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype
Junankar, S, Baker, LA, Roden, DL, Nair, R, Elsworth, B, Gallego-Ortega, D, Lacaze, P, Cazet, A, Nikolic, I, Teo, WS, Yang, J, McFarland, A, Harvey, K, Naylor, MJ, Lakhani, SR, Simpson, PT, Raghavendra, A, Saunus, J, Madore, J, Kaplan, W, Ormandy, C, Millar, EKA, OToole, S, Yun, K & Swarbrick, A 2015, Nature communications, vol 6, pp. 6548. DOI: 10.1038/ncomms7548

Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity
Chow, K-H, Shin, D-M, Jenkins, MH, Miller, EE, Shih, DJ, Choi, S, Low, BE, Philip, V, Rybinski, B, Bronson, RT, Taylor, MD & Yun, K 2014, Cancer Research, vol 74, no. 17, pp. 4864-74. DOI: 10.1158/0008-5472.CAN-13-3293

Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks
Dowell, KG, Simons, AK, Bai, H, Kell, B, Wang, ZZ, Yun, K & Hibbs, MA 2014, Stem cells (Dayton, Ohio), vol 32, no. 5, pp. 1161-72. DOI: 10.1002/stem.1612

Prom1 function in development, intestinal inflammation, and intestinal tumorigenesis
Karim, BO, Rhee, K-J, Liu, G, Yun, K & Brant, SR 2014, Frontiers in Oncology, vol 4, pp. 323. DOI: 10.3389/fonc.2014.00323

Notch1-induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma
Natarajan, S, Li, Y, Miller, EE, Shih, DJ, Taylor, MD, Stearns, TM, Bronson, RT, Ackerman, SL, Yoon, JK & Yun, K 2013, Cancer Research, vol 73, no. 17, pp. 5381-90. DOI: 10.1158/0008-5472.CAN-13-0033

Elevated Id2 expression results in precocious neural stem cell depletion and abnormal brain development
Park, HJ, Hong, M, Bronson, RT, Israel, MA, Frankel, WN & Yun, K 2013, Stem cells (Dayton, Ohio), vol 31, no. 5, pp. 1010-21. DOI: 10.1002/stem.1351

Cell-type-specific predictive network yields novel insights into mouse embryonic stem cell self-renewal and cell fate
Dowell, KG, Simons, AK, Wang, ZZ, Yun, K & Hibbs, MA 2013, PloS one, vol 8, no. 2, pp. e56810. DOI: 10.1371/journal.pone.0056810

Imaging glioma initiation in vivo through a polished and reinforced thin-skull cranial window
Zhang, L, Lapierre, A, Roy, B, Lim, M, Zhu, J, Wang, W, Sampson, SB, Yun, K, Lyons, B, Li, Y & Lin, D-T 2012, Journal of visualized experiments : JoVE, no. 69. DOI: 10.3791/4201

Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1
Li, Y, Hibbs, MA, Gard, AL, Shylo, NA & Yun, K 2012, Stem cells (Dayton, Ohio), vol 30, no. 4, pp. 741-52. DOI: 10.1002/stem.1030

Cancer stem cells are enriched in the side population cells in a mouse model of glioma
Harris, MA, Yang, H, Low, BE, Mukherjee, J, Mukherje, J, Guha, A, Bronson, RT, Shultz, LD, Israel, MA & Yun, K 2008, Cancer Research, vol 68, no. 24, pp. 10051-9. DOI: 10.1158/0008-5472.CAN-08-0786

Cancer stem cells
Yun, K & Tennent, B 2008, Drug Discovery Today: Disease Models, vol 4, no. 2, pp. 47-52. DOI: 10.1016/j.ddmod.2007.10.001

Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb
Nam, J-S, Park, E, Turcotte, TJ, Palencia, S, Zhan, X, Lee, J, Yun, K, Funk, WD & Yoon, JK 2007, Developmental Biology, vol 311, no. 1, pp. 124-35. DOI: 10.1016/j.ydbio.2007.08.023

Id4 regulates neural progenitor proliferation and differentiation in vivo
Yun, K, Mantani, A, Garel, S, Rubenstein, J & Israel, MA 2004, Development, vol 131, no. 21, pp. 5441-8. DOI: 10.1242/dev.01430