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Stephen T.C. Wong, PhD

  • Professor of Computer Science, Systems Medicine and Bioengineering in Oncology, Houston Methodist Research Institute
  • Associate Director, Cores, Biostatistics and Bioinformatics at the Houston Methodist Cancer Center
  • Houston Methodist computer scientist, bioengineer and systems biologist
  • John S. Dunn, Sr. Presidential Distinguished Chair in Biomedical Engineering, Houston Methodist Research Institute
Media Contact: Lisa Merkl , 832.667.5916

Stephen T.C. Wong, PhD

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Media Contact: Lisa Merkl , 832.667.5916

Areas of Expertise

  • Artificial Intelligence (AI)
  • Bioinformatics
  • Biological and medical imaging
  • Clinical neuroscience
  • Digital health
  • Drug combinations
  • Drug discovery
  • Drug repurposing / Drug repositioning
  • Health technology
  • Image-guided therapy
  • Mechanisms of cancer
  • Mechanisms of neurological disorders
  • Molecular imaging
  • Systems biology
  • Translational biophotonics

Credentials

Postdoctoral Fellowship, Japan Science and Technology Agency
MS, Lehigh University
PhD, Lehigh University
Postdoctoral Fellowship, National Science Foundation, ICOT, The Fifth Generation Computer Systems Project, MITI, Tokyo

Publications

BBox-Guided Segmentor: Leveraging expert knowledge for accurate stroke lesion segmentation using weakly supervised bounding box prior
Ou, Y, Huang, SX, Wong, KK, Cummock, J, Volpi, J, Wang, JZ & Wong, ST 2023, , Computerized Medical Imaging and Graphics, vol. 107, 102236, pp. 102236. https://doi.org/10.1016/j.compmedimag.2023.102236

Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome
Cheng, RYS, Ridnour, LA, Wink, AL, Gonzalez, AL, Femino, EL, Rittscher, H, Somasundaram, V, Heinz, WF, Coutinho, L, Rangel, MC, Edmondson, EF, Butcher, D, Kinders, RJ, Li, X, Wong, STC, McVicar, DW, Anderson, SK, Pore, M, Hewitt, SM, Billiar, TR, Glynn, SA, Chang, JC, Lockett, SJ, Ambs, S & Wink, DA 2023, , Cell Death and Disease, vol. 14, no. 5, 319, pp. 319. https://doi.org/10.1038/s41419-023-05834-9

Spatial Transcriptomics Depict Ligand-Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors
Ferri-Borgogno, S, Zhu, Y, Sheng, J, Burks, JK, Gomez, JA, Wong, KK, Wong, STC & Mok, SC 2023, , Cancer research, vol. 83, no. 9, pp. 1503-1516. https://doi.org/10.1158/0008-5472.CAN-22-1821

Addressing the genetic/nongenetic duality in cancer with systems biology
Kulkarni, P, Wiley, HS, Levine, H, Sauro, H, Anderson, A, Wong, STC, Meyer, AS, Iyengar, P, Corlette, K, Swanson, K, Mohanty, A, Bhattacharya, S, Patel, A, Jain, V & Salgia, R 2023, , Trends in Cancer, vol. 9, no. 3, pp. 185-187. https://doi.org/10.1016/j.trecan.2022.12.004

Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells
Zhang, W, Xu, Z, Hao, X, He, T, Li, J, Shen, Y, Liu, K, Gao, Y, Liu, J, Edwards, DG, Muscarella, AM, Wu, L, Yu, L, Xu, L, Chen, X, Wu, YH, Bado, IL, Ding, Y, Aguirre, S, Wang, H, Gugala, Z, Satcher, RL, Wong, STC & Zhang, XHF 2023, , Cancer Discovery, vol. 13, no. 2, pp. 474-495. https://doi.org/10.1158/2159-8290.CD-22-0220


Ryanodine receptor 1-mediated Ca2+ signaling and mitochondrial reprogramming modulate uterine serous cancer malignant phenotypes
Zhang, L, Au-Yeung, CL, Huang, C, Yeung, TL, Ferri-Borgogno, S, Lawson, BC, Kwan, SY, Yin, Z, Wong, ST, Thomas, V, Lu, KH, Yip, KP, Sham, JSK & Mok, SC 2022, , Journal of Experimental and Clinical Cancer Research, vol. 41, no. 1, 242. https://doi.org/10.1186/s13046-022-02419-w

Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density
Somasundaram, V, Ridnour, LA, Cheng, RY, Walke, AJ, Kedei, N, Bhattacharyya, DD, Wink, AL, Edmondson, EF, Butcher, D, Warner, AC, Dorsey, TH, Scheiblin, DA, Heinz, W, Bryant, RJ, Kinders, RJ, Lipkowitz, S, Wong, ST, Pore, M, Hewitt, SM, McVicar, DW, Anderson, SK, Chang, J, Glynn, SA, Ambs, S, Lockett, SJ & Wink, DA 2022, , Redox Biology, vol. 58, pp. 102529. https://doi.org/10.1016/j.redox.2022.102529

An AI-driven clinical care pathway to reduce 30-day readmission for chronic obstructive pulmonary disease (COPD) patients
Wang, L, Li, G, Ezeana, CF, Ogunti, R, Puppala, M, He, T, Yu, X, Wong, SSY, Yin, Z, Roberts, AW, Nezamabadi, A, Xu, P, Frost, A, Jackson, RE & Wong, STC 2022, , Scientific Reports, vol. 12, no. 1, 20633. https://doi.org/10.1038/s41598-022-22434-3

Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density
Somasundaram, V, Ridnour, LA, Cheng, RYS, Walke, AJ, Kedei, N, Bhattacharyya, DD, Wink, AL, Edmondson, EF, Butcher, D, Warner, AC, Dorsey, TH, Scheiblin, DA, Heinz, W, Bryant, RJ, Kinders, RJ, Lipkowitz, S, Wong, STC, Pore, M, Hewitt, SM, McVicar, DW, Anderson, SK, Chang, J, Glynn, SA, Ambs, S, Lockett, SJ & Wink, DA 2022, , Redox Biology, vol. 58, 102529. https://doi.org/10.1016/j.redox.2022.102529

An AI-driven clinical care pathway to reduce 30-day readmission for chronic obstructive pulmonary disease (COPD) patients
Wang, L, Li, G, Ezeana, CF, Ogunti, R, Puppala, M, He, T, Yu, X, Wong, SSY, Yin, Z, Roberts, AW, Nezamabadi, A, Xu, P, Frost, A, Jackson, RE & Wong, STC 2022, , Scientific Reports, vol. 12, no. 1, 20633, pp. 20633. https://doi.org/10.1038/s41598-022-22434-3, https://doi.org/10.1038/s41598-022-22434-3

Bone metastasis initiation is coupled with bone remodeling through osteogenic differentiation of NG2+ cells
Zhang, W, Xu, Z, Hao, X, He, T, Li, J, Shen, Y, Liu, K, Gao, Y, Liu, J, Edwards, DG, Muscarella, AM, Wu, L, Yu, L, Xu, L, Chen, X, Wu, YH, Bado, IL, Ding, Y, Aguirre, S, Wang, H, Gugala, Z, Satcher, RL, Wong, STC & Zhang, XHF 2023, , Cancer Discovery, vol. 13, no. 2, pp. 474-495. https://doi.org/10.1158/2159-8290.CD-22-0220

A personalized image-guided intervention system for peripheral lung cancer on patient-specific respiratory motion model
Wang, T, He, T, Zhang, Z, Chen, Q, Zhang, L, Xia, G, Yang, L, Wang, H, Wong, STC & Li, H 2022, , International Journal of Computer Assisted Radiology and Surgery, vol. 17, no. 10, pp. 1751-1764. https://doi.org/10.1007/s11548-022-02676-2

Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease
Faridar, A, Vasquez, M, Thome, AD, Yin, Z, Xuan, H, Wang, JH, Wen, S, Li, X, Thonhoff, JR, Zhao, W, Zhao, H, Beers, DR, Wong, STC, Masdeu, JC & Appel, SH 2022, , Acta Neuropathologica Communications, vol. 10, no. 1, 144. https://doi.org/10.1186/s40478-022-01447-z

Asymmetry Disentanglement Network for Interpretable Acute Ischemic Stroke Infarct Segmentation in Non-contrast CT Scans
Ni, H, Xue, Y, Wong, K, Volpi, J, Wong, STC, Wang, JZ & Huang, X 2022, . in L Wang, Q Dou, PT Fletcher, S Speidel & S Li (eds), Medical Image Computing and Computer Assisted Intervention – MICCAI 2022 - 25th International Conference, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 13438 LNCS, Springer Science and Business Media Deutschland GmbH, pp. 416-426, 25th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2022, Singapore, Singapore, 9/18/22. https://doi.org/10.1007/978-3-031-16452-1_40

Automatic Segmentation in Acute Ischemic Stroke: Prognostic Significance of Topological Stroke Volumes on Stroke Outcome
Wong, KK, Cummock, JS, Li, G, Ghosh, R, Xu, P, Volpi, JJ & Wong, STC 2022, , Stroke, vol. 53, no. 9, pp. 2896-2905. https://doi.org/10.1161/STROKEAHA.121.037982

DeepStroke: An efficient stroke screening framework for emergency rooms with multimodal adversarial deep learning
Cai, T, Ni, H, Yu, M, Huang, X, Wong, K, Volpi, J, Wang, JZ & Wong, STC 2022, , Medical Image Analysis, vol. 80, 102522. https://doi.org/10.1016/j.media.2022.102522

A comparative efficacy study of diagnostic digital breast tomosynthesis and digital mammography in BI-RADS 4 breast cancer diagnosis
Ezeana, CF, Puppala, M, Wang, L, Chang, JC & Wong, STC 2022, , European Journal of Radiology, vol. 153, 110361, pp. 110361. https://doi.org/10.1016/j.ejrad.2022.110361

Methyladenosine Modification in RNAs: From Regulatory Roles to Therapeutic Implications in Cancer
Qu, X, Zhang, Y, Sang, X, Ren, D, Zhao, H & Wong, STC 2022, , Cancers, vol. 14, no. 13, 3195. https://doi.org/10.3390/cancers14133195


Languages

  • English
  • Chinese (Mandarin, Cantonese, Taiwanese)
  • Japanese (limited)