Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Department of Neurosurgery

Britz Research Lab

The Cerebrovascular Research Laboratory studies brain microcirculation in normal and pathological conditions. Brain is critically dependent on the continuous and adequate blood supply for normal functioning. Such catastrophic events like stroke or subarachnoid hemorrhage not only damage the brain but lead to abnormalities of cerebrovascular circulation, which may aggravate the consequences of the perpetrating event. However, some of the changes of cerebrovascular circulation could be beneficial. In our research we study the mechanisms that lead to changes in cerebrovascular circulation following the initial insult. We explore what changes of microvascular circulation could actually be beneficial for the following recovery and which have negative effect on the recovery. We investigate the mechanisms by which abnormalities of cerebrovascular circulation damage the brain. In our studies we employ various in vitro and vivo techniques to understand the intimate relations between the initial causes, changes in microcirculation and role of the latter in brain damage. The ultimate goal of our studies is to develop new therapeutic approaches for the treatment of various neurological disturbances related to cerebrovascular circulation.

Group members

Gavin W. Britz, MBBCh, MPH, FAANS

Gavin W. Britz, MBBCh, MPH, FAANS

Chairman, Department of Neurosurgery

Co-Director, Methodist Neurological Institute

Eugene V. Golanov, M.D., Ph.D.

Eugene V. Golanov, M.D., Ph.D.

Director of Cerebrovascular Research
Department of Neurosurgery

 

Richard G. Federley, Ph.D.

Richard G. Federley, Ph.D.

Research Scientist
Department of Neurosurgery

Collaborators

  • Dr. Stephen Wong, Ph.D., P.E., Department of Systems Medicine and Bioengineering Houston Methodist
  • Dr. Maiken Nedergaard, M.D., D.M.Sc., University of Rochester
  • Dr. Robert M. Bryan, Jr., Ph.D., Baylor College of Medicine
  • Dr. Eng Lo, PhD., Massachusetts General Hospital
  • Dr. David Kleinfeld, Ph.D., UCSD