Stanley H. Appel, MD

  • Houston Methodist neurologist
  • Houston Methodist Neurological Institute co-director
  • Chairman of the Stanley H. Appel Department of Neurology at Houston Methodist Hospital
  • Peggy and Gary Edwards Distinguished Endowed Chair in ALS Research at Houston Methodist Hospital
  • Professor of neurology, Weill Cornell Medical College
  • Adjunct professor, Texas A&M Health Science Center College of Medicine

Stanley H. Appel, MD

Areas of Expertise

  • Amyotrophic lateral sclerosis (ALS)
  • Alzheimer’s disease
  • Inflammatory neuropathies (CIDP)
  • Neuromuscular disease
  • Parkinson’s disease
  • Multiple system atrophy


Neurology | American Board of Psychiatry and Neurology
Columbia University College of Physicians and Surgeons - New York, NY | 1960
Harvard University - Cambridge, MA
Neurology | Mount Sinai Medical Center - Miami Beach, FL
Duke University Medical Center - Durham, NC


Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis
Beers, DR, Zhao, W, Neal, DW, Thonhoff, JR, Thome, AD, Faridar, A, Wen, S, Wang, J & Appel, SH 2020, , Scientific Reports, vol. 10, no. 1, 15295.

Spinal Cord and Motor Neuron TDP-43 Pathology in a Sporadic Inclusion Body Myositis Patient
Cathcart, SJ, Greene, EP, Powell, SZ, Arumanayagam, AS, Rivera, AL, Tawil, R, Appel, SH & Cykowski, MD 2020, , Journal of Neuropathology and Experimental Neurology, vol. 79, no. 10, pp. 1130-1133.

Increased activation ability of monocytes from ALS patients
Du, Y, Zhao, W, Thonhoff, JR, Wang, J, Wen, S & Appel, SH 2020, Experimental Neurology, vol. 328, 113259.

Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls
Zhao, W, Beers, DR, Thonhoff, JR, Thome, AD, Faridar, A, Wang, J, Wen, S, Ornelas, L, Sareen, D, Goodridge, HS, Svendsen, CN & Appel, SH 2020, , iScience, vol. 23, no. 6, 101192.

Multimodal 18F-AV-1451 and MRI findings in nonfluent variant of primary progressive aphasia: Possible insights on nodal propagation of tau protein across the syntactic network
Pascual, B, Funk, Q, Zanotti-Fregonara, P, Pal, N, Rockers, E, Yu, MM, Spann, B, Román, GC, Schulz, PE, Karmonik, C, Appel, SH & Masdeu, JC 2020, Journal of Nuclear Medicine, vol. 61, no. 2, pp. 263-269.

Phenotypic characteristics of human bone marrow-derived endothelial progenitor cells in vitro support cell effectiveness for repair of the blood-spinal cord barrier in ALS
Garbuzova-Davis, S, Ehrhart, J, Mustafa, H, Llauget, A, Boccio, KJ, Sanberg, PR, Appel, SH & Borlongan, CV 2019, Brain Research, vol. 1724, 146428.

Dipeptide repeat (DPR) pathology in the skeletal muscle of ALS patients with C9ORF72 repeat expansion
Cykowski, MD, Dickson, DW, Powell, SZ, Arumanayagam, AS, Rivera, AL & Appel, SH 2019, , Acta Neuropathologica, vol. 138, no. 4, pp. 667-670.

Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain
Zanotti-Fregonara, P, Pascual, B, Veronese, M, Yu, M, Beers, D, Appel, SH & Masdeu, JC 2019, , European Journal of Nuclear Medicine and Molecular Imaging, vol. 46, no. 9, pp. 1822-1829.

Human Bone Marrow Endothelial Progenitor Cell Transplantation into Symptomatic ALS Mice Delays Disease Progression and Increases Motor Neuron Survival by Repairing Blood-Spinal Cord Barrier
Garbuzova-Davis, S, Kurien, C, Haller, E, Eve, DJ, Navarro, S, Steiner, G, Mahendrasah, A, Hailu, S, Khatib, M, Boccio, KJ, Borlongan, CV, Van Loveren, HR, Appel, SH & Sanberg, PR 2019, , Scientific Reports, vol. 9, no. 1, 5280.

Functional alterations of myeloid cells during the course of Alzheimer's disease
Thome, AD, Faridar, A, Beers, DR, Thonhoff, JR, Zhao, W, Wen, S, Pascual, B, Masdeu, JC & Appel, SH 2018, Molecular Neurodegeneration, vol. 13, no. 1, pp. 61.

Transplantation of human bone marrow stem cells into symptomatic ALS mice enhanced structural and functional blood-spinal cord barrier repair
Garbuzova-Davis, S, Haller, E, Navarro, S, Besong, TE, Boccio, KJ, Hailu, S, Khatib, M, Sanberg, PR, Appel, SH & Borlongan, CV 2018, , Experimental Neurology.

Head-to-head comparison of 11C-PBR28 and 18F-GE180 for quantification of the translocator protein in the human brain
Zanotti Fregonara, P, Pascual, MB, Rizzo, G, Yu, MM, Pal, N, Beers, D, Carter, R, Appel, SH, Atassi, N & Masdeu, JC 2018, , Journal of Nuclear Medicine, vol. 59, no. 8, pp. 1260-1266.

Neuroinflammatory mechanisms in amyotrophic lateral sclerosis pathogenesis
Thonhoff, JR, Simpson, EP & Appel, SH 2018, , Current opinion in neurology, vol. 31, no. 5, pp. 635-639.

Expanded autologous regulatory T-lymphocyte infusions in ALS
Thonhoff, JR, Beers, DR, Zhao, W, Pleitez, M, Simpson, EP, Berry, JD, Cudkowicz, ME & Appel, SH 2018, Neurology - Neuroimmunology Neuroinflammation, vol. 5, no. 4.

Expanded autologous regulatory T-lymphocyte infusions in ALS A phase I, first-in-human study
Thonhoff, JR, Beers, DR, Zhao, W, Pleitez, M, Simpson, EP, Berry, JD, Cudkowicz, ME & Appel, SH 2018, , Neurology: Neuroimmunology and NeuroInflammation, vol. 5, no. 4, e465, pp. e465.

The role of regulatory T lymphocytes in amyotrophic lateral sclerosis
Beers, D, Zhao, W & Appel, SH 2018, , JAMA Neurology, vol. 75, no. 6, pp. 656-658.

Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis
Cykowski, MD, Powell, SZ, Appel, JW, Arumanayagam, AS, Rivera, AL & Appel, SH 2018, , Acta Neuropathologica Communications, vol. 6, no. 1.

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
ITALSGEN Consortium, Genomic Translation for ALS Care (GTAC) Consortium, ALS Sequencing Consortium, NYGC ALS Consortium, Answer ALS Foundation, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, SLAGEN Consortium, French ALS Consortium & Project MinE ALS Sequencing Consortium 2018, , Neuron, vol. 97, no. 6, pp. 1268-1283.e6.

An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis
Fournier, CN, Schoenfeld, D, Berry, JD, Cudkowicz, ME, Chan, J, Quinn, C, Brown, RH, Salameh, JS, Tansey, MG, Beers, DR, Appel, SH & Glass, JD 2018, , Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol. 19, no. 3-4, pp. 242-249.


  • English