Cardiovascular 3D printing can help improve percutaneous structural interventions by providing preoperative access to enhanced anatomic and hemodynamic understanding, which can improve procedural planning and provide an environment for preoperative simulation. It also helps in communication with patients and trainees. 3D printing is used broadly, especially in congenital, vascular and valvular diseases, where emerging technologies are being developed and tested. In Circulation: Cardiovascular Imaging, we summarize the process of 3D printing, the workflow from imaging acquisition to model generation, and discuss the cardiac percutaneous structural intervention applications of 3D printing.