Clinical Trials

    Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)

    Investigator: Jun Zhang

    Study Coordinator: Gabrielle Hayes

    Status: Open Not Enrolling

    ClinicalTrials.gov Number: NCT04675294

    Phone: 734.415.918

    Protocol Number: PRO00035972

    Description


    This is a open-label, randomized phase 2 multi-center study of the anti-tumor efficacy of evorpacept (ALX148) + pembrolizumab and of pembrolizumab alone in patients with metastatic or unresectable, recurrent HNSCC that is PD-L1 positive (CPS =1 by an FDA-approved test) and who have not yet been treated for their advanced disease. The study comprises an initial safety lead-in cohort followed by a randomized portion.