Henry J. Pownall, PhD

  • Medical biochemist, Houston Methodist Research Institute
  • Professor of Biochemistry in Medicine, Houston Methodist Research Institute
  • Atherosclerosis & lipoprotein research director at Houston Methodist Research Institute
  • Professor of Bioenergetics, Houston Methodist Research Institute

Henry J. Pownall, PhD

Areas of Expertise

  • Atherogenesis
  • Cardiovascular sciences
  • Cholesterol transport
  • Energy metabolism / human lipid metabolism
  • Fluorescence
  • HDL structure, properties and function
  • High Density Lipoprotein (HDL) therapeutics
  • Molecular ethics
  • Obesity-linked diabetes
  • Physical chemistry

Credentials

Postdoctoral Fellowship, Baylor College of Medicine
PhD, Northeastern University
Postdoctoral Fellowship, The University of Houston
MS, Wilkes College, Wilkes-Barre, PA

Publications

Physico-chemical and physiological determinants of lipo-nanoparticle stability
Pownall, HJ, Liu, J, Gillard, BK, Yelamanchili, D & Rosales, C 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 33, 102361. https://doi.org/10.1016/j.nano.2021.102361

High-density lipoproteins, reverse cholesterol transport and atherogenesis
Pownall, HJ, Rosales, C, Gillard, BK & Gotto, AM 2021, , Nature Reviews Cardiology, vol. 18, no. 10, pp. 712-723. https://doi.org/10.1038/s41569-021-00538-z

High Free Cholesterol Bioavailability Drives the Tissue Pathologies in Scarb1-/-Mice
Liu, J, Gillard, BK, Yelamanchili, D, Gotto, AM, Rosales, C & Pownall, HJ 2021, , Arteriosclerosis, Thrombosis, and Vascular Biology, pp. E453-E467. https://doi.org/10.1161/ATVBAHA.121.316535

Highly conserved amino acid residues in apolipoprotein A1 discordantly induce high density lipoprotein assembly in vitro and in vivo
Yelamanchili, D, Liu, J, Gotto, AM, Hurley, AE, Lagor, WR, Gillard, BK, Davidson, WS, Pownall, HJ & Rosales, C 2020, , Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1865, no. 12, 158794. https://doi.org/10.1016/j.bbalip.2020.158794


Intensive Weight Loss Intervention and Cancer Risk in Adults with Type 2 Diabetes: Analysis of the Look AHEAD Randomized Clinical Trial
Yeh, HC, Bantle, JP, Cassidy-Begay, M, Blackburn, G, Bray, GA, Byers, T, Clark, JM, Coday, M, Egan, C, Espeland, MA, Foreyt, JP, Garcia, K, Goldman, V, Gregg, EW, Hazuda, HP, Hesson, L, Hill, JO, Horton, ES, Jakicic, JM, Jeffery, RW, Johnson, KC, Kahn, SE, Knowler, WC, Korytkowski, M, Kure, A, Lewis, CE, Mantzoros, C, Meacham, M, Montez, MG, Nathan, DM, Pajewski, N, Patricio, J, Peters, A, Xavier Pi-Sunyer, F, Pownall, H, Ryan, DH, Safford, M, Sedjo, RL, Steinburg, H, Vitolins, M, Wadden, TA, Wagenknecht, LE, Wing, RR, Wolff, AC, Wyatt, H & Yanovski, SZ 2020, , Obesity, vol. 28, no. 9, pp. 1678-1686. https://doi.org/10.1002/oby.22936


The alcohol–high-density lipoprotein athero-protective axis
Rosales, C, Gillard, BK, Gotto, A & Pownall, HJ 2020, , Biomolecules, vol. 10, no. 7, 987, pp. 1-16. https://doi.org/10.3390/biom10070987




Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease
Rodriguez, A, Trigatti, BL, Mineo, C, Knaack, D, Wilkins, JT, Sahoo, D, Asztalos, BF, Mora, S, Cuchel, M, Pownall, HJ, Rosales, C, Bernatchez, P, Ribeiro Martins da Silva, A, Getz, GS, Barber, JL, Shearer, GC, Zivkovic, AM, Tietge, UJF, Sacks, FM, Connelly, MA, Oda, MN, Davidson, WS, Sorci-Thomas, MG, Vaisar, T, Ruotolo, G, Vickers, KC & Martel, C 2019, , Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 39, no. 12, pp. 2457-2467. https://doi.org/10.1161/ATVBAHA.119.313340

Replacing Saturated Fat With Unsaturated Fat in Western Diet Reduces Foamy Monocytes and Atherosclerosis in Male Ldlr-/- Mice
Lian, Z, Perrard, XYD, Peng, X, Raya, JL, Hernandez, AA, Johnson, CG, Lagor, WR, Pownall, HJ, Hoogeveen, RC, Simon, SI, Sacks, FM, Ballantyne, CM & Wu, H 2020, , Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 40, no. 1, pp. 72-85. https://doi.org/10.1161/ATVBAHA.119.313078

Vulnerable Atherosclerotic Plaque Imaging by Small-Molecule High-Affinity Positron Emission Tomography Radiopharmaceutical
Yang, Z, Li, F, Yelamanchili, D, Zeng, Z, Rosales, C, Youker, KA, Shen, H, Ferrari, M, Mahmarian, J, Pownall, HJ, Hamilton, DJ & Li, Z 2019, advanced therapeutics, vol. 2, no. 8. https://doi.org/10.1002/adtp.201900005

Effects of Conserved Proline- APOA1 Variants on HDL Structure and Function.
Rosales, C, Yelamanchili, D, Gillard, BK, Gotto, A & Pownall, HJ 2019, .

Revisiting Reverse Cholesterol Transport in the Context of High-Density Lipoprotein Free Cholesterol Bioavailability
Rosales, C, Gillard, BK, Xu, B, Gotto, AM & Pownall, HJ 2019, , Methodist DeBakey cardiovascular journal, vol. 15, no. 1, pp. 47-54. https://doi.org/10.14797/mdcj-15-1-47

Lipids and Cardiovascular Disease: Putting It All Together
Pownall, HJ & Gotto, AM 2019, , Methodist DeBakey cardiovascular journal, vol. 15, no. 1, pp. 5-8. https://doi.org/10.14797/mdcj-15-1-5

Cholesterol: Can't Live With It, Can't Live Without It
Pownall, HJ & Gotto, AM 2019, , Methodist DeBakey cardiovascular journal, vol. 15, no. 1, pp. 9-15. https://doi.org/10.14797/mdcj-15-1-9

Vulnerable Atherosclerotic Plaque Imaging by Small-Molecule High-Affinity Positron Emission Tomography Radiopharmaceutical
Yang, Z, Li, F, Yelamanchili, D, Zeng, Z, Rosales, C, Youker, KA, Shen, H, Ferrari, M, Mahmarian, J, Pownall, HJ, Hamilton, DJ & Li, Z 2019, , Advanced Therapeutics, vol. 2, no. 8, 1900005. https://doi.org/10.1002/adtp.201900005

Rethinking apolipoprotein A-II in lipid metabolism
Pownall, HJ 2018, , American Journal of Clinical Nutrition, vol. 108, no. 1, pp. 4-5. https://doi.org/10.1093/ajcn/nqy136

Languages

  • English