Publications


Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice;
Mojiri, A, Walther, BK, Jiang, C, Matrone, G, Holgate, R, Xu, Q, Morales, E, Wang, G, Gu, J, Wang, R & Cooke, JP 2021, , European heart journal, vol. 42, no. 42, pp. 4352-4369. https://doi.org/10.1093/eurheartj/ehab547

Wnt/ß-catenin-mediated p53 suppression is indispensable for osteogenesis of mesenchymal progenitor cells;
Zhou, X, Beilter, A, Xu, Z, Gao, R, Xiong, S, Paulucci-Holthauzen, A, Lozano, G, de Crombrugghe, B & Gorlick, R 2021, , Cell Death and Disease, vol. 12, no. 6, 521. https://doi.org/10.1038/s41419-021-03758-w

MEDALT: single-cell copy number lineage tracing enabling gene discovery;
Wang, F, Wang, Q, Mohanty, V, Liang, S, Dou, J, Han, J, Minussi, DC, Gao, R, Ding, L, Navin, N & Chen, K 2021, , Genome Biology, vol. 22, no. 1, 70, pp. 70. https://doi.org/10.1186/s13059-021-02291-5

Role of Endothelial and Mesenchymal Cell Transitions in Heart Failure and Recovery Thereafter;
Wang, G, Cruz, AS, Youker, K, Marcos-Abdala, HG, Thandavarayan, RA, Cooke, JP, Torre-Amione, G, Chen, K & Bhimaraj, A 2021, , Frontiers in Genetics, vol. 11, 609262, pp. 609262. https://doi.org/10.3389/fgene.2020.609262

MACMIC Reveals A Dual Role of CTCF in Epigenetic Regulation of Cell Identity Genes;
Wang, G, Xia, B, Zhou, M, Lv, J, Zhao, D, Li, Y, Bu, Y, Wang, X, Cooke, JP, Cao, Q, Lee, MG, Zhang, L & Chen, K 2021, , Genomics, Proteomics and Bioinformatics, vol. 19, no. 1, pp. 140-153. https://doi.org/10.1016/j.gpb.2020.10.008

Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes;
Gao, R, Bai, S, Henderson, Y, Lin, Y, Schalck, A, Yan, Y, Kumar, T, Hu, M, Sei, E, Davis, A, Wang, F, Shaitelman, S, Wang, JR, Chen, K, Moulder, S, Lai, S & Navin, N 2021, , Nature Biotechnology, vol. 39, no. 5, pp. 599-608. https://doi.org/10.1038/s41587-020-00795-2

Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes;
Gao, R, Bai, S, Henderson, YC, Lin, Y, Schalck, A, Yan, Y, Kumar, T, Hu, M, Sei, E, Davis, A, Wang, F, Shaitelman, SF, Wang, JR, Chen, K, Moulder, S, Lai, SY & Navin, NE 2021, , Nature Biotechnology. https://doi.org/10.1038/s41587-020-00795-2

Beclin 2 negatively regulates innate immune signaling and tumor development;
Zhu, M, Deng, G, Tan, P, Xing, C, Guan, C, Jiang, C, Zhang, Y, Ning, B, Li, C, Yin, B, Chen, K, Zhao, Y, Wang, HY, Levine, B, Nie, G & Wang, RF 2020, , Journal of Clinical Investigation, vol. 130, no. 10, pp. 5349-5369. https://doi.org/10.1172/JCI133283

Antihistamine drug ebastine inhibits cancer growth by targeting polycomb group protein EZH2;
Li, Q, Liu, KY, Liu, Q, Wang, G, Jiang, W, Meng, Q, Yi, Y, Yang, Y, Wang, R, Zhu, S, Li, C, Wu, L, Zhao, D, Yan, L, Zhang, L, Kim, JS, Zu, X, Kozielski, AJ, Qian, W, Chang, JC, Patnaik, A, Chen, K & Cao, Q 2020, , Molecular Cancer Therapeutics, vol. 19, no. 10, pp. 2023-2033. https://doi.org/10.1158/1535-7163.MCT-20-0250

MIF as a biomarker and therapeutic target for overcoming resistance to proteasome inhibitors in human myeloma;
Wang, Q, Zhao, D, Xian, M, Wang, Z, Bi, E, Su, P, Qian, J, Ma, X, Yang, M, Liu, L, Zu, Y, Pingali, SR, Chen, K, Cai, Z & Yi, Q 2020, , Blood, vol. 136, no. 22, pp. 2557-2573. https://doi.org/10.1182/blood.2020005795