Gavin W. Britz, MBBCh, MPH, MBA, FAANS

Chair, Department of Neurosurgery
Professor of Neurosurgery, Institute for Academic Medicine
Full Member, Research Institute
Director, Center for Regenerative and Restorative Neurosurgery
Director, Neurological Institute
Houston Methodist
Weill Cornell Medical College


Britz Lab - Cerebrovascular Research


Phone:
713.441.3800


Biography

Dr. Gavin Britz earned his MBBCh at the University of the Witwatersrand School of Medicine, South Africa in 1987.  He completed a surgical internship in general surgery and fellowship in general surgery at Johns Hopkins Hospital, Baltimore in 1993 and in 2002 he completed his residency in neurosurgery.  During his residency he attended St. George’s Medical School, The University of London, UK and served as a Neurosurgical Registrar and Senior Registrar.  After residency, he took a cerebrovascular fellowship in 2002 and an Interventional Neuroradiology Fellowship in 2003 at the University of Washington Medical School, Seattle.  In 2003 he earned his MPH at the University of Washington, Seattle. He also obtained an MBA from George Washington University in 2015. He held faculty appointments at the University of Washington and Duke University before becoming a member of Houston Methodist Research Institute in 2014.

Description of Research

My basic science research focuses on understanding the cerebral microcirculation. This is largely in relation to the alteration of the microcirculation following an aneurysmal subarachnoid hemorrhage. Subarachnoid hemorrhage resulting from rupture of a brain aneurysm often demonstrates significant morbidity and mortality in spite of aneurysm obliteration to prevent re-hemorrhage. In humans, delayed vascular constriction can occur 5-7 days after SAH: proximal blood vessels lose reactivity and demonstrate narrowing unresponsive to smooth muscle relaxants, often leading to delayed cerebral ischemia. However, ischemic deficits can also arise from regions with minimal vasoconstriction on angiography or transcranial Doppler studies, and drugs preventing large vessel vasoconstriction may fail to improve clinical outcome. Microvascular dysfunction and acute brain injury from SAH are also important in the evolution of ischemia. Animal models of SAH can replicate features of human SAH, particularly partial vessel rupture and release of arterial blood, ischemic and cognitive changes but demonstrate a shorter time course of vasoconstriction (maximum at 2-3 days). Hippocampus has a less robust blood supply than neocortex, with resulting lower oxygen values in vivo, in addition to a predisposition to ischemia and cell loss. My laboratory has clearly demonstrated that both the pial and penetrating arterioles are affected and therefore may account for some of the morbidity despite successful treatment of the aneurysm.

My clinical research includes evaluating new and novel tools to treat a wide variety of problems such as brain aneurysms and skull base tumors.

Areas Of Expertise

Brain Tumors Aneurysms Acoustic Neuroma AVM arteriovenous malformation Moyamoya Meningioma Carotid Endarterectomy Neuro-Vascular Surgery Pituitary Surgery Skull Based Surgery Trigeminal Neuralgia
Education & Training

, George Washington University
, Johns Hopkins University and Hospital
, University of Washington
, University of the Witwatersrand
Publications

The Safety and Feasibility of Image-Guided BrainPath-Mediated Transsulcul Hematoma Evacuation: A Multicenter Study
Labib, MA, Shah, M, Kassam, AB, Young, R, Zucker, L, Maioriello, A, Britz, G, Agbi, C, Day, JD, Gallia, G, Kerr, R, Pradilla, G, Rovin, R, Kulwin, C & Bailes, J 2016, Neurosurgery. DOI:

Early Trigeminal Nerve Stimulation Reduces Brain Edema and Lesion Volumes Following Controlled Cortical Impact Traumatic Brain Inju
Golanov, E & Britz, GW 2016, AANS , Chicago, IL, United States, 4/30/16 - 5/4/16, .

Three-dimensional printing of anatomically accurate, patient specific intracranial aneurysm models
Anderson, JR, Thompson, WL, Alkattan, AK, Diaz, O, Klucznik, R, Zhang, YJ, Britz, GW, Grossman, RG & Karmonik, C 2016, Journal of NeuroInterventional Surgery, vol 8, no. 5, pp. 517-520. DOI:

Three-dimensional printing of anatomically accurate, patient specific intracranial aneurysm models
Anderson, JR, Thompson, WL, Alkattan, AK, Diaz, O, Klucznik, R, Zhang, YJ, Britz, GW, Grossman, RG & Karmonik, C 2016, Journal of NeuroInterventional Surgery, vol 8, no. 5, pp. 517-520.

In vitro investigation of contrast flow jet timing in patient-specific intracranial aneurysms
Jou, L-D, Desai, V & Britz, GW 2016, Quantitative Imaging in Medicine and Surgery, vol 6, no. 2, pp. 134-43. DOI:

Astrocytic Tissue Factor Plays An Important Role In Regulation Of CSF Circulation And Control Of Blood Spread Following Subarachnoid Hemorrhage
Golanov, E, Bovshik, E, Foster, C, Zhang, YJ, Wong, K, Wong, ST & Britz, GW 2016, pp. 636.

