Xian Chang Li, MD, PhD

  • Transplant Research Chair, Houston Methodist Immunobiology & Transplant Science Center
  • Professor of Transplant Immunology in Surgery, Houston Methodist Research Institute
  • Director, Houston Methodist Immunobiology & Transplant Science Center
  • Vice Chair of Research, Houston Methodist Hospital Department of Surgery
  • Max and Lillie Frosch Centennial Chair in Transplant Research, Houston Methodist Immunobiology & Transplant Science Center 

Xian Chang Li, MD, PhD

Areas of Expertise

  • Allograft rejection
  • Clinical translation of basic discoveries into biotherapeutics
  • Developing new therapeutics to treat diseases caused by abnormal immune responses, such as diabetes, lupus, arthritis and multiple sclerosis
  • Immunology
  • Immunotherapeutics
  • Improve transplant outcomes & success
  • Regulatory cell function
  • Tolerance induction
  • Translation of basic science into clinical therapies
  • Translational immunology
  • Transplant
  • Transplant biology


Postdoctoral Fellowship, University of Toronto
Postdoctoral Fellowship, Harvard University
MD, Qingdao Medical School, Qingdao, China
Research Fellowship, University of Western Ontario
PhD, Western University, London, Canada


IRF4 ablation in B cells abrogates allogeneic B cell responses and prevents chronic transplant rejection
Wang, G, Zou, D, Wang, Y, Gonzalez, NM, Yi, SG, Li, XC, Chen, W & Gaber, AO 2021, , Journal of Heart and Lung Transplantation, vol. 40, no. 10, pp. 1122-1132. https://doi.org/10.1016/j.healun.2021.06.008

Pre-transplant T-cell Clonality: An Observational Study of a Biomarker for Prediction of Sepsis in Liver Transplant Recipients
Jones, SL, Moore, LW, Li, XC, Mobley, CM, Fields, PA, Graviss, EA, Nguyen, DT, Nolte Fong, J, Saharia, A, Hobeika, MJ, McMillan, RR, Victor, DW, Minze, LJ, Gaber, AO & Ghobrial, RM 2021, , Annals of surgery, vol. 274, no. 3, pp. 411-418. https://doi.org/10.1097/SLA.0000000000004998

Transgenic Expression of a Mutant Ribonuclease Regnase-1 in T Cells Disturbs T Cell Development and Functions
Kong, G, Dou, Y, Xiao, X, Wang, Y, Ming, Y & Li, XC 2021, , Frontiers in immunology, vol. 12, 682220. https://doi.org/10.3389/fimmu.2021.682220

Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells
Xing, J, Zhang, A, Du, Y, Fang, M, Minze, LJ, Liu, Y-J, Li, XC & Zhang, Z 2021, , Nature Communications, vol. 12, no. 1, 2681, pp. 2681. https://doi.org/10.1038/s41467-021-23003-4

The pursuit of regulatory t cells in the induction of transplant tolerance
Arnold, PR & Li, XC 2021, . in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1278, Springer, pp. 273-287. https://doi.org/10.1007/978-981-15-6407-9_14

Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation
Paez-Mayorga, J, Capuani, S, Hernandez, N, Farina, M, Chua, YX, Blanchard, R, Sizovs, A, Liu, HC, Fraga, DW, Niles, JA, Salazar, HF, Corradetti, B, Sikora, AG, Kloc, M, Li, XC, Gaber, AO, Nichols, J & Grattoni, A 2020, , Biomaterials, vol. 257, 120232. https://doi.org/10.1016/j.biomaterials.2020.120232

Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics
Chen, S, Zhang, L, Ying, Y, Wang, Y, Arnold, PR, Wang, G, Li, J, Ghobrial, RM, Chen, W, Xiao, X & Li, XC 2020, , American Journal of Transplantation, vol. 20, no. 9, pp. 2366-2379. https://doi.org/10.1111/ajt.15845

PIRs mediate innate myeloid cell memory to nonself MHC molecules
Dai, H, Lan, P, Zhao, D, Abou-Daya, K, Liu, W, Chen, W, Friday, AJ, Williams, AL, Sun, T, Chen, J, Chen, W, Mortin-Toth, S, Danska, JS, Wiebe, C, Nickerson, P, Li, T, Mathews, LR, Turnquist, HR, Nicotra, ML, Gingras, S, Takayama, E, Kubagawa, H, Shlomchik, MJ, Oberbarnscheidt, MH, Li, XC & Lakkis, FG 2020, , Science, vol. 368, no. 6495, pp. 1122-1127. https://doi.org/10.1126/science.aax4040

Innate Allorecognition and Memory in Transplantation
Zhao, D, Abou-Daya, KI, Dai, H, Oberbarnscheidt, MH, Li, XC & Lakkis, FG 2020, , Frontiers in immunology, vol. 11, 918. https://doi.org/10.3389/fimmu.2020.00918

EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells
Zhang, A, Xing, J, Xia, T, Zhang, H, Fang, M, Li, S, Du, Y, Li, XC, Zhang, Z & Zeng, M-S 2020, , EMBO Reports, pp. e49666. https://doi.org/10.15252/embr.201949666

T cell exhaustion is associated with antigen abundance and promotes transplant acceptance
Zou, D, Dai, Y, Zhang, X, Wang, G, Xiao, X, Jia, P, Li, XC, Guo, Z & Chen, W 2020, , American Journal of Transplantation, vol. 20, no. 9, pp. 2540-2550. https://doi.org/10.1111/ajt.15870

The many shades of macrophages in regulating transplant outcome
Chen, S, Lakkis, FG & Li, XC 2020, , Cellular Immunology, vol. 349, 104064. https://doi.org/10.1016/j.cellimm.2020.104064

T follicular helper and memory cell responses and the mTOR pathway in murine heart transplantation
Xie, A, Yan, H, Fu, J, He, A, Xiao, X, Li, XC & Chen, W 2020, , Journal of Heart and Lung Transplantation, vol. 39, no. 2, pp. 134-144. https://doi.org/10.1016/j.healun.2019.11.017

Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate
Arnold, PR, Wells, AD & Li, XC 2020, , Frontiers in Cell and Developmental Biology, vol. 7, 377. https://doi.org/10.3389/fcell.2019.00377

The transcription factor RelB restrains group 2 innate lymphoid cells and type 2 immune pathology in vivo
Zhang, L, Ying, Y, Chen, S, Arnold, PR, Tian, F, Minze, LJ, Xiao, X & Li, XC 2021, , Cellular and Molecular Immunology, vol. 18, no. 1, pp. 230-242. https://doi.org/10.1038/s41423-020-0404-0

The First Case of Ischemia-Free Kidney Transplantation in Humans
He, X, Chen, G, Zhu, Z, Zhang, Z, Yuan, X, Han, M, Zhao, Q, Zheng, Y, Tang, Y, Huang, S, Wang, L, van Leeuwen, OB, Wang, X, Chen, C, Mo, L, Jiao, X, Li, X, Wang, C, Huang, J, Cui, J & Guo, Z 2019, , Frontiers in Medicine, vol. 6, 276. https://doi.org/10.3389/fmed.2019.00276

Adaptive features of innate immune cells and their relevance to graft rejection
Wang, G, Kong, G & Li, XC 2019, , Current opinion in organ transplantation, vol. 24, no. 6, pp. 664-669. https://doi.org/10.1097/MOT.0000000000000707

Delayed implantation of pumped kidneys decreases renal allograft futility in combined liver-kidney transplantation
Lunsford, KE, Agopian, VG, Yi, S, Nguyen, DTM, Graviss, EA, Harlander-Locke, MP, Saharia, A, Kaldas, FM, Mobley, CM, Zarrinpar, A, Hobeika, MJ, Veale, JL, Podder, H, Farmer, DG, Knight, RJ, Danovitch, GM, Gritsch, HA, Li, XC, Ghobrial, RM, Busuttil, RW & Gaber, AO 2020, , Transplantation, vol. 104, no. 8, pp. 1591-1603. https://doi.org/10.1097/TP.0000000000003040

Identification of the E3 ligase TRIM29 as a critical checkpoint regulator of NK cell functions
Dou, Y, Xing, J, Kong, G, Wang, G, Lou, X, Xiao, X, Vivier, E, Li, XC & Zhang, Z 2019, , Journal of immunology (Baltimore, Md. : 1950), vol. 203, no. 4, pp. 873-880. https://doi.org/10.4049/jimmunol.1900171


  • English