Welcome to The Department of Systems Medicine and Bioengineering (SMAB) at Houston Methodist Research Institute. Our mission is to engineer better medicine and to advance therapeutic sciences as well as train clinicians and researchers in using cutting-edge systems approach to advance medicine and healthcare delivery.
In the biomedical sciences, the trend moves from a reductionist approach to a "systems understanding" paradigm that aims to understand biology and pathophysiology in a holistic manner, making use of increasing amounts of -omics data, pathways information, phenotypic images, and other quantitative data. The challenge, however, is to convert scientific advances made in molecular and cellular biology and the availability of massive amounts of experimental and clinical data into "new" medical knowledge and clinical utility that benefit patients and improve quality of life.
To this end, systems medicine is an emerging discipline that investigates and integrates systems biology approaches with methodological principles of engineering to translational research and medical practice. It integrates a variety of biological, chemical, and medical data at multiple scale of biology, ranging from genes, proteins and cells to tissues, organs, and populations using the power of computational analysis, information sciences, and mathematical modeling to better understand the disease mechanisms and devise cost-effective strategies for disease management and treatment. New medical knowledge gained in turns also helps guide the creative development of next generation medical devices and tools. We believe that the systematic integration of systems biology and engineering methodologies with experimental biology and clinical medicine holds the key to translating scientific discoveries effectively from bench to bedside and back.
SMAB faculty collaborate actively with scientists, physicians and patients around the globe to combat disease problems using a combination of systems biology, bioimaging, and bioengineering methods.