E. Brian Butler, MD

Jim and Joan Harrell Chair in Radiation Oncology, Department of Radiation Oncology
Professor of Radiation Oncology, Institute for Academic Medicine
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


After completing his postdoctoral training in 1987, Dr. Butler returned to the Wilford Hall USAF Medical Center in San Antonio, Texas where he became both the Chief of Radiation Oncology and the Chief of Brachytherapy. He also joined the faculty at The University of Texas Health Science Center at San Antonio as a Clinical Assistant Professor that same year. Dr. Butler would later join the Baylor College of Medicine where he would eventually become a full professor and the Chief of Radiation Oncology for both the medical school and the VA Hospital. He became the Medical Director of Radiation Oncology at Methodist in 1991, and received his faculty appointment at the Weill Medical School in 2006.

Description of Research

Dr. Butler’s research centers on preclinical and clinical studies that combine radiation therapy and gene therapy for the treatment of prostate cancer. In recent years, he has extended these successful studies to other cancers, notably pancreatic cancer. His research interests also include three-dimensional reconstruction of body organs to assist in better localization of radiation therapy.

Areas Of Expertise

Radiation therapy Prostate cancer Gene therapy Pancreatic cancer Computer visualization techniques
Education & Training

Residency, Stanford School of Medicine
MD, Georgetown University

Omission of radiotherapy in elderly women with early stage metaplastic breast cancer
Haque, W, Verma, V, Butler, EB & Teh, BS 2018, Breast, vol 38, pp. 154-159. DOI: 10.1016/j.breast.2018.01.005

The impact of comorbidity on overall survival in elderly nasopharyngeal carcinoma patients: A National Cancer Data Base analysis
Huang, Y, Chen, W, Haque, W, Verma, V, Xing, Y, Teh, BS & Brian Butler, E 2018, Cancer Medicine. DOI: 10.1002/cam4.1377

Radiation Oncology in the Face of Natural Disaster: The Experience of Houston Methodist Hospital
Mireles, M, Pino, R, Teh, BS, Farach, A, Joseph, A & Butler, EB 2018, International Journal of Radiation Oncology Biology Physics, vol 100, no. 4, pp. 813-815. DOI: 10.1016/j.ijrobp.2017.12.002

Radiation dose in neoadjuvant chemoradiation therapy for esophageal cancer: Patterns of care and outcomes from the National Cancer Data Base
Haque, W, Verma, V, Butler, EB & Teh, BS 2018, Journal of Gastrointestinal Oncology, vol 9, no. 1, pp. 80-89. DOI: 10.21037/jgo.2017.09.12

Trends in Cardiac Mortality in Patients With Locally Advanced Non-Small Cell Lung Cancer
Haque, W, Verma, V, Fakhreddine, M, Butler, EB, Teh, BS & Simone, CB 2018, International Journal of Radiation Oncology Biology Physics, vol 100, no. 2, pp. 470-477. DOI: 10.1016/j.ijrobp.2017.10.031

Metaplastic Breast Cancer: Practice Patterns, Outcomes, and the Role of Radiotherapy
Haque, W, Verma, V, Naik, N, Butler, EB & Teh, BS 2018, Annals of Surgical Oncology, pp. 1-9. DOI: 10.1245/s10434-017-6316-2

The role of adjuvant chemotherapy in locally advanced bladder cancer
Haque, W, Lewis, GD, Verma, V, Darcourt, JG, Butler, EB & Teh, BS 2017, Acta Oncologica, pp. 1-7. DOI: 10.1080/0284186X.2017.1415461

Practice Patterns and Outcomes in Elderly Stage I Non-Small-cell Lung Cancer: A 2004 to 2012 SEER Analysis
Dalwadi, SM, Szeja, SS, Bernicker, EH, Butler, EB, Teh, BS & Farach, AM 2017, Clinical Lung Cancer. DOI: 10.1016/j.cllc.2017.11.004

Management of pathologic node-positive disease following initial surgery for clinical T1-2 N0 esophageal cancer: patterns of care and outcomes from the national cancer data base
Haque, W, Verma, V, Bernicker, E, Butler, EB & Teh, BS 2017, Acta Oncologica, pp. 1-8. DOI: 10.1080/0284186X.2017.1409435

Addition of chemotherapy to hypofractionated radiotherapy for glioblastoma: practice patterns, outcomes, and predictors of survival
Haque, W, Verma, V, Butler, EB & Teh, BS 2017, Journal of Neuro-Oncology, pp. 1-9. DOI: 10.1007/s11060-017-2654-y

Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination
Mujoo, K, Pandita, RK, Tiwari, A, Charaka, V, Chakraborty, S, Singh, DK, Hambarde, S, Hittelman, WN, Horikoshi, N, Hunt, CR, Khanna, KK, Kots, AY, Butler, EB, Murad, F & Pandita, TK 2017, Stem Cell Reports, vol 9, no. 5, pp. 1660-1674. DOI: 10.1016/j.stemcr.2017.10.002

National Practice Patterns and Outcomes for T4b Urothelial Cancer of the Bladder
Haque, W, Verma, V, Butler, EB & Teh, BS 2017, Clinical Genitourinary Cancer. DOI: 10.1016/j.clgc.2017.08.013

Treatment Outcomes and Prognostic Factors in Male Patients With Stage IV Breast Cancer: A Population-based Study
Chen, W, Huang, Y, Lewis, GD, Szeja, SS, Hatch, SS, Farach, A, Miltenburg, D, Butler, EB, Chang, JC & Teh, BS 2017, Clinical Breast Cancer. DOI: 10.1016/j.clbc.2017.07.005

Radiation therapy utilization and outcomes for older women with breast cancer: Impact of molecular subtype and tumor grade
Haque, W, Kee Yuan, DM, Verma, V, Butler, EB, Teh, BS, Wiederhold, L & Hatch, S 2017, Breast, vol 35, pp. 34-41. DOI: 10.1016/j.breast.2017.06.011

Radical cystectomy versus chemoradiation for muscle-invasive bladder cancer: Impact of treatment facility and sociodemographics
Haque, W, Verma, V, Butler, EB & Teh, BS 2017, Anticancer Research, vol 37, no. 10, pp. 5603-5608. DOI: 10.21873/anticanres.11994

Definitive chemoradiation at high volume facilities is associated with improved survival in glioblastoma
Haque, W, Verma, V, Butler, EB & Teh, BS 2017, Journal of Neuro-Oncology, pp. 1-9. DOI: 10.1007/s11060-017-2563-0

Stereotactic body radiation therapy for prostate cancer-a review
Haque, W, Butler, EB & Teh, BS 2017, Chinese Clinical Oncology, vol 6, S10. DOI: 10.21037/cco.2017.06.05

The utility of positron emission tomography/computed tomography in target delineation for stereotactic body radiotherapy for liver metastasis from primary gastric cancer: An illustrative case report and literature review
Lewis, GD, Chiang, SB, Butler, EB & Teh, BS 2017, Journal of Gastrointestinal Oncology, vol 8, no. 3, pp. E39-E42. DOI: 10.21037/jgo.2017.01.18

Patterns of care and outcomes of multi-agent versus single-agent chemotherapy as part of multimodal management of low grade glioma
Haque, W, Verma, V, Butler, EB & Teh, BS 2017, Journal of Neuro-Oncology. DOI: 10.1007/s11060-017-2443-7

Trends in the use of implantable accelerated partial breast irradiation for ductal carcinoma in situ: Implications of the recent amendments to the American Society for Radiation Oncology consensus guidelines
Haque, W, Verma, V, Haque, A, Butler, EB & Teh, BS 2017, Brachytherapy, vol 16, no. 2, pp. 402-408. DOI: 10.1016/j.brachy.2016.12.002