John P. Cooke, MD, PhD

  • Chair, Houston Methodist Research Institute Department of Cardiovascular Sciences
  • Director, Houston Methodist Center for Cardiovascular Regeneration
  • Professor of Cardiovascular Sciences, Houston Methodist Research Institute
  • Joseph C. “Rusty” Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research, Houston Methodist Research Institute

John P. Cooke, MD, PhD

Areas of Expertise

  • Aging research
  • Cardiovascular Regeneration
  • Endothelium
  • Regenerative medicine
  • Stem cells
  • Studies reversing aging in progeria
  • Telomeres
  • Vascular disease

Credentials

Clinical Fellowship, Mayo Graduate School of Medicine, Rochester, MN
Residency, Mayo Graduate School of Medicine, Rochester, MN
Internship, Mayo Graduate School of Medicine, Rochester, MN
MD, Wayne State Univ. School of Medicine
PhD, Mayo Graduate School of Medicine, Rochester, NY
Research Fellowship, Mayo Graduate School of Medicine, Rochester, NY

Publications

Endotheliopathy of Obesity
Cooke, JP 2020, , Circulation, vol. 142, no. 4, pp. 380-383. https://doi.org/10.1161/CIRCULATIONAHA.120.047574

Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome
Mu, X, Tseng, C, Hambright, WS, Matre, P, Lin, CY, Chanda, P, Chen, W, Gu, J, Ravuri, S, Cui, Y, Zhong, L, Cooke, JP, Niedernhofer, LJ, Robbins, PD & Huard, J 2020, , Aging Cell. https://doi.org/10.1111/acel.13152

Machine learning uncovers cell identity regulator by histone code
Xia, B, Zhao, D, Wang, G, Zhang, M, Lv, J, Tomoiaga, AS, Li, Y, Wang, X, Meng, S, Cooke, JP, Cao, Q, Zhang, L & Chen, K 2020, Nature Communications, vol. 11, no. 1, 2696. https://doi.org/10.1038/s41467-020-16539-4

TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription
Wang, G, Meng, Q, Xia, B, Zhang, S, Lv, J, Zhao, D, Li, Y, Wang, X, Zhang, L, Cooke, JP, Cao, Q & Chen, K 2020, Genome Biology, vol. 21, no. 1, 84. https://doi.org/10.1186/s13059-020-01992-7

Rapamycin-Loaded Biomimetic Nanoparticles Reverse Vascular Inflammation
Boada, C, Zinger, A, Tsao, C, Zhao, P, Martinez, JO, Hartman, K, Naoi, T, Sukhoveshin, R, Sushnitha, M, Molinaro, R, Trachtenberg, BH, Cooke, JP & Tasciotti, E 2020, , Circulation Research, vol. 126, no. 1, pp. 25-37. https://doi.org/10.1161/CIRCRESAHA.119.315185

Nanobiosensing with graphene and carbon quantum dots: Recent advances
Walther, BK, Dinu, CZ, Guldi, DM, Sergeyev, VG, Creager, SE, Cooke, JP & Guiseppi-Elie, A 2020, Materials Today. https://doi.org/10.1016/j.mattod.2020.04.008

Vascular Regeneration in Peripheral Artery Disease
Meng, S & Cooke, JP 2020, , Arteriosclerosis, Thrombosis, and Vascular Biology, pp. 1627-1634. https://doi.org/10.1161/ATVBAHA.120.312862

AYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model
Chen, J, Ma, Q, King, JS, Sun, Y, Xu, B, Zhang, X, Zohrabian, S, Guo, H, Cai, W, Li, G, Bruno, IG, Cooke, JP, Wang, C, Kontaridis, M, Wang, DZ, Luo, H, Pu, WT & Lin, Z 2020, , Life Science Alliance, vol. 3, no. 1, e201900424. https://doi.org/10.26508/lsa.201900424

Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase
Kotla, S, Le, N-T, Vu, HT, Ko, KA, Gi, YJ, Thomas, TN, Giancursio, C, Lusis, AJ, Cooke, JP, Fujiwara, K & Abe, JI 2019, Metabolism: Clinical and Experimental, vol. 100, 153962. https://doi.org/10.1016/j.metabol.2019.153962

Rapamycin-Loaded Leukosomes Reverse Vascular Inflammation
Boada, C, Zinger, A, Tsao, C, Zhao, P, MARTINEZ JONATHAN, O, Hartman, KA, Naoi, T, Sukhovershin, R, Sushnitha, M, Molinaro, R, Trachtenberg, BH, Cooke, JP & Tasciotti, E 2019, Circulation Research.

Dysfunction of iPSC-derived endothelial cells in human Hutchinson–Gilford progeria syndrome
Matrone, G, Thandavarayan, RA, Walther, BK, Meng, S, Mojiri, A & Cooke, JP 2019, , Cell Cycle, vol. 18, no. 19, pp. 2495-2508. https://doi.org/10.1080/15384101.2019.1651587

Nuclear S-nitrosylation defines an optimal zone for inducing pluripotency
Chanda, PK, Meng, S, Lee, J, Leung, HE, Chen, K & Cooke, JP 2019, Circulation, vol. 140, no. 13, pp. 1081-1099. https://doi.org/10.1161/CIRCULATIONAHA.119.042371

Transient introduction of human telomerase mRNA improves hallmarks of progeria cells
Li, Y, Zhou, G, Bruno, IG, Zhang, N, Sho, S, Tedone, E, Lai, TP, Cooke, JP & Shay, JW 2019, , Aging Cell, vol. 18, no. 4, e12979. https://doi.org/10.1111/acel.12979

Cardiovascular Risk of Proton Pump Inhibitors
Ariel, H & Cooke, JP 2019, Methodist DeBakey cardiovascular journal, vol. 15, no. 3, pp. 214-219. https://doi.org/10.14797/mdcj-15-3-214

Dietary Supplements: Facts and Fallacies
Raizner, AE & Cooke, JP 2019, Methodist DeBakey cardiovascular journal, vol. 15, no. 3, pp. 169-170. https://doi.org/10.14797/mdcj-15-3-169

Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2–interacting protein
Kotla, S, Vu, HT, Ko, KA, Wang, Y, Imanishi, M, Heo, KS, Fujii, Y, Thomas, TN, Gi, YJ, Mazhar, H, Paez-Mayorga, J, Shin, JH, Tao, Y, Giancursio, CJ, Medina, JLM, Taunton, J, Lusis, AJ, Cooke, JP, Fujiwara, K, Le, N-T & Abe, JI 2019, , JCI insight, vol. 4, no. 9, e124867. https://doi.org/10.1172/jci.insight.124867

Inflammation and Its Role in Regeneration and Repair
Cooke, JP 2019, , Circulation Research, vol. 124, no. 8, pp. 1166-1168. https://doi.org/10.1161/CIRCRESAHA.118.314669

MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis
Abe, J-I, Ko, KA, Kotla, S, Wang, Y, Paez-Mayorga, J, Shin, IJ, Imanishi, M, Vu, HT, Tao, Y, Leiva-Juarez, MM, Thomas, TN, Medina, JL, Won, JH, Fujii, Y, Giancursio, CJ, McBeath, E, Shin, J-H, Guzman, L, Abe, RJ, Taunton, J, Mochizuki, N, Faubion, W, Cooke, JP, Fujiwara, K, Evans, SE & Le, N-T 2019, , JCI insight, vol. 4, no. 7. https://doi.org/10.1172/jci.insight.125570

AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate
Gu, Q, Yang, X, Lv, J, Zhang, J, Xia, B, Kim, JD, Wang, R, Xiong, F, Meng, S, Clements, TP, Tandon, B, Wagner, DS, Diaz, MF, Wenzel, PL, Miller, YI, Traver, D, Cooke, JP, Li, W, Zon, LI, Chen, K, Bai, Y & Fang, L 2019, , Science, pp. eaav1749. https://doi.org/10.1126/science.aav1749

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure
Berry, JL, Zhu, W, Tang, YL, Krishnamurthy, P, Ge, Y, Cooke, JP, Chen, Y, Garry, DJ, Yang, HT, Rajasekaran, NS, Koch, WJ, Li, S, Domae, K, Qin, G, Cheng, K, Kamp, TJ, Ye, L, Hu, S, Ogle, BM, Rogers, JM, Abel, ED, Davis, ME, Prabhu, SD, Liao, R, Pu, WT, Wang, Y, Ping, P, Bursac, N, Vunjak-Novakovic, G, Wu, JC, Bolli, R, Menasché, P & Zhang, J 2019, , Circulation Research, vol. 124, no. 1, pp. 161-169. https://doi.org/10.1161/CIRCRESAHA.118.314216

Languages

  • English