Alessandro Grattoni, PhD

  • Chair, Houston Methodist Research Institute Department of Nanomedicine 
  • Professor of Nanomedicine, Houston Methodist Research Institute

Alessandro Grattoni, PhD

Areas of Expertise

  • Drug delivery
  • Implantable devices
  • Nanofluidics
  • Nanomedicine
  • Silicon technologies
  • Space medicine

Credentials

MSc, Politecnico di Torino
PhD, Politecnico di Torino
Postdoctoral Fellowship, The University of Texas Health Science Center

Publications

Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation
Paez-Mayorga, J, Capuani, S, Hernandez, N, Farina, M, Chua, YX, Blanchard, R, Sizovs, A, Liu, HC, Fraga, DW, Niles, JA, Salazar, HF, Corradetti, B, Sikora, AG, Kloc, M, Li, XC, Gaber, AO, Nichols, J & Grattoni, A 2020, , Biomaterials, vol. 257, 120232. https://doi.org/10.1016/j.biomaterials.2020.120232

Gold Nanoparticles Radio-Sensitize and Reduce Cell Survival in Lewis Lung Carcinoma
Pandey, A, Vighetto, V, Di Marzio, N, Ferraro, F, Hirsch, M, Ferrante, N, Mitra, S, Grattoni, A & Filgueira, CS 2020, , Nanomaterials, vol. 10, no. 9. https://doi.org/10.3390/nano10091717

Trans-urocanic acid enhances tenofovir alafenamide stability for long-acting HIV applications
Sizovs, A, Pons-Faudoa, FP, Malgir, G, Shelton, KA, Bushman, LR, Chua, YX, Anderson, PL, Nehete, PN, Sastry, KJ & Grattoni, A 2020, , International Journal of Pharmaceutics, vol. 587, 119623. https://doi.org/10.1016/j.ijpharm.2020.119623

Silicon nanofluidic membrane for electrostatic control of drugs and analytes elution
Di Trani, N, Silvestri, A, Wang, Y, Demarchi, D, Liu, X & Grattoni, A 2020, , Pharmaceutics, vol. 12, no. 7, 679, pp. 1-16. https://doi.org/10.3390/pharmaceutics12070679

Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery
Di Trani, N, Silvestri, A, Sizovs, A, Wang, Y, Erm, DR, Demarchi, D, Liu, X & Grattoni, A 2020, , Lab on a Chip, vol. 20, no. 9, pp. 1562-1576. https://doi.org/10.1039/d0lc00121j

Finite-Size Charged Species Diffusion and pH Change in Nanochannels
Di Trani, N, Pimpinelli, A & Grattoni, A 2020, , ACS Applied Materials and Interfaces, vol. 12, no. 10, pp. 12246-12255. https://doi.org/10.1021/acsami.9b19182

Preventive efficacy of a tenofovir alafenamide fumarate nanofluidic implant in SHIV-challenged nonhuman primates
Pons-Faudoa, FP, Sizovs, A, Shelton, KA, Momin, Z, Bushman, LR, Xu, J, Chua, CYX, Nichols, JE, Hawkins, T, Rooney, JF, Marzinke, MA, Kimata, JT, Anderson, PL, Nehete, PN, Arduino, RC, Ferrari, M, Sastry, KJ & Grattoni, A 2020, , bioRxiv, pp. 2020.05.13.091694. https://doi.org/10.1101/2020.05.13.091694

Enhanced In Vivo Vascularization of 3D-Printed Cell Encapsulation Device Using Platelet-Rich Plasma and Mesenchymal Stem Cells
Paez-Mayorga, J, Capuani, S, Farina, M, Lotito, ML, Niles, JA, Salazar, HF, Rhudy, J, Esnaola, L, Chua, CYX, Taraballi, F, Corradetti, B, Shelton, KA, Nehete, PN, Nichols, JE & Grattoni, A 2020, , Advanced Healthcare Materials, vol. 9, no. 19, 2000670. https://doi.org/10.1002/adhm.202000670

Potentiating Antitumor Efficacy Through Radiation and Sustained Intratumoral Delivery of Anti-CD40 and Anti-PDL1
Liu, HC, Viswanath, DI, Pesaresi, F, Xu, Y, Zhang, L, Di Trani, N, Paez-Mayorga, J, Hernandez, N, Wang, Y, Erm, DR, Ho, J, Susnjar, A, Liu, X, Demaria, S, Chen, SH, Teh, BS, Butler, EB, Xuan Chua, CY & Grattoni, A 2020, , International Journal of Radiation Oncology Biology Physics. https://doi.org/10.1016/j.ijrobp.2020.07.2326

Technologies for intrapericardial delivery of therapeutics and cells
Filgueira, CS, Igo, SR, Wang, DK, Hirsch, M, Schulz, DG, Bruckner, BA & Grattoni, A 2019, , Advanced Drug Delivery Reviews, vol. 151-152, pp. 222-232. https://doi.org/10.1016/j.addr.2019.02.006

2-Hydroxypropyl-ß-cyclodextrin-enhanced pharmacokinetics of cabotegravir from a nanofluidic implant for HIV pre-exposure prophylaxis
Pons-Faudoa, FP, Sizovs, A, Di Trani, N, Paez-Mayorga, J, Bruno, G, Rhudy, J, Manohar, M, Gwenden, K, Martini, C, Chua, YX, Varchi, G, Marzinke, MA & Grattoni, A 2019, , Journal of Controlled Release, vol. 306, pp. 89-96. https://doi.org/10.1016/j.jconrel.2019.05.037

Remotely controlled nanofluidic implantable platform for tunable drug delivery
Di Trani, N, Silvestri, A, Bruno, G, Geninatti, T, Chua, CYX, Gilbert, A, Rizzo, G, Filgueira, CS, Demarchi, D & Grattoni, A 2019, , Lab on a Chip, vol. 19, no. 13, pp. 2192-2204. https://doi.org/10.1039/c9lc00394k

Advanced implantable drug delivery technologies: transforming the clinical landscape of therapeutics for chronic diseases
Pons-Faudoa, FP, Ballerini, A, Sakamoto, J & Grattoni, A 2019, Biomedical Microdevices, vol. 21, no. 2, 47. https://doi.org/10.1007/s10544-019-0389-6

Nanofluidic microsystem for sustained intraocular delivery of therapeutics
Di Trani, N, Jain, P, Chua, CYX, Ho, JS, Bruno, G, Susnjar, A, Pons-Faudoa, FP, Sizovs, A, Lyle Hood, R, Smith, ZW, Ballerini, A, Filgueira, CS & Grattoni, A 2019, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 16, pp. 1-9. https://doi.org/10.1016/j.nano.2018.11.002

METHOD AND APPARATUS FOR THE FAIL-SAFE TERMINATION OF IN VIVO DRUG DELIVERY FROM AN IMPLANTABLE DRUG DELIVERY SYSTEM
Farina, M, Hood, RL & Grattoni, A 2018, , Patent No. US2018280617, IPC No. A61M 5/ 142 A I.

Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxis
Chua, CYX, Jain, P, Ballerini, A, Bruno, G, Hood, RL, Gupte, M, Gao, S, Di Trani, N, Susnjar, A, Shelton, K, Bushman, LR, Folci, M, Filgueira, CS, Marzinke, MA, Anderson, PL, Hu, M, Nehete, P, Arduino, RC, Sastry, JK & Grattoni, A 2018, , Journal of Controlled Release, vol. 286, pp. 315-325. https://doi.org/10.1016/j.jconrel.2018.08.010

Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy in triple negative breast cancer
Chua, YX, Jain, P, Susnjar, A, Rhudy, J, Folci, M, Ballerini, A, Gilbert, A, Singh, S, Bruno, G, Filgueira, CS, Yee, C, Butler, EB & Grattoni, A 2018, , Journal of Controlled Release, vol. 285, pp. 23-34. https://doi.org/10.1016/j.jconrel.2018.06.035

Transcutaneously refillable, 3D-printed biopolymeric encapsulation system for the transplantation of endocrine cells
Farina, M, Chua, YX, Ballerini, A, Thekkedath, U, Alexander, JF, Rhudy, JR, Torchio, G, Fraga, D, Pathak, RR, Villanueva, M, Shin, CS, Niles, JA, Sesana, R, Demarchi, D, Sikora, AG, Acharya, GS, Gaber, AO, Nichols, J & Grattoni, A 2018, , Biomaterials, vol. 177, pp. 125-138. https://doi.org/10.1016/j.biomaterials.2018.05.047

Efficacy of sustained delivery of GC-1 from a Nanofluidic system in a spontaneously obese non-human primate: a case study
Filgueira, CS, Bruno, G, Smith, ZW, Chua, YX, Ballerini, A, Folci, M, Gilbert, AL, Jain, P, Sastry, JK, Nehete, PN, Shelton, KA, Hill, LR, Ali, A, Youker, KA & Grattoni, A 2018, , Biomedical Microdevices, vol. 20, no. 2, 49. https://doi.org/10.1007/s10544-018-0296-2

Adipocytes impair efficacy of antiretroviral therapy
Couturier, J, Winchester, LC, Suliburk, JW, Wilkerson, GK, Podany, AT, Agarwal, N, Xuan Chua, CY, Nehete, PN, Nehete, BP, Grattoni, A, Sastry, KJ, Fletcher, CV, Lake, JE, Balasubramanyam, A & Lewis, DE 2018, , Antiviral Research, vol. 154, pp. 140-148. https://doi.org/10.1016/j.antiviral.2018.04.002

Languages

  • English
  • Italian