John P. Cooke, MD, PhD

  • Chair, Houston Methodist Research Institute Department of Cardiovascular Sciences
  • Director, Houston Methodist Center for Cardiovascular Regeneration
  • Professor of Cardiovascular Sciences, Houston Methodist Research Institute
  • Joseph C. “Rusty” Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research, Houston Methodist Research Institute

John P. Cooke, MD, PhD

Areas of Expertise

  • Aging research
  • Cardiovascular Regeneration
  • Endothelium
  • Regenerative medicine
  • Stem cells
  • Studies reversing aging in progeria
  • Telomeres
  • Vascular disease

Credentials

Clinical Fellowship, Mayo Graduate School of Medicine, Rochester, MN
Residency, Mayo Graduate School of Medicine, Rochester, MN
Internship, Mayo Graduate School of Medicine, Rochester, MN
MD, Wayne State Univ. School of Medicine
PhD, Mayo Graduate School of Medicine, Rochester, NY
Research Fellowship, Mayo Graduate School of Medicine, Rochester, NY

Publications

RBFOX2 is required for establishing RNA regulatory networks essential for heart development
Verma, SK, Deshmukh, V, Thatcher, K, Belanger, KAK, Rhyner, AM, Meng, S, Holcomb, RJ, Bressan, M, Martin, JF, Cooke, JP, Wythe, JD, Widen, SG, Lincoln, J & Kuyumcu-Martinez, MN 2022, , Nucleic Acids Research, vol. 50, no. 4, pp. 2270-2286. https://doi.org/10.1093/nar/gkac055

Emerging nanotechnologies in cardiovascular medicine
Grattoni, A & Cooke, JP 2022, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 39, 102472. https://doi.org/10.1016/j.nano.2021.102472

Free Cholesterol Bioavailability and Atherosclerosis
Abe, RJ, Abe, JI, Nguyen, MTH, Olmsted-Davis, EA, Mamun, A, Banerjee, P, Cooke, JP, Fang, L, Pownall, H & Le, NT 2022, , Current Atherosclerosis Reports, vol. 24, no. 5, pp. 323-336. https://doi.org/10.1007/s11883-022-01011-z

Hospital-Based RNA Therapeutics
Damase, TR, Sukhovershin, R, Zhang, M, Kiss, DL & Cooke, JP 2021, . in mRNA Therapeutics: Springer.

Unsupervised learning for automated detection of coronary artery disease subgroups
Flores, AM, Schuler, A, Eberhard, AV, Olin, JW, Cooke, JP, Leeper, NJ, Shah, NH & Ross, EG 2021, , Journal of the American Heart Association, vol. 10, no. 23, e021976. https://doi.org/10.1161/JAHA.121.021976

Nuclear S-nitrosylation impacts tissue regeneration in zebrafish
Matrone, G, Jung, SY, Choi, JM, Jain, A, Leung, HCE, Rajapakshe, K, Coarfa, C, Rodor, J, Denvir, MA, Baker, AH & Cooke, JP 2021, , Nature Communications, vol. 12, no. 1, 6282. https://doi.org/10.1038/s41467-021-26621-0

Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice
Mojiri, A, Walther, BK, Jiang, C, Matrone, G, Holgate, R, Xu, Q, Morales, E, Wang, G, Gu, J, Wang, R & Cooke, JP 2021, , European heart journal, vol. 42, no. 42, pp. 4352-4369. https://doi.org/10.1093/eurheartj/ehab547

Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation
Kotla, S, Zhang, A, Imanishi, M, Ko, KA, Lin, SH, Gi, YJ, Moczygemba, M, Isgandarova, S, Schadler, KL, Chung, C, Milgrom, SA, Banchs, J, Yusuf, SW, Amaya, DN, Guo, H, Thomas, TN, Shen, YH, Deswal, A, Herrmann, J, Kleinerman, ES, Entman, ML, Cooke, JP, Schifitto, G, Maggirwar, SB, McBeath, E, Gupte, AA, Krishnan, S, Patel, ZS, Yoon, Y, Burks, JK, Fujiwara, K, Brookes, PS, Le, N-T, Hamilton, DJ & Abe, J-I 2021, , Redox Biology, vol. 47, 102132, pp. 102132. https://doi.org/10.1016/j.redox.2021.102132

Fli1+ cells transcriptional analysis reveals an Lmo2-Prdm16 axis in angiogenesis
Matrone, G, Xia, B, Chen, K, Denvir, MA, Baker, AH & Cooke, JP 2021, , Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 31, e2008559118. https://doi.org/10.1073/pnas.2008559118

Induced endothelial cells from peripheral arterial disease patients and neonatal fibroblasts have comparable angiogenic properties
Hywood, JD, Sadeghipour, S, Clayton, ZE, Yuan, J, Stubbs, C, Wong, JWT, Cooke, JP & Patel, S 2021, , PLoS ONE, vol. 16, no. 8 August, e0255075. https://doi.org/10.1371/journal.pone.0255075

Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice
Mojiri, A, Walther, BK, Jiang, C, Matrone, G, Holgate, R, Xu, Q, Morales, E, Wang, G, Gu, J, Wang, R & Cooke, JP 2021, , European heart journal, vol. 42, no. 42, pp. 4352-4369. https://doi.org/10.1093/eurheartj/ehab547

Biomimetic and immunomodulatory therapeutics as an alternative to natural exosomes for vascular and cardiac applications
Villarreal-Leal, RA, Cooke, JP & Corradetti, B 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 35, 102385, pp. 102385. https://doi.org/10.1016/j.nano.2021.102385

Mechanotransduction-on-chip: Vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response
Walther, BK, Rajeeva Pandian, NK, Gold, KA, Kiliç, ES, Sama, V, Gu, J, Gaharwar, AK, Guiseppi-Elie, A, Cooke, JP & Jain, A 2021, , Lab on a Chip, vol. 21, no. 9, pp. 1738-1751. https://doi.org/10.1039/d0lc01283a

RNA therapeutics for cardiovascular disease
Boada, C, Sukhovershin, R, Pettigrew, R & Cooke, JP 2021, , Current Opinion in Cardiology, vol. 36, no. 3, pp. 256-263. https://doi.org/10.1097/HCO.0000000000000850

The Limitless Future of RNA Therapeutics
Damase, TR, Sukhovershin, R, Boada, C, Taraballi, F, Pettigrew, RI & Cooke, JP 2021, , Frontiers in Bioengineering and Biotechnology, vol. 9, 628137. https://doi.org/10.3389/fbioe.2021.628137

mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration
Chanda, PK, Sukhovershin, R & Cooke, JP 2021, , Cells, vol. 10, no. 1, 187, pp. 1-13. https://doi.org/10.3390/cells10010187

Biomimetic nano drug delivery carriers for treating cardiovascular diseases
Zinger, A, Cooke, JP & Taraballi, F 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 33, 102360, pp. 102360. https://doi.org/10.1016/j.nano.2021.102360

Role of Endothelial and Mesenchymal Cell Transitions in Heart Failure and Recovery Thereafter
Wang, G, Cruz, AS, Youker, K, Marcos-Abdala, HG, Thandavarayan, RA, Cooke, JP, Torre-Amione, G, Chen, K & Bhimaraj, A 2021, , Frontiers in Genetics, vol. 11, 609262, pp. 609262. https://doi.org/10.3389/fgene.2020.609262

Endothelial Dysfunction-related Neurological Bleeds with Continuous Flow-Left Ventricular Assist Devices Measured by Digital Thermal Monitor
Ali, A, Uribe, C, Araujo-Gutierrez, R, Cruz-Solbes, AS, Marcos-Abdala, HG, Youker, KA, Guha, A, Torre-Amione, G, Nguyen, DT, Graviss, EA, Cooke, JP & Bhimaraj, A 2021, , ASAIO Journal, pp. 561-566. https://doi.org/10.1097/MAT.0000000000001281


Languages

  • English