Clinical Trials

    Showing 1 - 10 of 29 surgery

    A Phase III Randomised Clinical Trial Comparing Sentinel Node Biopsy With No Retroperitoneal Node Dissection in Apparent Early-Stage Endometrial Cancer

    Status: Enrolling

    Investigator: Behrouz Zand

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    Endometrial cancer (EC) is the most common gynaecological cancer. Current treatment of EC typically includes removal of the uterus and to determine the extent of the disease (removal of fallopian tubes, ovaries & if required a lymph node dissection (... Read more >

    A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative

    Status: Open Not Enrolling

    Investigator: Polly Niravath

    Study Coordinator: Alexys Brock

    Phone: 346.238.4814

    This randomized phase III trial studies standard or comprehensive radiation therapy in treating patients with early-stage breast cancer who have undergone surgery. Radiation therapy uses high-energy x rays to kill tumor cells. It is not yet known whe... Read more >

    A Randomized, Double-Blind, Phase III Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed by Adjuvant Continuation of Atezolizumab or Placebo

    Status: Open Not Enrolling

    Investigator: Polly Niravath

    Study Coordinator: Alexys Brock

    Phone: 346.238.4814

    The main purpose of this study is to learn if the usual chemotherapy given before surgery (neoadjuvant therapy) for breast cancer plus the experimental drug, atezolizumab, is better than the usual chemotherapy plus a placebo. (A placebo is a drug tha... Read more >

    A151216 - Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery ALCHEMIST

    Status: Open Not Enrolling

    Investigator: Jun Zhang

    Study Coordinator: Gabrielle Hayes

    Phone: 734.415.918

    This research trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. Studying the genes in a patient's tumor cells may help doctors select the best treatment for ... Read more >

    ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

    Status: Open Not Enrolling

    Investigator: Neal Kleiman

    Study Coordinator: Deena Victor

    Phone: 713.441.4536

    Brief Summary: To evaluate safety and effectiveness of the ACURATE Transfemoral Aortic Valve System for transcatheter aortic valve replacement (TAVR) in subjects with severe native aortic stenosis who are indicated for TAVR. Detailed Description: ... Read more >

    Adjuvant Nivolumab in Resected Lung Cancers (ANVIL)-A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-small Cell Lung Cancers

    Status: Open Not Enrolling

    Investigator: Jun Zhang

    Study Coordinator: Gabrielle Hayes

    Phone: 734.415.918

    This randomized phase III trial studies how well nivolumab after surgery and chemotherapy work in treating patients with stage IB-IIIA non-small cell lung cancer. Monoclonal antibodies, such as nivolumab, may stimulate the immune system in different ... Read more >

    Amplatzer Amulet LAAO vs. NOAC (CATALYST)

    Status: Enrolling

    Investigator: Miguel Valderrabano

    Study Coordinator: Aneesch Martin

    Phone: 713.441.6548

    Brief Summary: The objective of this trial is to evaluate the safety and effectiveness of the Amulet LAA occluder compared to NOAC therapy in patients with non-valvular AF at increased risk for ischemic stroke and who are recommended for long-term N... Read more >

    B49: Docetaxel and Cyclophosphamide Compared to Anthracycline-Based Chemotherapy in Treating Women With HER2-Negative Breast Cancer

    Status: Open Not Enrolling

    Investigator: Polly Niravath

    Study Coordinator: Alexys Brock

    Phone: 346.238.4814

    RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of breast cancer cells, either by killing the cells or by stopping them from dividing. Giving the drugs in different combinations may kill more breast cancer cells. Givin... Read more >

    Cephea Early Feasibility Study

    Status: Enrolling

    Investigator: Sachin Goel

    Study Coordinator: Deena Victor

    Phone: 713.441.4536

    Brief Summary: The objective of this study is to evaluate the preliminary safety and effectiveness of the Cephea Mitral Valve System for the treatment of symptomatic patients with mitral regurgitation = Grade III in whom transcatheter therapy is dee... Read more >

    Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial (CLASP IID/IIF)

    Status: Enrolling

    Investigator: Neal Kleiman

    Study Coordinator: Deena Victor

    Phone: 713.441.4536

    Brief Summary: To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Valve Repair System in patients with degenerative mitral regurgitation (DMR) who have been determined to be at prohibitive risk for mitral valve surgery by ... Read more >

