James C. Major, MD, PhD

Assistant Professor of Clinical Ophthalmology, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College

Education & Training

, Bascom Palmer Eye Inst & Hosp
, Carilion Roanoke Memorial Hospital
, Baylor College of Medicine

Khurana, RN, Wykoff, CC, Bansal, AS, Akiyama, K, Palmer, JD, Chen, E, Chang, LK, Major, JC, Wu, C, Wang, R, Croft, DE & Wong, TP 2016, Retina. DOI:

Choroidal Neovascularization Secondary to Alexandrite Laser Exposure
Wang, R, Wykoff, CC, Christie, L, Croft, DE, Major, JC, Fish, RH & Brown, DM 2016, Retinal Cases and Brief Reports, vol 10, no. 3, pp. 244-248. DOI:

ENDOPHTHALMITIS AFTER INTRAVITREAL INJECTION: Role of Prophylactic Topical Ophthalmic Antibiotics
Li, AL, Wykoff, CC, Wang, R, Chen, E, Benz, MS, Fish, RH, Wong, TP, Major, JC, Brown, DM, Schefler, AC, Kim, RY & OMalley, RE 2015, Retina. DOI:

Diagnostic and Therapeutic Challenges
Phillis, CA, Bourke, RD & Major, JC 2015, Retina. DOI:

Aflibercept for pigment epithelial detachment for previously treated neovascular age-related macular degeneration
Major, JC , Wykoff, CC, Croft, DE, Wang, R, Mariani, AF, Lehmann, AE & Brown, DM 2015, Canadian Journal of Ophthalmology, vol 50, no. 5, 715, pp. 373-377. DOI:

5Q with James C. Major Jr, MD, PHD
Major, JC 2015, Retina Today, vol 2015, no. September2015, pp. 81-82.

Progressive retinal nonperfusion in ischemic central retinal vein occlusion
Wykoff, CC , Brown, DM, Croft, DE, Major, JC & Wong, TP 2015, Retina, vol 35, no. 1, pp. 43-47. DOI:

Occult retinal detachment after mild traumatic brain injury: Case report and literature review
Bedgood, A, Rand, SE & Major, J 2014, Clinical Journal of Sport Medicine. DOI:

Comparison of spectral-domain and time-domain optical coherence tomography in the detection of neovascular age-related macular degeneration activity
Major, JC , Wykoff, CC, Mariani, AF, Chen, E, Croft, DE & Brown, DM 2014, Retina, vol 34, no. 1, pp. 48-54. DOI:

Purtscher-like retinopathy associated with pemphigus vulgaris
Mariani, AF, Major, JC, Brown, DM, Wykoff, CC, Benz, MS & Kegley, EN 2013, Retinal Cases and Brief Reports, vol 7, no. 4, pp. 304-306. DOI:

Current concepts in managing wet AMD suboptimally responsive to anti-VEGF therapy
Hariprasad, SM & Major, JC 2013, Ophthalmic Surgery Lasers and Imaging Retina, vol 44, no. 3, pp. 225-226. DOI:

SAVE (super-dose anti-VEGF) trial: 2.0 mg ranibizumab for recalcitrant neovascular age-related macular degeneration: 1-year results
Wykoff, CC , Brown, DM , Chen, E , Major, JC, Croft, DE, Mariani, A & Wong, TP 2013, Ophthalmic Surgery Lasers and Imaging Retina, vol 44, no. 2, pp. 121-126. DOI:

Super-dose anti-VEGF (SAVE) trial: 2.0 mg Intravitreal ranibizumab for recalcitrant neovascular macular degeneration-primary end point
Brown, DM , Chen, E, Mariani, A & Major, JC 2013, Ophthalmology, vol 120, no. 2, pp. 349-354. DOI:

Use of nepafenac (Nevanac®)in combination with intravitreal anti-VEGF agents in the treatment of recalcitrant exudative macular degeneration requiring monthly injections
Chen, E, Benz, MS, Fish, RH, Brown, DM, Wong, TP, Kim, RY & Major, JC 2010, Clinical Ophthalmology, vol 4, no. 1, pp. 1249-1252. DOI:

Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy (the "flying saucer" sign)
Chen, E , Brown, DM, Benz, MS, Fish, RH, Wong, TP, Kim, RY & Major, JC 2010, Clinical Ophthalmology, vol 4, no. 1, pp. 1151-1158. DOI:

Retinal detachment despite aggressive management of aggressive posterior retinopathy of prematurity.
Suk, KK, Berrocal, AM, Murray, TG, Rich, R, Major, JC, Hess, D & Johnson, RA 2010, Journal of pediatric ophthalmology and strabismus, vol 47 Online.

Retinal structure of birds of prey revealed by ultra-high resolution spectral-domain optical coherence tomography
Ruggeri, M, Major, JC, McKeown, C, Knighton, RW, Puliafito, CA & Jiao, S 2010, Investigative Ophthalmology and Visual Science, vol 51, no. 11, pp. 5789-5795. DOI:

Staphylococcus aureus Endophthalmitis: Antibiotic Susceptibilities, Methicillin Resistance, and Clinical Outcomes
Major, JC, Engelbert, M, Flynn, HW, Miller, D, Smiddy, WE & Davis, JL 2010, American Journal of Ophthalmology, vol 149, no. 2. DOI:

Ultra high-resolution optical coherence tomography for ocular imaging of small animals
Ruggeri, M, Jiao, S, Major, JC, Cebulla, C, Rosenfeld, P, Gregori, G, Tsechpenakis, G, Wang, J, Murray, T & Porciatti, V 2009, . in IFMBE Proceedings. vol. 24, pp. 11-12, 25th Southern Biomedical Engineering Conference 2009, Miami, FL, United States, 15-17 May. DOI:

Ultra high-resolution optical coherence tomography for non-contact ocular imaging of small animals
Ruggeri, M, Wehbe, H, Jiao, S, Wang, J, Jockovich, ME, Rosenfeld, PJ, Major, JC, McKeown, C & Puliafito, CA 2008, . in Biomedical Optics, BIOMED 2008. Biomedical Optics, BIOMED 2008, St. Petersburg, FL, United States, 16-19 March.