Showing 1 - 10 of 29 Breast Cancers

Status: Enrolling

Investigator: Warren Ellsworth

Study Coordinator: Sergio Ibarra Cortez

Phone: 956.543.5198

This is a multicenter registry study to collect utilization, safety, and outcomes data from medical record chart review of nerve reconstruction procedures throughout the body with Avance® Nerve Graft. Addendum 1 (MATCH) establishes a comparat ... Read more >

Status: Enrolling

Investigator: Jenny Chang

Study Coordinator: Minh Truong

Phone: 346.238.6403

Breast implants are the most common way of rebuilding the shape of the breasts after breast cancer surgery. However, current breast implants cannot completely match individual differences in breast shape. It is also often difficult to match the ... Read more >

Status: Enrolling

Investigator: Aldona Spiegel

Study Coordinator: Sergio Ibarra Cortez

Phone: 956.543.5198

This is a multicenter registry study to collect utilization, safety, and outcomes data from medical record chart review of nerve reconstruction procedures throughout the body with Avance® Nerve Graft. Addendum 1 (MATCH) establishes a comparat ... Read more >

Status: Open Not Enrolling

Investigator: Jenny Chang

Study Coordinator:

Phone:

This is a pilot study is evaluating the effect of hydroxytyrosol, a component of Olive oil, on mammographic density in women at high risk of breast through assessing whether mammographic density is reduced in women at high risk of breast cancer ... Read more >

Status: Enrolling

Investigator: Sandra Templeton

Study Coordinator: Elizabeth Soriano

Phone: 713.441.14203

This is a prospective cohort study for patients diagnosed with ductal carcinoma in situ (DCIS) of the breast. The primary objective of the study is to create a de-identified database of patients, test results, treatment decisions and outcomes th ... Read more >

Status: Enrolling

Investigator: Polly Niravath

Study Coordinator: Elizabeth Soriano

Phone: 713.441.14203

This randomized phase III trial studies standard or comprehensive radiation therapy in treating patients with early-stage breast cancer who have undergone surgery. Radiation therapy uses high-energy x rays to kill tumor cells. It is not yet know ... Read more >

Status: Enrolling

Investigator: Polly Niravath

Study Coordinator: Jose Cruz

Phone: 713.441.4457

The main purpose of this study is to learn if the usual chemotherapy given before surgery (neoadjuvant therapy) for breast cancer plus the experimental drug, atezolizumab, is better than the usual chemotherapy plus a placebo. (A placebo is a dru ... Read more >

Status: Enrolling

Investigator: Charles Geyer

Study Coordinator: Toniva Boone

Phone: 713.441.0686

This randomized phase III trial studies how well paclitaxel, trastuzumab, and pertuzumab with or without atezolizumab works in treating patients with breast cancer that has spread to other parts of the body (metastatic). Drugs used in chemothera ... Read more >

Status: Enrolling

Investigator: Polly Niravath

Study Coordinator: Mary Rose Silvas

Phone: 713.441.1952

This randomized phase III trial studies how well pembrolizumab works in treating triple-negative breast cancer. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread. ... Read more >

Status: Enrolling

Investigator: Polly Niravath

Study Coordinator: Minh Truong

Phone: 346.238.6403

A single arm pilot study of 20 patients will be used to determine the feasibility of EA as a treatment for cancer survivors who have been treated with curative intent, but who have persistent CIPN for ?3 months after the cancer treatment is comp ... Read more >

Status: Open Not Enrolling

Investigator: Jenny Chang

Study Coordinator: Lacey Burey

Phone: 713.441.1159

This study will examine the safety and efficacy of pertuzumab in combination with high-dose trastuzumab in adult participants with HER2-positive MBC with CNS metastases and disease progression in the brain following radiotherapy. ... Read more >

Status: Enrolling

Investigator: Polly Niravath

Study Coordinator: Elizabeth Soriano

Phone: 713.441.14203

This phase II trial studies how well biopsy of breast after chemotherapy works in predicting pathologic response in patients with stage II-IIIA breast cancer undergoing breast conserving surgery. Tumor tissue collected from biopsy before surgery ... Read more >

Status: Open Not Enrolling

Investigator: Polly Niravath

Study Coordinator: Toniva Boone

Phone: 713.441.0686

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of breast cancer cells, either by killing the cells or by stopping them from dividing. Giving the drugs in different combinations may kill more breast cancer cells. ... Read more >

Status: Enrolling

Investigator: Polly Niravath

Study Coordinator: Daniel (cancer) Le (cancer)

Phone: 346.238.5655

This is a Phase Ib/II study assessing the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), recommended Phase 2 dose (RP2D), and efficacy of L-NMMA when combined with docetaxel in refractory locally advanced or metastatic triple neg ... Read more >

Status: Open Not Enrolling

Investigator: Jenny Chang

Study Coordinator: Minh Truong

Phone: 346.238.6403

Hormone receptor positive breast cancer HRBC is the most common cause of BC-related death. HRBC is characterized by a non-immunogenic microenvironment and consequently, modest responses have been observed with immune checkpoint blockade ICB alon ... Read more >

Status: Enrolling

Investigator: Polly Niravath

Study Coordinator: Syed Muhammad Saad

Phone: 281.276.5263

The reason for this trial is to compare DS-8201a to other treatments being used for HER2-low breast cancer that has spread to other parts of the body. DS-8201a is a new medicine for breast cancer that has not been approved yet by the Food and ... Read more >

Status: Enrolling

Investigator: Polly Niravath

Study Coordinator: Erick Villarreal-Williams

Phone: 346.238.5594

This study is designed to compare the anti-tumor activity as well as the safety and efficacy of DS-8201a versus T-DM1 in HER2-positive, unresectable and/or metastatic breast cancer subjects previously treated with trastuzumab and taxane. ... Read more >

Status: Enrolling

Investigator: Polly Niravath

Study Coordinator: Jose Cruz

Phone: 713.441.4457

Primary Objective: • To compare the efficacy of DS-8201a to investigator’s choice by means of progression-free survival (PFS). Secondary Objectives: • To further investigate the efficacy of DS-8201a compared to investigator’s choice on: ? ... Read more >

Status: Enrolling

Investigator: Jenny Chang

Study Coordinator: Elizabeth Soriano

Phone: 713.441.14203

The purpose of this research study is to test the safety and effectiveness of using durvalumab with trastuzumab and pertuzumab in participants with human epidermal growth factor receptor 2 (HER2)-enriched breast cancer. ... Read more >

Status: Active

Investigator: Jenny Chang

Study Coordinator:

Phone:

This is an open label phase II clinical trial to determine the efficacy, toxicity, and safety of TAK-228 plus tamoxifen in patients with newly diagnosed ER-positive, HER2-negative breast cancer. ... Read more >

Status: Open Not Enrolling

Investigator: Charles Geyer

Study Coordinator: Minh Truong

Phone: 346.238.6403

This is a prospective, two arm, international, multicenter, randomized, open-label Phase III study evaluating the addition of 2 years of palbociclib to standard adjuvant endocrine therapy for patients with HR+ / HER2- early breast cancer (EBC). ... Read more >

Status: Enrolling

Investigator: Polly Niravath

Study Coordinator: Jose Cruz

Phone: 713.441.4457

This is an open-label, randomized, multicenter Phase 3 study to compare the efficacy and safety of Sacituzumab Govitecan versus TPC in subjects with metastatic or locally recurrent inoperable HR+/HER2- MBC, after failure of at least 2, and no mo ... Read more >

Status: Enrolling

Investigator: Jenny Chang

Study Coordinator:

Phone:

This is a phase Ib/II Study of Leronlimab (PRO 140) combined with Carboplatin in Patients with CCR5+ Metastatic Triple Negative Breast Cancer (mTNBC). Study population will consist of patients with CCR5-positive, locally advanced or metastati ... Read more >

Status: Open Not Enrolling

Investigator: Jenny Chang

Study Coordinator:

Phone:

The major purpose of this research study is to better understand how therapy works on different patients. This study is being offered to patients with a diagnosis of advanced or metastatic breast cancer who have failed anthracycline based therap ... Read more >

Status: Enrolling

Investigator: Jenny Chang

Study Coordinator: Toniva Boone

Phone: 713.441.0686

This is a Phase II trial to determine the efficacy and safety of stereotactic body radiation therapy (SBRT) and in situ oncolytic virus therapy used as a window of opportunity treatment before pembrolizumab in patients with metastatic triple neg ... Read more >

Status: Enrolling

Investigator: Polly Niravath

Study Coordinator: Mary Rose Silvas

Phone: 713.441.1952

This study is investigating whether breast cancer patients who experience vaginal dryness while on anti-estrogen treatment could benefit from either vaginal estrogen or from a vaginal moisturizer called Replens. ... Read more >

Status: Open Not Enrolling

Investigator: Polly Niravath

Study Coordinator: Jose Cruz

Phone: 713.441.4457

This is an expanded access, open-label, multicenter program of tucatinib in combination with capecitabine and trastuzumab in patients with previously treated unresectable locally advanced or metastatic HER2 breast cancer. The purpose of this p ... Read more >

Status: Open Not Enrolling

Investigator: Polly Niravath

Study Coordinator:

Phone:

RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy, using tamoxifen citrate, may fight breast cancer by blocking the use of estrogen by the tumor cells. Aromatase inhibitors, such as anastrozole, letrozole, and exem ... Read more >

Status: Enrolling

Investigator: Jenny Chang

Study Coordinator: Elizabeth Soriano

Phone: 713.441.14203

This study is a two-cohort, open-label, multicenter, phase 2 study of a short course of immunotherapy consisting of sequential decitabine followed by pembrolizumab administered prior to a standard neoadjuvant chemotherapy regimen for patients wi ... Read more >

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