Transulcal parafascicular minimally invasive approach to deep and subcortical cavernomas: technical note
Scranton, RA, Fung, SH & Britz, GW 2016, Journal of Neurosurgery, pp. 1-7. DOI:

Predictors of poor outcome despite recanalization: A multiple regression analysis of the NASA registry
Linfante, I, Starosciak, AK, Walker, GR, Dabus, G, Castonguay, AC, Gupta, R, Sun, CHJ, Martin, C, Holloway, WE, Mueller-Kronast, N, English, JD, Malisch, TW, Marden, FA, Bozorgchami, H, Xavier, A, Rai, AT, Froehler, MT, Badruddin, A, Nguyen, TN, Taqi, MA, Abraham, MG, Janardhan, V, Shaltoni, H, Novakovic, R, Yoo, AJ, Abou-Chebl, A, Chen, PR, Britz, GW, Kaushal, R, Nanda, A, Issa, MA, Nogueira, RG & Zaidat, OO 2016, Journal of NeuroInterventional Surgery, vol 8, no. 3, pp. 224-229. DOI:

The Anterior Subcallosal Approach to Third Ventricular and Suprasellar Lesions: Anatomical Description and Technical Note
Liebelt, BD, Hooten, KG & Britz, GW 2016, World Neurosurgery, vol 87, pp. 187-194. DOI:

Impaired CSF flow following subarachnoid hemorrhage, the role of tissue factor
Golanov, E , Britz, GW & Scranton, RA 2016, TEXAS ASSOCIATION OF NEUROLOGICAL SURGEONS ANNUAL MEETING, Fort Worth, United States, 2/18/16 - 2/21/16, .

Correlation between Aneurysm Size and Hemodynamics in One Individual with Multiple Small Intracranial Aneurysms
Jou, L-D & Britz, GW 2016, Cureus, vol 8, no. 7. DOI:

Diving Response in Rats: Role of the Subthalamic Vasodilator Area
Golanov, EV, Shiflett, JM & Britz, GW 2016, Frontiers in Neurology, vol 7, pp. 157. DOI:

Subarachnoid hemorrhage triggers acute apnea in mice
Golanov, E & Britz, GW 2016, Society for Neuroscience, San Diego, United States, 11/12/16 - 11/16/16, .

Relationships and redundancies of selected hemodynamic and structural parameters for characterizing virtual treatment of cerebral aneurysms with flow diverter devices
Karmonik, C, Anderson, JR, Beilner, J, Ge, JJ, Partovi, S, Klucznik, RP, Diaz, O, Zhang, YJ, Britz, GW, Grossman, RG, Lv, N & Huang, Q 2015, Journal of Biomechanics. DOI:

Quantification of velocity reduction after flow diverter placement in intracranial aneurysm: An ex vivo study with 3D printed replicas
Anderson, JR, Klucznik, R, Diaz, O, Zhang, YJ, Britz, GW, Grossman, RG & Karmonik, C 2015, . in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. vol. 2015-November, 7320077, IEEE, pp. 7300-7303, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 25-29 August. DOI:

Comprehensive Overview of Contemporary Management Strategies for Cerebral Aneurysms
Manhas, A, Nimjee, SM, Agrawal, A, Zhang, J, Diaz, O, Zomorodi, AR, Smith, T, Powers, CJ, Sauvageau, E, Klucznik, RP, Ferrell, A, Golshani, K, Stieg, PE & Britz, GW 2015, World Neurosurgery, vol 84, no. 4, pp. 1147-1160. DOI:

Comments
Britz, G 2015, Neurosurgery, vol 78, no. 1, pp. 52. DOI:

Comments
Britz, GW 2015, Neurosurgery, vol 77, no. 5, pp. 717. DOI:

Predictors of Mortality in Acute Ischemic Stroke Intervention: Analysis of the North American Solitaire Acute Stroke Registry
Linfante, I, Walker, GR, Castonguay, AC, Dabus, G, Starosciak, AK, Yoo, AJ, Abou-Chebl, A, Britz, GW, Marden, FA, Alvarez, A, Gupta, R, Sun, C-HJ, Martin, C, Holloway, WE, Mueller-Kronast, N, English, JD, Malisch, TW, Bozorgchami, H, Xavier, A, Rai, AT, Froehler, MT, Badruddin, A, Nguyen, TN, Taqi, MA, Abraham, MG, Janardhan, V, Shaltoni, H, Novakovic, R, Chen, PR, Kaushal, R, Nanda, A, Issa, MA, Nogueira, RG & Zaidat, OO 2015, Stroke, vol 46, no. 8, pp. 2305-2308. DOI:

Perception Versus Actual Performance in Timely Tissue Plasminogen Activation Administration in the Management of Acute Ischemic Stroke
Lin, CB, Cox, M, Olson, DM, Britz, GW, Constable, M, Fonarow, GC, Schwamm, L, Peterson, ED & Shah, BR 2015, Journal of the American Heart Association, vol 4, no. 7. DOI: