Status: Enrolling
Investigator: Dipan Shah
Study Coordinator: Wajeeha Abrar
Phone: 346.238.6402
This study is designed to evaluate the efficacy of Dotarem enhanced MRI compared to Magnevist and Gadavist enhanced MRI in identifying myocardial infarct. Eighty patients will be recruited for this study. Patients with known CAD and undergoing c ... Read more >
Status: Enrolling
Investigator: Lawrence Rice
Study Coordinator: Erin Webb
Phone: 713.441.1111
To purpose of this study is to assess safety and efficacy of BAX 930 in the prevention and treatment of acute episodes of thrombotic thrombocytopenic purpura (TTP) in subjects with severe hereditary deficiency of ADAMTS13 (cTTP; defined as plasm ... Read more >
Status: Enrolling
Investigator: Lawrence Rice
Study Coordinator:
Phone:
This study will assess the ability of eltrombopag to induce sustained treatment-free remission in ITP subjects who relapsed or failed to respond to an initial treatment with steroids. There is limited, mainly retrospective evidence that earli ... Read more >
Status: Enrolling
Investigator: Alpesh Shah
Study Coordinator: Saba Khan
Phone: 713.441.2116
A Clinical Evaluation of Absorb™ BVS, the Everolimus Eluting Bioresorbable Vascular Scaffold in the Treatment of Subjects with de novo Native Coronary Artery Lesions This is a prospective, randomized, single-blind, multi-center trial, conducte ... Read more >
Status: Open Not Enrolling
Investigator: Richard Klucznik
Study Coordinator:
Phone:
.The primary objective of this study is to demonstrate effectiveness and safety of the NeuroForm Atlas stent system for use with bare metal embolic coils ... Read more >
Status: Open Not Enrolling
Investigator: Neal Kleiman
Study Coordinator: Saba Khan
Phone: 713.441.2116
This is a prospective, randomized, parallel-controlled, multicenter clinical evaluation of the MitraClip device for the treatment of clinically significant functional mitral regurgitation in symptomatic subjects too high risk to undergo mitral v ... Read more >
Status: Open Not Enrolling
Investigator: Alpesh Shah
Study Coordinator:
Phone:
This is a prospective, multi-center, non-randomized, single arm clinical trial that will be conducted at up to 40 sites in the United States and OUS. A minimum of 40% of total patients will be enrolled in the US. This study will enroll patient ... Read more >
Status: Open Not Enrolling
Investigator: Neal Kleiman
Study Coordinator:
Phone:
The study is being done study to obtain data on the safety and performance of the Medtronic CoreValve® System. The Medtronic CoreValve® System has been developed to replace a diseased aortic heart valve without the need for open heart surgery. T ... Read more >
Status: Enrolling
Investigator: Neal Kleiman
Study Coordinator: Patricia Brinegar
Phone: 713.441.3506
The primary objective of the study is to evaluate the safety and effectiveness of the Medtronic CoreValve® System (MCS) in a subset of subjects excluded from the U.S. Extreme Risk Pivotal Trial population due to one or more additional co-morbidi ... Read more >
Status: Open Not Enrolling
Investigator: Neal Kleiman
Study Coordinator: Patricia Brinegar
Phone: 713.441.3506
To evaluate the safety and efficacy of the CoreValve Evolut R System in patients with severe symptomatic aortic stenosis who are considered at high through extreme risk for surgical aortic valve replacement ... Read more >
Status: Enrolling
Investigator: David Chiu
Study Coordinator:
Phone:
Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asym ... Read more >
Status: Enrolling
Investigator: Barry Trachtenberg
Study Coordinator: Marcos DeOliveira
Phone: 171.344.19837
The purpose of this study is to evaluate the efficacy and safety of a single transendocardial delivery in the cardiac catheterization laboratory of human bone marrow-derived allogeneic MPCs (rexlemestrocel-L) for improvement in clinical outcomes ... Read more >
Status: Open Not Enrolling
Investigator: Mahendra Jain
Study Coordinator: Bela Jain
Phone: 281.485.3434
To evaluate whether long-term treatment with bempedoic acid 180 mg/day versus placebo reduces the risk of major adverse cardiovascular events (MACE) in patients with, or at high risk for, cardiovascular disease (CVD) who are statin intolerant. ... Read more >
Status: Enrolling
Investigator: Alpesh Shah
Study Coordinator: Saba Khan
Phone: 713.441.2116
The purpose of this study is to determine whether Fractional flow reserve (FFR, (coronary pressure wire-based index for assessing the ischemic potential of a coronary lesion)-guided percutaneous coronary intervention (PCI) in patients with multi ... Read more >
Status: Enrolling
Investigator: Sherif Nagueh
Study Coordinator: Rachel Kronman-Gross
Phone: 713.441.6539
Hypertrophic cardiomyopathy (HCM) is the most common monogenic heart disease and the most frequent cause of sudden cardiac death (SCD) in the young. It is characterized by unexplained left ventricular hypertrophy (LVH), diffuse and patchy fibros ... Read more >
Status: Enrolling
Investigator: Erik Suarez
Study Coordinator: Deborah Barr
Phone: 713.441.3916
atients will be approached to participate in this PAS after the HeartWare® Ventricular Assist System receives PMA approval for the indicated use as a bridge to cardiac transplantation. Patients who participated in prior trials will be approac ... Read more >
Status: Open Not Enrolling
Investigator: Mahendra Jain
Study Coordinator: Bela Jain
Phone: 281.485.3434
This is a multicenter, prospective, randomized, double-blind, active-controlled trial comparing two doses of influenza vaccine in high risk cardiovascular patients (history of myocardial infarction or heart failure).- ... Read more >
Status: Enrolling
Investigator: Dipan Shah
Study Coordinator: Bevin Lopez
Phone: 713.441.6537
The American Diabetes Association estimates that 25.8 million individuals or 8.3% of the United States population have diabetes mellitus (DM). Individuals with diabetes have an increased risk for cardiovascular disease (CVD) and CVD events accou ... Read more >
Status: Enrolling
Investigator: Michael Reardon
Study Coordinator: Patricia Brinegar
Phone: 713.441.3506
To evaluate the safety and effectiveness of the Model 400 bovine pericardial stented aortic bioprosthesis in a patient population undergoing surgical aortic valve replacement. The collected data will be used to support regulatory applications in ... Read more >
Status: Open Not Enrolling
Investigator: Miguel Valderrabano
Study Coordinator:
Phone:
This Continued Access Protocol is a prospective, non-randomized, multicenter study to allow continued access to the WATCHMAN LAA Closure Technology during the data analysis, reporting and review of the PREVAIL pivotal study Pre-Market Applicatio ... Read more >
Status: Enrolling
Investigator: Neal Kleiman
Study Coordinator: Patricia Brinegar
Phone: 713.441.3506
The objective of this study is to evaluate the safety and effectiveness of the Lotus™ Valve System for transcatheter aortic valve replacement (TAVR) in symptomatic subjects with calcific, severe native aortic stenosis who are considered at extre ... Read more >
Status: Enrolling
Investigator: Neal Kleiman
Study Coordinator: Patricia Brinegar
Phone: 713.441.3506
The purpose of the study is to investigate the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with severe, symptomatic Aortic Stenosis (AS) at intermediate surgical risk by randomizing patients to either Surgic ... Read more >
Status: Enrolling
Investigator: Stephen Little
Study Coordinator: Patricia Brinegar
Phone: 713.441.3506
This study will create a registry of patient data associated with treatment provided at the Methodist DeBakey Heart & Vascular Center Valve Clinic. In the database, details of patients treated at the valve clinic will be entered, including pre-, ... Read more >
