Inflammation is a significant component of Alzheimer’s disease pathology. While neuroprotective microglia are important for containment/clearance of Amyloid plaques and maintaining neuronal survival, Alzheimer inflammatory microglia may play a detrimental role by eliciting tau pathogenesis and accelerating neurotoxicity. Regulatory T cells have been shown to suppress microglia-mediated inflammation in Alzheimer’s disease. However, the role of regulatory T cells in ameliorating the proinflammatory immune response in Alzheimer’s disease requires further investigation.

For the full analysis, see Brain Communications to view the paper from neurologist Alireza Faridar, MD, Chair of Neurology, Stanley H. Appel, MD and neurologist, Joseph C. Masdeu, MD, PhD.