The Center for Transport Oncophysics (CTO) desires to understand the physics of mass transport within a cancer lesion and mass exchanges between cancer and surrounding host biology. Once such mechanisms are understood, the CTO hopes to develop and improve cancer diagnosis and treatment. With improved cancer diagnosis and treatment, the burden of cancer will be lessened and the eradication of cancer possible.
The CTO will focus on two specific cancer types: colorectal cancer, the second leading cause of cancer death in the U.S., and liver metastasis, the most common site of metastatic disease.
Our investigators will integrate mathematics, innovative engineered transport probes and state-of-the-art imaging to elucidate the transport physics of various physical and biological barriers related to tumorigenesis and drug delivery. Notably, this trans-disciplinary team will study the physical barriers to the evolution of liver metastasis from colorectal cancer and the administration of novel carriers to surpass these barriers.
Ultimately, these studies will provide a clearer grasp of the function and physics of biological barriers, and in turn will accelerate basic discovery and assist in the design for potential therapeutics.