About ALS

Find a Specialist Near You

Houston Methodist ALS specialists offer patients and families the education, support and hope to manage the symptoms of this complex neuromuscular condition.

Houston Methodist is home to the nation’s first multidisciplinary ALS Clinic . The compassionate specialists who comprise “Team Hope” offer innovative, personalized care to patients from throughout the U.S., in collaboration with the Muscular Dystrophy Association (MDA) and the ALS Association (ALSA).  

Amyotrophic lateral sclerosis or ALS (also known as Lou Gehrig’s disease or motor neuron disease) is a neuromuscular disorder that causes muscle weakness and interferes with a patient’s ability to function physically. The nerve cells that control movement of muscles gradually die and muscles progressively weaken and atrophy.

Symptoms vary among patients and grow more severe over time. Early diagnosis is key to preserving function and quality of life — the more we know about your condition, the better we can customize your care plan.

Symptoms of ALS

ALS causes loss of upper and lower motor neurons — nerve cells that project from the brain to the spinal cord and from the spinal cord to the muscles. Approximately 20% of patients first notice reduced ability to speak. Muscle weakness eventually becomes the most intense symptom. 

Over time, patients may experience a range of symptoms that progressively become worse:

 

  • Cramps in arms, shoulders and tongue
  • Difficulty holding their head up or maintaining good posture
  • Trouble walking
  • Twitching in the arms and legs
  • Limited dexterity in the hands
  • Weakness in legs, feet or ankles
  • Slurring of speech or trouble swallowing

 

Pain is uncommon with ALS, and the condition usually does not affect cognition, the senses, sexual function or bowel and bladder control. However, ALS slowly diminishes the ability to control the muscles used to move, speak, eat and breathe. Most patients experience progressive muscle weakness over a three-to-five-year time frame.

ALS Education for Patients & Families

Find Patient Resources

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Get information to prepare for your visit, as well as answers to frequently asked questions.

Find Clinical Trials

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We participate in multiple clinical research trials to improve and advance ALS treatment.

Innovations in ALS Research

By developing a clinical trial to expand and infuse a patient’s dysfunctional  T-regulatory cells, our researchers are working toward a treatment to potentially stop the progression of ALS. 

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