Showing 1 - 10 of 29 Breast Cancers

Status: Open Not Enrolling

Investigator: Jenny Chang

Study Coordinator: Kelsey Banaglorioso

Phone: 346.238.5740

The purpose of this research study is to test the safety and effectiveness of docetaxel chemotherapy and pembrolizumab plus adenoviral-mediated interleukin-12 (ADV/IL-12) gene therapy in patients with anthracycline-refractory, triple negative br ... Read more >

Status: Enrolling

Investigator: Warren Ellsworth

Study Coordinator: Valentina Villarroel

Phone: 346.238.4384

This is a multicenter registry study to collect utilization, safety, and outcomes data from medical record chart review of nerve reconstruction procedures throughout the body with Avance® Nerve Graft. Addendum 1 (MATCH) establishes a comparat ... Read more >

Status: Enrolling

Investigator: Aldona Spiegel

Study Coordinator: Valentina Villarroel

Phone: 346.238.4384

This is a multicenter registry study to collect utilization, safety, and outcomes data from medical record chart review of nerve reconstruction procedures throughout the body with Avance® Nerve Graft. Addendum 1 (MATCH) establishes a comparat ... Read more >

Status: Open Not Enrolling

Investigator: Hanh Mai

Study Coordinator: Rabia Hashmani

Phone: 346.238.5894

Patients with HER2-positive primary breast cancer (BC) who do not achieve complete response after appropriate neoadjuvant therapy are at higher risk of disease recurrence. More effective treatment options are needed for this patient population. ... Read more >

Status: Open Not Enrolling

Investigator: Jenny Chang

Study Coordinator:

Phone:

This is a pilot study is evaluating the effect of hydroxytyrosol, a component of Olive oil, on mammographic density in women at high risk of breast through assessing whether mammographic density is reduced in women at high risk of breast cancer ... Read more >

Status: Open Not Enrolling

Investigator: Sandra Templeton

Study Coordinator: Juan Morales Viera

Phone: 786.803.2333

This is a prospective cohort study for patients diagnosed with ductal carcinoma in situ (DCIS) of the breast. The primary objective of the study is to create a de-identified database of patients, test results, treatment decisions and outcomes th ... Read more >

Status: Open Not Enrolling

Investigator: Polly Niravath

Study Coordinator: Alexys Brock

Phone: 346.238.4814

This randomized phase III trial studies standard or comprehensive radiation therapy in treating patients with early-stage breast cancer who have undergone surgery. Radiation therapy uses high-energy x rays to kill tumor cells. It is not yet know ... Read more >

Status: Open Not Enrolling

Investigator: Polly Niravath

Study Coordinator: Alexys Brock

Phone: 346.238.4814

The main purpose of this study is to learn if the usual chemotherapy given before surgery (neoadjuvant therapy) for breast cancer plus the experimental drug, atezolizumab, is better than the usual chemotherapy plus a placebo. (A placebo is a dru ... Read more >

Status: Open Not Enrolling

Investigator: Polly Niravath

Study Coordinator: Kelsey Banaglorioso

Phone: 346.238.5740

This randomized phase III trial studies how well paclitaxel, trastuzumab, and pertuzumab with or without atezolizumab works in treating patients with breast cancer that has spread to other parts of the body (metastatic). Drugs used in chemothera ... Read more >

Status: Open Not Enrolling

Investigator: Kai Sun

Study Coordinator: Rabia Hashmani

Phone: 346.238.5894

This is a Phase III, global, randomized, open-label, multicenter, study evaluating the efficacy and safety of adjuvant giredestrant compared with endocrine therapy of physician's choice in participants with medium- and high-risk Stage I-III hist ... Read more >

Status: Enrolling

Investigator: Kai Sun

Study Coordinator: Rabia Hashmani

Phone: 346.238.5894

This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard endocrine therapy in patients with ER+/HER2 - early breast cancer with intermediate or high risk for disease recurrence who completed definitiv ... Read more >

Status: Enrolling

Investigator: Hanh Mai

Study Coordinator: Rabia Hashmani

Phone: 346.238.5894

This is a Phase III, randomized, open-label, 3-arm, multicenter, international study assessing the efficacy and safety of Dato-DXd with or without durvalumab compared with ICT in participants with stage I to III TNBC with residual invasive disea ... Read more >

Status: Open Not Enrolling

Investigator: Polly Niravath

Study Coordinator: Alexys Brock

Phone: 346.238.4814

A single arm pilot study of 20 patients will be used to determine the feasibility of EA as a treatment for cancer survivors who have been treated with curative intent, but who have persistent CIPN for ?3 months after the cancer treatment is comp ... Read more >

Status: Open Not Enrolling

Investigator: Polly Niravath

Study Coordinator: Alexys Brock

Phone: 346.238.4814

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of breast cancer cells, either by killing the cells or by stopping them from dividing. Giving the drugs in different combinations may kill more breast cancer cells. ... Read more >

