Robert C. Krencik, PhD

  • Neuroscientist, Houston Methodist Research Institute
  • Assistant Professor of Neurosurgery, Houston Methodist Hospital Department of Neurosurgery
  • Assistant Professor of Neuroscience in Neurological Surgery, Houston Methodist Research Institute
  • Principle Investigator, Houston Methodist Neurological Institute Center for Neuroregeneration Astrocellular Therapeutics Lab

Robert C. Krencik, PhD

Areas of Expertise

  • Astrocellular therapeutics
  • Astrocytes
  • Astroplasticity
  • Disease modeling
  • Mini-brains
  • Neural stem cells
  • Neuron-Glia interactions
  • Neuroregeneration
  • Neuroscience
  • Physiology
  • Repairing brain function
  • Spinal cord injury
  • Stem cells
  • Translational medicine



Biomimetic Targeting of Neural Cells With Nanoparticles
Cvetkovic, C, Zinger, A, Tasciotti, E & Krencik, RC 2019, .

Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes
Jones, JR, Kong, L, Hanna, MG, Hoffman, B, Krencik, R, Bradley, R, Hagemann, T, Choi, J, Doers, M, Dubovis, M, Sherafat, MA, Bhattacharyya, A, Kendziorski, C, Audhya, A, Messing, A & Zhang, SC 2018, , Cell Reports, vol. 25, no. 4, pp. 947-958.e4.

Synaptic microcircuit modeling with 3D cocultures of astrocytes and neurons from human pluripotent stem cells
Cvetkovic, C, Basu, N & Krencik, R 2018, , Journal of visualized experiments : JoVE, vol. 2018, no. 138, e58034.

Concepts toward directing human astroplasticity to promote neuroregeneration
Patel, R, Muir, M, Cvetkovic, C & Krencik, R 2018, , Developmental Dynamics, pp. 21-33.

Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner
Krejciova, Z, Alibhai, J, Zhao, C, Krencik, R, Rzechorzek, NM, Ullian, EM, Manson, J, Ironside, JW, Head, MW & Chandran, S 2017, , The Journal of experimental medicine, vol. 214, no. 12, pp. 3481-3495.

Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes
Krencik, R, Seo, K, van Asperen, JV, Basu, N, Cvetkovic, C, Barlas, S, Chen, R, Ludwig, C, Wang, C, Ward, ME, Gan, L, Horner, PJ, Rowitch, DH & Ullian, EM 2017, , Stem Cell Reports, vol. 9, no. 6, pp. 1745-1753.

Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment
Yeh, E, Dao, DQ, Wu, ZY, Kandalam, SM, Camacho, FM, Tom, C, Zhang, W, Krencik, R, Rauen, KA, Ullian, EM & Weiss, LA 2018, , Molecular Psychiatry, vol. 23, no. 8, pp. 1687-1698.

Zika virus cell tropism in the developing human brain and inhibition by azithromycin
Retallack, H, Di Lullo, E, Arias, C, Knopp, KA, Laurie, MT, Sandoval-Espinosa, C, Mancia Leon, WR, Krencik, R, Ullian, EM, Spatazza, J, Pollen, AA, Mandel-Brehm, C, Nowakowski, TJ, Kriegstein, AR & DeRisi, JL 2016, , Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 50, pp. 14408-14413.

Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells
Hu, Y, Qu, Z-Y, Cao, S-Y, Li, Q, Ma, L, Krencik, R, Xu, M & Liu, Y 2016, , Journal of Neuroscience Methods, vol. 266, pp. 42-9.

Targeting brain’s star-shaped cells may yield autism drugs
Krencik, R, , 2016, Web publication/site.

Efficient generation of region-specific forebrain neurons from human pluripotent stem cells under highly defined condition
Yuan, F, Fang, K-H, Cao, S-Y, Qu, Z-Y, Li, Q, Krencik, R, Xu, M, Bhattacharyya, A, Su, Y-W, Zhu, D-Y & Liu, Y 2015, , Scientific Reports, vol. 5, pp. 18550.

Dysregulation of astrocyte extracellular signaling in Costello syndrome
Krencik, R, Hokanson, KC, Narayan, AR, Dvornik, J, Rooney, GE, Rauen, KA, Weiss, LA, Rowitch, DH & Ullian, EM 2015, , Science translational medicine, vol. 7, no. 286, pp. 286ra66.

Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits
Liu, Y, Weick, JP, Liu, H, Krencik, R, Zhang, X, Ma, L, Zhou, G, Ayala, M & Zhang, S-C 2013, , Nature Biotechnology, vol. 31, no. 5, pp. 440-7.

Astrocytes and disease: a neurodevelopmental perspectiv
Molofsky, AV, Krencik, R, Ullian, EM, Ullian, E, Tsai, H, Deneen, B, Richardson, WD, Barres, BA & Rowitch, DH 2012, Genes & development, vol. 26, no. 9, pp. 891-907.

Specification of transplantable astroglial subtypes from human pluripotent stem cells
Krencik, R, Weick, JP, Liu, Y, Zhang, Z-J & Zhang, S-C 2011, , Nature Biotechnology, vol. 29, no. 6, pp. 528-34.


  • English