Jenny C. Chang,

Houston Methodist
Weill Cornell Medical College


Areas Of Expertise

Cancer Stem cells Breast cancer High throughput
Publications

Bromodomain and extraterminal protein inhibition blocks growth of triple-negative breast cancers through the suppression of Aurora kinases
Sahni, JM, Gayle, SS, Bonk, KLW, Vite, LC, Yori, JL, Webb, B, Ramos, EK, Seachrist, DD, Landis, MD, Chang, JC, Bradner, JE & Keri, RA 2016, Journal of Biological Chemistry, vol 291, no. 45, pp. 23756-23768. DOI:

HOXC10 expression supports the development of chemotherapy resistance by fine tuning DNA repair in breast cancer cells
Sadik, H, Korangath, P, Nguyen, NK, Gyorffy, B, Kumar, R, Hedayati, M, Teo, WW, Park, S, Panday, H, Munoz, TG, Menyhart, O, Shah, N, Pandita, RK, Chang, JC, DeWeese, T, Chang, HY, Pandita, TK & Sukumar, S 2016, Cancer Research, vol 76, no. 15, pp. 4443-4456. DOI:

Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion
Mazumdar, A, Poage, GM, Shepherd, J, Tsimelzon, A, Hartman, ZC, Den Hollander, P, Hill, J, Zhang, Y, Chang, J, Hilsenbeck, SG, Fuqua, S, Kent Osborne, C, Mills, GB & Brown, PH 2016, Breast Cancer Research and Treatment, pp. 1-14. DOI:

The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair
Liang, DH, Choi, DS, Ensor, JE, Kaipparettu, BA, Bass, BL & Chang, JC 2016, Cancer Letters, vol 376, no. 2, pp. 249-258. DOI:

Trastuzumab emtansine (T-DM1) plus docetaxel with or without pertuzumab in patients with HER2-positive locally advanced or metastatic breast cancer: Results from a phase Ib/IIa study
Martin, M, Fumoleau, P, Dewar, JA, Albanell, J, Limentani, SA, Campone, M, Chang, JC, Patre, M, Strasak, A, de Haas, SL, Xu, J & Garcia-Saenz, JA 2016, Annals of Oncology, vol 27, no. 7, mdw157, pp. 1249-1256. DOI:

The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair
Liang, DH, Choi, DS, Ensor, JE, Kaipparettu, BA, Bass, BL & Chang, JC 2016, Cancer Letters, vol 376, no. 2, pp. 249-58. DOI:

Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence
Balko, JM, Schwarz, LJ, Luo, N, Estrada, MV, Giltnane, JM, Dávila-González, D, Wang, K, Sánchez, V, Dean, PT, Combs, SE, Hicks, D, Pinto, JA, Landis, MD, Doimi, FD, Yelensky, R, Miller, VA, Stephens, PJ, Rimm, DL, Gómez, H, Chang, JC, Sanders, ME, Cook, RS & Arteaga, CL 2016, Science Translational Medicine, vol 8, no. 334, 334ra53. DOI:

Phosphatase PTP4A3 promotes triple-negative breast cancer growth and predicts poor patient survival
Hollander, PD, Rawls, K, Tsimelzon, A, Shepherd, J, Mazumdar, A, Hill, J, Fuqua, SAW, Chang, JC, Osborne, CK, Hilsenbeck, SG, Mills, GB & Brown, PH 2016, Cancer Research, vol 76, no. 7, pp. 1942-1953. DOI:

A comparison between DASL and Affymetrix on probing the whole-transcriptome
Jeong, J, Audet, R, Chang, J, Wong, H, Willis, S, Young, B, Edgerton, S, Thor, A, Sledge, G, Duchnowska, R, Jassem, J, Adamowicz, K, Leyland-Jones, B & Shen, C 2016, Journal of the Korean Statistical Society, vol 45, no. 1, pp. 149-155. DOI:

Antitumor activity of Cetuximab in combination with Ixabepilone on triple negative breast cancer stem cells
Tanei, T, Choi, DS, Rodriguez, AA, Liang, DH, Dobrolecki, L, Ghosh, M, Landis, MD & Chang, JC 2016, Breast Cancer Research, vol 18, no. 1, 6. DOI:

