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Elvin Blanco, PhD

Assistant Research Professor in Nanomedicine, Institute for Academic Medicine
Assistant Research Member, Research Institute
Houston Methodist


Education & Training

, U.T Southwestern Medical Center
, Case Western Reserve University
Publications

Enzyme-responsive multistage vector for drug delivery to tumor tissue
Mi, Y, Wolfram, J, Mu, C, Liu, X, Blanco, E, Shen, H & Ferrari, M 2016, Pharmacological Research, vol 113, pp. 92-99. DOI:

Strategies for improving drug delivery: nanocarriers and microenvironmental priming
Khalid, A, Persano, S, Shen, H, Zhao, Y, Blanco, E, Ferrari, M & Wolfram, J 2016, Expert Opinion on Drug Delivery, pp. 1-13. DOI:

Label-Free Isothermal Amplification Assay for Specific and Highly Sensitive Colorimetric miRNA Detection
Persano, S, Guevara, ML, Wolfram, J, Blanco, E, Shen, H, Ferrari, M & Pompa, PP 2016, ACS omega, vol 1, no. 3, pp. 448-455. DOI:

A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells
Scott, B, Shen, J, Nizzero, S, Boom, K, Persano, S, Mi, Y, Liu, X, Zhao, Y, Blanco, E, Shen, H, Ferrari, M & Wolfram, J 2016, Pharmacological Research, vol 111, pp. 413-421. DOI:

Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases
Deshpande, D, Janero, DR, Segura-Ibarra, V, Blanco, E & Amiji, MM 2016, Houston Methodist DeBakey Cardiovascular Journal, vol 12, no. 3, pp. 134-140. DOI:

A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells
Scott, B, Shen, J, Nizzero, S, Boom, K, Persano, S, Mi, Y, Liu, X, Zhao, Y, Blanco, E, Shen, H, Ferrari, M & Wolfram, J 2016, Pharmacological Research.

A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis
Mi, Y, Mu, C, Wolfram, J, Deng, Z, Hu, TY, Liu, X, Blanco, E, Shen, H & Ferrari, M 2016, Advanced Healthcare Materials, vol 5, no. 8, pp. 936-46. DOI:

An injectable nanoparticle generator enhances delivery of cancer therapeutics
Xu, R, Zhang, G, Mai, J, Deng, X, Segura-Ibarra, V, Wu, S, Shen, J, Liu, H, Hu, Z, Chen, L, Huang, Y, Koay, E, Huang, Y, Liu, J, Ensor, JE, Blanco, E, Liu, X, Ferrari, M & Shen, H 2016, Nature Biotechnology, vol 34, no. 4, pp. 414-418. DOI:

A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis
Mi, Y, Mu, C, Wolfram, J, Deng, Z, Hu, T, Liu, X, Blanco, E, Shen, H & Ferrari, M 2016, Advanced Healthcare Materials, vol 5, no. 8, pp. 936-46. DOI:

A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: A new strategy for heart failure diagnostics and therapeutics
Ruiz-Esparza, GU, Segura-Ibarra, V, Cordero-Reyes, AM, Youker, KA, Serda, RE, Cruz-Solbes, AS, Amione-Guerra, J, Yokoi, K, Kirui, DK, Cara, FE, Paez-Mayorga, J, Flores-Arredondo, JH, Guerrero-Beltrán, CE, Garcia-Rivas, G, Ferrari, M, Blanco, E & Torre-Amione, G 2016, European Journal of Heart Failure, vol 18, no. 2, pp. 169-178. DOI:

Rapamycin Polymer Nanotherapeutics for Pulmonary Hypertension Treatment
Segura-Ibarra, V, Amione-Guerra, J, Cruz-Solbes, AS, Torre, G, Youker, KA, Ashrith, G & Blanco, E 2016, American College of Cardiology (ACC) 2016, Chicago, United States, 4/2/16 - 4/4/16, .

Polymer Based Nanotherapeutics Prevent the Progression of Pulmonary Hypertension in a Rat Model
Segura-Ibarra, V, Amione-Guerra, J, Cruz-Solbes, AS, Youker, KA, Torre, G, Guha, A & Blanco, E 2016, The International Society for Heart & Lung Transplantation, Washington, DC, United States, 4/27/16 - 4/30/16, .

Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E , Shen, H & Ferrari, M 2015, Nature Biotechnology, vol 33, no. 9, pp. 941-951. DOI:

Mass partitioning effects in diffusion transport
Kojic, M, Milosevic, M, Wu, S, Blanco, E, Ferrari, M & Ziemys, A 2015, Physical Chemistry Chemical Physics, vol 17, no. 32, pp. 20630-20635. DOI:

Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer
Granados-Principal, S, Liu, Y, Guevara, ML, Blanco, E, Choi, DS, Qian, W, Patel, T, Rodriguez, AA, Cusimano, J, Weiss, HL, Zhao, H, Landis, MD, Dave, B, Gross, SS & Chang, JC 2015, Breast Cancer Research, vol 17, no. 1, 25. DOI:

Site-specific time and sequential nanoparticle delivery of chemotherapeutics for synergy enhancement
Segura-Ibarra, V, Wu, S, Cara, FE, Meric-Bernstam, F, Ferrari, M & Blanco, E 2015, 42nd Controlled Release Society (CRS) Annual Meeting and Exposition, Edinburgh, United Kingdom, 7/26/15 - 7/29/15, .

Temporospatial delivery of chemotherapeutics from nanoparticles for synergy enhancement
Segura-Ibarra, V, Wu, S, Cara, FE, Ferrari, M, Meric-Bernstam, F & Blanco, E 2015, San Antonio Breast Cancer Symposium 2015, San Antonio, United States, 12/6/15 - 12/10/15, .

Multistage delivery of RNA interfering nanotherapeutics targeting the PI3K/Akt/mTOR pathway
Blanco, E, Wu, S, Cara, FE, Segura-Ibarra, V, Ferrari, M & Meric-Bernstam, F 2015, American Association for Cancer Research Annual Meeting 2015, United States, 4/18/15 - 4/22/15, .

Polymer nanoparticles encased in a cyclodextrin complex shell for potential site- and sequence-specific drug release
Ruiz-Esparza, GU, Wu, S, Segura-Ibarra, V, Cara, FE, Evans, KW, Milosevic, M, Ziemys, A, Kojic, M, Meric-Bernstam, F, Ferrari, M & Blanco, E 2014, Advanced Functional Materials, vol 24, no. 30, pp. 4753-4761. DOI:

Nanoparticle-based polychemotherapy: Optimizing drug synergy for efficacious cancer treatment
Blanco, E 2014, Therapeutic Delivery, vol 5, no. 7, pp. 737-739. DOI: