Showing 1 - 10 of 25 Heart and Blood Diseases

Status: Enrolling

Investigator: Dipan Shah

Study Coordinator: Christopher Mattair

Phone: 713.363.9956

This study is designed to evaluate the efficacy of Dotarem enhanced MRI compared to Magnevist and Gadavist enhanced MRI in identifying myocardial infarct. Eighty patients will be recruited for this study. Patients with known CAD and undergoing c ... Read more >

Status: Enrolling

Investigator: Lawrence Rice

Study Coordinator: Elizabeth Soriano

Phone: 713.441.14203

To purpose of this study is to assess safety and efficacy of BAX 930 in the prevention and treatment of acute episodes of thrombotic thrombocytopenic purpura (TTP) in subjects with severe hereditary deficiency of ADAMTS13 (cTTP; defined as plasm ... Read more >

Status: Enrolling

Investigator: Lawrence Rice

Study Coordinator:

Phone:

This study will assess the ability of eltrombopag to induce sustained treatment-free remission in ITP subjects who relapsed or failed to respond to an initial treatment with steroids. There is limited, mainly retrospective evidence that earli ... Read more >

Status: Enrolling

Investigator: Alpesh Shah

Study Coordinator: Saba Khan

Phone: 713.441.2116

A Clinical Evaluation of Absorb™ BVS, the Everolimus Eluting Bioresorbable Vascular Scaffold in the Treatment of Subjects with de novo Native Coronary Artery Lesions This is a prospective, randomized, single-blind, multi-center trial, conducte ... Read more >

Status: Open Not Enrolling

Investigator: Richard Klucznik

Study Coordinator:

Phone:

.The primary objective of this study is to demonstrate effectiveness and safety of the NeuroForm Atlas stent system for use with bare metal embolic coils ... Read more >

Status: Open Not Enrolling

Investigator: Neal Kleiman

Study Coordinator: Saba Khan

Phone: 713.441.2116

This is a prospective, randomized, parallel-controlled, multicenter clinical evaluation of the MitraClip device for the treatment of clinically significant functional mitral regurgitation in symptomatic subjects too high risk to undergo mitral v ... Read more >

Status: Open Not Enrolling

Investigator: Alpesh Shah

Study Coordinator:

Phone:

This is a prospective, multi-center, non-randomized, single arm clinical trial that will be conducted at up to 40 sites in the United States and OUS. A minimum of 40% of total patients will be enrolled in the US. This study will enroll patient ... Read more >

Status: Open Not Enrolling

Investigator: Neal Kleiman

Study Coordinator:

Phone:

The study is being done study to obtain data on the safety and performance of the Medtronic CoreValve® System. The Medtronic CoreValve® System has been developed to replace a diseased aortic heart valve without the need for open heart surgery. T ... Read more >

Status: Open Not Enrolling

Investigator: Neal Kleiman

Study Coordinator: LaShawna Green

Phone: 713.441.6548

The purpose of the study is to evaluate the safety and efficacy of the Medtronic CoreValve® System in the treatment of symptomatic severe aortic stenosis in subjects who have a predicted high risk for aortic valve surgery and/or very high risk f ... Read more >

Status: Enrolling

Investigator: Michael Reardon

Study Coordinator: LaShawna Green

Phone: 713.441.6548

The purpose of the study is to evaluate the safety and efficacy of the Medtronic CoreValve® System in the treatment of symptomatic severe aortic stenosis in subjects who have a predicted high risk for aortic valve surgery and/or very high risk f ... Read more >

Status: Enrolling

Investigator: Neal Kleiman

Study Coordinator: Patricia Brinegar

Phone: 713.441.3506

The primary objective of the study is to evaluate the safety and effectiveness of the Medtronic CoreValve® System (MCS) in a subset of subjects excluded from the U.S. Extreme Risk Pivotal Trial population due to one or more additional co-morbidi ... Read more >

Status: Open Not Enrolling

Investigator: Neal Kleiman

Study Coordinator: LaShawna Green

Phone: 713.441.6548

To evaluate the safety and efficacy of the CoreValve Evolut R System in patients with severe symptomatic aortic stenosis who are considered at high through extreme risk for surgical aortic valve replacement ... Read more >

