Stephen T.C. Wong, PhD

  • Professor of Computer Science, Systems Medicine and Bioengineering in Oncology, Houston Methodist Research Institute
  • Associate Director, Cores, Biostatistics and Bioinformatics at the Houston Methodist Cancer Center
  • Houston Methodist computer scientist, bioengineer and systems biologist
  • John S. Dunn, Sr. Presidential Distinguished Chair in Biomedical Engineering, Houston Methodist Research Institute

Stephen T.C. Wong, PhD

Areas of Expertise

  • Artificial Intelligence (AI)
  • Bioinformatics
  • Biological and medical imaging
  • Clinical neuroscience
  • Digital health
  • Drug combinations
  • Drug discovery
  • Drug repurposing / Drug repositioning
  • Health technology
  • Image-guided therapy
  • Mechanisms of cancer
  • Mechanisms of neurological disorders
  • Molecular imaging
  • Systems biology
  • Translational biophotonics


Postdoctoral Fellowship, Japan Science and Technology Agency
MS, Lehigh University
PhD, Lehigh University
Postdoctoral Fellowship, National Science Foundation, ICOT, The Fifth Generation Computer Systems Project, MITI, Tokyo


Deep learning powers cancer diagnosis in digital pathology
He, Y, Zhao, H & Wong, STC 2021, , Computerized Medical Imaging and Graphics, vol. 88, 101820.

Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
Li, Z, Liu, H, He, J, Wang, Z, Yin, Z, You, G, Wang, Z, Davis, RE, Lin, P, Bergsagel, PL, Manasanch, EE, Wong, STC, Esnaola, NF, Chang, JC, Orlowski, RZ, Yi, Q & Yang, J 2021, , Cell Metabolism, vol. 33, no. 1, pp. 78-93.e7.

Analysis of the Implementation of Telehealth Visits for Care of Patients With Cancer in Houston During the COVID-19 Pandemic
Darcourt, JG, Aparicio, K, Dorsey, PM, Ensor, JE, Zsigmond, EM, Wong, ST, Ezeana, CF, Puppala, M, Heyne, KE, Geyer, CE, Phillips, RA, Schwartz, RL & Chang, JC 2021, , JCO oncology practice, vol. 17, no. 1, pp. e36-e43.

A multifaceted study of hospital variables and interventions to improve inpatient satisfaction in a multi-hospital system
Puppala, M, Ezeana, CF, Alvarado, MVY, Goode, KN, Danforth, RL, Wong, SSY, Vassallo, ML & Wong, STC 2020, , Medicine, vol. 99, no. 51, pp. e23669.

The bone microenvironment invigorates metastatic seeds for further dissemination
Zhang, W, Bado, IL, Hu, J, Wan, YW, Wu, L, Wang, H, Gao, Y, Jeong, HH, Xu, Z, Hao, X, Lege, BM, Al-Ouran, R, Li, L, Li, J, Yu, L, Singh, S, Lo, HC, Niu, M, Liu, J, Jiang, W, Li, Y, Wong, STC, Cheng, C, Liu, Z & Zhang, XHF 2020, , Unknown Journal.

Guest Editorial
Tseng, VS, Wong, STC, Cook, DJ & Liu, J 2020, , IEEE Computational Intelligence Magazine, vol. 15, no. 4, 9225205, pp. 8-9.

Computational Intelligence Techniques for Combating COVID-19: A Survey
Tseng, VS, Jia-Ching Ying, J, Wong, STC, Cook, DJ & Liu, J 2020, , IEEE Computational Intelligence Magazine, vol. 15, no. 4, 9225219, pp. 10-22.

ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
Au-Yeung, CL, Yeung, TL, Achreja, A, Zhao, H, Yip, KP, Kwan, SY, Onstad, M, Sheng, J, Zhu, Y, Baluya, DL, Co, NN, Rynne-Vidal, A, Schmandt, R, Anderson, ML, Lu, KH, Wong, STC, Nagrath, D & Mok, SC 2020, , Nature Communications, vol. 11, no. 1, 3546.

Emerging treatment strategies for breast cancer brain metastasis: from translational therapeutics to real-world experience
Ren, D, Cheng, H, Wang, X, Vishnoi, M, Teh, BS, Rostomily, R, Chang, JC, Wong, ST & Zhao, H 2020, , Therapeutic Advances in Medical Oncology, vol. 12.

OCIAD1 contributes to neurodegeneration in Alzheimer’s disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages
Li, X, Wang, L, Cykowski, MD, He, T, Liu, T, Chakranarayan, J, Rivera, A, Zhao, H, Powell, SZ-E, Xia, W & Wong, ST 2020, , EBioMedicine, vol. 51, 102569.

Differential contributions of pre- And post-EMT tumor cells in breast cancer metastasis
Lourenco, AR, Ban, Y, Crowley, MJ, Lee, SB, Ramchandani, D, Du, W, Elemento, O, George, JT, Jolly, MK, Levine, H, Sheng, J, Wong, ST, Altorki, NK & Gao, D 2020, , Cancer research, vol. 80, no. 2, pp. 163-169.

Toward Rapid Stroke Diagnosis with Multimodal Deep Learning
Yu, M, Cai, T, Huang, X, Wong, K, Volpi, JJ, Wang, JZ & Wong, STC 2020, . in AL Martel, P Abolmaesumi, D Stoyanov, D Mateus, MA Zuluaga, SK Zhou, D Racoceanu & L Joskowicz (eds), Medical Image Computing and Computer Assisted Intervention – MICCAI 2020 - 23rd International Conference, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 12263 LNCS, Springer Science and Business Media Deutschland GmbH, pp. 616-626, 23rd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2020, Lima, Peru, 10/4/20.

Sepsis outcomes in solid organ transplant recipients
Gotur, DB, Masud, FN, Ezeana, CF, Nisar, T, Paranilam, J, Chen, S, Puppala, M, Wong, ST & Zimmerman, JL 2019, , Transplant Infectious Disease, vol. 22, no. 1, e13214.

Anticancer immunotherapy by MFAP5 blockade inhibits fibrosis and enhances chemosensitivity in ovarian and pancreatic cancer
Yeung, TL, Leung, CS, Yip, KP, Sheng, J, Vien, L, Bover, LC, Birrer, MJ, Wong, STC & Mok, SC 2019, , Clinical Cancer Research, vol. 25, no. 21, pp. 6417-6428.

Driver network as a biomarker: Systematic integration and network modeling of multi-omics data to derive driver signaling pathways for drug combination prediction
Huang, L, Brunell, D, Stephan, C, Mancuso, J, Yu, X, He, B, Thompson, TC, Zinner, R, Kim, J, Davies, P & Wong, STC 2019, , Bioinformatics, vol. 35, no. 19, pp. 3709-3717.

A multi-scale level set method based on local features for segmentation of images with intensity inhomogeneity
Min, H, Xia, L, Han, J, Wang, X, Pan, Q, Fu, H, Wang, H, Wong, ST & Li, H 2019, , Pattern Recognition, vol. 91, pp. 69-85.

A Deep Learning-Based Decision Support Tool for Precision Risk Assessment of Breast Cancer
He, T, Puppala, M, Ezeana, CF, Huang, Y-S, Chou, P-H, Yu, X, Chen, S, Wang, L, Yin, Z, Danforth, RL, Ensor, J, Chang, J, Patel, T & Wong, STC 2020, , JCO Clinical Cancer Informatics, vol. 3, pp. 1-12.

Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape
Nan, X, Wang, J, Liu, HN, Wong, STC & Zhao, H 2019, journal of clinical medicine, vol. 8, no. 5.


  • English
  • Chinese (Mandarin, Cantonese, Taiwanese)
  • Japanese (limited)