Robert C. Krencik, PhD

  • Neuroscientist, Houston Methodist Research Institute
  • Assistant Professor of Neurosurgery, Houston Methodist Hospital Department of Neurosurgery
  • Assistant Professor of Neuroscience in Neurological Surgery, Houston Methodist Research Institute
  • Principle Investigator, Houston Methodist Neurological Institute Center for Neuroregeneration Astrocellular Therapeutics Lab

Robert C. Krencik, PhD

Areas of Expertise

  • Astrocellular therapeutics
  • Astrocytes
  • Astroplasticity
  • Disease modeling
  • Mini-brains
  • Neural stem cells
  • Neuron-Glia interactions
  • Neuroregeneration
  • Neuroscience
  • Physiology
  • Repairing brain function
  • Spinal cord injury
  • Stem cells
  • Translational medicine

Credentials

Publications



Biomimetic Targeting of Neural Cells With Nanoparticles
Cvetkovic, C, Zinger, A, Tasciotti, E & Krencik, RC 2019, .

Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes
Jones, JR, Kong, L, Hanna, MG, Hoffman, B, Krencik, R, Bradley, R, Hagemann, T, Choi, J, Doers, M, Dubovis, M, Sherafat, MA, Bhattacharyya, A, Kendziorski, C, Audhya, A, Messing, A & Zhang, SC 2018, , Cell Reports, vol. 25, no. 4, pp. 947-958.e4. https://doi.org/10.1016/j.celrep.2018.09.083

Synaptic microcircuit modeling with 3D cocultures of astrocytes and neurons from human pluripotent stem cells
Cvetkovic, C, Basu, N & Krencik, R 2018, , Journal of visualized experiments : JoVE, vol. 2018, no. 138, e58034. https://doi.org/10.3791/58034

Concepts toward directing human astroplasticity to promote neuroregeneration
Patel, R, Muir, M, Cvetkovic, C & Krencik, R 2018, , Developmental Dynamics, pp. 21-33. https://doi.org/10.1002/dvdy.24655

Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner
Krejciova, Z, Alibhai, J, Zhao, C, Krencik, R, Rzechorzek, NM, Ullian, EM, Manson, J, Ironside, JW, Head, MW & Chandran, S 2017, , The Journal of experimental medicine, vol. 214, no. 12, pp. 3481-3495. https://doi.org/10.1084/jem.20161547

Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes
Krencik, R, Seo, K, van Asperen, JV, Basu, N, Cvetkovic, C, Barlas, S, Chen, R, Ludwig, C, Wang, C, Ward, ME, Gan, L, Horner, PJ, Rowitch, DH & Ullian, EM 2017, , Stem Cell Reports, vol. 9, no. 6, pp. 1745-1753. https://doi.org/10.1016/j.stemcr.2017.10.026

Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment
Yeh, E, Dao, DQ, Wu, ZY, Kandalam, SM, Camacho, FM, Tom, C, Zhang, W, Krencik, R, Rauen, KA, Ullian, EM & Weiss, LA 2018, , Molecular Psychiatry, vol. 23, no. 8, pp. 1687-1698. https://doi.org/10.1038/mp.2017.238

Zika virus cell tropism in the developing human brain and inhibition by azithromycin
Retallack, H, Di Lullo, E, Arias, C, Knopp, KA, Laurie, MT, Sandoval-Espinosa, C, Mancia Leon, WR, Krencik, R, Ullian, EM, Spatazza, J, Pollen, AA, Mandel-Brehm, C, Nowakowski, TJ, Kriegstein, AR & DeRisi, JL 2016, , Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 50, pp. 14408-14413. https://doi.org/10.1073/pnas.1618029113


Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells
Hu, Y, Qu, Z-Y, Cao, S-Y, Li, Q, Ma, L, Krencik, R, Xu, M & Liu, Y 2016, , Journal of Neuroscience Methods, vol. 266, pp. 42-9. https://doi.org/10.1016/j.jneumeth.2016.03.017

Targeting brain’s star-shaped cells may yield autism drugs
Krencik, R, , 2016, Web publication/site.

Efficient generation of region-specific forebrain neurons from human pluripotent stem cells under highly defined condition
Yuan, F, Fang, K-H, Cao, S-Y, Qu, Z-Y, Li, Q, Krencik, R, Xu, M, Bhattacharyya, A, Su, Y-W, Zhu, D-Y & Liu, Y 2015, , Scientific Reports, vol. 5, pp. 18550. https://doi.org/10.1038/srep18550

Dysregulation of astrocyte extracellular signaling in Costello syndrome
Krencik, R, Hokanson, KC, Narayan, AR, Dvornik, J, Rooney, GE, Rauen, KA, Weiss, LA, Rowitch, DH & Ullian, EM 2015, , Science translational medicine, vol. 7, no. 286, pp. 286ra66. https://doi.org/10.1126/scitranslmed.aaa5645

Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits
Liu, Y, Weick, JP, Liu, H, Krencik, R, Zhang, X, Ma, L, Zhou, G, Ayala, M & Zhang, S-C 2013, , Nature Biotechnology, vol. 31, no. 5, pp. 440-7. https://doi.org/10.1038/nbt.2565


Astrocytes and disease: a neurodevelopmental perspectiv
Molofsky, AV, Krencik, R, Ullian, EM, Ullian, E, Tsai, H, Deneen, B, Richardson, WD, Barres, BA & Rowitch, DH 2012, Genes & development, vol. 26, no. 9, pp. 891-907. https://doi.org/10.1101/gad.188326.112


Specification of transplantable astroglial subtypes from human pluripotent stem cells
Krencik, R, Weick, JP, Liu, Y, Zhang, Z-J & Zhang, S-C 2011, , Nature Biotechnology, vol. 29, no. 6, pp. 528-34. https://doi.org/10.1038/nbt.1877

Languages

  • English