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Stephen T.C. Wong, PhD

  • Professor of Computer Science, Systems Medicine and Bioengineering in Oncology, Houston Methodist Research Institute
  • Associate Director, Cores, Biostatistics and Bioinformatics at the Houston Methodist Cancer Center
  • Houston Methodist computer scientist, bioengineer and systems biologist
  • John S. Dunn, Sr. Presidential Distinguished Chair in Biomedical Engineering, Houston Methodist Research Institute
Media Contact: Lisa Merkl , 832.667.5916

Stephen T.C. Wong, PhD

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Media Contact: Lisa Merkl , 832.667.5916

Areas of Expertise

  • Artificial Intelligence (AI)
  • Bioinformatics
  • Biological and medical imaging
  • Clinical neuroscience
  • Digital health
  • Drug combinations
  • Drug discovery
  • Drug repurposing / Drug repositioning
  • Health technology
  • Image-guided therapy
  • Mechanisms of cancer
  • Mechanisms of neurological disorders
  • Molecular imaging
  • Systems biology
  • Translational biophotonics

Credentials

Postdoctoral Fellowship, Japan Science and Technology Agency
MS, Lehigh University
PhD, Lehigh University
Postdoctoral Fellowship, National Science Foundation, ICOT, The Fifth Generation Computer Systems Project, MITI, Tokyo

Publications

Prevalence of Delirium After Abdominal Surgery and Association With Ketamine: A Retrospective, Propensity-Matched Cohort Study
Faisal, H, Qamar, F, Hsu, ES, Xu, J, Lai, EC, Wong, ST & Masud, FN 2024, , Critical care explorations, vol. 6, no. 1, pp. E1032. https://doi.org/10.1097/CCE.0000000000001032

CD4+ T cell immunity is dependent on an intrinsic stem-like program
Zou, D, Yin, Z, Yi, SG, Wang, G, Guo, Y, Xiao, X, Li, S, Zhang, X, Gonzalez, NM, Minze, LJ, Wang, L, Wong, STC, Osama Gaber, A, Ghobrial, RM, Li, XC & Chen, W 2024, , Nature immunology, vol. 25, no. 1, pp. 66-76. https://doi.org/10.1038/s41590-023-01682-z

Life-Course Brain Health as a Determinant of Late-Life Mental Health: American Association for Geriatric Psychiatry Expert Panel Recommendations
Eyre, HA, Stirland, LE, Jeste, DV, Reynolds, CF, Berk, M, Ibanez, A, Dawson, WD, Lawlor, B, Leroi, I, Yaffe, K, Gatchel, JR, Karp, JF, Newhouse, P, Rosand, J, Letourneau, N, Bayen, E, Farina, F, Booi, L, Devanand, DP, Mintzer, J, Madigan, S, Jayapurwala, I, Wong, STC, Falcoa, VP, Cummings, JL, Reichman, W, Lock, SL, Bennett, M, Ahuja, R, Steffens, DC, Elkind, MSV & Lavretsky, H 2023, , American Journal of Geriatric Psychiatry, vol. 31, no. 12, pp. 1017-1031. https://doi.org/10.1016/j.jagp.2023.09.013



A Deep Learning Decision Support Tool to Improve Risk Stratification and Reduce Unnecessary Biopsies in BI-RADS 4 Mammograms
Ezeana, CF, He, T, Patel, TA, Kaklamani, V, Elmi, M, Brigmon, E, Otto, PM, Kist, KA, Speck, H, Wang, L, Ensor, J, Shih, YCT, Kim, B, Pan, IW, Cohen, AL, Kelley, K, Spak, D, Yang, WT, Chang, JC & Wong, STC 2023, , Radiology: Artificial Intelligence, vol. 5, no. 6, e220259, pp. e220259. https://doi.org/10.1148/ryai.220259



Generation of Whole Brain Net Water Uptake Map Using Non-contrast Computed Tomography
Wong, K, Hodics, T, Ghosh, R, Volpi, JJ & Wong, ST 2023, , 15th World Stroke Congress, Toronto, Canada, 10/10/23 - 10/12/23.

Artificial Intelligence-Powered Acoustic Analysis System for Dysarthria Severity Assessment
Zhang, Z, Shang, X, Yang, LZ, Ai, W, Wang, J, Wang, H, Wong, STC, Wang, X & Li, H 2023, , Advanced Intelligent Systems, vol. 5, no. 10, 2300097. https://doi.org/10.1002/aisy.202300097

The promise of digital healthcare technologies
Wong, ST, Yeung, AWK, Torkamani, A, Butte, AJ, Glicksberg, BS, Schuller, B, Rodriquez, B, Ting, DSW, Bates, D, Schaden, E, Peng, H, Willschke, H, van der Laak, J, Car, J, Rahimi, K, Celi, LA, Banach, M, Kletecka-Pulker, M, Kimberger, O, Eils, R, Eyre, HA, Shariful Islam, SM, Wong, TY, Gao, W, Brunak, S & Atanasov, AG 2023, , Biotechnology Advances, vol. 11, 1196596, pp. 1196596. https://doi.org/10.3389/fpubh.2023.1196596

BBox-Guided Segmentor: Leveraging expert knowledge for accurate stroke lesion segmentation using weakly supervised bounding box prior
Ou, Y, Huang, SX, Wong, KK, Cummock, J, Volpi, J, Wang, JZ & Wong, ST 2023, , Computerized Medical Imaging and Graphics, vol. 107, 102236, pp. 102236. https://doi.org/10.1016/j.compmedimag.2023.102236

Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome
Cheng, RYS, Ridnour, LA, Wink, AL, Gonzalez, AL, Femino, EL, Rittscher, H, Somasundaram, V, Heinz, WF, Coutinho, L, Rangel, MC, Edmondson, EF, Butcher, D, Kinders, RJ, Li, X, Wong, STC, McVicar, DW, Anderson, SK, Pore, M, Hewitt, SM, Billiar, TR, Glynn, SA, Chang, JC, Lockett, SJ, Ambs, S & Wink, DA 2023, , Cell Death and Disease, vol. 14, no. 5, 319, pp. 319. https://doi.org/10.1038/s41419-023-05834-9

Spatial Transcriptomics Depict Ligand-Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors
Ferri-Borgogno, S, Zhu, Y, Sheng, J, Burks, JK, Gomez, JA, Wong, KK, Wong, STC & Mok, SC 2023, , Cancer research, vol. 83, no. 9, pp. 1503-1516. https://doi.org/10.1158/0008-5472.CAN-22-1821

Exosomal non-coding RNAs as a biomarker to improve early ovarian cancer detection.
Wong, ST, Sheng, J, Mok, S, Cao, Y & Han, C 2023, , AACR Annual Meeting 2023, Orlando, United States, 4/14/23 - 4/19/23. https://doi.org/10.1158/1538-7445.AM2023-3333


G1 or Bust? “Mother” Knows Best: Stress Activated Kinases in Mother Cells Promotes ERK-mediated Proliferation during G1 of Daughter Cells in BRAF Driven Melanomas
Wong, ST, Yin, Z & Wang, L 2023, , Cancer Systems Biology Consortium (CSBS), Aurora, United States, 3/16/23 - 3/17/23.

Addressing the genetic/nongenetic duality in cancer with systems biology
Kulkarni, P, Wiley, HS, Levine, H, Sauro, H, Anderson, A, Wong, STC, Meyer, AS, Iyengar, P, Corlette, K, Swanson, K, Mohanty, A, Bhattacharya, S, Patel, A, Jain, V & Salgia, R 2023, , Trends in Cancer, vol. 9, no. 3, pp. 185-187. https://doi.org/10.1016/j.trecan.2022.12.004

Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells
Zhang, W, Xu, Z, Hao, X, He, T, Li, J, Shen, Y, Liu, K, Gao, Y, Liu, J, Edwards, DG, Muscarella, AM, Wu, L, Yu, L, Xu, L, Chen, X, Wu, YH, Bado, IL, Ding, Y, Aguirre, S, Wang, H, Gugala, Z, Satcher, RL, Wong, STC & Zhang, XHF 2023, , Cancer Discovery, vol. 13, no. 2, pp. 474-495. https://doi.org/10.1158/2159-8290.CD-22-0220

Automated catheter segmentation and tip detection in cerebral angiography with topology-aware geometric deep learning
Ghosh, R, Wong, K, Zhang, YJ, Britz, GW & Wong, STC 2023, , Journal of neurointerventional surgery, vol. 16, no. 3, pp. 290-295. https://doi.org/10.1136/jnis-2023-020300

Languages

  • English
  • Chinese (Mandarin, Cantonese, Taiwanese)
  • Japanese (limited)