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John P. Cooke, MD, PhD

  • Chair, Houston Methodist Research Institute Department of Cardiovascular Sciences
  • Director, Houston Methodist Center for Cardiovascular Regeneration
  • Professor of Cardiovascular Sciences, Houston Methodist Research Institute
  • Joseph C. “Rusty” Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research, Houston Methodist Research Institute
Media Contact: Lisa Merkl , 832.667.5916

John P. Cooke, MD, PhD

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Media Contact: Lisa Merkl , 832.667.5916

Areas of Expertise

  • Aging research
  • Cardiovascular Regeneration
  • Endothelium
  • Regenerative medicine
  • Stem cells
  • Studies reversing aging in progeria
  • Telomeres
  • Vascular disease

Credentials

Clinical Fellowship, Mayo Graduate School of Medicine, Rochester, MN
Residency, Mayo Graduate School of Medicine, Rochester, MN
Internship, Mayo Graduate School of Medicine, Rochester, MN
MD, Wayne State Univ. School of Medicine
PhD, Mayo Graduate School of Medicine, Rochester, NY
Research Fellowship, Mayo Graduate School of Medicine, Rochester, NY

Publications

Design and rationale of re-energize fontan: Randomized exercise intervention designed to maximize fitness in fontan patients
Selamet Tierney, ES, Palaniappan, L, Leonard, M, Long, J, Myers, J, Dávila, T, Lui, MC, Kogan, F, Olson, I, Punn, R, Desai, M, Schneider, LM, Wang, CH, Cooke, JP & Bernstein, D 2023, , American Heart Journal, vol. 259, pp. 68-78. https://doi.org/10.1016/j.ahj.2023.02.006

A relay velocity model infers cell-dependent RNA velocity
Li, S, Zhang, P, Chen, W, Ye, L, Brannan, KW, Le, NT, Abe, JI, Cooke, JP & Wang, G 2023, , Nature Biotechnology. https://doi.org/10.1038/s41587-023-01728-5

Long noncoding RNA LEENE promotes angiogenesis and ischemic recovery in diabetes models
Tang, X, Luo, Y, Yuan, D, Calandrelli, R, Malhi, NK, Sriram, K, Miao, Y, Lou, CH, Tsark, W, Tapia, A, Chen, AT, Zhang, G, Roeth, D, Kalkum, M, Wang, ZV, Chien, S, Natarajan, R, Cooke, JP, Zhong, S & Chen, ZB 2023, , Journal of Clinical Investigation, vol. 133, no. 3, e161759. https://doi.org/10.1172/JCI161759

Coronary Microvascular Health in Patients With Prior COVID-19 Infection
Ahmed, AI, Saad, JM, Han, Y, Alahdab, F, Malahfji, M, Nabi, F, Mahmarian, JJ, Cooke, JP, Zoghbi, WA & Al-Mallah, MH 2022, , JACC: Cardiovascular Imaging, vol. 15, no. 12, pp. 2153-2155. https://doi.org/10.1016/j.jcmg.2022.07.006

Radiation therapy induces immunosenescence mediated by p90RSK
Imanishi, M, Cheng, H, Kotla, S, Deswal, A, Le, N-T, Chini, E, Ko, KA, Samanthapudi, VSK, Lee, L-L, Herrmann, J, Xu, X, Reyes-Gibby, C, Yeung, S-CJ, Schadler, KL, Yusuf, SW, Liao, Z, Nurieva, R, Amir, E-AD, Burks, JK, Palaskas, NL, Cooke, JP, Lin, SH, Kobayashi, M, Yoshimoto, M & Abe, J-I 2022, , Frontiers in cardiovascular medicine, vol. 9, pp. 988713. https://doi.org/10.3389/fcvm.2022.988713

Radiation therapy induces immunosenescence mediated by p90RSK
Imanishi, M, Cheng, H, Kotla, S, Deswal, A, Le, NT, Chini, E, Ko, KA, Samanthapudi, VSK, Lee, LL, Herrmann, J, Xu, X, Reyes-Gibby, C, Yeung, SCJ, Schadler, KL, Yusuf, SW, Liao, Z, Nurieva, R, Amir, EAD, Burks, JK, Palaskas, NL, Cooke, JP, Lin, SH, Kobayashi, M, Yoshimoto, M & Abe, JI 2022, , Frontiers in Cardiovascular Medicine, vol. 9, 988713. https://doi.org/10.3389/fcvm.2022.988713

Endothelial thioredoxin interacting protein (TXNIP) modulates endothelium-dependent vasorelaxation in hyperglycemia
Lam, YT, Tan, RP, Michael, P, Yang, N, Dunn, LL, Cooke, JP, Celermajer, DS, Wise, SG & Ng, MKC 2022, , Microvascular Research, vol. 143, 104396. https://doi.org/10.1016/j.mvr.2022.104396