Cell-free DNA as a molecular tool for monitoring disease progression and response to therapy in breast cancer patients
Liang, DH, Ensor, JE, Liu, ZB, Patel, A, Patel, TA, Chang, JC & Rodriguez, AA 2016, Breast Cancer Research and Treatment, vol 155, no. 1, pp. 139-149. DOI:

Correlating mammographic and pathologic findings in clinical decision support using natural language processing and data mining methods
Patel, TA, Puppala, M, Ogunti, RO, Ensor, Jr. JE, He, T, Shewale, JB, Ankerst, DP, Kaklamani, VG, Rodriguez, AA, Wong, STC & Chang, JC 2016, Cancer. DOI:

Cancer stem cells: Role in tumor growth, recurrence, metastasis, and treatment resistance
Chang, JC 2016, Medicine (United States), vol 95, no. 1, pp. S20-S25. DOI:

Cell-free DNA as a molecular tool for monitoring disease progression and response to therapy in breast cancer patients
Liang, DH, Ensor, JE, Liu, Z-B, Patel, A, Patel, TA, Chang, JC & Rodriguez, AA 2016, Breast Cancer Research and Treatment, vol 155, no. 1, pp. 139-49. DOI:

Correlating mammographic and pathologic findings in clinical decision support using natural language processing and data mining methods
Patel, TA, Puppala, M, Ogunti, RO, Ensor, JE, He, T, Shewale, JB, Ankerst, DP, Kaklamani, VG, Rodriguez, AA, Wong, STC & Chang, JC 2016, Cancer. DOI:

Correlating mammographic and pathologic findings in clinical decision support using natural language processing and data mining methods
Patel, TA, Puppala, M, Ogunti, RO, Ensor, JE, He, T, Shewale, JB, Ankerst, DP, Kaklamani, VG, Rodriguez, AA, Wong, STC & Chang, JC 2016, Cancer. DOI:

Therapeutic targeting of casein kinase 1d in breast cancer
Rosenberg, LH, Lafitte, M, Quereda, V, Grant, W, Chen, W, Bibian, M, Noguchi, Y, Fallahi, M, Yang, C, Chang, JC, Roush, WR, Cleveland, JL & Duckett, DR 2015, Science Translational Medicine, vol 7, no. 318, 318ra202. DOI:

Upregulation of ER signaling as an adaptive mechanism of cell survival in HER2-positive breast tumors treated with Anti-HER2 therapy
Giuliano, M, Hu, H, Wang, YC, Fu, X, Nardone, A, Herrera, S, Mao, S, Contreras, A, Gutierrez, C, Wang, T, Hilsenbeck, SG, Angelis, CD, Wang, NJ, Heiser, LM, Gray, JW, Lopez-Tarruella, S, Pavlick, AC, Trivedi, MV, Chamness, GC, Chang, JC, Osborne, CK, Rimawi, MF & Schiff, R 2015, Clinical Cancer Research, vol 21, no. 17, pp. 3995-4003. DOI:

Activating PIK3CA mutations induce an epidermal growth factor receptor (EGFR)/extracellular signal-regulated Kinase (ERK) paracrine signaling axis in basal-like breast cancer
Young, CD, Zimmerman, LJ, Hoshino, D, Formisano, L, Hanker, AB, Gatza, ML, Morrison, MM, Moore, PD, Whitwell, CA, Dave, B, Stricker, T, Bhola, NE, Silva, GO, Patel, P, Brantley-Sieders, DM, Levin, M, Horiates, M, Palma, NA, Wang, K, Stephens, PJ, Perou, CM, Weaver, AM, OShaughnessy, JA, Chang, JC, Park, BH, Liebler, DC, Cook, RS & Arteaga, CL 2015, Molecular and Cellular Proteomics, vol 14, no. 7, pp. 1959-1976. DOI:

Effects of a green tea extract, Polyphenon E, on systemic biomarkers of growth factor signalling in women with hormone receptor-negative breast cancer
Crew, KD, Ho, KA, Brown, P, Greenlee, H, Bevers, TB, Arun, B, Sneige, N, Hudis, C, Mcarthur, HL, Chang, J, Rimawi, M, Cornelison, TL, Cardelli, J, Santella, RM, Wang, A, Lippman, SM & Hershman, DL 2015, Journal of Human Nutrition and Dietetics, vol 28, no. 3, pp. 272-282. DOI: