Clinical Trials

    IDE196 (Darovasertib) in Combination With Crizotinib Versus Investigator's Choice of Treatment as First-line Therapy in HLA-A2 Negative Metastatic Uveal Melanoma (DAR-UM-2)

    Investigator: Anaum Maqsood

    Study Coordinator: Safiya Joseph

    Status: Enrolling

    ClinicalTrials.gov Number: NCT05987332

    Phone: 203.308.8567

    Protocol Number: PRO00037834

    Description


    This is a Phase 2/3, multi-arm, multi-stage, open-label study of human leukocyte antigen (HLA)-A*02:01 negative participants with metastatic uveal melanoma (MUM) who will be randomized to receive either IDE196 + crizotinib or investigator's choice of treatment (pembrolizumab, ipilimumab + nivolumab, or dacarbazine).