MAGI1 inhibits interferon signaling to promote influenza A infection
Wang, Y, Abe, JI, Chau, KM, Wang, Y, Vu, HT, Reddy Velatooru, L, Gulraiz, F, Imanishi, M, Samanthapudi, VSK, Nguyen, MTH, Ko, KA, Lee, LL, Thomas, TN, Olmsted-Davis, EA, Kotla, S, Fujiwara, K, Cooke, JP, Zhao, D, Evans, SE & Le, NT 2022, , Frontiers in Cardiovascular Medicine, vol. 9, no. 36082118, 791143, pp. 791143. https://doi.org/10.3389/fcvm.2022.791143, https://doi.org/10.3389/fcvm.2022.791143

MAGI1 inhibits interferon signaling to promote influenza A infection
Wang, Y, Abe, J-I, Chau, KM, Wang, Y, Vu, HT, Reddy Velatooru, L, Gulraiz, F, Imanishi, M, Samanthapudi, VSK, Nguyen, MTH, Ko, KA, Lee, L-L, Thomas, TN, Olmsted-Davis, EA, Kotla, S, Fujiwara, K, Cooke, JP, Zhao, D, Evans, SE & Le, N-T 2022, , Frontiers in cardiovascular medicine, vol. 9, no. 36082118, pp. 791143. https://doi.org/10.3389/fcvm.2022.791143


Vascular senescence in progeria: role of endothelial dysfunction
Xu, Q, Mojiri, A, Boulahouache, L, Morales, E, Walther, BK & Cooke, JP 2022, , European heart journal open, vol. 2, no. 4, pp. oeac047. https://doi.org/10.1093/ehjopen/oeac047

Vascular senescence in progeria: role of endothelial dysfunction
Xu, Q, Mojiri, A, Boulahouache, L, Morales, E, Walther, BK & Cooke, JP 2022, , European Heart Journal Open, vol. 2, no. 4. https://doi.org/10.1093/ehjopen/oeac047

Cardiac Shockwave Therapy – A Novel Therapy for Ischemic Cardiomyopathy?
Graber, M, Nägele, F, Hirsch, J, Pölzl, L, Schweiger, V, Lechner, S, Grimm, M, Cooke, JP, Gollmann-Tepeköylü, C & Holfeld, J 2022, , Frontiers in Cardiovascular Medicine, vol. 9, 875965. https://doi.org/10.3389/fcvm.2022.875965

Biomimetic Collagen Membranes Functionalized with mRNA-loaded Lipid Nanoparticles for Fibroblast Transdifferentiation to Endothelial Cells
Villarreal-Leal, RA, Williams, ME, Taraballi, F, Cooke, JP & Corradetti, B 2022, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 36. https://doi.org/10.1096/fasebj.2022.36.S1.L7813

Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications
Banerjee, P, Olmsted-Davis, EA, Deswal, A, Nguyen, MT, Koutroumpakis, E, Palaskas, NL, Lin, SH, Kotla, S, Reyes-Gibby, C, Yeung, S-CJ, Yusuf, SW, Yoshimoto, M, Kobayashi, M, Yu, B, Schadler, K, Herrmann, J, Cooke, JP, Jain, A, Chini, E, Le, N-T & Abe, J-I 2022, , The journal of cardiovascular aging, vol. 2. https://doi.org/10.20517/jca.2022.13

RBFOX2 is required for establishing RNA regulatory networks essential for heart development
Verma, SK, Deshmukh, V, Thatcher, K, Belanger, KAK, Rhyner, AM, Meng, S, Holcomb, RJ, Bressan, M, Martin, JF, Cooke, JP, Wythe, JD, Widen, SG, Lincoln, J & Kuyumcu-Martinez, MN 2022, , Nucleic Acids Research, vol. 50, no. 4, pp. 2270-2286. https://doi.org/10.1093/nar/gkac055

Emerging nanotechnologies in cardiovascular medicine
Grattoni, A & Cooke, JP 2022, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 39, 102472. https://doi.org/10.1016/j.nano.2021.102472

Free Cholesterol Bioavailability and Atherosclerosis
Abe, RJ, Abe, JI, Nguyen, MTH, Olmsted-Davis, EA, Mamun, A, Banerjee, P, Cooke, JP, Fang, L, Pownall, H & Le, NT 2022, , Current Atherosclerosis Reports, vol. 24, no. 5, pp. 323-336. https://doi.org/10.1007/s11883-022-01011-z

Hospital-Based RNA Therapeutics
Damase, TR, Sukhovershin, R, Zhang, M, Kiss, DL & Cooke, JP 2022, . in RNA Technologies. RNA Technologies, vol. 13, Springer Science and Business Media Deutschland GmbH, pp. 73-92. https://doi.org/10.1007/978-3-031-08415-7_4

Future Impact of mRNA Therapy on Cardiovascular Diseases
Cooke, JP & Youker, KA 2022, , Methodist DeBakey cardiovascular journal, vol. 18, no. 5, pp. 64-73. https://doi.org/10.14797/mdcvj.1169

Languages

  • English