John P. Cooke, MD, PhD

  • Chair, Houston Methodist Research Institute Department of Cardiovascular Sciences
  • Director, Houston Methodist Center for Cardiovascular Regeneration
  • Professor of Cardiovascular Sciences, Houston Methodist Research Institute
  • Joseph C. “Rusty” Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research, Houston Methodist Research Institute

John P. Cooke, MD, PhD

Areas of Expertise

  • Aging research
  • Cardiovascular Regeneration
  • Endothelium
  • Regenerative medicine
  • Stem cells
  • Studies reversing aging in progeria
  • Telomeres
  • Vascular disease

Credentials

Clinical Fellowship, Mayo Graduate School of Medicine, Rochester, MN
Residency, Mayo Graduate School of Medicine, Rochester, MN
Internship, Mayo Graduate School of Medicine, Rochester, MN
MD, Wayne State Univ. School of Medicine
PhD, Mayo Graduate School of Medicine, Rochester, NY
Research Fellowship, Mayo Graduate School of Medicine, Rochester, NY

Publications


Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis
Ahmed, AI, Al Rifai, M, Alahdab, F, Saad, JM, Han, Y, Alfawara, MS, Nayfeh, M, Malahfji, M, Nabi, F, Mahmarian, JJ, Cooke, JP, Zoghbi, WA & Al-Mallah, MH 2023, , European Heart Journal Cardiovascular Imaging, vol. 24, no. 11, pp. 1544-1554. https://doi.org/10.1093/ehjci/jead118

Disrupted stiffness ratio alters nuclear mechanosensing
Walther, BK, Sears, AP, Mojiri, A, Avazmohammadi, R, Gu, J, Chumakova, OV, Rajeeva Pandian, NK, Dominic, A, Martiel, JL, Yazdani, SK, Cooke, JP, Ohayon, J & Pettigrew, RI 2023, , Matter, vol. 6, no. 10, pp. 3608-3630. https://doi.org/10.1016/j.matt.2023.08.010


A2AR-mediated lymphangiogenesis via VEGFR2 signaling prevents salt-sensitive hypertension
Zhuang, T, Lei, Y, Chang, JJ, Zhou, YP, Li, Y, Li, YX, Yang, YF, Chen, MH, Meng, T, Fu, SM, Huang, LH, Cheang, WS, Cooke, JP, Dong, ZH, Bai, YN & Ruan, CC 2023, , European heart journal, vol. 44, no. 29, pp. 2730-2742. https://doi.org/10.1093/eurheartj/ehad377

An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis
Abe, J-I, Imanishi, M, Li, S, Zhang, A, Ko, KA, Samanthapudi, VSK, Lee, L-L, Bojorges, AP, Gi, YJ, Hobbs, BP, Deswal, A, Herrmann, J, Lin, SH, Chini, EN, Shen, YH, Schadler, KL, Nguyen, T-H-M, Gupte, AA, Reyes-Gibby, C, Yeung, S-CJ, Abe, RJ, Olmsted-Davis, EA, Krishnan, S, Dantzer, R, Palaskas, NL, Cooke, JP, Pownall, HJ, Yoshimoto, M, Fujiwara, K, Hamilton, DJ, Burks, JK, Wang, G, Le, N-T & Kotla, S 2023, , Circulation Research, vol. 133, no. 1, pp. 25-44. https://doi.org/10.1161/CIRCRESAHA.122.322017

Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis
Ahmed, AI, Al Rifai, M, Alahdab, F, Saad, JM, Han, Y, Alfawara, MS, Nayfeh, M, Malahfji, M, Nabi, F, Mahmarian, JJ, Cooke, JP, Zoghbi, WA & Al-Mallah, MH 2023, , European Heart Journal Cardiovascular Imaging, vol. 24, no. 11, pp. 1544-1554. https://doi.org/10.1093/ehjci/jead118

Publisher Correction: Epigenetic landscape reveals MECOM as an endothelial lineage regulator
Lv, J, Meng, S, Gu, Q, Zheng, R, Gao, X, Kim, JD, Chen, M, Xia, B, Zuo, Y, Zhu, S, Zhao, D, Li, Y, Wang, G, Wang, X, Meng, Q, Cao, Q, Cooke, JP, Fang, L, Chen, K & Zhang, L 2023, , Nature Communications, vol. 14, no. 1, 2842, pp. 2842. https://doi.org/10.1038/s41467-023-38708-x

Design and rationale of re-energize fontan: Randomized exercise intervention designed to maximize fitness in fontan patients
Selamet Tierney, ES, Palaniappan, L, Leonard, M, Long, J, Myers, J, Dávila, T, Lui, MC, Kogan, F, Olson, I, Punn, R, Desai, M, Schneider, LM, Wang, CH, Cooke, JP & Bernstein, D 2023, , American Heart Journal, vol. 259, pp. 68-78. https://doi.org/10.1016/j.ahj.2023.02.006

Epigenetic landscape reveals MECOM as an endothelial lineage regulator
Lv, J, Meng, S, Gu, Q, Zheng, R, Gao, X, Kim, JD, Chen, M, Xia, B, Zuo, Y, Zhu, S, Zhao, D, Li, Y, Wang, G, Wang, X, Meng, Q, Cao, Q, Cooke, JP, Fang, L, Chen, K & Zhang, L 2023, , Nature Communications, vol. 14, no. 1, 2390, pp. 2390. https://doi.org/10.1038/s41467-023-38002-w

A relay velocity model infers cell-dependent RNA velocity
Li, S, Zhang, P, Chen, W, Ye, L, Brannan, KW, Le, NT, Abe, JI, Cooke, JP & Wang, G 2023, , Nature Biotechnology, vol. 42, no. 1, pp. 99-108. https://doi.org/10.1038/s41587-023-01728-5

Long noncoding RNA LEENE promotes angiogenesis and ischemic recovery in diabetes models
Tang, X, Luo, Y, Yuan, D, Calandrelli, R, Malhi, NK, Sriram, K, Miao, Y, Lou, CH, Tsark, W, Tapia, A, Chen, AT, Zhang, G, Roeth, D, Kalkum, M, Wang, ZV, Chien, S, Natarajan, R, Cooke, JP, Zhong, S & Chen, ZB 2023, , Journal of Clinical Investigation, vol. 133, no. 3, e161759. https://doi.org/10.1172/JCI161759

Possible molecular mechanisms underlying the development of atherosclerosis in cancer survivors
Banerjee, P, Rosales, JE, Chau, K, Nguyen, MTH, Kotla, S, Lin, SH, Deswal, A, Dantzer, R, Olmsted-Davis, EA, Nguyen, H, Wang, G, Cooke, JP, Abe, JI & Le, NT 2023, , Frontiers in cardiovascular medicine, vol. 10, 1186679, pp. 1186679. https://doi.org/10.3389/fcvm.2023.1186679

Role of angiogenic transdifferentiation in vascular recovery
Cooke, JP & Lai, L 2023, , Frontiers in Cardiovascular Medicine, vol. 10, 1155835, pp. 1155835. https://doi.org/10.3389/fcvm.2023.1155835

Electrically stimulated gene expression under exogenously applied electric fields
Abasi, S, Jain, A, Cooke, JP & Guiseppi-Elie, A 2023, , Frontiers in Molecular Biosciences, vol. 10, 1161191, pp. 1161191. https://doi.org/10.3389/fmolb.2023.1161191

Telomerase mRNA Enhances Human Skin Engraftment for Wound Healing
Chang, DF, Court, KA, Holgate, R, Davis, EA, Bush, KA, Quick, AP, Spiegel, AJ, Rahimi, M, Cooke, JP & Godin, B 2023, , Advanced Healthcare Materials, vol. 13, no. 2, 2302029, pp. e2302029. https://doi.org/10.1002/adhm.202302029

Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition
Nguyen, MTH, Imanishi, M, Li, S, Chau, K, Banerjee, P, Velatooru, LR, Ko, KA, Samanthapudi, VSK, Gi, YJ, Lee, LL, Abe, RJ, McBeath, E, Deswal, A, Lin, SH, Palaskas, NL, Dantzer, R, Fujiwara, K, Borchardt, MK, Turcios, EB, Olmsted-Davis, EA, Kotla, S, Cooke, JP, Wang, G, Abe, JI & Le, NT 2023, , Frontiers in Cardiovascular Medicine, vol. 10, 1187490, pp. 1187490. https://doi.org/10.3389/fcvm.2023.1187490

Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights
Jain, A, Casanova, D, Padilla, AV, Paniagua Bojorges, A, Kotla, S, Ko, KA, Samanthapudi, VSK, Chau, K, Nguyen, MTH, Wen, J, Hernandez Gonzalez, SL, Rodgers, SP, Olmsted-Davis, EA, Hamilton, DJ, Reyes-Gibby, C, Yeung, SCJ, Cooke, JP, Herrmann, J, Chini, EN, Xu, X, Yusuf, SW, Yoshimoto, M, Lorenzi, PL, Hobbs, B, Krishnan, S, Koutroumpakis, E, Palaskas, NL, Wang, G, Deswal, A, Lin, SH, Abe, JI & Le, NT 2023, , Frontiers in Cardiovascular Medicine, vol. 10, 1212174, pp. 1212174. https://doi.org/10.3389/fcvm.2023.1212174

Is Cardiovascular Regeneration Possible?
Cooke, JP 2023, , Methodist DeBakey cardiovascular journal, vol. 19, no. 5, pp. 1-4. https://doi.org/10.14797/mdcvj.1307

Mechanisms of Atherosclerosis in Peripheral Arterial Diseases
Cooke, JP 2023, . in Peripheral Arterial Disease Handbook. CRC Press, pp. 3-20. https://doi.org/10.1201/9780429191497-2

Languages

  • English