Daniel Y. Lee, MD, PhD

Assistant Research Professor of Translational Imaging, Institute for Academic Medicine
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Lee graduated with honors from the University of California at Berkeley where he also received the Eric Hoffer Essay Prize his senior year. From 1992 until 2001, he earned a M.D. and Ph.D. degrees from the Stanford University Medical School in Stanford, California. While there, Dr. Li was mentored under a Medical Scientist Training Program grant from the National Institute of General Medical Sciences. Dr. Lee is the first author on several key research papers, including one on histone acetylation that was published in Cell while he was still in medical school. Dr. Lee assumed his positions at Methodist in 2008.

Description of Research

Dr. Lee is an accomplished expert in nuclear medicine, biophysics, and molecular biology. His research specifically centers on pathophysiology from a molecular imaging approach. He studies the epigenetics of cancer, and develops new tools for the study of biochemical and intracellular signaling pathways, as well as platform technology for targeted radiotherapy.

Areas Of Expertise

Cancer Nanoparticles Pathophysiology Radiotherapy
Education & Training

Residency , UCLA School of Medicine
Internship , UCLA School of Medicine
Clinical Fellowship , Stanford School of Medicine
MD , Stanford University School of Medicine
Postdoctoral Fellowship , Department of Nuclear Medicine, University of California at Los Angeles
Postdoctoral Fellowship , Department of Radiology, Stanford University Medical School, Stanford, CA
PhD , Stanford University Medical School

Design and synthesis of a mitochondria-targeting carrier for small molecule drugs
Han, J, Lee, TH, Tung, CH & Lee, DY 2014, Organic and Biomolecular Chemistry, vol 12, no. 48, pp. 9793-9796. DOI:

Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein-Barr virus latent membrane proteins
Bollard, CM, Gottschalk, S, Torrano, V, Diouf, O, Ku, S, Hazrat, Y, Carrum, G, Ramos, C, Fayad, L, Shpall, EJ, Pro, B, Liu, H, Wu, MF, Lee, D, Sheehan, AM, Zu, Y, Gee, AP, Brenner, MK, Heslop, HE & Rooney, CM 2014, Journal of Clinical Oncology, vol 32, no. 8, pp. 798-808. DOI:

Current therapy and novel agents for relapsed or refractory acute lymphoblastic leukemia
Dinner, S, Lee, D & Liedtke, M 2014, Leukemia and Lymphoma, vol 55, no. 8, pp. 1715-1724. DOI:

A tyrosine kinase inhibitor-based high-affinity PET radiopharmaceutical targets vascular endothelial growth factor receptor
Li, F, Jiang, S, Zu, Y, Lee, DY & Li, Z 2014, Journal of Nuclear Medicine, vol 55, no. 9, pp. 1525-1531. DOI:

Systemic inflammatory response syndrome after administration of unmodified T lymphocytes
Papadopoulou, A, Krance, RA, Allen, CE, Lee, D, Rooney, CM, Brenner, MK, Leen, AM & Heslop, HE 2014, Molecular Therapy, vol 22, no. 6, pp. 1134-1138. DOI:

Positron emitting magnetic nanoconstructs for PET/MR imaging
Aryal, S, Key, J, Stigliano, C, Landis, MD, Lee, DY & Decuzzi, P 2014, Small, vol 10, no. 13, pp. 2688-2696. DOI:

Imaging of genetically engineered T cells by PET using gold nanoparticles complexed to Copper-64
Bhatnagar, P, Li, Z, Choi, Y, Guo, J, Li, F, Lee, DY, Figliola, M, Huls, H, Lee, DA, Zal, T, Li, KC & Cooper, LJN 2013, Integrative Biology (United Kingdom), vol 5, no. 1, pp. 231-238. DOI:

Molecular theranostics: A primer for the imaging professional
Lee, DY & Li, KCP 2011, American Journal of Roentgenology, vol 197, no. 2, pp. 318-324. DOI:

Radiosynthesis of [ 18F]fluoromethyldeoxyspergualin for molecular imaging of heat shock proteins
Ghosh, P, Li, KC & Lee, DY 2011, Applied Radiation and Isotopes, vol 69, no. 3, pp. 609-613. DOI:

Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells
Choi, Y, Torikai, H, Lee, DY, Li, Z, Lo, D, Qin, G, Tung, CH, Tasciotti, E, Raphael, R, Biswal, SL, Ang, S, Lee, DA, Li, KC & Cooper, LJN 2010, . in Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010. vol. 3, pp. 376-379, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010, Anaheim, CA, United States, 21-24 June.

Computer-Assisted Quantitative Evaluation of Therapeutic Responses for Lymphoma Using Serial PET/CT Imaging
Gao, X, Xue, Z, Xing, J, Lee, DY, Gottschalk, SM, Heslop, HE, Bollard, CM & Wong, STC 2010, Academic Radiology, vol 17, no. 4, pp. 479-488. DOI:

Synthesis and evaluation of a near-infrared fluorescent non-peptidic bivalent integrin avß3 antagonist for cancer imaging
Li, F, Liu, J, Jas, GS, Zhang, J, Qin, G, Xing, J, Cotes, C, Zhao, H, Wang, X, Diaz, LA, Shi, ZZ, Lee, DY, Li, KCP & Li, Z 2010, Bioconjugate Chemistry, vol 21, no. 2, pp. 270-278. DOI:

Systems diagnostics: The systems approach to molecular imaging
Lee, DY & Li, KCP 2009, American Journal of Roentgenology, vol 193, no. 2, pp. 287-294. DOI:

A novel antiangiogenesis therapy using an integrin antagonist or anti-Flk-1 antibody coated 90Y-labeled nanoparticles
Li, L, Wartchow, CA, Danthi, SN, Shen, Z, Dechene, N, Pease, J, Choi, HS, Doede, T, Chu, P, Ning, S, Lee, DY, Bednarski, MD & Knox, SJ 2004, International Journal of Radiation Oncology Biology Physics, vol 58, no. 4, pp. 1215-1227. DOI:

Functional genomics guided with MR imaging: Mouse tumor model study
Guccione, S, Yang, YS, Shi, G, Lee, DY, Li, KCP & Bednarski, MD 2003, Radiology, vol 228, no. 2, pp. 560-568. DOI:

Initiation of mitochondrial DNA replication by transcription and R-loop processing
Lee, DY & Clayton, DA 1998, Journal of Biological Chemistry, vol 273, no. 46, pp. 30614-30621. DOI:

RNase mitochondrial RNA processing correctly cleaves a novel R loop at the mitochondrial DNA leading-strand origin of replication
Lee, DY & Clayton, DA 1997, Genes and Development, vol 11, no. 5, pp. 582-592.

Properties of a primer RNA-DNA hybrid at the mouse mitochondrial DNA leading-strand origin of replication
Lee, DY & Clayton, DA 1996, Journal of Biological Chemistry, vol 271, no. 39, pp. 24262-24269. DOI: