Stephen T.C. Wong, PhD

  • Professor of Computer Science, Systems Medicine and Bioengineering in Oncology, Houston Methodist Research Institute
  • Associate Director, Cores, Biostatistics and Bioinformatics at the Houston Methodist Cancer Center
  • Houston Methodist computer scientist, bioengineer and systems biologist
  • John S. Dunn, Sr. Presidential Distinguished Chair in Biomedical Engineering, Houston Methodist Research Institute

Stephen T.C. Wong, PhD

Areas of Expertise

  • Artificial Intelligence (AI)
  • Bioinformatics
  • Biological and medical imaging
  • Clinical neuroscience
  • Digital health
  • Drug combinations
  • Drug discovery
  • Drug repurposing / Drug repositioning
  • Health technology
  • Image-guided therapy
  • Mechanisms of cancer
  • Mechanisms of neurological disorders
  • Molecular imaging
  • Systems biology
  • Translational biophotonics

Credentials

Postdoctoral Fellowship, Japan Science and Technology Agency
MS, Lehigh University
PhD, Lehigh University
Postdoctoral Fellowship, National Science Foundation, ICOT, The Fifth Generation Computer Systems Project, MITI, Tokyo

Publications

Artificial intelligence-augmented, label-free molecular imaging method for tissue identification, cancer diagnosis, and cancer margin detection
Li, J, Liu, J, Wang, Y, He, Y, Liu, K, Raghunathan, R, Shen, SS, He, T, Yu, X, Danforth, R, Zheng, F, Zhao, H & Wong, STC 2021, , Biomedical Optics Express, vol. 12, no. 9, pp. 5559-5582. https://doi.org/10.1364/BOE.428738

Radiation-activated secretory proteins of Scgb1a1 + club cells increase the efficacy of immune checkpoint blockade in lung cancer
Ban, Y, Markowitz, GJ, Zou, Y, Ramchandani, D, Kraynak, J, Sheng, J, Lee, SB, Wong, STC, Altorki, NK, Gao, D & Mittal, V 2021, , Nature Cancer, vol. 2, no. 9, pp. 919-931. https://doi.org/10.1038/s43018-021-00245-1

The Progress of Label-Free Optical Imaging in Alzheimer’s Disease Screening and Diagnosis
Liu, K, Li, J, Raghunathan, R, Zhao, H, Li, X & Wong, STC 2021, , Frontiers in Aging Neuroscience, vol. 13, 699024. https://doi.org/10.3389/fnagi.2021.699024

Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility
Kong, R, Bharadwaj, U, Eckols, TK, Kolosov, M, Wu, H, Cruz-Pavlovich, FJS, Shaw, A, Ifelayo, OI, Zhao, H, Kasembeli, MM, Wong, STC & Tweardy, DJ 2021, , Pharmacological Research, vol. 169, 105637. https://doi.org/10.1016/j.phrs.2021.105637

Risk factors for and frequency of ct scans, steroid use, and repeat visits in inflammatory bowel disease patients seen at a single-center emergency department: A retrospective cohort study
Euers, L, Abughazaleh, S, Glassner, K, Gajula, P, Jones-Pauley, M, Ezeana, C, Puppala, M, Wang, L, Wong, S, Oglat, A, Nickerson, S & Abraham, BP 2021, , Journal of Clinical Medicine, vol. 10, no. 12, 2679. https://doi.org/10.3390/jcm10122679

The bone microenvironment invigorates metastatic seeds for further dissemination
Zhang, W, Bado, IL, Hu, J, Wan, YW, Wu, L, Wang, H, Gao, Y, Jeong, HH, Xu, Z, Hao, X, Lege, BM, Al-Ouran, R, Li, L, Li, J, Yu, L, Singh, S, Lo, HC, Niu, M, Liu, J, Jiang, W, Li, Y, Wong, STC, Cheng, C, Liu, Z & Zhang, XHF 2021, , Cell, vol. 184, no. 9, pp. 2471-2486.e20. https://doi.org/10.1016/j.cell.2021.03.011

Sio: A spatioimageomics pipeline to identify prognostic biomarkers associated with the ovarian tumor microenvironment
Zhu, Y, Ferri-Borgogno, S, Sheng, J, Yeung, TL, Burks, JK, Cappello, P, Jazaeri, AA, Kim, JH, Han, GH, Birrer, MJ, Mok, SC & Wong, STC 2021, , Cancers, vol. 13, no. 8, 1777. https://doi.org/10.3390/cancers13081777

An imageomics and multi-network based deep learning model for risk assessment of liver transplantation for hepatocellular cancer
He, T, Fong, JN, Moore, LW, Ezeana, CF, Victor, D, Divatia, M, Vasquez, M, Ghobrial, RM & Wong, STC 2021, , Computerized Medical Imaging and Graphics, vol. 89, 101894. https://doi.org/10.1016/j.compmedimag.2021.101894

The effect of platelet G proteins on platelet extravasation and tumor growth in the murine model of ovarian cancer
Cho, MS, Li, J, Gonzalez-Delgado, R, Lee, H, Vasquez, M, He, T, He, Y, Liu, K, Sasano, T, Nürnberg, B, Sood, AK, Wong, STC & Afshar-Kharghan, V 2021, , Blood Advances, vol. 5, no. 7, pp. 1947-1951. https://doi.org/10.1182/BLOODADVANCES.2020003410

Deep learning powers cancer diagnosis in digital pathology
He, Y, Zhao, H & Wong, STC 2021, , Computerized Medical Imaging and Graphics, vol. 88, 101820. https://doi.org/10.1016/j.compmedimag.2020.101820

Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
Li, Z, Liu, H, He, J, Wang, Z, Yin, Z, You, G, Wang, Z, Davis, RE, Lin, P, Bergsagel, PL, Manasanch, EE, Wong, STC, Esnaola, NF, Chang, JC, Orlowski, RZ, Yi, Q & Yang, J 2021, , Cell Metabolism, vol. 33, no. 1, pp. 78-93.e7. https://doi.org/10.1016/j.cmet.2020.12.011

Analysis of the Implementation of Telehealth Visits for Care of Patients With Cancer in Houston During the COVID-19 Pandemic
Darcourt, JG, Aparicio, K, Dorsey, PM, Ensor, JE, Zsigmond, EM, Wong, ST, Ezeana, CF, Puppala, M, Heyne, KE, Geyer, CE, Phillips, RA, Schwartz, RL & Chang, JC 2021, , JCO oncology practice, vol. 17, no. 1, pp. e36-e43. https://doi.org/10.1200/OP.20.00572

Memory-Augmented Capsule Network for Adaptable Lung Nodule Classification
Mobiny, A, Yuan, P, Cicalese, PA, Moulik, SK, Garg, N, Wu, CC, Wong, K, Wong, ST, He, TC & Nguyen, HV 2021, , IEEE Transactions on Medical Imaging, vol. 40, no. 10, pp. 2869-2879. https://doi.org/10.1109/TMI.2021.3051089

A multifaceted study of hospital variables and interventions to improve inpatient satisfaction in a multi-hospital system
Puppala, M, Ezeana, CF, Alvarado, MVY, Goode, KN, Danforth, RL, Wong, SSY, Vassallo, ML & Wong, STC 2020, , Medicine, vol. 99, no. 51, pp. e23669. https://doi.org/10.1097/MD.0000000000023669

The bone microenvironment invigorates metastatic seeds for further dissemination
Zhang, W, Bado, IL, Hu, J, Wan, YW, Wu, L, Wang, H, Gao, Y, Jeong, HH, Xu, Z, Hao, X, Lege, BM, Al-Ouran, R, Li, L, Li, J, Yu, L, Singh, S, Lo, HC, Niu, M, Liu, J, Jiang, W, Li, Y, Wong, STC, Cheng, C, Liu, Z & Zhang, XHF 2020, , Unknown Journal. https://doi.org/10.1101/2020.11.16.383828

Guest Editorial
Tseng, VS, Wong, STC, Cook, DJ & Liu, J 2020, , IEEE Computational Intelligence Magazine, vol. 15, no. 4, 9225205, pp. 8-9. https://doi.org/10.1109/MCI.2020.3019872

Computational Intelligence Techniques for Combating COVID-19: A Survey
Tseng, VS, Jia-Ching Ying, J, Wong, STC, Cook, DJ & Liu, J 2020, , IEEE Computational Intelligence Magazine, vol. 15, no. 4, 9225219, pp. 10-22. https://doi.org/10.1109/MCI.2020.3019873

SCOR: A secure international informatics infrastructure to investigate COVID-19
Raisaro, JL, Marino, F, Troncoso-Pastoriza, J, Beau-Lejdstrom, R, Bellazzi, R, Murphy, R, Bernstam, EV, Wang, H, Bucalo, M, Chen, Y, Gottlieb, A, Harmanci, A, Kim, M, Kim, Y, Klann, J, Klersy, C, Malin, BA, Meán, M, Prasser, F, Scudeller, L, Torkamani, A, Vaucher, J, Puppala, M, Wong, STC, Frenkel-Morgenstern, M, Xu, H, Musa, BM, Habib, AG, Cohen, T, Wilcox, A, Salihu, HM, Sofia, H, Jiang, X & Hubaux, JP 2020, , Journal of the American Medical Informatics Association, vol. 27, no. 11, pp. 1721-1726. https://doi.org/10.1093/jamia/ocaa172

ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
Au-Yeung, CL, Yeung, TL, Achreja, A, Zhao, H, Yip, KP, Kwan, SY, Onstad, M, Sheng, J, Zhu, Y, Baluya, DL, Co, NN, Rynne-Vidal, A, Schmandt, R, Anderson, ML, Lu, KH, Wong, STC, Nagrath, D & Mok, SC 2020, , Nature Communications, vol. 11, no. 1, 3546. https://doi.org/10.1038/s41467-020-17383-2

Emerging treatment strategies for breast cancer brain metastasis: from translational therapeutics to real-world experience
Ren, D, Cheng, H, Wang, X, Vishnoi, M, Teh, BS, Rostomily, R, Chang, JC, Wong, ST & Zhao, H 2020, , Therapeutic Advances in Medical Oncology, vol. 12. https://doi.org/10.1177/1758835920936151

Languages

  • English
  • Chinese (Mandarin, Cantonese, Taiwanese)
  • Japanese (limited)