Carly S. Filgueira

Carly S. Filgueira, PhD

Assistant Professor of Nanomedicine, Academic Institute
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Filgueira Lab


Phone:
713.441.1996


csfilgueira@houstonmethodist.org
Biography

Dr. Carly Filgueira obtained her Bachelor of Science degree in Chemistry Magna Cum Laude from The George Washington University in Washington, DC. In her second year as an undergraduate, she was awarded the A.D. Britt scholarship which sponsored her to perform research in the Chemistry Department at GWU under the direction of Dr. J. Houston Miller. She continued in the Miller lab until undergraduate graduation, where they worked on the application of UV-VIS spectroscopy and elastic/inelastic light scattering to examine the chemistry between gold nanoparticles and biopolymers.

Dr. Filgueira obtained her masters and doctorate degrees in Chemistry from Rice University in 2005 and 2009. As a pre-doctoral student, she fabricated and characterized optically responsive nanostructures and their plasmonic interactions under the direction of Dr. Naomi Halas. She was awarded several honors, including a NIH Keck Nanobiology training fellowship, NSF sponsorship to attend the 55th Lindau Nobel Laureate Meeting in Germany, and a Dean's Office Travel Award. She was also honored with both The Harry B. Weiser Award for Excellence in Service and The Harry B. Weiser Research Award in Recognition of Research Excellence at Rice University.

Dr. Filgueira joined Houston Methodist in 2011 as a postdoctoral student under the direction of Dr. Anders Berkenstam and Dr. Paul Webb in collaboration with Dr. Jan-Ake Gustafsson. She focused on nuclear hormone receptors, specifically Estrogen Receptor beta and Liver X Receptor beta, and small molecule screening using a combination of direct binding and cell based assays.

Dr. Filgueira is currently a member of the Department of Nanomedicine with appointments as Assistant Member in the Research Institute, Assistant Professor of Nanomedicine in the Academic Institute, and with the Department of Cardiovascular Surgery. 

Description of Research

Dr. Filgueira is currently interested in finding alternative treatment approaches for physiological disorders through sustained release harnessing nanotechnological approaches.

Areas Of Expertise

Nanomedicine Nanofluidics Cardiovascular disease Nanoparticles Thyroid hormones Implantable devices Metabolic Syndrome Bone growth Hormone Replacement Therapy
Patents

COCRYSTALLINE DHEA FORMULATIONS

Patent Number: EP2986634, Feb 24 2016


COCRYSTALLINE DHEA FORMULATIONS

Patent Number: WO2014172706, Oct 23 2014


Cocrystalline DHEA Formulations

Patent Number: US2014315833, Oct 23 2014


All optical nanoscale sensor

Patent Number: US2008176212, Jul 24 2008

Publications

On the generality of the finite element modeling physical fields in biological systems by the multiscale smeared concept (Kojic transport model)
Kojic, M, Milosevic, M, Simic, V, Milicevic, B, Terracciano, R & Filgueira, CS 2024, , Heliyon, vol. 10, no. 5, pp. e26354. https://doi.org/10.1016/j.heliyon.2024.e26354

Developing a Hypothyroid Rat Model for Myocardial Infarction
Eversole, E, Carcamo-Bahena, Y, Royal, ALR, Fallon, BC, Brero, G, Bhimaraj, A, Youker, KA & Filgueira, CS 2022, , Nanomedicine Symposium HMRI, 12/5/22.

Zonal Intratumoral Delivery of Nanoparticles Guided by Surface Functionalization
Terracciano, R, Carcamo-Bahena, Y, Royal, ALR, Messina, L, Delk, J, Butler, EB, Demarchi, D, Grattoni, A, Wang, Z, Cristini, V, Dogra, P & Filgueira, CS 2022, , Langmuir, vol. 38, no. 45, pp. 13983-13994. https://doi.org/10.1021/acs.langmuir.2c02319

Zonal Intratumoral Delivery of Nanoparticles Guided by Surface Functionalization
Terracciano, R, Carcamo-Bahena, Y, Royal, ALR, Messina, L, Delk, J, Butler, EB, Demarchi, D, Grattoni, A, Wang, Z, Cristini, V, Dogra, P & Filgueira, CS 2022, , Langmuir, vol. 38, no. 45, pp. 13983-13994. https://doi.org/10.1021/acs.langmuir.2c02319

Quantitative high-resolution 7T MRI to assess longitudinal changes in articular cartilage after anterior cruciate ligament injury in a rabbit model of post-traumatic osteoarthritis
Terracciano, R, Carcamo-Bahena, Y, Royal, ALR, Demarchi, D, Labis, JS, Harris, JD, Weiner, BK, Gupta, N & Filgueira, CS 2022, , Osteoarthritis and Cartilage Open, vol. 4, no. 2, 100259. https://doi.org/10.1016/j.ocarto.2022.100259

Near-infrared sensitive nanoparticle-mediated photothermal ablation of ventricular myocardium
Mathuria, N, Royal, ALR, Enterría-Rosales, J, Carcamo-Bahena, Y, Terracciano, R, Dave, A, Valderrabano, M & Filgueira, CS 2022, , Heart Rhythm, vol. 19, no. 9, pp. 1550-1556. https://doi.org/10.1016/j.hrthm.2022.05.006

Hyaluronate-thiol passivation enhances gold nanoparticle peritumoral distribution when administered intratumorally in lung cancer
Terracciano, R, Carcamo-Bahena, Y, Butler, EB, Demarchi, D, Grattoni, A & Filgueira, CS 2021, , Biomedicines, vol. 9, no. 11, 1561. https://doi.org/10.3390/biomedicines9111561

Nanotechnology applications for cardiovascular disease treatment: Current and future perspectives
Wang, DK, Rahimi, M & Filgueira, CS 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 34, 102387. https://doi.org/10.1016/j.nano.2021.102387

Nanotechnology applications for cardiovascular disease treatment: Current and future perspectives
Wang, DK, Rahimi, M & Filgueira, CS 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 34, 102387, pp. 102387. https://doi.org/10.1016/j.nano.2021.102387

Effects of surface protein adsorption on the distribution and retention of intratumorally administered gold nanoparticles
Terracciano, R, Zhang, A, Butler, EB, Demarchi, D, Hafner, JH, Grattoni, A & Filgueira, CS 2021, , Pharmaceutics, vol. 13, no. 2, 216, pp. 1-19. https://doi.org/10.3390/pharmaceutics13020216

Effects of surface protein adsorption on the distribution and retention of intratumorally administered gold nanoparticles
Terracciano, R, Zhang, A, Butler, EB, Demarchi, D, Hafner, JH, Grattoni, A & Filgueira, CS 2021, , Pharmaceutics, vol. 13, no. 2, 216, pp. 1-19. https://doi.org/10.3390/pharmaceutics13020216

Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity
Karaboga, H, Huang, W, Srivastava, S, Widmann, S, Addanki, S, Gamage, KT, Mazhar, Z, Ebalunode, JO, Briggs, JM, Gustafsson, J-Å, Filgueira, CS, Gilbertson, SR & Lin, C-Y 2020, , ACS Chemical Biology. https://doi.org/10.1021/acschembio.0c00546

Gold Nanoparticles Radio-Sensitize and Reduce Cell Survival in Lewis Lung Carcinoma
Pandey, A, Vighetto, V, Marzio, ND, Ferraro, F, Hirsch, M, Ferrante, N, Mitra, S, Grattoni, A & Filgueira, CS 2020, , Nanomaterials, vol. 10, no. 9, 1717. https://doi.org/10.3390/nano10091717, https://doi.org/10.3390/nano10091717

Gold nanoparticles radio-sensitize and reduce cell survival in lewis lung carcinoma
Pandey, A, Vighetto, V, Marzio, ND, Ferraro, F, Hirsch, M, Ferrante, N, Mitra, S, Grattoni, A & Filgueira, CS 2020, , Nanomaterials, vol. 10, no. 9, 1717, pp. 1-9. https://doi.org/10.3390/nano10091717

Technologies for intrapericardial delivery of therapeutics and cells
Filgueira, CS, Igo, SR, Wang, DK, Hirsch, M, Schulz, DG, Bruckner, BA & Grattoni, A 2019, , Advanced Drug Delivery Reviews, vol. 151-152, pp. 222-232. https://doi.org/10.1016/j.addr.2019.02.006

Remotely controlled nanofluidic implantable platform for tunable drug delivery
Di Trani, N, Silvestri, A, Bruno, G, Geninatti, T, Chua, CYX, Gilbert, A, Rizzo, G, Filgueira, CS, Demarchi, D & Grattoni, A 2019, , Lab on a Chip, vol. 19, no. 13, pp. 2192-2204. https://doi.org/10.1039/c9lc00394k

Nanofluidic microsystem for sustained intraocular delivery of therapeutics
Di Trani, N, Jain, P, Chua, CYX, Ho, JS, Bruno, G, Susnjar, A, Pons-Faudoa, FP, Sizovs, A, Lyle Hood, R, Smith, ZW, Ballerini, A, Filgueira, CS & Grattoni, A 2019, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 16, pp. 1-9. https://doi.org/10.1016/j.nano.2018.11.002

Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxis
Chua, CYX, Jain, P, Ballerini, A, Bruno, G, Hood, RL, Gupte, M, Gao, S, Di Trani, N, Susnjar, A, Shelton, K, Bushman, LR, Folci, M, Filgueira, CS, Marzinke, MA, Anderson, PL, Hu, M, Nehete, P, Arduino, RC, Sastry, JK & Grattoni, A 2018, , Journal of Controlled Release, vol. 286, pp. 315-325. https://doi.org/10.1016/j.jconrel.2018.08.010

Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy in triple negative breast cancer
Chua, CYX, Jain, P, Susnjar, A, Rhudy, J, Folci, M, Ballerini, A, Gilbert, A, Singh, S, Bruno, G, Filgueira, CS, Yee, C, Butler, EB & Grattoni, A 2018, , Journal of Controlled Release, vol. 285, pp. 23-34. https://doi.org/10.1016/j.jconrel.2018.06.035

Efficacy of sustained delivery of GC-1 from a Nanofluidic system in a spontaneously obese non-human primate: a case study
Filgueira, CS, Bruno, G, Smith, ZW, Chua, CYX, Ballerini, A, Folci, M, Gilbert, AL, Jain, P, Sastry, JK, Nehete, PN, Shelton, KA, Hill, LR, Ali, A, Youker, KA & Grattoni, A 2018, , Biomedical Microdevices, vol. 20, no. 2, 49. https://doi.org/10.1007/s10544-018-0296-2