Status: Enrolling

Investigator: David Chiu

Study Coordinator: Jason Lee

Phone: 713.394.6479

Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asym ... Read more >

Status: Enrolling

Investigator: Barry Trachtenberg

Study Coordinator: Marcos DeOliveira

Phone: 171.344.19837

The purpose of this study is to evaluate the efficacy and safety of a single transendocardial delivery in the cardiac catheterization laboratory of human bone marrow-derived allogeneic MPCs (rexlemestrocel-L) for improvement in clinical outcomes ... Read more >

Status: Open Not Enrolling

Investigator: Mahendra Jain

Study Coordinator: Bela Jain

Phone: 281.485.3434

To evaluate whether long-term treatment with bempedoic acid 180 mg/day versus placebo reduces the risk of major adverse cardiovascular events (MACE) in patients with, or at high risk for, cardiovascular disease (CVD) who are statin intolerant. ... Read more >

Status: Enrolling

Investigator: Alpesh Shah

Study Coordinator: Saba Khan

Phone: 713.441.2116

The purpose of this study is to determine whether Fractional flow reserve (FFR, (coronary pressure wire-based index for assessing the ischemic potential of a coronary lesion)-guided percutaneous coronary intervention (PCI) in patients with multi ... Read more >

Status: Enrolling

Investigator: Sherif Nagueh

Study Coordinator: Christopher Mattair

Phone: 713.363.9956

Hypertrophic cardiomyopathy (HCM) is the most common monogenic heart disease and the most frequent cause of sudden cardiac death (SCD) in the young. It is characterized by unexplained left ventricular hypertrophy (LVH), diffuse and patchy fibros ... Read more >

Status: Enrolling

Investigator: Erik Suarez

Study Coordinator: Deborah Barr

Phone: 713.441.3916

atients will be approached to participate in this PAS after the HeartWare® Ventricular Assist System receives PMA approval for the indicated use as a bridge to cardiac transplantation. Patients who participated in prior trials will be approac ... Read more >

Status: Open Not Enrolling

Investigator: Mahendra Jain

Study Coordinator: Bela Jain

Phone: 281.485.3434

This is a multicenter, prospective, randomized, double-blind, active-controlled trial comparing two doses of influenza vaccine in high risk cardiovascular patients (history of myocardial infarction or heart failure).- ... Read more >

Status: Enrolling

Investigator: Dipan Shah

Study Coordinator: Bevin Lopez

Phone: 713.441.6537

The American Diabetes Association estimates that 25.8 million individuals or 8.3% of the United States population have diabetes mellitus (DM). Individuals with diabetes have an increased risk for cardiovascular disease (CVD) and CVD events accou ... Read more >

Status: Enrolling

Investigator: Michael Reardon

Study Coordinator: Patricia Brinegar

Phone: 713.441.3506

To evaluate the safety and effectiveness of the Model 400 bovine pericardial stented aortic bioprosthesis in a patient population undergoing surgical aortic valve replacement. The collected data will be used to support regulatory applications in ... Read more >

Status: Open Not Enrolling

Investigator: Miguel Valderrabano

Study Coordinator: Michelle Guthrie

Phone: 713.441.6564

This Continued Access Protocol is a prospective, non-randomized, multicenter study to allow continued access to the WATCHMAN LAA Closure Technology during the data analysis, reporting and review of the PREVAIL pivotal study Pre-Market Applicatio ... Read more >

Status: Enrolling

Investigator: Neal Kleiman

Study Coordinator: Patricia Brinegar

Phone: 713.441.3506

The objective of this study is to evaluate the safety and effectiveness of the Lotus™ Valve System for transcatheter aortic valve replacement (TAVR) in symptomatic subjects with calcific, severe native aortic stenosis who are considered at extre ... Read more >

Status: Enrolling

Investigator: Neal Kleiman

Study Coordinator: Patricia Brinegar

Phone: 713.441.3506

The purpose of the study is to investigate the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with severe, symptomatic Aortic Stenosis (AS) at intermediate surgical risk by randomizing patients to either Surgic ... Read more >

Status: Enrolling

Investigator: Stephen Little

Study Coordinator: Patricia Brinegar

Phone: 713.441.3506

This study will create a registry of patient data associated with treatment provided at the Methodist DeBakey Heart & Vascular Center Valve Clinic. In the database, details of patients treated at the valve clinic will be entered, including pre-, ... Read more >