Status: Enrolling

Investigator: Kai Sun

Study Coordinator: Kelsey Banaglorioso

Phone: 346.238.5740

A Phase Ib/III Open-label, Randomised Study of Capivasertib plus CDK4/6 Inhibitors and Fulvestrant versus CDK4/6 Inhibitors and Fulvestrant in Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Locally Advanced, Unre ... Read more >

Status: Open Not Enrolling

Investigator: Polly Niravath

Study Coordinator: Rabia Hashmani

Phone: 346.238.5894

This is a Phase Ib/II study assessing the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), recommended Phase 2 dose (RP2D), and efficacy of L-NMMA when combined with docetaxel in refractory locally advanced or metastatic triple neg ... Read more >

Status: Open Not Enrolling

Investigator: Jenny Chang

Study Coordinator: Rabia Hashmani

Phone: 346.238.5894

Hormone receptor positive breast cancer HRBC is the most common cause of BC-related death. HRBC is characterized by a non-immunogenic microenvironment and consequently, modest responses have been observed with immune checkpoint blockade ICB alon ... Read more >

Status: Enrolling

Investigator: Jenny Chang

Study Coordinator: Alexys Brock

Phone: 346.238.4814

The study will investigate if a one month drug holiday from the CDK4/6 inhibitor drug, abemaciclib, will restore the body's sensitivity to the drug and make the subsequent treatment of abemaciclib plus fulvestrant more effective. ... Read more >

Status: Enrolling

Investigator: Hanh Mai

Study Coordinator: Natolie Hamilton

Phone: 469.267.9275

This phase III clinical trial will evaluate the impact on survival of adding chaplain-provided spiritual care or psychotherapy/meditation to standard-of-care (SOC) and palliative measures, plus chemotherapy if recommended, and comparing it with ... Read more >

Status: Enrolling

Investigator: Jenny Chang

Study Coordinator: Alexys Brock

Phone: 346.238.4814

This is a Phase I/Ib study testing the safety and preliminary efficacy of olaparib and vorinostat when used together in participants with relapsed/refractory and or metastatic breast cancer. Cancer cells grow in an uncontrolled manner and this c ... Read more >

Status: Open Not Enrolling

Investigator: Jenny Chang

Study Coordinator: Rabia Hashmani

Phone: 346.238.5894

The purpose of this research study is to test the safety and effectiveness of using durvalumab with trastuzumab and pertuzumab in participants with human epidermal growth factor receptor 2 (HER2)-enriched breast cancer. ... Read more >

Status: Open Not Enrolling

Investigator: Polly Niravath

Study Coordinator: Kelsey Banaglorioso

Phone: 346.238.5740

This is a prospective, two arm, international, multicenter, randomized, open-label Phase III study evaluating the addition of 2 years of palbociclib to standard adjuvant endocrine therapy for patients with HR+ / HER2- early breast cancer (EBC). ... Read more >

Status: Enrolling

Investigator: Kai Sun

Study Coordinator: Kelsey Banaglorioso

Phone: 346.238.5740

The phase III trial compares the effect of pembrolizumab to observation for the treatment of patients with early-stage triple-negative breast cancer who achieved a pathologic complete response after preoperative chemotherapy in combination with ... Read more >

Status: Enrolling

Investigator: Polly Niravath

Study Coordinator: Alexys Brock

Phone: 346.238.4814

This study is investigating whether breast cancer patients who experience vaginal dryness while on anti-estrogen treatment could benefit from either vaginal estrogen or from a vaginal moisturizer called Replens. ... Read more >

Status: Open Not Enrolling

Investigator: Jenny Chang

Study Coordinator: Kelsey Banaglorioso

Phone: 346.238.5740

This is a First-in-Human Phase IA/IB/II open label dose escalation study of intravenous (IV) administration of ONC-392, a humanized anti-CTLA4 IgG1 monoclonal antibody, as single agent and in combination with pembrolizumab in participants with a ... Read more >

Status: Open Not Enrolling

Investigator: Sindhu Nair

Study Coordinator: Misbah Baloch

Phone: 713.790.3311

This Phase III, randomized, open-label, multicenter study will evaluate the efficacy and safety of giredestrant plus everolimus compared with the physician's choice of endocrine therapy plus everolimus in participants with estrogen receptor (ER) ... Read more >

Status: Open Not Enrolling

Investigator: Polly Niravath

Study Coordinator: Kelsey Banaglorioso

Phone: 346.238.5740

RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy, using tamoxifen citrate, may fight breast cancer by blocking the use of estrogen by the tumor cells. Aromatase inhibitors, such as anastrozole, letrozole, and exem ... Read more >

Status: Enrolling

Investigator: Bin Teh

Study Coordinator: Derek Cole

Phone: 713.441.5607

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiati ... Read more >

Status: Enrolling

Investigator: Kai Sun

Study Coordinator: Rabia Hashmani

Phone: 346.238.5894

This phase III trial studies how well trastuzumab emtansine (T-DM1) and tucatinib work in preventing breast cancer from coming back (relapsing) in patients with high risk, HER2 positive breast cancer. T-DM1 is a monoclonal antibody, called trast ... Read more >