Status: Enrolling
Investigator: Jun Zhang
Study Coordinator: Lacey Burey
Phone: 713.441.1159
This phase II/III trial studies how well chemotherapy and radiation therapy (chemoradiation) with or without atezolizumab works in treating patients with limited stage small cell lung cancer. Drugs used in chemotherapy, such as etoposide, cispla ... Read more >
Status: Enrolling
Investigator: Eric Bernicker
Study Coordinator: Jose Cruz
Phone: 713.441.4457
This randomized phase III trial studies how well crizotinib works and compares it to placebo in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called ALK. Mutation ... Read more >
Status: Open Not Enrolling
Investigator: Eric Bernicker
Study Coordinator:
Phone:
This is a Phase III, global, multicenter, open-label, randomized study to compare the efficacy and safety of 16 cycles (1 cycle duration=21 days) of atezolizumab (MPDL3280A) treatment compared with best supportive care (BSC) in participants with ... Read more >
Status: Enrolling
Investigator: Eric Bernicker
Study Coordinator: Juan Morales Viera
Phone: 786.803.2333
Major pathological response (MPR) rate of canakinumab given as a neoadjuvant treatment, either as single agent or in combination with pembrolizumab, in addition to evaluate the MPR rate of pembrolizumab as a single agent. Additionally the dynami ... Read more >
Status: Open Not Enrolling
Investigator: Eric Bernicker
Study Coordinator: Pej Hemati
Phone: 713.441.3926
This randomized, open-label study will evaluate the safety and efficacy of atezolizumab (an engineered anti-programmed death-ligand 1 [PD-L1] antibody) in combination with carboplatin+paclitaxel with or without bevacizumab compared with treatmen ... Read more >
Status: Enrolling
Investigator: Eric Bernicker
Study Coordinator: Minh Truong
Phone: 346.238.6403
This research trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. Studying the genes in a patient's tumor cells may help doctors select the best treatment ... Read more >
Status: Open Not Enrolling
Investigator: Eric Bernicker
Study Coordinator: Toniva Boone
Phone: 713.441.0686
This randomized phase III trial studies how well nivolumab after surgery and chemotherapy work in treating patients with stage IB-IIIA non-small cell lung cancer. Monoclonal antibodies, such as nivolumab, may stimulate the immune system in diffe ... Read more >
Status: Open Not Enrolling
Investigator: Jenny Chang
Study Coordinator: Mary Rose Silvas
Phone: 713.441.1952
The purpose of this exploratory biomarker study is to further our understanding of the role of cancer stem cells (CSCs) and other biomarkers in the progression of COPD to lung cancer by examining the CSC population and other related biomarkers, ... Read more >
Status: Enrolling
Investigator: Jun Zhang
Study Coordinator: Syed Muhammad Saad
Phone: 281.276.5263
This is a Phase III, randomized, placebo-controlled, double-blind, multi-center study assessing the efficacy and safety of durvalumab versus placebo following SoC SBRT in patients with unresected clinical Stage I/II lymph node-negative (T1 to T3 ... Read more >
Status: Enrolling
Investigator: Eric Bernicker
Study Coordinator:
Phone:
This is a Phase II trial to determine the efficacy and safety of in situ gene therapy and stereotactic body radiation therapy (SBRT) used as a window of opportunity treatment before nivolumab in patients with metastatic squamous and non-squamous ... Read more >
Status: Open Not Enrolling
Investigator: Lisa Kopas
Study Coordinator:
Phone:
The purpose of this research is to study a medical device that is designed to produce lung volume reduction. This device is called the PulmonX Endobronchial Valve (EBV). It has not been approved by the Food and Drug Administration (FDA) and is c ... Read more >
Status: Open Not Enrolling
Investigator: Jenny Chang
Study Coordinator: Syed Muhammad Saad
Phone: 281.276.5263
The purpose of this exploratory biomarker study is to further our understanding of the role of CSCs in lung cancer metastasis by examining the CSC population in metastatic tissue. ... Read more >
Status: Enrolling
Investigator: Eric Bernicker
Study Coordinator:
Phone:
This study is designed to identify the target Non-Small Cell Lung Cancer (NSCLC) population(s) that over express c-Met (c-Met+) best suited for telisotuzumab vedotin therapy in the second line or third line setting (Stage 1) and then to expand t ... Read more >
Status: Enrolling
Investigator: Jorge Darcourt
Study Coordinator: Elizabeth Soriano
Phone: 713.441.14203
The purpose of this Phase Ib study is to test the safety of NG-monomethyl-L-arginine (L-NMMA) and pembrolizumab when used together in participants with melanoma, non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), ... Read more >
Status: Open Not Enrolling
Investigator: Eric Bernicker
Study Coordinator: Lacey Burey
Phone: 713.441.1159
The purpose of this pilot study is to characterize the composition/diversity of the gut microbiome in patients with metastatic NSCLC who are receiving standard of care checkpoint blockade immunotherapy. This study will lay the groundwork for lar ... Read more >
Status: Open Not Enrolling
Investigator: Eric Bernicker
Study Coordinator: Minh Truong
Phone: 346.238.6403
This randomized phase III trial studies how well erlotinib hydrochloride compared to placebo works in treating patients with stage IB-IIIA non-small cell lung cancer that has been completely removed by surgery. Erlotinib hydrochloride may stop t ... Read more >
Status: Enrolling
Investigator: Kirk Heyne
Study Coordinator:
Phone:
The purpose of this study is to investigate nivolumab combined with Debio 1143. The study will focus on subjects with specific solid tumors for whom tumors were previously treated with anti-PD-1/PD-L1 therapy as a single therapy (or when used wi ... Read more >
