Joseph C. Masdeu, MD, PhD

  • Houston Methodist neurologist
  • Director of the Houston Methodist Nantz National Alzheimer Center
  • Graham Family Distinguished Endowed Chair in Neurological Sciences
  • Professor of Neurology, Weill Cornell Medical College

Joseph C. Masdeu, MD, PhD

Areas of Expertise

  • Alzheimer’s disease
  • Behavioral disorders
  • Gait disorders
  • Memory disorders
  • Neurodegenerative disorders
  • Neuroimaging
  • Traumatic brain injury

Credentials

BOARD CERTIFICATION
American Board of Psychiatry and Neurology, Neurology
Neuroimaging | The United Council for Neurological Subspecialties
MEDICAL SCHOOL
Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain | 1969
INTERNSHIP
Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain
RESIDENCY
Neurology, Mount Sinai Hospital, Chicago, Illinois

Publications

Anatomy of 18F-GE180, a failed radioligand for the TSPO protein
Zanotti-Fregonara, P, Pascual, B, Rostomily, RC, Rizzo, G, Veronese, M, Masdeu, JC & Turkheimer, F 2020, European Journal of Nuclear Medicine and Molecular Imaging, vol. 47, no. 10, pp. 2233-2236. https://doi.org/10.1007/s00259-020-04732-y

Reclassifying neurodegenerative diseases
Villoslada, P, Baeza-Yates, R & Masdeu, JC 2020, , Nature Biomedical Engineering, vol. 4, no. 8, pp. 759-760. https://doi.org/10.1038/s41551-020-0600-3

Longitudinal Positron Emission Tomography of Dopamine Synthesis in Subjects with GBA1 Mutations
Lopez, G, Eisenberg, DP, Gregory, MD, Ianni, AM, Grogans, SE, Masdeu, JC, Kim, J, Groden, C, Sidransky, E & Berman, KF 2020, Annals of Neurology, vol. 87, no. 4, pp. 652-657. https://doi.org/10.1002/ana.25692

A 70-Year Old Man with Dystonic and Choreiform Movements
Perez, A, Roman, GC, Powell, SZ-E, Fisher, R, Rivera, AL, Masdeu, JC & Cykowski, MD 2020, Brain Pathology, vol. 30, no. 2, pp. 415-416. https://doi.org/10.1111/bpa.12819

Posterior primary progressive prosopagnosia: Structural and molecular imaging
Pascual, B, Masdeu, JC, Funk, Q, Zanotti-Fregonara, P, Shyer, M, Rockers, E & Schulz, PE 2020, Neurology, vol. 94, no. 8, pp. 360-361. https://doi.org/10.1212/WNL.0000000000009001


Neuroimaging of Diseases Causing Dementia
Masdeu, JC 2020, Neurologic Clinics, vol. 38, no. 1, pp. 65-94. https://doi.org/10.1016/j.ncl.2019.08.003

Multimodal 18F-AV-1451 and MRI findings in nonfluent variant of primary progressive aphasia: Possible insights on nodal propagation of tau protein across the syntactic network
Pascual, B, Funk, Q, Zanotti-Fregonara, P, Pal, N, Rockers, E, Yu, MM, Spann, B, Román, GC, Schulz, PE, Karmonik, C, Appel, SH & Masdeu, JC 2020, Journal of Nuclear Medicine, vol. 61, no. 2, pp. 263-269. https://doi.org/10.2967/jnumed.118.225508

Medicare for All?
Masdeu, JC 2020, Annals of Neurology, vol. 87, no. 1, pp. 155-156. https://doi.org/10.1002/ana.25631

Positron Emission Tomography Imaging with [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes
Fleisher, AS, Pontecorvo, MJ, Devous, MD, Lu, M, Arora, AK, Truocchio, SP, Aldea, P, Flitter, M, Locascio, T, Devine, M, Siderowf, A, Beach, TG, Montine, TJ, Serrano, GE, Curtis, C, Perrin, A, Salloway, S, Daniel, M, Wellman, C, Joshi, AD, Irwin, DJ, Lowe, VJ, Seeley, WW, Ikonomovic, MD, Masdeu, JC, Kennedy, I, Harris, T, Navitsky, M, Southekal, S & Mintun, MA 2020, , JAMA Neurology. https://doi.org/10.1001/jamaneurol.2020.0528


End of life: Expert care and support, not physician-hastened death
Masdeu, JC, Aksamit, AJ, Carver, AC, Foley, KM, Kass, JS, Martin, RA, McCusker, EA, McQuillen, MP, Mehanna, R, Payne, R, Victor, SJ & Warach, S 2019, Neurology, vol. 93, no. 17, pp. 729-734. https://doi.org/10.1212/WNL.0000000000008356

Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain
Zanotti-Fregonara, P, Pascual, B, Veronese, M, Yu, M, Beers, D, Appel, SH & Masdeu, JC 2019, , European Journal of Nuclear Medicine and Molecular Imaging, vol. 46, no. 9, pp. 1822-1829. https://doi.org/10.1007/s00259-019-04349-w


“Ears of the lynx” MRI sign is associated with SPG11 and SPG15 hereditary spastic paraplegia
Pascual, MB, De Bot, ST, Daniels, MR, França, MC, Toro, C, Riverol, M, Hedera, P, Bassi, MT, Bresolin, N, Van De Warrenburg, BP, Kremer, B, Nicolai, J, Charles, P, Xu, J, Singh, S, Patronas, NJ, Fung, SH, Gregory, MD & Masdeu, JC 2019, , American Journal of Neuroradiology, vol. 40, no. 1, pp. 199-203. https://doi.org/10.3174/ajnr.A5935

The validity of 18 F-GE180 as a TSPO imaging agent
Zanotti-Fregonara, P, Veronese, M, Pascual, B, Rostomily, RC, Turkheimer, F & Masdeu, JC 2019, , European Journal of Nuclear Medicine and Molecular Imaging, vol. 46, no. 6, pp. 1205-1207. https://doi.org/10.1007/s00259-019-4268-4

Functional alterations of myeloid cells during the course of Alzheimer's disease
Thome, AD, Faridar, A, Beers, DR, Thonhoff, JR, Zhao, W, Wen, S, Pascual, B, Masdeu, JC & Appel, SH 2018, Molecular Neurodegeneration, vol. 13, no. 1, pp. 61. https://doi.org/10.1186/s13024-018-0293-1

Clinical findings in a multicenter MRI study of mild TBI
Shetty, T, Nguyen, JT, Cogsil, T, Tsiouris, AJ, Niogi, SN, Kim, EU, Dalal, A, Halvorsen, K, Cummings, K, Zhang, T, Masdeu, JC, Mukherjee, P & Marinelli, L 2018, , Frontiers in Neurology, vol. 9, no. OCT, 836. https://doi.org/10.3389/fneur.2018.00836


Head-to-head comparison of 11C-PBR28 and 18F-GE180 for quantification of the translocator protein in the human brain
Zanotti Fregonara, P, Pascual, MB, Rizzo, G, Yu, MM, Pal, N, Beers, D, Carter, R, Appel, SH, Atassi, N & Masdeu, JC 2018, , Journal of Nuclear Medicine, vol. 59, no. 8, pp. 1260-1266. https://doi.org/10.2967/jnumed.117.203109

Languages

  • English
  • Spanish