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Stanley H. Appel, MD

Houston Methodist Department of Neurology


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Phone: 713-441-3760


6560 Fannin St. Suite 802
Scurlock Tower
Houston, TX 77030

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Stanley H. Appel, MD is director of Houston Methodist Neurological Institute, chair of the Department of Neurology and the Peggy and Gary Edwards Distinguished Chair in ALS at Houston Methodist Hospital. He also is professor of neurology at Weill Cornell Medical College.

An internationally renowned researcher and neurologist, Dr. Appel is dedicated to the treatment of patients with ALS and is one of the nation’s foremost experts on the disease. He has spent more than 40 years devoted to understanding the human brain. Dr. Appel is creator and director of what is now the Houston Methodist Neurological Institute's MDA/ALS Research and Clinical Center in Houston. Established in 1982, the center was the first of its kind dedicated to ALS patient care and research in the United States. Dr. Appel’s laboratory focuses on developing new insights into ALS, Parkinson’s disease and Alzheimer’s disease, and was the first to document regulatory T-lymphocytes modulate disease progression in ALS patients. His focus is on enhancing the protective immunity of T-reg cells and anti-inflammatory microglia in neurodegeneration.

Dr. Appel has written 15 books and more than 400 articles. His achievements include the Gold Medal for Excellence in Biomedical Research from Columbia College of Physicians and Surgeons, Sheila Essey Award for ALS Research, Texas Neurological Society Lifetime Achievement Award, Forbes Norris Award from the International Alliance of ALS/MND Associations and John P. McGovern Compleat Physician Award from the Houston Academy of Medicine.

Interests & Special Procedures

Alzheimers Disease
Neuro-Muscular Disease
Amyotrophic Lateral Sclerosis (ALS)
Parkinsons Disease
Education & Training

Medical School: Columbia University College of Physicians and Surgeons - 1960
office Locations
6560 Fannin St. Suite 802
Scurlock Tower
Houston, TX 77030
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Houston Methodist Hospital
6565 Fannin Street
Houston, TX 77030
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