18F-MK-6240 Tau PET and Brain Inflammation in Alzheimer’s Disease

Investigator: Joseph Masdeu, MD

Study Coordinator: Nilene Crisci

Status: Enrolling

ClinicalTrials.gov Number: N/A

Phone: 281.222.1782

Protocol Number: Pro00020634

Description

To clarify the role of inflammation in the pathogenesis of AD, it is important to measure inflammation in brain of people with AD and its relationship with abnormal tau, as the disease progresses. So far, there is no in vivo data in humans verifying either a neuroprotective or harmful role of inflammation in the progression of AD, associated with tau spreading. To measure tau, we have so far used a single tracer, [18F]AV-1451. However, a more advanced tracer, [18F]MK-6240, is now available. In this project, we will use [18F]MK-6240 to determine the amount and distribution of tau in the brain, comparing it with the amount and distribution of inflammation, measured with [11C]ER-176 PET.
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