CCCExplorer is a java-based software that predicts and visualizes the gene signaling network to aid research on crosstalk identification in the tumor microenvironment. CCCExplorer integrates a computational model that we developed to uncover cell-cell communication as a direct and connected network. These cell communications range from ligand-receptor interactions to transcription factors and their target genes. Learn more about CCCExplorer software.
- Yeung TL, Sheng J, Leung CS, Li F, Kim J, Ho SY, Matzuk MM, Lu KH, Wong STC*, Mok SC*. Systematic Identification of Druggable Epithelial-Stromal Crosstalk Signaling Networks in Ovarian Cancer. J Natl Cancer Inst. 2018 May 31. PMID: 29860390.
- Choi H, Sheng J, Gao D, Li F, Durrans A, Ryu S, Lee SB, Narula N, Rafii S, Elemento O, Altorki NK, Wong ST*, Mittal V*. Transcriptome analysis of individual stromal cell populations identifies stroma-tumor crosstalk in mouse lung cancer model. Cell Reports. 2015 Feb 24;10(7):1187-201. PMID: 2570482
Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma. Medulloblastoma (MB) is the most common malignant brain tumor of childhood. Although outcomes have improved in recent decades, new treatments are still needed to improve survival and reduce treatment-related complications.
Drug combinations that simultaneously suppress multiple cancer driver signaling pathways increase therapeutic options and may reduce drug resistance. We have developed a computational systems biology tool, DrugComboExplorer, to identify driver signaling pathways and predict synergistic drug combinations by integrating the knowledge embedded in vast amounts of available pharmacogenomics and omics data. Learn more about DrugComboExplorer software.
DrugComboRanker is a computational tool that prioritizes synergistic drug combinations and uncovers their mechanisms of action. Learn more about DrugComboRanker.
Morphological plasticity is critical to organism development - as exemplified by the reversible conversion of embryonic non-migratory epithelial cells to motile mesenchymal cells required for tissue Morphological plasticity is critical to organism development as exemplified by the reversible conversion of embryonic non-migratory epithelial cells to motile mesenchymal cells required for tissue positioning and organization.