John P. Cooke, MD, PhD

  • Chair, Houston Methodist Research Institute Department of Cardiovascular Sciences
  • Director, Houston Methodist Center for Cardiovascular Regeneration
  • Professor of Cardiovascular Sciences, Houston Methodist Research Institute
  • Joseph C. “Rusty” Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research, Houston Methodist Research Institute

John P. Cooke, MD, PhD

Areas of Expertise

  • Aging research
  • Cardiovascular Regeneration
  • Endothelium
  • Regenerative medicine
  • Stem cells
  • Studies reversing aging in progeria
  • Telomeres
  • Vascular disease

Credentials

Clinical Fellowship, Mayo Graduate School of Medicine, Rochester, MN
Residency, Mayo Graduate School of Medicine, Rochester, MN
Internship, Mayo Graduate School of Medicine, Rochester, MN
MD, Wayne State Univ. School of Medicine
PhD, Mayo Graduate School of Medicine, Rochester, NY
Research Fellowship, Mayo Graduate School of Medicine, Rochester, NY

Publications

Biomimetic and immunomodulatory therapeutics as an alternative to natural exosomes for vascular and cardiac applications
Villarreal-Leal, RA, Cooke, JP & Corradetti, B 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 35, 102385. https://doi.org/10.1016/j.nano.2021.102385

Mechanotransduction-on-chip: Vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response
Walther, BK, Rajeeva Pandian, NK, Gold, KA, Kiliç, ES, Sama, V, Gu, J, Gaharwar, AK, Guiseppi-Elie, A, Cooke, JP & Jain, A 2021, , Lab on a Chip, vol. 21, no. 9, pp. 1738-1751. https://doi.org/10.1039/d0lc01283a

RNA therapeutics for cardiovascular disease
Boada, C, Sukhovershin, R, Pettigrew, R & Cooke, JP 2021, , Current Opinion in Cardiology, vol. 36, no. 3, pp. 256-263. https://doi.org/10.1097/HCO.0000000000000850

The Limitless Future of RNA Therapeutics
Damase, TR, Sukhovershin, R, Boada, C, Taraballi, F, Pettigrew, RI & Cooke, JP 2021, , Frontiers in Bioengineering and Biotechnology, vol. 9, 628137. https://doi.org/10.3389/fbioe.2021.628137

mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration
Chanda, PK, Sukhovershin, R & Cooke, JP 2021, , Cells, vol. 10, no. 1. https://doi.org/10.3390/cells10010187

Biomimetic nano drug delivery carriers for treating cardiovascular diseases
Zinger, A, Cooke, JP & Taraballi, F 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 33, pp. 102360. https://doi.org/10.1016/j.nano.2021.102360

Endothelial Dysfunction-related Neurological Bleeds with Continuous Flow-Left Ventricular Assist Devices Measured by Digital Thermal Monitor
Ali, A, Uribe, C, Araujo-Gutierrez, R, Cruz-Solbes, AS, Marcos-Abdala, HG, Youker, KA, Guha, A, Torre-Amione, G, Nguyen, DT, Graviss, EA, Cooke, JP & Bhimaraj, A 2021, , ASAIO Journal, pp. 561-566. https://doi.org/10.1097/MAT.0000000000001281


Microengineered Human Vein-Chip Recreates Venous Valve Architecture and Its Contribution to Thrombosis
Rajeeva Pandian, NK, Walther, BK, Suresh, R, Cooke, JP & Jain, A 2020, , Small, vol. 16, no. 49, 2003401. https://doi.org/10.1002/smll.202003401

Broad genic repression domains signify enhanced silencing of oncogenes
Zhao, D, Zhang, L, Zhang, M, Xia, B, Lv, J, Gao, X, Wang, G, Meng, Q, Yi, Y, Zhu, S, Tomoiaga, AS, Lee, MG, Cooke, JP, Cao, Q & Chen, K 2020, , Nature Communications, vol. 11, no. 1, 5560. https://doi.org/10.1038/s41467-020-18913-8

Microengineered Human Vein-Chip Recreates Venous Valve Architecture and Its Contribution to Thrombosis
Rajeeva Pandian, NK, Walther, BK, Suresh, R, Cooke, JP & Jain, A 2020, , Small (Weinheim an der Bergstrasse, Germany), vol. 16, no. 49, pp. e2003401. https://doi.org/10.1002/smll.202003401


Endothelial Dysfunction-related Neurological Bleeds with Continuous Flow-Left Ventricular Assist Devices Measured by Digital Thermal Monitor
Ali, A, Uribe, C, Araujo-Gutierrez, R, Cruz-Solbes, AS, Marcos-Abdala, HG, Youker, KA, Guha, A, Torre-Amione, G, Nguyen, DT, Graviss, EA, Cooke, JP & Bhimaraj, A 2020, , ASAIO journal (American Society for Artificial Internal Organs : 1992). https://doi.org/10.1097/MAT.0000000000001281

Nanobiosensing with graphene and carbon quantum dots: Recent advances
Walther, BK, Dinu, CZ, Guldi, DM, Sergeyev, VG, Creager, SE, Cooke, JP & Guiseppi-Elie, A 2020, , Materials Today, vol. 39, pp. 23-46. https://doi.org/10.1016/j.mattod.2020.04.008

Caveats on modeling of nuclear biomechanics
Walther, BK, Mojiri, A, Ohayon, J, Cooke, JP & Pettigrew, RI 2020, , Molecular Biology of the Cell, vol. 31, no. 22, pp. 2421-2422. https://doi.org/10.1091/MBC.E20-05-0281

Endotheliopathy of obesity
Cooke, JP 2020, , Circulation, vol. 142, no. 4, pp. 380-383. https://doi.org/10.1161/CIRCULATIONAHA.120.047574

Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome
Mu, X, Tseng, C, Hambright, WS, Matre, P, Lin, CY, Chanda, P, Chen, W, Gu, J, Ravuri, S, Cui, Y, Zhong, L, Cooke, JP, Niedernhofer, LJ, Robbins, PD & Huard, J 2020, , Aging Cell, vol. 19, no. 8, e13152. https://doi.org/10.1111/acel.13152

Machine learning uncovers cell identity regulator by histone code
Xia, B, Zhao, D, Wang, G, Zhang, M, Lv, J, Tomoiaga, AS, Li, Y, Wang, X, Meng, S, Cooke, JP, Cao, Q, Zhang, L & Chen, K 2020, , Nature Communications, vol. 11, no. 1, 2696. https://doi.org/10.1038/s41467-020-16539-4

TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription
Wang, G, Meng, Q, Xia, B, Zhang, S, Lv, J, Zhao, D, Li, Y, Wang, X, Zhang, L, Cooke, JP, Cao, Q & Chen, K 2020, , Genome Biology, vol. 21, no. 1, 84. https://doi.org/10.1186/s13059-020-01992-7

Asymmetric dimethylarginine predicts impaired epicardial coronary vasomotion in patients with angina in the absence of obstructive coronary artery disease
Parikh, RV, Pargaonkar, V, Ball, RL, Kobayashi, Y, Kimura, T, Yeung, AC, Cooke, JP & Tremmel, JA 2020, , International Journal of Cardiology, vol. 299, pp. 7-11. https://doi.org/10.1016/j.ijcard.2019.07.062

Languages

  • English