Status: Enrolling
Investigator: Dipan Shah
Study Coordinator: Nadia Alsalih
Phone: 713.441.3576
This study is designed to evaluate the efficacy of Dotarem enhanced MRI compared to Magnevist and Gadavist enhanced MRI in identifying myocardial infarct. Eighty patients will be recruited for this study. Patients with known CAD and undergoing c ... Read more >
Status: Enrolling
Investigator: Alpesh Shah
Study Coordinator: Saba Khan
Phone: 713.441.2116
A Clinical Evaluation of Absorb™ BVS, the Everolimus Eluting Bioresorbable Vascular Scaffold in the Treatment of Subjects with de novo Native Coronary Artery Lesions This is a prospective, randomized, single-blind, multi-center trial, conducte ... Read more >
Status: Enrolling
Investigator: Mahendra Jain
Study Coordinator: Bela Jain
Phone: 281.485.3434
To determine the efficacy of CaPre 4 g daily, compared to placebo, in lowering fasting triglyceride levels in patients with fasting levels ≥500 mg/dL and ≤1500 mg/dL after 12 weeks of treatment. ... Read more >
Status: Enrolling
Investigator: Brian Bruckner
Study Coordinator: Deborah Barr
Phone: 713.441.3916
This study is evaluating the effectiveness of PleuraFlow System Active Clearance Technology (ACT) in the management of blood evacuation. The Pleuraflow System ACT is a guided wire with a distal loop that rests at the end of a chest tube. The sys ... Read more >
Status: Enrolling
Investigator: Arvind Bhimaraj
Study Coordinator: Marcos DeOliveira
Phone: 171.344.19837
The objective of this registry is to observe short and long term clinical outcomes in heart transplant recipients who receive regular AlloMap testing as part of allograft rejection surveillance ... Read more >
Status: Open Not Enrolling
Investigator: Richard Klucznik
Study Coordinator: Vivian Vasquez Escamilla
Phone: 713.363.7005
.The primary objective of this study is to demonstrate effectiveness and safety of the NeuroForm Atlas stent system for use with bare metal embolic coils ... Read more >
Status: Enrolling
Investigator: Alpesh Shah
Study Coordinator: Amber Jacobs
Phone: 713.441.3905
The objective of this study is to assess the safety and efficacy of the Orsiro Sirolimus Eluting Coronary Stent System in the treatment of subjects with up to three native de novo or restenotic (standard PTCA only) coronary artery lesions compar ... Read more >
Status: Open Not Enrolling
Investigator: Neal Kleiman
Study Coordinator: Saba Khan
Phone: 713.441.2116
This is a prospective, randomized, parallel-controlled, multicenter clinical evaluation of the MitraClip device for the treatment of clinically significant functional mitral regurgitation in symptomatic subjects too high risk to undergo mitral v ... Read more >
Status: Open Not Enrolling
Investigator: Alpesh Shah
Study Coordinator: Patricia Brinegar
Phone: 713.441.3506
This is a prospective, multi-center, non-randomized, single arm clinical trial that will be conducted at up to 40 sites in the United States and OUS. A minimum of 40% of total patients will be enrolled in the US. This study will enroll patient ... Read more >
Status: Enrolling
Investigator: Alan Lumsden
Study Coordinator: Kim Donlon
Phone: 713.441.9394
This prospective, multicenter, single-arm clinical study will further evaluate the safety and effectiveness of Cook's permanent and retrievable inferior vena cava (IVC) filters (specifically, the Günther Tulip® Vena Cava Filter and Cook Celect® ... Read more >
Status: Open Not Enrolling
Investigator: Neal Kleiman
Study Coordinator: LaShawna Green
Phone: 713.441.6548
The study is being done study to obtain data on the safety and performance of the Medtronic CoreValve® System. The Medtronic CoreValve® System has been developed to replace a diseased aortic heart valve without the need for open heart surgery. T ... Read more >
Status: Open Not Enrolling
Investigator: Neal Kleiman
Study Coordinator: LaShawna Green
Phone: 713.441.6548
The purpose of the study is to evaluate the safety and efficacy of the Medtronic CoreValve® System in the treatment of symptomatic severe aortic stenosis in subjects who have a predicted high risk for aortic valve surgery and/or very high risk f ... Read more >
Status: Enrolling
Investigator: Michael Reardon
Study Coordinator: LaShawna Green
Phone: 713.441.6548
The purpose of the study is to evaluate the safety and efficacy of the Medtronic CoreValve® System in the treatment of symptomatic severe aortic stenosis in subjects who have a predicted high risk for aortic valve surgery and/or very high risk f ... Read more >
Status: Enrolling
Investigator: Neal Kleiman
Study Coordinator: LaShawna Green
Phone: 713.441.6548
The primary objective of the study is to evaluate the safety and effectiveness of the Medtronic CoreValve® System (MCS) in a subset of subjects excluded from the U.S. Extreme Risk Pivotal Trial population due to one or more additional co-morbidi ... Read more >
Status: Open Not Enrolling
Investigator: Neal Kleiman
Study Coordinator: LaShawna Green
Phone: 713.441.6548
To evaluate the safety and efficacy of the CoreValve Evolut R System in patients with severe symptomatic aortic stenosis who are considered at high through extreme risk for surgical aortic valve replacement ... Read more >
Status: Enrolling
Investigator: David Chiu
Study Coordinator: Jason Lee
Phone: 713.394.6479
Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asym ... Read more >
Status: Enrolling
Investigator: Barry Trachtenberg
Study Coordinator: Enya Rentas-Sherman
Phone: 713.441.3963
The purpose of this study is to evaluate the efficacy and safety of a single transendocardial delivery in the cardiac catheterization laboratory of human bone marrow-derived allogeneic MPCs (rexlemestrocel-L) for improvement in clinical outcomes ... Read more >
Status: Enrolling
Investigator: Mahendra Jain
Study Coordinator: Bela Jain
Phone: 281.485.3434
To evaluate whether long-term treatment with bempedoic acid 180 mg/day versus placebo reduces the risk of major adverse cardiovascular events (MACE) in patients with, or at high risk for, cardiovascular disease (CVD) who are statin intolerant. ... Read more >
Status: Enrolling
Investigator: Alpesh Shah
Study Coordinator: Saba Khan
Phone: 713.441.2116
The purpose of this study is to determine whether Fractional flow reserve (FFR, (coronary pressure wire-based index for assessing the ischemic potential of a coronary lesion)-guided percutaneous coronary intervention (PCI) in patients with multi ... Read more >
Status: Open Not Enrolling
Investigator: Sherman Tang
Study Coordinator: Sheila Moore
Phone: 281.274.8062
In this part of the Registry Program patients with non-valvular atrial fibrillation (AF) at risk for stroke are enrolled to characterize the target population and to collect real world data on important outcome events. For administrative purpose ... Read more >
Status: Enrolling
Investigator: Sherif Nagueh
Study Coordinator: Christopher Mattair
Phone: 713.363.9956
Hypertrophic cardiomyopathy (HCM) is the most common monogenic heart disease and the most frequent cause of sudden cardiac death (SCD) in the young. It is characterized by unexplained left ventricular hypertrophy (LVH), diffuse and patchy fibros ... Read more >
Status: Enrolling
Investigator: Brian Bruckner
Study Coordinator: Deborah Barr
Phone: 713.441.3916
The MOMENTUM III Clinical Trial is designed to evaluate the safety and effectiveness of the HeartMate III Left Ventricular Assist System (LVAS) by demonstrating non-inferiority to the HeartMate II Left Ventricular Assist System when used for the ... Read more >
Status: Enrolling
Investigator: Brian Bruckner
Study Coordinator: Deborah Barr
Phone: 713.441.3916
atients will be approached to participate in this PAS after the HeartWare® Ventricular Assist System receives PMA approval for the indicated use as a bridge to cardiac transplantation. Patients who participated in prior trials will be approac ... Read more >
Status: Enrolling
Investigator: Mahendra Jain
Study Coordinator: Bela Jain
Phone: 281.485.3434
This is a multicenter, prospective, randomized, double-blind, active-controlled trial comparing two doses of influenza vaccine in high risk cardiovascular patients (history of myocardial infarction or heart failure).- ... Read more >
Status: Open Not Enrolling
Investigator: Alpesh Shah
Study Coordinator: Patricia Brinegar
Phone: 713.441.3506
The purpose of this study is to evaluate acute and long term clinical and economic outcomes of endovascular procedures to treat Peripheral Arterial Disease (PAD) ... Read more >
Status: Open Not Enrolling
Investigator: Imran Mohiuddin
Study Coordinator: Sheila Moore
Phone: 281.274.8062
The purpose of this study is to evaluate acute and long term clinical and economic outcomes of endovascular procedures to treat Peripheral Arterial Disease (PAD). ... Read more >
Status: Enrolling
Investigator: Dipan Shah
Study Coordinator: Bevin Lopez
Phone: 713.441.6537
The American Diabetes Association estimates that 25.8 million individuals or 8.3% of the United States population have diabetes mellitus (DM). Individuals with diabetes have an increased risk for cardiovascular disease (CVD) and CVD events accou ... Read more >
Status: Enrolling
Investigator: Michael Reardon
Study Coordinator: Amber Jacobs
Phone: 713.441.3905
To evaluate the safety and effectiveness of the Model 400 bovine pericardial stented aortic bioprosthesis in a patient population undergoing surgical aortic valve replacement. The collected data will be used to support regulatory applications in ... Read more >
Status: Open Not Enrolling
Investigator: Miguel Valderrabano
Study Coordinator: Michelle Prystash
Phone: 713.441.6564
This Continued Access Protocol is a prospective, non-randomized, multicenter study to allow continued access to the WATCHMAN LAA Closure Technology during the data analysis, reporting and review of the PREVAIL pivotal study Pre-Market Applicatio ... Read more >
Status: Enrolling
Investigator: Miguel Valderrabano
Study Coordinator: Michelle Prystash
Phone: 713.441.6564
The broad, long-term objective of this project is to evaluate the therapeutic value of vein of Marshall (VOM) ethanol infusion when added to catheter ablation of atrial fibrillation (AF). AF is the most common sustained arrhythmia in adults, and ... Read more >
Status: Enrolling
Investigator: Su Min Chang
Study Coordinator: Christopher Mattair
Phone: 713.363.9956
The aim of this study is to compare the image quality of the half radioisotope dose scans obtained using a CZT (cadmium zinc telluride) camera with scans acquired using a standard of care imaging protocol/radioisotope dose performed on a traditi ... Read more >
Status: Enrolling
Investigator: Neal Kleiman
Study Coordinator: LaShawna Green
Phone: 713.441.6548
The objective of this study is to evaluate the safety and effectiveness of the Lotus™ Valve System for transcatheter aortic valve replacement (TAVR) in symptomatic subjects with calcific, severe native aortic stenosis who are considered at extre ... Read more >
Status: Enrolling
Investigator: Neal Kleiman
Study Coordinator: LaShawna Green
Phone: 713.441.6548
The purpose of the study is to investigate the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with severe, symptomatic Aortic Stenosis (AS) at intermediate surgical risk by randomizing patients to either Surgic ... Read more >
Status: Enrolling
Investigator: Stephen Little
Study Coordinator: Jeannie Arredondo
Phone: 713.441.3574
This study will create a registry of patient data associated with treatment provided at the Methodist DeBakey Heart & Vascular Center Valve Clinic. In the database, details of patients treated at the valve clinic will be entered, including pre-, ... Read more >
