Charles C. Wykoff, MD, PhD

Assistant Professor of Clinical Ophthalmology, Institute for Academic Medicine
Assistant Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Charles Wykoff, MD, PhD, graduated Phi Beta Kappa from MIT, received his PhD from Oxford University in England while on a Marshall Scholarship, and his MD from Harvard Medical School. As a medical student he co-authored the book Fighting Global Blindness. While pursuing vitreoretinal training at Bascom Palmer Eye Institute he was awarded a Heed Fellowship, the Ronald G. Michels Fellowship Award, and served as Chief Resident/Co-Director of Ocular Trauma.

Dr. Wykoff has extensive expertise in clinical trial design and coordination. His research interests pertain to angiogenesis and retinal vascular diseases including age-related macular degeneration, diabetic retinopathy, and venous occlusive diseases, as well as vitreoretinal surgery topics such as retinal detachment and macular surgery. Dr. Wykoff has written and published over 120 peer-reviewed scientific manuscripts, book chapters, national meeting presentations and abstracts. Dr. Wykoff is Director of the Retina Consultants of Houston and Houston Methodist Hospital joint Argus II retinal prosthetic program – the only Gulf Coast site approved for surgical implantation of this unique technology for patients blind from retinitis pigmentosa. Dr. Wykoff is Co-Director of the Greater Houston Retina Research Foundation, was awarded the American Academy of Ophthalmology Achievement Award in 2015 and is an elected member of the Retina Society and the Macula Society. He also serves as the Academic Program Director for the Vit-buckle Society Annual Meeting, and is a member of the AAO, ARVO, ASRS and FACS.

Areas Of Expertise

Retina Macular degeneration Diabetic retinopathy Vitreoretinal surgery
Education & Training

, Bascom Palmer Eye Inst & Hosp
, Harvard University

Khurana, RN, Wykoff, CC, Bansal, AS, Akiyama, K, Palmer, JD, Chen, E, Chang, LK, Major, JC, Wu, C, Wang, R, Croft, DE & Wong, TP 2016, Retina. DOI:

Regulatory Factors Influencing Usage of Retinal Pharmaceuticals: A Look Both Home and Abroad
Croft, DE, Wykoff, CC, Michels, S, Chakravarthy, U & Cruess, AF 2016, American Journal of Ophthalmology, vol 169, pp. xiv-xvi. DOI:

DRCR Protocol-T: Reconciling 1- and 2-year data for managing diabetic macular edema
Wykoff, CC & Hariprasad, SM 2016, Ophthalmic surgery, lasers & imaging retina, vol 47, no. 4, pp. 308-312. DOI:

DRCR Protocol-T: Reconciling 1- and 2-year data for managing diabetic macular edema
Wykoff, CC & Hariprasad, SM 2016, Ophthalmic Surgery Lasers and Imaging Retina, vol 47, no. 4, pp. 308-312. DOI:

Diagnostic and Therapeutic Challenges
Corvi, F, Lattanzio, R, Miserocchi, E, Querques, L, Bandello, F, Querques, G, Croft, DE & Wykoff, CC 2016, Retina. DOI:

Choroidal Neovascularization Secondary to Alexandrite Laser Exposure
Wang, R, Wykoff, CC, Christie, L, Croft, DE, Major, JC, Fish, RH & Brown, DM 2016, Retinal Cases and Brief Reports, vol 10, no. 3, pp. 244-248. DOI:

Wang, R, Wykoff, CC & Brown, DM 2015, Retinal Cases and Brief Reports. DOI:

ENDOPHTHALMITIS AFTER INTRAVITREAL INJECTION: Role of Prophylactic Topical Ophthalmic Antibiotics
Li, AL, Wykoff, CC, Wang, R, Chen, E, Benz, MS, Fish, RH, Wong, TP, Major, JC, Brown, DM, Schefler, AC, Kim, RY & OMalley, RE 2015, Retina. DOI:

Predictors of Diabetic Macular Edema Treatment Frequency with Ranibizumab During the Open-Label Extension of the RIDE and RISE Trials
Wykoff, C, Elman, MJ, Regillo, C, Ding, B, Lu, N & Stoilov, I 2015, Ophthalmology. DOI:

Not all retina is created equal: Metabolic quantification of ultra-widefield images
Croft, DE, Wykoff, CC, Van Hemert, J, Verhoek, M & Brown, DM 2015, Ophthalmology, vol 122, no. 12, pp. 2580-2582. DOI:

Prospective trial of treat-and-extend versus monthly dosing for neovascular age-related macular degeneration: TREX-AMD 1-year results
Wykoff, CC, Croft, DE, Brown, DM, Wang, R, Payne, JF, Clark, L, Abdelfattah, NS & Sadda, SR 2015, Ophthalmology, vol 122, no. 12, pp. 2514-2522. DOI:

Primary rhegmatogenous retinal detachment repair: Evidence supports an individualised approach
Wykoff, CC, Schwartz, SG, Adelman, RA, Brucker, AJ & Flynn, HW 2015, British Journal of Ophthalmology, vol 99, no. 11, pp. 1451-1453. DOI:

Aflibercept for pigment epithelial detachment for previously treated neovascular age-related macular degeneration
Major, JC , Wykoff, CC, Croft, DE, Wang, R, Mariani, AF, Lehmann, AE & Brown, DM 2015, Canadian Journal of Ophthalmology, vol 50, no. 5, 715, pp. 373-377. DOI:

Brown, DM , Wykoff, CC, Croft, DE & Wong, TP 2015, Retina, vol 35, no. 10, pp. e61-e63.

Comparing aflibercept, bevacizumab, and ranibizumab for DME: Analysis of DRCR protocol T
Wykoff, CC & Hariprasad, SM 2015, Ophthalmic Surgery Lasers and Imaging Retina, vol 46, no. 3, pp. 302-305. DOI:

Progressive retinal nonperfusion in ischemic central retinal vein occlusion
Wykoff, CC , Brown, DM, Croft, DE, Major, JC & Wong, TP 2015, Retina, vol 35, no. 1, pp. 43-47. DOI:

Exogenous fungal endophthalmitis: An analysis of isolates and susceptibilities to antifungal agents over a 20-year period (1990-2010)
Silva, RA, Sridhar, J, Miller, D, Wykoff, CC & Flynn, HW 2015, American Journal of Ophthalmology, vol 159, no. 2, pp. 257-264.e1. DOI:

Monthly versus as-needed ranibizumab injections in patients with retinal vein occlusion: The SHORE study
Campochiaro, PA, Wykoff, CC, Singer, M, Johnson, R, Marcus, D, Yau, L & Sternberg, G 2014, Ophthalmology, vol 121, no. 12, pp. 2432-2442. DOI:

Ranibizumab in preproliferative (ischemic) central retinal vein occlusion: the rubeosis anti-VEGF (RAVE) trial
Brown, DM , Wykoff, CC , Wong, TP, Mariani, AF, Croft, DE & Schuetzle, KL 2014, Retina (Philadelphia, Pa.), vol 34, no. 9, pp. 1728-1735. DOI:

Precise montaging and metric quantification of retinal surface area from ultra-widefield fundus photography and fluorescein angiography
Croft, DE, van Hemert, J, Wykoff, CC, Clifton, D, Verhoek, M, Fleming, A & Brown, DM 2014, Ophthalmic surgery, lasers & imaging retina, vol 45, no. 4, pp. 312-317. DOI: