Clinical Trials

    Showing 1 - 10 of 32 heart

    Status: Open Not Enrolling

    Investigator: Dipan Shah

    Study Coordinator: Fareeha Dadabhoy

    Phone: 713.441.2116

    This study is designed to evaluate the efficacy of Dotarem enhanced MRI compared to Magnevist and Gadavist enhanced MRI in identifying myocardial infarct. Eighty patients will be recruited for this study. Patients with known CAD and undergoing clinic... Read more >

    Status: Enrolling

    Investigator: Mahwash Kassi

    Study Coordinator: Jan-Michael Ragunton

    Phone: 346.238.0218

    NCT06183931 The primary objective of this study is to access the efficacy of ALXN2220 in the treatment of adult participants with ATTR-CM by evaluating the difference between the ALXN2220 and placebo groups as assessed by the total occurrences of al... Read more >

    Status: Enrolling

    Investigator: Maham Rahimi

    Study Coordinator: Solange Basagoitia

    Phone: 713.441.0176

    This study aims to determine the safety and effectiveness of IMPEDE-FX RapidFill to increase the percentage of subjects with shrinkage of the abdominal aortic aneurysm sac when used as an adjunct to on-label endovascular aneurysm repair (EVAR) stent ... Read more >

    Status: Open Not Enrolling

    Investigator: Sherif Nagueh

    Study Coordinator: Nirali Patel

    Phone: 713.441.2116

    Multicenter, Randomized, Double-blind, Parallel-group Extension to Study AC-058B201 to Investigate the Long-term Safety, Tolerability, and Efficacy of Three Doses of ACT-128800, an Oral S1P1 Receptor Agonist, in Patients With Relapsing-remitting Mult... Read more >

    Status: Open Not Enrolling

    Investigator: Neal Kleiman

    Study Coordinator: Deena Victor

    Phone: 713.441.4536

    Brief Summary: To evaluate safety and effectiveness of the ACURATE Transfemoral Aortic Valve System for transcatheter aortic valve replacement (TAVR) in subjects with severe native aortic stenosis who are indicated for TAVR. Detailed Description: ... Read more >

    Status: Enrolling

    Investigator: Miguel Valderrabano

    Study Coordinator: Aneesch Martin

    Phone: 713.441.6548

    Brief Summary: The objective of this trial is to evaluate the safety and effectiveness of the Amulet LAA occluder compared to NOAC therapy in patients with non-valvular AF at increased risk for ischemic stroke and who are recommended for long-term N... Read more >

    Status: Enrolling

    Investigator: Marvin Atkins

    Study Coordinator: Padmaja Naik

    Phone: 713.441.7386

    The purpose of this study is to characterize the safety and effectiveness of the Medtronic Avalus Ultra aortic valve bioprosthesis in patients with aortic valve disease.... Read more >

    Status: Open Not Enrolling

    Investigator: Mahwash Kassi

    Study Coordinator: Jan-Michael Ragunton

    Phone: 346.238.0218

    To evaluate the efficacy of eplontersen compared to placebo for 120 weeks in patients with ATTR-CM receiving available standard of care (SoC). For more information, please visit https://www.cardio-ttransform.com.... Read more >

    Status: Enrolling

    Investigator: Sachin Goel

    Study Coordinator: Deena Victor

    Phone: 713.441.4536

    Brief Summary: The objective of this study is to evaluate the preliminary safety and effectiveness of the Cephea Mitral Valve System for the treatment of symptomatic patients with mitral regurgitation = Grade III in whom transcatheter therapy is dee... Read more >

    Status: Open Not Enrolling

    Investigator: Neal Kleiman

    Study Coordinator: Deena Victor

    Phone: 713.441.4536

    The primary objective of the study is to evaluate the safety and effectiveness of the Medtronic CoreValve® System (MCS) in a subset of subjects excluded from the U.S. Extreme Risk Pivotal Trial population due to one or more additional co-morbidities,... Read more >

    Status: Enrolling

    Investigator: David Chiu

    Study Coordinator:

    Phone:

    Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptoma... Read more >

    Status: Enrolling

    Investigator: Neal Kleiman

    Study Coordinator: Deena Victor

    Phone: 713.441.4536

    Brief Summary: To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Valve Repair System in patients with degenerative mitral regurgitation (DMR) who have been determined to be at prohibitive risk for mitral valve surgery by ... Read more >

    Status: Enrolling

    Investigator: Alpesh Shah

    Study Coordinator: Padmaja Naik

    Phone: 713.441.7386

    To demonstrate the safety and effectiveness of the Reducer system for treatment of patients with refractory angina pectoris treated with maximally tolerated guideline-directed medical therapy who demonstrate objective evidence of reversible myocardia... Read more >

    Status: Enrolling

    Investigator: Sachin Goel

    Study Coordinator: Tia McGaughy

    Phone: 346.238.4576

    The objective of ENVISION is to evaluate the safety and effectiveness of the Navitor Transcatheter Aortic Valve Implantation (TAVI) System for treating patients with symptomatic, severe native aortic stenosis who are considered intermediate or low ri... Read more >

    Status: Enrolling

    Investigator: Neal Kleiman

    Study Coordinator: Deena Victor

    Phone: 713.441.4536

    Brief Summary: Obtain safety and effectiveness data to support indication expansion for the Medtronic TAVR System to include patients with moderate, symptomatic AS. Detailed Description: Multi-center, international, prospective, randomized study... Read more >

    Status: Open Not Enrolling

    Investigator: Alpesh Shah

    Study Coordinator: Iris Alanis

    Phone: 713.441.6548

    The purpose of this study is to determine whether Fractional flow reserve (FFR, (coronary pressure wire-based index for assessing the ischemic potential of a coronary lesion)-guided percutaneous coronary intervention (PCI) in patients with multivesse... Read more >

    Status: Open Not Enrolling

    Investigator: Sherif Nagueh

    Study Coordinator: Carlos Marin

    Phone: 346.238.4815

    Hypertrophic cardiomyopathy (HCM) is the most common monogenic heart disease and the most frequent cause of sudden cardiac death (SCD) in the young. It is characterized by unexplained left ventricular hypertrophy (LVH), diffuse and patchy fibrosis, a... Read more >

    Status: Open Not Enrolling

    Investigator: Mahwash Kassi

    Study Coordinator: Jan-Michael Ragunton

    Phone: 346.238.0218

    This study will evaluate the efficacy and safety of vutrisiran 25 mg administered subcutaneously (SC) once every 3 months (q3M) compared to placebo in patients with ATTR amyloidosis with cardiomyopathy.... Read more >

    Status: Enrolling

    Investigator: Neal Kleiman

    Study Coordinator: Padmaja Naik

    Phone: 713.441.7386

    The purpose of this study is to assess if using the Impella® CP (or Impella® 2.5) device during high-risk PCI in patients with reduced left-sided heart function will result in an improvement in symptoms, heart function and health after a heart proced... Read more >

    Status: Enrolling

    Investigator: Ross Reul

    Study Coordinator: Deena Victor

    Phone: 713.441.4536

    This trial is a prospective, randomized, multicenter, multinational, blinded, superiority trial. The objective of this trial is to evaluate the effectiveness of left atrial appendage exclusion (LAAE) for the prevention of ischemic stroke or systemic ... Read more >

    Status: Enrolling

    Investigator: Sachin Goel

    Study Coordinator: Tia McGaughy

    Phone: 346.238.4576

    Brief Summary: The objective of this randomized controlled trial (RCT) is to compare the clinical outcome of MitraClip™ device versus surgical repair in patients with severe primary MR who are at moderate surgical risk and whose mitral valve has bee... Read more >

    Status: Enrolling

    Investigator: Khurram Nasir

    Study Coordinator: Zulqarnain Javed

    Phone: 346.356.1481

    In this comparative effectiveness trial, the aim of this study is to answer the research question of whether a remote blood pressure (BP) management program (RBPM, inclusive of home BP monitoring and telehealth visits with a nurse or pharmacist) alon... Read more >

    Status: Enrolling

    Investigator: Rayan Yousefzai

    Study Coordinator: Jan-Michael Ragunton

    Phone: 346.238.0218

    Characterize the impact of pulmonary artery denervation on the quality of life in Heart Failure Patients with Group 2 Pulmonary Hypertension... Read more >

    Status: Enrolling

    Investigator: Sandeep Sahay

    Study Coordinator: Herpreet Sandhu

    Phone: 713.441.5660

    Study GMS-PH-001 is a multicenter, open-label, non-randomized study to prospectively evaluate screening strategies of pulmonary hypertension (PH) in patients with interstitial lung disease (ILD). In this study, subjects will undergo a broad range of... Read more >

    Status: Enrolling

    Investigator: Alpesh Shah

    Study Coordinator: Padmaja Naik

    Phone: 713.441.7386

    The purpose of this single-arm interventional study is to evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in subjects treated with renal denervation. Additionally, long-term follow-up data will also be colle... Read more >

    Status: Open Not Enrolling

    Investigator: Maham Rahimi

    Study Coordinator: Sohaib Mhaidi

    Phone: 346.238.6402

    This is a multi-surgeon monocentric study at Houston Methodist Hospital (HMH) to decrease the number of groin wound complications using BIASURGE Advanced Surgical Solution (BIASURGE) after common femoral artery exposure for vascular surgery procedure... Read more >

    Status: Open Not Enrolling

    Investigator: Neal Kleiman

    Study Coordinator: Tia McGaughy

    Phone: 346.238.4576

    The purpose of the study is to investigate the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with severe, symptomatic Aortic Stenosis (AS) at intermediate surgical risk by randomizing patients to either Surgical Ao... Read more >

    Status: Enrolling

    Investigator: Michael Reardon

    Study Coordinator: Yejide Oyewole

    Phone: 346.238.2294

    Brief Summary: To collect information about treatment for symptomatic severe Aortic Regurgitation (AR), which affects the aortic valve in the heart. Aortic regurgitation is a condition where aortic valve in the heart does not close tightly and allow... Read more >

    Status: Enrolling

    Investigator: Neal Kleiman

    Study Coordinator: Tia McGaughy

    Phone: 346.238.4576

    Brief Summary: Multi-center, global, prospective, non-randomized, interventional, pre-market trial. All subjects enrolled with receive the study device. Inclusion Criteria: Moderate to severe or severe symptomatic mitral regurgitation Local sit... Read more >

    Status: Enrolling

    Investigator: Sachin Goel

    Study Coordinator: Yejide Oyewole

    Phone: 346.238.2294

    This is a prospective multicenter clinical investigation designed to evaluate the safety and effectiveness of the TricValve® Transcatheter Bicaval Valve System for improving outcomes in symptomatic subjects with severe TR deemed by the local Heart Te... Read more >

    Status: Open Not Enrolling

    Investigator: Stephen Little

    Study Coordinator: Padmaja Naik

    Phone: 713.441.7386

    Brief Summary: The primary objective of this trial is to demonstrate the safety and effectiveness of the TriClip device in improving clinical outcomes in symptomatic patients with severe tricuspid regurgitation (TR), who are at intermediate or great... Read more >

    Status: Enrolling

    Investigator: Sachin Goel

    Study Coordinator: Tia McGaughy

    Phone: 346.238.4576

    Brief Summary: The objective of this early feasibility study is to gain early clinical insight into the performance of the Intrepid transcatheter tricuspid valve replacement (TTVR) system intended for transfemoral access to deliver a self-expanding ... Read more >