Joseph C. Masdeu, MD, PhD

  • Houston Methodist neurologist
  • Director of the Houston Methodist Nantz National Alzheimer Center
  • Graham Family Distinguished Endowed Chair in Neurological Sciences
  • Professor of Neurology, Weill Cornell Medical College

Joseph C. Masdeu, MD, PhD

Areas of Expertise

  • Alzheimer’s disease
  • Behavioral disorders
  • Gait disorders
  • Memory disorders
  • Neurodegenerative disorders
  • Neuroimaging
  • Traumatic brain injury

Credentials

BOARD CERTIFICATION
American Board of Psychiatry and Neurology, Neurology
Neuroimaging | The United Council for Neurological Subspecialties
MEDICAL SCHOOL
Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain | 1969
INTERNSHIP
Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain
RESIDENCY
Neurology, Mount Sinai Hospital, Chicago, Illinois

Publications

Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease
Alzheimers Disease Neuroimaging Initiative 2021, , Nature Communications, vol. 12, no. 1, 4001. https://doi.org/10.1038/s41467-021-24220-7


Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057

Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti-Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057

Parametric Mapping for TSPO PET Imaging with Spectral Analysis Impulsive Response Function
Veronese, M, Tuosto, M, Marques, TR, Howes, O, Pascual, B, Yu, M, Masdeu, JC, Turkheimer, F, Bertoldo, A & Zanotti-Fregonara, P 2021, , Molecular Imaging and Biology, vol. 23, no. 4, pp. 560-571. https://doi.org/10.1007/s11307-020-01575-9

Polymorphism in the ZNF804A Gene and Variation in D1 and D2/D3 Dopamine Receptor Availability in the Healthy Human Brain: A Dual Positron Emission Tomography Study
Hegarty, CE, Ianni, AM, Kohn, PD, Kolachana, B, Gregory, M, Masdeu, JC, Eisenberg, DP & Berman, KF 2021, , Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. https://doi.org/10.1016/j.bpsc.2020.12.006


Anatomy of 18F-GE180, a failed radioligand for the TSPO protein
Zanotti-Fregonara, P, Pascual, B, Rostomily, RC, Rizzo, G, Veronese, M, Masdeu, JC & Turkheimer, F 2020, , European Journal of Nuclear Medicine and Molecular Imaging, vol. 47, no. 10, pp. 2233-2236. https://doi.org/10.1007/s00259-020-04732-y

Reclassifying neurodegenerative diseases
Villoslada, P, Baeza-Yates, R & Masdeu, JC 2020, , Nature Biomedical Engineering, vol. 4, no. 8, pp. 759-760. https://doi.org/10.1038/s41551-020-0600-3

Longitudinal Positron Emission Tomography of Dopamine Synthesis in Subjects with GBA1 Mutations
Lopez, G, Eisenberg, DP, Gregory, MD, Ianni, AM, Grogans, SE, Masdeu, JC, Kim, J, Groden, C, Sidransky, E & Berman, KF 2020, , Annals of Neurology, vol. 87, no. 4, pp. 652-657. https://doi.org/10.1002/ana.25692

A 70-Year Old Man with Dystonic and Choreiform Movements
Perez, A, Roman, GC, Powell, SZ-E, Fisher, R, Rivera, AL, Masdeu, JC & Cykowski, MD 2020, , Brain Pathology, vol. 30, no. 2, pp. 415-416. https://doi.org/10.1111/bpa.12819

Posterior primary progressive prosopagnosia: Structural and molecular imaging
Pascual, B, Masdeu, JC, Funk, Q, Zanotti-Fregonara, P, Shyer, M, Rockers, E & Schulz, PE 2020, , Neurology, vol. 94, no. 8, pp. 360-361. https://doi.org/10.1212/WNL.0000000000009001


Neuroimaging of Diseases Causing Dementia
Masdeu, JC 2020, , Neurologic Clinics, vol. 38, no. 1, pp. 65-94. https://doi.org/10.1016/j.ncl.2019.08.003

Multimodal 18F-AV-1451 and MRI findings in nonfluent variant of primary progressive aphasia: Possible insights on nodal propagation of tau protein across the syntactic network
Pascual, B, Funk, Q, Zanotti-Fregonara, P, Pal, N, Rockers, E, Yu, MM, Spann, B, Román, GC, Schulz, PE, Karmonik, C, Appel, SH & Masdeu, JC 2020, , Journal of Nuclear Medicine, vol. 61, no. 2, pp. 263-269. https://doi.org/10.2967/jnumed.118.225508

Medicare for All?
Masdeu, JC 2020, , Annals of Neurology, vol. 87, no. 1, pp. 155-156. https://doi.org/10.1002/ana.25631

Positron Emission Tomography Imaging with [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes
Fleisher, AS, Pontecorvo, MJ, Devous, MD, Lu, M, Arora, AK, Truocchio, SP, Aldea, P, Flitter, M, Locascio, T, Devine, M, Siderowf, A, Beach, TG, Montine, TJ, Serrano, GE, Curtis, C, Perrin, A, Salloway, S, Daniel, M, Wellman, C, Joshi, AD, Irwin, DJ, Lowe, VJ, Seeley, WW, Ikonomovic, MD, Masdeu, JC, Kennedy, I, Harris, T, Navitsky, M, Southekal, S & Mintun, MA 2020, , JAMA Neurology, vol. 77, no. 7, pp. 829-839. https://doi.org/10.1001/jamaneurol.2020.0528


Restoring regulatory T-cell dysfunction in Alzheimer's disease through ex vivo expansion
Faridar, A, Thome, AD, Zhao, W, Thonhoff, JR, Beers, DR, Pascual, B, Masdeu, JC & Appel, SH 2020, , Brain communications, vol. 2, no. 2, pp. fcaa112. https://doi.org/10.1093/braincomms/fcaa112

End of life: Expert care and support, not physician-hastened death
Masdeu, JC, Aksamit, AJ, Carver, AC, Foley, KM, Kass, JS, Martin, RA, McCusker, EA, McQuillen, MP, Mehanna, R, Payne, R, Victor, SJ & Warach, S 2019, , Neurology, vol. 93, no. 17, pp. 729-734. https://doi.org/10.1212/WNL.0000000000008356

Languages

  • English
  • Spanish