Joseph C. Masdeu, MD, PhD

  • Houston Methodist neurologist
  • Director of the Houston Methodist Nantz National Alzheimer Center
  • Graham Family Distinguished Endowed Chair in Neurological Sciences
  • Professor of Neurology, Weill Cornell Medical College

Joseph C. Masdeu, MD, PhD

Areas of Expertise

  • Alzheimer’s disease
  • Behavioral disorders
  • Gait disorders
  • Memory disorders
  • Neurodegenerative disorders
  • Neuroimaging
  • Traumatic brain injury

Credentials

BOARD CERTIFICATION
American Board of Psychiatry and Neurology, Neurology
Neuroimaging | The United Council for Neurological Subspecialties
MEDICAL SCHOOL
Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain | 1969
INTERNSHIP
Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain
RESIDENCY
Neurology, Mount Sinai Hospital, Chicago, Illinois

Publications

Research Participants' Perspectives on Precision Diagnostics for Alzheimer's Disease
Smith, HS, Robinson, JO, Levchenko, A, Pereira, S, Pascual, B, Bradbury, K, Arbones, V, Fong, J, Shulman, JM, Mcguire, AL & Masdeu, J 2024, , Journal of Alzheimers Disease, vol. 97, no. 3, pp. 1261-1274. https://doi.org/10.3233/JAD-230609


A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease
Faridar, A, Eid, AM, Thome, AD, Zhao, W, Beers, DR, Pascual, MB, Nakawah, MO, Roman, GC, Davis, CS, Grundman, M, Masdeu, JC & Appel, SH 2023, , Translational Neurodegeneration, vol. 12, no. 1, 54, pp. 54. https://doi.org/10.1186/s40035-023-00387-5

A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer's disease
Faridar, A, Eid, AM, Thome, AD, Zhao, W, Beers, DR, Pascual, MB, Nakawah, MO, Roman, GC, Davis, CS, Grundman, M, Masdeu, JC & Appel, SH 2023, , Translational Neurodegeneration, vol. 12, no. 1, pp. 54. https://doi.org/10.1186/s40035-023-00387-5

Sex and APOE e4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer's disease
Nemes, S, Logan, PE, Manchella, MK, Mundada, NS, La Joie, R, Polsinelli, AJ, Hammers, DB, Koeppe, RA, Foroud, TM, Nudelman, KN, Eloyan, A, Iaccarino, L, Dorsant-Ardón, V, Taurone, A, Thangarajah, M, Dage, JL, Aisen, P, Grinberg, LT, Jack, CR, Kramer, J, Kukull, WA, Murray, ME, Rumbaugh, M, Soleimani-Meigooni, DN, Toga, A, Touroutoglou, A, Vemuri, P, Atri, A, Day, GS, Duara, R, Graff-Radford, NR, Honig, LS, Jones, DT, Masdeu, J, Mendez, MF, Musiek, E, Onyike, CU, Riddle, M, Rogalski, E, Salloway, S, Sha, SJ, Turner, RS, Wingo, TS, Womack, KB, Wolk, DA, Rabinovici, GD, Carrillo, MC, Dickerson, BC & Apostolova, LG 2023, , Alzheimers and Dementia, vol. 19, no. S9, pp. S49-S63. https://doi.org/10.1002/alz.13403

Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data
Alzheimers Disease Metabolomics Consortium (ADMC) & Alzheimers Disease Neuroimaging Initiative (ADNI) 2023, , EBioMedicine, vol. 97, 104820. https://doi.org/10.1016/j.ebiom.2023.104820

Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study
Dage, JL, Eloyan, A, Thangarajah, M, Hammers, DB, Fagan, AM, Gray, JD, Schindler, SE, Snoddy, C, Nudelman, KNH, Faber, KM, Foroud, T, Aisen, P, Griffin, P, Grinberg, LT, Iaccarino, L, Kirby, K, Kramer, J, Koeppe, R, Kukull, WA, La Joie, R, Mundada, NS, Murray, ME, Rumbaugh, M, Soleimani-Meigooni, DN, Toga, AW, Touroutoglou, A, Vemuri, P, Atri, A, Beckett, LA, Day, GS, Graff-Radford, NR, Duara, R, Honig, LS, Jones, DT, Masdeu, JC, Mendez, MF, Musiek, E, Onyike, CU, Riddle, M, Rogalski, E, Salloway, S, Sha, SJ, Turner, RS, Wingo, TS, Wolk, DA, Womack, KB, Carrillo, MC, Dickerson, BC, Rabinovici, GD & Apostolova, LG 2023, , Alzheimers and Dementia, vol. 19, no. S9, pp. S115-S125. https://doi.org/10.1002/alz.13399

