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Elvin Blanco, PhD

Assistant Research Professor in Nanomedicine, Institute for Academic Medicine
Assistant Research Member, Research Institute
Houston Methodist

Education & Training

PhD , U.T Southwestern Medical Center
MS , Case Western Reserve University
BS , Case Western Reserve University

Methotraxate-Loaded Hybrid Nanoconstructs Target Vascular Lesions and Inhibit Atherosclerosis Progression in ApoE-/- Mice
Stigliano, C, Ramirez, MR, Singh, JV, Aryal, S, Key, J, Blanco, E & Decuzzi, P 2017, Advanced Healthcare Materials. DOI:

Rapamycin nanoparticles localize in diseased lung vasculature and prevent pulmonary arterial hypertension
Segura-Ibarra, V, Amione-Guerra, J, Cruz-Solbes, AS, Cara, FE, Iruegas-Nunez, DA, Wu, S, Youker, KA, Bhimaraj, A, Torre-Amione, G, Ferrari, M, Karmouty-Quintana, H, Guha, A & Blanco, E 2017, International Journal of Pharmaceutics, vol 524, no. 1-2, pp. 257-267. DOI:

Enzyme-responsive multistage vector for drug delivery to tumor tissue
Mi, Y, Wolfram, J, Mu, C, Liu, X, Blanco, E, Shen, H & Ferrari, M 2016, Pharmacological Research, vol 113, pp. 92-99. DOI:

Strategies for improving drug delivery: nanocarriers and microenvironmental priming
Khalid, A, Persano, S, Shen, H, Zhao, Y, Blanco, E, Ferrari, M & Wolfram, J 2016, Expert Opinion on Drug Delivery, pp. 1-13. DOI:

Label-Free Isothermal Amplification Assay for Specific and Highly Sensitive Colorimetric miRNA Detection
Persano, S, Guevara, ML, Wolfram, J, Blanco, E, Shen, H, Ferrari, M & Pompa, PP 2016, ACS omega, vol 1, no. 3, pp. 448-455. DOI:

Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases
Deshpande, D, Janero, DR, Segura-Ibarra, V, Blanco, E & Amiji, MM 2016, Houston Methodist DeBakey Cardiovascular Journal, vol 12, no. 3, pp. 134-140. DOI:

A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells
Scott, B, Shen, J, Nizzero, S, Boom, K, Persano, S, Mi, Y, Liu, X, Zhao, Y, Blanco, E, Shen, H, Ferrari, M & Wolfram, J 2016, Pharmacological Research, vol 111, pp. 413-421. DOI:

Nanotechnology toward advancing personalized medicine
Sakamoto, JH , Godin, B, Hu, Y, Blanco, E, van de Ven, AL, Vellaichamy, A, Murphy, MB, La Francesca, S, Schuenemeyer, T, Given, B, Meyn, A & Ferrari, M 2016, . in Handbook of Clinical Nanomedicine: Law, Business, Regulation, Safety, and Risk. vol. 2, Pan Stanford Publishing Pte. Ltd. pp. 1347-1411. DOI:

An injectable nanoparticle generator enhances delivery of cancer therapeutics
Xu, R, Zhang, G, Mai, J, Deng, X, Segura-Ibarra, V, Wu, S, Shen, J, Liu, H, Hu, Z, Chen, L, Huang, Y, Koay, E, Huang, Y, Liu, J, Ensor, JE, Blanco, E, Liu, X, Ferrari, M & Shen, H 2016, Nature Biotechnology, vol 34, no. 4, pp. 414-418. DOI:

A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis
Mi, Y, Mu, C, Wolfram, J, Deng, Z, Hu, T, Liu, X, Blanco, E, Shen, H & Ferrari, M 2016, Advanced Healthcare Materials, vol 5, no. 8, pp. 936-46. DOI:

A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: A new strategy for heart failure diagnostics and therapeutics
Ruiz-Esparza, GU, Segura-Ibarra, V, Cordero-Reyes, AM, Youker, KA, Serda, RE, Cruz-Solbes, AS, Amione-Guerra, J, Yokoi, K, Kirui, DK, Cara, FE, Paez-Mayorga, J, Flores-Arredondo, JH, Guerrero-Beltrán, CE, Garcia-Rivas, G, Ferrari, M, Blanco, E & Torre-Amione, G 2016, European Journal of Heart Failure, vol 18, no. 2, pp. 169-178. DOI:

Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E , Shen, H & Ferrari, M 2015, Nature Biotechnology, vol 33, no. 9, pp. 941-951. DOI:

Mass partitioning effects in diffusion transport
Kojic, M, Milosevic, M, Wu, S, Blanco, E, Ferrari, M & Ziemys, A 2015, Physical Chemistry Chemical Physics, vol 17, no. 32, pp. 20630-20635. DOI:

Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer
Granados-Principal, S, Liu, Y, Guevara, ML, Blanco, E, Choi, DS, Qian, W, Patel, T, Rodriguez, AA, Cusimano, J, Weiss, HL, Zhao, H, Landis, MD, Dave, B, Gross, SS & Chang, JC 2015, Breast Cancer Research, vol 17, no. 1, 25. DOI:

Polymer nanoparticles encased in a cyclodextrin complex shell for potential site- and sequence-specific drug release
Ruiz-Esparza, GU, Wu, S, Segura-Ibarra, V, Cara, FE, Evans, KW, Milosevic, M, Ziemys, A, Kojic, M, Meric-Bernstam, F, Ferrari, M & Blanco, E 2014, Advanced Functional Materials, vol 24, no. 30, pp. 4753-4761. DOI:

Nanoparticle-based polychemotherapy: Optimizing drug synergy for efficacious cancer treatment
Blanco, E 2014, Therapeutic Delivery, vol 5, no. 7, pp. 737-739. DOI:

Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1
Choi, DS, Blanco, E, Kim, YS, Rodriguez, AA, Zhao, H, Huang, THM, Chen, CL, Jin, G, Landis, MD, Burey, LA, Qian, W, Granados, SM, Dave, B, Wong, HH, Ferrari, M, Wong, STC & Chang, JC 2014, Stem Cells, vol 32, no. 9, pp. 2309-2323. DOI:

Colocalized delivery of rapamycin and paclitaxel to tumors enhances synergistic targeting of the PI3K/Akt/mTOR pathway
Blanco, E, Sangai, T, Wu, S, Hsiao, A, Ruiz-Esparza, GU, Gonzalez-Delgado, CA, Cara, FE, Granados-Principal, S, Evans, KW, Akcakanat, A, Wang, Y, Do, KA, Meric-Bernstam, F & Ferrari, M 2014, Molecular Therapy, vol 22, no. 7, pp. 1310-1319. DOI:

Emerging nanotherapeutic strategies in breast cancer
Blanco, E & Ferrari, M 2013, Breast, vol 23, no. 1, pp. 10-18. DOI:

Multistage delivery of chemotherapeutic nanoparticles for breast cancer treatment
Blanco, E, Sangai, T, Hsiao, A, Ferrati, S, Bai, L, Liu, X, Meric-Bernstam, F & Ferrari, M 2013, Cancer Letters, vol 334, no. 2, pp. 245-252. DOI: