Glutathione in Mild Cognitive Impairment

Investigator: Joseph Masdeu, MD

Study Coordinator: Rejani Nair

Status: Enrolling Number: NCT03493178

Phone: 346.238.0083

Protocol Number: Pro00018465


Elderly humans have an increased risk of dementia which begins as mild defects in memory called mild cognitive impairment. Glutathione (GSH), a key endogenous antioxidant has been linked to cognition. This exploratory study will investigate mechanisms linked to GSH for cognitive impairment (and improvement) by studying humans with mild cognitive impairment who will be evaluated 12-weeks after receiving either N-acetylcysteine and glycine (GSH precursors), or receiving alanine, and a further 12-weeks after stopping these supplements.
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