    Evolut EXPAND TAVR II Pivotal Trial

    Status: Enrolling

    Investigator: Neal Kleiman

    Study Coordinator: Deena Victor

    Phone: 713.441.4536

    Brief Summary: Obtain safety and effectiveness data to support indication expansion for the Medtronic TAVR System to include patients with moderate, symptomatic AS. Detailed Description: Multi-center, international, prospective, randomized study... Read more >

    FAME 3

    Status: Open Not Enrolling

    Investigator: Alpesh Shah

    Study Coordinator: Iris Alanis

    Phone: 713.441.6548

    The purpose of this study is to determine whether Fractional flow reserve (FFR, (coronary pressure wire-based index for assessing the ischemic potential of a coronary lesion)-guided percutaneous coronary intervention (PCI) in patients with multivesse... Read more >

    Integration of Immunotherapy Into Adjuvant Therapy for Resected NSCLC: ALCHEMIST Chemo-IO (ACCIO)

    Status: Open Not Enrolling

    Investigator: Jun Zhang

    Study Coordinator: Derek Cole

    Phone: 713.441.5607

    This phase III ALCHEMIST trial tests the addition of pembrolizumab to usual chemotherapy for the treatment of stage IIA, IIB IIIA or IIIB non-small cell lung cancer that has been removed by surgery. Immunotherapy with monoclonal antibodies, such as p... Read more >

    Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial (LeAAPS)

    Status: Enrolling

    Investigator: Ross Reul

    Study Coordinator: Deena Victor

    Phone: 713.441.4536

    This trial is a prospective, randomized, multicenter, multinational, blinded, superiority trial. The objective of this trial is to evaluate the effectiveness of left atrial appendage exclusion (LAAE) for the prevention of ischemic stroke or systemic ... Read more >

    Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

    Status: Enrolling

    Investigator: Pedro Ramirez

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    This phase III trial compares minimally invasive surgery (MIS) to laparotomy in treating patients with stage IIIC-IV ovarian, primary peritoneal, or fallopian tube cancer who are receiving chemotherapy before and after surgery (neoadjuvant chemothera... Read more >

    MitraClip REPAIR MR Study

    Status: Enrolling

    Investigator: Sachin Goel

    Study Coordinator: Tia McGaughy

    Phone: 346.238.4576

    Brief Summary: The objective of this randomized controlled trial (RCT) is to compare the clinical outcome of MitraClip™ device versus surgical repair in patients with severe primary MR who are at moderate surgical risk and whose mitral valve has bee... Read more >

    Neoadjuvant Atezolizumab in Patients With Non-Metastatic Resectable High-Risk Cutaneous Melanoma

    Status: Open Not Enrolling

    Investigator: Nestor Esnaola

    Study Coordinator: Safiya Joseph

    Phone: 203.308.8567

    The purpose of this research study is to see whether using atezolizumab before surgery is safe and does not cause side effects that delay surgery in participants with cutaneous melanoma that has not spread to other areas of the body (non-metastatic) ... Read more >

    Neoadjuvant Folfirinox Combined With Pembrolizumab Followed by Surgery for Patients With Resectable Pancreatic Cancer

    Status: Enrolling

    Investigator: Nestor Esnaola

    Study Coordinator: Safiya Joseph

    Phone: 203.308.8567

    Neoadjuvant FOLFIRINOX combined with Pembrolizumab followed by surgery for patients with resectable pancreatic cancer Trial Phase: Phase II Clinical Indication: Pancreatic ductal adenocarcinoma; Adenocarcinoma; AJCC I, II, or III; 1st Line neoadjuvan... Read more >

    NWBT 020221 - DC-Vax

    Status: Open Not Enrolling

    Investigator: David Baskin

    Study Coordinator: Helga Jones

    Phone: 713.363.9388

    " Purpose The primary purpose of the study is to determine the efficacy of an investigational therapy called DCVax(R)-L in patients with newly diagnosed GBM for whom surgery is indicated. Patients must enter screening at a participating site prior ... Read more >

    Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

    Status: Enrolling

    Investigator: Kai Sun

    Study Coordinator: Kelsey Banaglorioso

    Phone: 346.238.5740

    The phase III trial compares the effect of pembrolizumab to observation for the treatment of patients with early-stage triple-negative breast cancer who achieved a pathologic complete response after preoperative chemotherapy in combination with pembr... Read more >

    Phase I Trial Evaluating the Safety of the Dietary Supplement Honokiol in Early-Stage Resectable Non-Small Cell Lung Cancer

    Status: Enrolling

    Investigator: Jun Zhang

    Study Coordinator: Derek Cole

    Phone: 713.441.5607

    The goal of this research study is to find the highest, safest dose of honokiol (a type of dietary supplement) that can be given to patients who have resectable early-stage NSCLC. Researchers also want to learn if giving honokiol before surgery can... Read more >

    Phase I-II Study Evaluating HSV-tk + Valacyclovir Gene Therapy Combination with Radiotherapy and Chemotherapy for Recurrent Glioblastoma Multiforme

    Status: Enrolling

    Investigator: David Baskin

    Study Coordinator: Melissa Daly

    Phone: 713.441.3834

    NCT03596086 This is a prospective phase I-II study to assess the efficacy and toxicity of HSV-tk + valacyclovir gene therapy in combination with radiotherapy and standard of care chemotherapy in recurrent anaplastic astrocytoma or glioblastoma multi... Read more >

    Randomized Study of Erlotinib vs Observation in Patients With Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-small Cell Lung Cancer (NSCLC)

    Status: Open Not Enrolling

    Investigator: Jun Zhang

    Study Coordinator: Gabrielle Hayes

    Phone: 734.415.918

    This randomized phase III trial studies how well erlotinib hydrochloride compared to placebo works in treating patients with stage IB-IIIA non-small cell lung cancer that has been completely removed by surgery. Erlotinib hydrochloride may stop the gr... Read more >

    Surgical Irrigation with Synergistic Surgical Solution (BIASURGE) Application Impact on the Reduction of Groin Wound Complications in Vascular Surgery Wounds

    Status: Open Not Enrolling

    Investigator: Maham Rahimi

    Study Coordinator: Sohaib Mhaidi

    Phone: 346.238.6402

    This is a multi-surgeon monocentric study at Houston Methodist Hospital (HMH) to decrease the number of groin wound complications using BIASURGE Advanced Surgical Solution (BIASURGE) after common femoral artery exposure for vascular surgery procedure... Read more >

    The JenaValve ALIGN-AR Pivotal Trial (ALIGN-AR)

    Status: Enrolling

    Investigator: Michael Reardon

    Study Coordinator: Yejide Oyewole

    Phone: 346.238.2294

    Brief Summary: To collect information about treatment for symptomatic severe Aortic Regurgitation (AR), which affects the aortic valve in the heart. Aortic regurgitation is a condition where aortic valve in the heart does not close tightly and allow... Read more >

    Transcatheter Mitral Valve Replacement With the Medtronic Intrepid TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. (APOLLO)

    Status: Enrolling

    Investigator: Neal Kleiman

    Study Coordinator: Tia McGaughy

    Phone: 346.238.4576

    Brief Summary: Multi-center, global, prospective, non-randomized, interventional, pre-market trial. All subjects enrolled with receive the study device. Inclusion Criteria: Moderate to severe or severe symptomatic mitral regurgitation Local sit... Read more >

    TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (TRICAV) (TRICAV)

    Status: Enrolling

    Investigator: Sachin Goel

    Study Coordinator: Yejide Oyewole

    Phone: 346.238.2294

    This is a prospective multicenter clinical investigation designed to evaluate the safety and effectiveness of the TricValve® Transcatheter Bicaval Valve System for improving outcomes in symptomatic subjects with severe TR deemed by the local Heart Te... Read more >

    TRILUMINATE Pivotal Trial

    Status: Open Not Enrolling

    Investigator: Stephen Little

    Study Coordinator: Padmaja Naik

    Phone: 713.441.7386

    Brief Summary: The primary objective of this trial is to demonstrate the safety and effectiveness of the TriClip device in improving clinical outcomes in symptomatic patients with severe tricuspid regurgitation (TR), who are at intermediate or great... Read more >

    TTVR Early Feasibility Study

    Status: Enrolling

    Investigator: Sachin Goel

    Study Coordinator: Tia McGaughy

    Phone: 346.238.4576

    Brief Summary: The objective of this early feasibility study is to gain early clinical insight into the performance of the Intrepid transcatheter tricuspid valve replacement (TTVR) system intended for transfemoral access to deliver a self-expanding ... Read more >