The Sporadic Early-onset Alzheimer's Disease Signature Of Atrophy: Preliminary Findings From The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) Cohort
Touroutoglou, A, Katsumi, Y, Brickhouse, M, Zaitsev, A, Eckbo, R, Aisen, P, Beckett, L, Dage, JL, Eloyan, A, Foroud, T, Ghetti, B, Griffin, P, Hammers, D, Jack, CR, Kramer, JH, Iaccarino, L, Joie, RL, Mundada, NS, Koeppe, R, Kukull, WA, Murray, ME, Nudelman, K, Polsinelli, AJ, Rumbaugh, M, Soleimani-Meigooni, DN, Toga, A, Vemuri, P, Atri, A, Day, GS, Duara, R, Graff-Radford, NR, Honig, LS, Jones, DT, Masdeu, JC, Mendez, MF, Musiek, E, Onyike, CU, Riddle, M, Rogalski, E, Salloway, S, Sha, S, Turner, RS, Wingo, TS, Wolk, DA, Womack, K, Carrillo, MC, Rabinovici, GD, Apostolova, LG & Dickerson, BC 2023, , Alzheimers and Dementia, vol. 19, no. S9, pp. S74-S88. https://doi.org/10.1002/alz.13466

Influence of amyloid and diagnostic syndrome on non-traditional memory scores in early-onset Alzheimer's disease
Bushnell, J, Hammers, DB, Aisen, P, Dage, JL, Eloyan, A, Foroud, T, Grinberg, LT, Iaccarino, L, Jack, CR, Kirby, K, Kramer, J, Koeppe, R, Kukull, WA, La Joie, R, Mundada, NS, Murray, ME, Nudelman, K, Rumbaugh, M, Soleimani-Meigooni, DN, Toga, A, Touroutoglou, A, Vemuri, P, Atri, A, Day, GS, Duara, R, Graff-Radford, NR, Honig, LS, Jones, DT, Masdeu, J, Mendez, M, Musiek, E, Onyike, CU, Riddle, M, Rogalski, E, Salloway, S, Sha, S, Turner, RS, Wingo, TS, Wolk, DA, Carrillo, MC, Dickerson, BC, Rabinovici, GD, Apostolova, LG & Clark, DG 2023, , Alzheimers and Dementia, vol. 19, no. S9, pp. S29-S41. https://doi.org/10.1002/alz.13434


White matter hyperintensities are higher among early-onset Alzheimer's disease participants than their cognitively normal and early-onset nonAD peers: Longitudinal Early-onset Alzheimer's Disease Study (LEADS)
Eloyan, A, Thangarajah, M, An, N, Borowski, BJ, Reddy, AL, Aisen, P, Dage, JL, Foroud, T, Ghetti, B, Griffin, P, Hammers, D, Iaccarino, L, Jack, CR, Kirby, K, Kramer, J, Koeppe, R, Kukull, WA, La Joie, R, Mundada, NS, Murray, ME, Nudelman, K, Rumbaugh, M, Soleimani-Meigooni, DN, Toga, A, Touroutoglou, A, Atri, A, Day, GS, Duara, R, Graff-Radford, NR, Honig, LS, Jones, DT, Masdeu, J, Mendez, MF, Musiek, E, Onyike, CU, Rogalski, E, Salloway, S, Sha, S, Turner, RS, Wingo, TS, Wolk, DA, Womack, K, Beckett, L, Gao, S, Carrillo, MC, Rabinovici, G, Apostolova, LG, Dickerson, B & Vemuri, P 2023, , Alzheimers and Dementia, vol. 19, no. S9, pp. S89-S97. https://doi.org/10.1002/alz.13402

PET-measured human dopamine synthesis capacity and receptor availability predict trading rewards and time-costs during foraging
Ianni, AM, Eisenberg, DP, Boorman, ED, Constantino, SM, Hegarty, CE, Gregory, MD, Masdeu, JC, Kohn, PD, Behrens, TE & Berman, KF 2023, , Nature Communications, vol. 14, no. 1, 6122, pp. 6122. https://doi.org/10.1038/s41467-023-41897-0

Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration
Asken, BM, Ljubenkov, PA, Staffaroni, AM, Casaletto, KB, Vandevrede, L, Cobigo, Y, Rojas-Rodriguez, JC, Rankin, KP, Kornak, J, Heuer, H, Shigenaga, J, Appleby, BS, Bozoki, AC, Domoto-Reilly, K, Ghoshal, N, Huey, E, Litvan, I, Masdeu, JC, Mendez, MF, Pascual, B, Pressman, P, Tartaglia, MC, Kremers, W, Forsberg, LK, Boeve, BF, Boxer, AL, Rosen, HJ & Kramer, JH 2023, , Journal of Neurology, Neurosurgery and Psychiatry, vol. 94, no. 7, pp. 541-549. https://doi.org/10.1136/jnnp-2022-330866

Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration
ALLFTD Consortium Investigators 2023, , Journal of neurology, neurosurgery, and psychiatry, vol. 94, no. 7, pp. 541-549. https://doi.org/10.1136/jnnp-2022-330866


Developments in understanding early onset Alzheimer's disease
Griffin, P, Apostolova, L, Dickerson, BC, Rabinovici, G, Salloway, S, Brandt, K, Masdeu, J, Hammers, D, Raghuram, S, Hall, S & Carrillo, MC 2023, , Alzheimers and Dementia, vol. 19 Suppl 9, no. Suppl 9, pp. S126-S131. https://doi.org/10.1002/alz.13353


Learning slopes in early-onset Alzheimer's disease
Hammers, DB, Nemes, S, Diedrich, T, Eloyan, A, Kirby, K, Aisen, P, Kramer, J, Nudelman, K, Foroud, T, Rumbaugh, M, Atri, A, Day, GS, Duara, R, Graff-Radford, NR, Honig, LS, Jones, DT, Masdeu, JC, Mendez, MF, Musiek, E, Onyike, CU, Riddle, M, Rogalski, E, Salloway, S, Sha, SJ, Turner, RS, Weintraub, S, Wingo, TS, Wolk, DA, Wong, B, Carrillo, MC, Dickerson, BC, Rabinovici, GD & Apostolova, LG 2023, , Alzheimers and Dementia, vol. 19 Suppl 9, no. S9, pp. S19-S28. https://doi.org/10.1002/alz.13159

Profiling baseline performance on the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort near the midpoint of data collection
Hammers, DB, Eloyan, A, Taurone, A, Thangarajah, M, Beckett, L, Gao, S, Kirby, K, Aisen, P, Dage, JL, Foroud, T, Griffin, P, Grinberg, LT, Jack, CR, Kramer, J, Koeppe, R, Kukull, WA, Mundada, NS, La Joie, R, Soleimani-Meigooni, DN, Iaccarino, L, Murray, ME, Nudelman, K, Polsinelli, AJ, Rumbaugh, M, Toga, A, Touroutoglou, A, Vemuri, P, Atri, A, Day, GS, Duara, R, Graff-Radford, NR, Honig, LS, Jones, DT, Masdeu, J, Mendez, MF, Womack, K, Musiek, E, Onyike, CU, Riddle, M, Rogalski, E, Salloway, S, Sha, SJ, Turner, RS, Wingo, TS, Wolk, DA, Carrillo, MC, Dickerson, BC, Rabinovici, GD & Apostolova, LG 2023, , Alzheimers and Dementia, vol. 19 Suppl 9, no. S9, pp. S8-S18. https://doi.org/10.1002/alz.13160

Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research
Taylor, JC, Heuer, HW, Clark, AL, Wise, AB, Manoochehri, M, Forsberg, L, Mester, C, Rao, M, Brushaber, D, Kramer, J, Welch, AE, Kornak, J, Kremers, W, Appleby, B, Dickerson, BC, Domoto-Reilly, K, Fields, JA, Ghoshal, N, Graff-Radford, N, Grossman, M, Hall, MG, Huey, ED, Irwin, D, Lapid, MI, Litvan, I, Mackenzie, IR, Masdeu, JC, Mendez, MF, Nevler, N, Onyike, CU, Pascual, B, Pressman, P, Rankin, KP, Ratnasiri, B, Rojas, JC, Tartaglia, MC, Wong, B, Gorno-Tempini, ML, Boeve, BF, Rosen, HJ, Boxer, AL & Staffaroni, AM 2023, , Alzheimers and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 15, no. 2, pp. e12423. https://doi.org/10.1002/dad2.12423

Languages

  • English
  • Spanish