William G. Ondo, MD

  • Houston Methodist neurologist
  • Director, Houston Methodist Movement Disorders Clinic

William G. Ondo, MD

Areas of Expertise

  • Botulinum toxin administration
  • Dystonia
  • Huntington’s disease
  • Movement disorders
  • Parkinson’s disease
  • Restless leg syndrome
  • Tardive dyskinesia
  • Tourette’s syndrome
  • Tremors


American Board of Psychiatry and Neurology, Neurology
American Board of Psychiatry and Neurology, Sleep Medicine
University of Virginia School of Medicine, Charlottesville, Virginia | 1991
University of North Carolina Hospital, Chapel Hill, North Carolina
Movement Disorders, Baylor College of Medicine, Houston, Texas
Neurology, Duke University Medical Center, Durham, North Carolina


Prodromal Markers of Parkinson's Disease in Patients With Essential Tremor
Wang, XX, Feng, Y, Li, X, Zhu, XY, Truong, D, Ondo, WG & Wu, YC 2020, , Frontiers in Neurology, vol. 11, 874. https://doi.org/10.3389/fneur.2020.00874

Restless abdomen: a spectrum or a phenotype variant of restless legs syndrome?
Wang, XX, Zhu, XY, Wang, Z, Dong, JW, Ondo, WG & Wu, YC 2020, , BMC neurology, vol. 20, no. 1. https://doi.org/10.1186/s12883-020-01875-1

Current and Emerging Treatments of Essential Tremor
Ondo, WG 2020, Neurologic Clinics, vol. 38, no. 2, pp. 309-323. https://doi.org/10.1016/j.ncl.2020.01.002

Correlates of Nonanemic Iron Deficiency in Restless Legs Syndrome
Zhu, XY, Wu, TT, Wang, HM, Li, X, Ni, LY, Chen, TJ, Qiu, MY, Shen, J, Liu, T, Ondo, WG & Wu, YC 2020, , Frontiers in Neurology, vol. 11, 298. https://doi.org/10.3389/fneur.2020.00298

Safety and Efficacy of RimabotulinumtoxinB for Treatment of Sialorrhea in Adults: A Randomized Clinical Trial
Isaacson, SH, Ondo, W, Jackson, CE, Trosch, RM, Molho, E, Pagan, F, Lew, M, Dashtipour, K, Clinch, T & Espay, AJ 2020, , JAMA Neurology, vol. 77, no. 4, pp. 461-469. https://doi.org/10.1001/jamaneurol.2019.4565

Essential tremor-plus: a controversial new concept
Louis, ED, Bares, M, Benito-Leon, J, Fahn, S, Frucht, SJ, Jankovic, J, Ondo, WG, Pal, PK & Tan, EK 2020, , The Lancet Neurology, vol. 19, no. 3, pp. 266-270. https://doi.org/10.1016/S1474-4422(19)30398-9

Prospective home-use study on non-invasive neuromodulation therapy for essential tremor
Isaacson, SH, Peckham, E, Tse, W, Waln, O, Way, C, Petrossian, MT, Dahodwala, N, Soileau, MJ, Lew, M, Dietiker, C, Luthra, N, Agarwal, P, Dhall, R, Morgan, J, Calakos, N, Zesiewicz, TA, Shamim, EA, Kumar, R, Lewitt, P, Shill, HA, Simmons, A, Pagan, FL, Khemani, P, Tate, J, Maddux, B, Luo, L, Ondo, W, Hallett, M, Rajagopal, A, Chidester, P, Rosenbluth, KH, Delp, SL & Pahwa, R 2020, , Tremor and Other Hyperkinetic Movements, vol. 10, no. 1, 29, pp. 1-16. https://doi.org/10.5334/tohm.59

Long-term safety and efficacy of deutetrabenazine for the treatment of tardive dyskinesia
Fernandez, HH, Stamler, D, Davis, MD, Factor, SA, Hauser, RA, Jimenez-Shahed, J, Ondo, WG, Jarskog, LF, Woods, SW, Bega, D, Ledoux, MS, Shprecher, DR & Anderson, KE 2019, Journal of Neurology, Neurosurgery and Psychiatry, vol. 90, no. 12, pp. 1317-1323. https://doi.org/10.1136/jnnp-2018-319918

Clinical features and subtypes of restless legs syndrome in Chinese population: a study of 359 patients
Zhu, XY, Wu, TT, Wang, HM, Ni, LY, Li, X, Liu, Y, Zhang, XJ, Chen, YJ, Cui, XX, Ondo, WG & Wu, YC 2019, , Sleep Medicine, vol. 59, pp. 15-23. https://doi.org/10.1016/j.sleep.2019.01.053

Systematic literature review of quetiapine for the treatment of psychosis in patients with Parkinsonism
Chen, JJ, Hua, H, Massihi, L, Portillo, I, Alipour, A, Ondo, W & Dashtipour, K 2019, , Journal of Neuropsychiatry and Clinical Neurosciences, vol. 31, no. 3, pp. 188-195. https://doi.org/10.1176/appi.neuropsych.18080180

Restless legs syndrome in end stage renal disease patients undergoing hemodialysis
Lin, XW, Zhang, JF, Qiu, MY, Ni, LY, Yu, HL, Kuo, SH, Ondo, WG, Yu, Q & Wu, YC 2019, , BMC neurology, vol. 19, no. 1, 47. https://doi.org/10.1186/s12883-019-1265-y

45 Long-term Treatment with Deutetrabenazine Is Associated with Continued Improvement in Tardive Dyskinesia: Results from an Open-label Extension Study
Hauser, RA, Fernandez, HH, Stamler, D, Davis, MD, Factor, SA, Jimenez-Shahed, J, Ondo, WG, Jarskog, LF, Woods, SW, LeDoux, MS, Shprecher, DR & Anderson, KE 2019, , CNS spectrums, vol. 24, no. 1, pp. 200-201. https://doi.org/10.1017/S1092852919000385

46 Confirmed Safety of Deutetrabenazine for Tardive Dyskinesia in a 2-Year Open-label Extension Study
Fernandez, HH, Stamler, D, Davis, MD, Factor, SA, Hauser, RA, Jimenez-Shahed, J, Ondo, WG, Jarskog, LF, Woods, SW, LeDoux, MS, Shprecher, DR & Anderson, KE 2019, CNS spectrums, vol. 24, no. 1. https://doi.org/10.1017/S1092852919000397

Treatment of restless legs syndrome and periodic limb movements
Ondo, WG 2019, . in Current Clinical Neurology. Current Clinical Neurology, Humana Press, pp. 329-331. https://doi.org/10.1007/978-3-319-97897-0_76

Clinical and radiological characteristics of restless legs syndrome following acute lacunar infarction
Tuo, H, Tian, Z, Ma, X, Cui, Y, Xue, Y, Che, J, Xu, C, Chen, K, Zhang, Y, Zhang, L, Bi, H, Le, W & Ondo, W 2019, , Sleep Medicine, vol. 53, pp. 81-87. https://doi.org/10.1016/j.sleep.2018.06.004

Conversion of L-dopa to Extended Release L-dopa (Rytary®) in Patients with Fluctuating Parkinson's Disease: Predictor's of Dose
Ondo, WG, Coss, P, Christie, M & Pascual, MB 2019, , Journal of Parkinsons disease, vol. 9, no. 1, pp. 153-156. https://doi.org/10.3233/JPD-181427

Comparison of the Fahn-Tolosa-Marin Clinical Rating Scale and the Essential Tremor Rating Assessment Scale
Ondo, WG, Hashem, V, LeWitt, PA, Pahwa, R, Shih, L, Tarsy, D, Zesiewicz, T & Elble, R 2018, , Movement Disorders Clinical Practice, vol. 5, no. 1, pp. 60-65. https://doi.org/10.1002/mdc3.12560

In Reply—Additional Safety Considerations Before Prescribing Opioids to Manage Restless Legs Syndrome
Silber, MH, Becker, PM, Buchfuhrer, MJ, Earley, CJ, Ondo, WG, Walters, AS & Winkelman, JW 2018, , Mayo Clinic Proceedings, vol. 93, no. 7, pp. 955-956. https://doi.org/10.1016/j.mayocp.2018.03.021

Onabotulinum toxin-A injections for sleep bruxism: A double-blind, placebo-controlled study
Ondo, WG, Simmons, JH, Shahid, MH, Hashem, V, Hunter, C & Jankovic, J 2018, , Neurology, vol. 90, no. 7, pp. e559-e564. https://doi.org/10.1212/WNL.0000000000004951


  • English