Not found

David Beers, PhD

Associate Research Professor of Neurology, Institute for Academic Medicine
Associate Research Member, Research Institute
Houston Methodist


dbeers@houstonmethodist.org
Publications

A robust, good manufacturing practice–compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy
Alsuliman, A, Appel, SH, Beers, DR, Basar, R, Shaim, H, Kaur, I, Zulovich, J, Yvon, E, Muftuoglu, M, Imahashi, N, Kondo, K, Liu, E, Shpall, EJ & Rezvani, K 2016, Cytotherapy, vol 18, no. 10, pp. 1312-1324. DOI:

TDP-43 activates microglia through NF-?B and NLRP3 inflammasome
Zhao, W , Beers, DR, Bell, S, Wang, J, Wen, S, Baloh, RH & Appel, SH 2015, Experimental Neurology, vol 273, pp. 24-35. DOI:

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis
Hooten, KG, Beers, DR, Zhao, W & Appel, SH 2015, Neurotherapeutics, vol 12, no. 2, pp. 364-375. DOI:

The Role of Regulatory T Cells and Microglia in Amyotrophic Lateral Sclerosis
Beers, DR , Zhao, W, Hooten, KG & Appel, SH 2015, . in S David (ed.), Neuroinflammation: New Insights into Beneficial and Detrimental Functions. John Wiley & Sons, Inc. pp. 235-249. DOI:

Role of Inflammation in Neurodegenerative Diseases
Appel, SH , Beers, DR & Zhao, W 2014, . in Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. Elsevier, pp. 380-395. DOI:

Neuroimmunology of Amyotrophic Lateral Sclerosis
Henkel, JS, Beers, DR, Zhao, W & Appel, SH 2014, . in Neuroinflammation and CNS Disorders. Wiley Blackwell, pp. 185-209. DOI:

Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis
Zhao, W , Beers, DR & Appel, SH 2013, Journal of Neuroimmune Pharmacology, vol 8, no. 4, pp. 888-899. DOI:

Erratum: Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival [EMBO Mol Med 5, 1] DOI: 10.1002/emmm.201201544
Henkel, JS, Beers, DR, Wen, S, Rivera, AL, Toennis, KM, Appel, JE, Zhao, W, Moore, DH, Powell, SZ & Appel, SH 2013, EMBO Molecular Medicine, vol 5, no. 2. DOI:

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival
Henkel, JS, Beers, DR, Wen, S, Rivera, AL, Toennis, KM, Appel, JE, Zhao, W, Moore, DH, Powell, SZ & Appel, SH 2013, EMBO Molecular Medicine, vol 5, no. 1, pp. 64-79. DOI:

Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms
Zhao, W , Beers, DR, Liao, B, Henkel, JS & Appel, SH 2012, Neurobiology of Disease, vol 48, no. 3, pp. 418-428. DOI:

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS
Liao, B, Zhao, W, Beers, DR, Henkel, JS & Appel, SH 2012, Experimental Neurology, vol 237, no. 1, pp. 147-152. DOI:

Reactive oxygen and nitrogen species - A driving force in amyotrophic lateral sclerosis
Henkel, JS, Beers, DR, Zhao, W & Appel, SH 2012, . in Systems Biology of Free Radicals and Antioxidants. Springer-Verlag Berlin Heidelberg, pp. 3141-3165. DOI:

Peripheral nerve inflammation in als mice: Cause or consequence
Kano, O, Beers, DR, Henkel, JS & Appel, SH 2012, Neurology, vol 78, no. 11, pp. 833-835. DOI:

Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis
Vaknin, I, Kunis, G, Miller, O, Butovsky, O, Bukshpan, S, Beers, DR, Henkel, JS, Yoles, E, Appel, SH & Schwartz, M 2011, PLoS ONE, vol 6, no. 11, e26921. DOI:

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice
Beers, DR , Zhao, W, Liao, B, Kano, O, Wang, J, Huang, A, Appel, SH & Henkel, JS 2011, Brain, Behavior, and Immunity, vol 25, no. 5, pp. 1025-1035. DOI:

The microglial-motoneuron dialogue in ALS
Appel, SH , Zhao, W , Beers, DR & Henkel, JS 2011, Acta Myologica, vol 30, no. JUNE, pp. 4-8.

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis
Beers, DR, Henkel, JS, Zhao, W, Wang, J, Huang, A, Wen, S, Liao, B & Appel, SH 2011, Brain, vol 134, no. 5, pp. 1293-1314. DOI:

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury
Zhao, W , Beers, DR, Henkel, JS, Zhang, W, Urushitani, M, Julien, JP & Appel, SH 2010, GLIA, vol 58, no. 2, pp. 231-243. DOI:

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?
Appel, SH , Beers, DR & Henkel, JS 2010, Trends in Immunology, vol 31, no. 1, pp. 7-17. DOI:

Microglia in ALS: The good, the bad, and the resting
Henkel, JS, Beers, DR, Zhao, W & Appel, SH 2009, Journal of Neuroimmune Pharmacology, vol 4, no. 4, pp. 389-398. DOI: