Parkinsonism & Parkinson’s Disease

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Houston Methodist offers patients with Parkinson’s disease the most advanced treatment options — including innovative therapies not widely available at other medical centers. Our integrated neurologists provide expertise and education to improve patients’ quality of life.

Houston Methodist offers a comprehensive approach to treating patients with Parkinson's disease and parkinsonism disorders that reduce dopamine levels in the brain. Our expert team provides compassionate patient care, backed by leading-edge diagnostic technology and innovative clinical research.

Parkinson’s disease is a progressive condition of the nervous system that affects movement. Symptoms worsen over time, causing challenges in communication and performing daily activities. Our specialized neurology team at Houston Methodist offers an ongoing partnership with you — from diagnosis through every stage of Parkinson’s disease. We will be by your side to help you and your family lead a comfortable, high-quality life. 

Diagnosing & Treating Parkinson’s Disease

How is Parkinson’s disease diagnosed?

Parkinson’s symptoms can resemble those of other neuromuscular disorders, and there is no specific test to identify Parkinson’s disease. Houston Methodist neurologists collate decades of experience in neuromuscular disease research and care to provide accurate, personalized diagnoses.

Our first step is to discuss your symptoms in depth. The first signs of Parkinson’s disease may be vague, such as a slight tremor in one hand, not swinging the arms while walking or lost ability to show facial expressions. Over time, symptoms will worsen and may progress to include:


  • Cognitive deficit
  • Decreased ability to perform automatic movements such as blinking 
  • Depression
  • Difficulty writing
  • Dragging the feet
  • Fecal or urinary incontinence
  • Impaired speech and swallowing
  • Muscle stiffness or rigidity
  • Posture and balance problems
  • Severe tremors in both hands
  • Sexual dysfunction
  • Slow movement (bradykinesia)
  • Sudden drops in blood pressure (orthostatic hypotension)
  • Taking shorter steps 
  • Trouble sleeping


Once we have a clear picture of your symptoms, we will conduct a neurological and physical examination to rule out any underlying conditions and provide an appropriate diagnosis.

What treatment options are available?

Though there is no cure for Parkinson's disease, Houston Methodist's integrated neurology team is on the leading edge of treatment innovations. We will create a comprehensive best treatment plan to reduce your symptoms and improve your quality of life. 

A range of medications can help manage Parkinson’s symptoms:


  • A combination of carbidopa and levodopa can introduce more dopamine to the brain
  • Dopamine agonists (such as pramipexole) mimic the effects of dopamine in the brain
  • MAO-B inhibitors prevent the breakdown of dopamine
  • Catechol O-methyltransferase inhibitors prolong the effect of levodopa therapy
  • Oral medication, such as Botox®
  • Intrathecal administration of baclofen


Behavior Modifications
Getting regular exercise and incorporating rest time into your day can help relieve mild to moderate parkinsonism symptoms. Participating in physical therapy can help reduce muscle stiffness, rigidity and balance problems.

Houston Methodist offers deep brain stimulation (DBS), a procedure in which a neurosurgeon implants electrodes into the brain, which are then connected to a generator that is surgically placed in the patient’s chest. The DBS device sends electrical pulses to the brain that are proven to reduce stiffness, tremors and dyskinesia (involuntary movements). DBS enables many patients to respond to medication up to a decade longer.

Advancements in MRI-guided surgery allows us to perform this procedure with even greater precision. We are leading clinical research to determine whether DBS offers the added benefit of reducing the risk of fall-related injuries in patients with Parkinson’s disease.

I need advanced care or a second opinion.

Houston Methodist is a national leader in parkinsonism diagnosis, treatment and clinical research. Our neurologists bring decades of compassionate experience in movement disorder management. We educate patients and families on comprehensive treatment options, including clinical trial therapies that are not yet widely available at other centers.  

Parkinson’s disease symptoms and treatment needs change over time. Our integrated neurologists are part of a multidisciplinary team — we will partner with you to manage your unique condition every step of the way.

Patient Success

After a Parkinson's disease diagnosis, John Sinclair found relief from involuntary movement symptoms through deep brain stimulation (DBS).

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