Clinical Trials

    Showing 1 - 10 of 24 Urinary Tract, Sexual Organs,

    A Double-blind, Randomized, Controlled Dose Escalation Trial of Autologous Mesenchymal Stromal Cells in Living Donor Kidney Transplant Recipients

    Status: Enrolling

    Investigator: Ahmed Gaber

    Study Coordinator:

    Phone:

    Kidney transplantation is a good treatment option for people with kidney disease. However, there is still much to learn about how to best care for the transplanted kidney and keep it functioning for a long time. Transplant recipients receive inductio... Read more >

    A Phase 2, Randomized, Placebo-Controlled Study to Evaluate Fingolimod for the Abrogation of Interstitial Fibrosis and Tubular Atrophy Following Kidney Transplantation

    Status: Enrolling

    Investigator: Ahmed Gaber

    Study Coordinator: Jack Curtis

    Phone: 913.486.9249

    This is a randomized, double-blind, placebo-controlled trial in de novo kidney transplant patients to determine if the addition of fingolimod (brand name Gilenya®, candidate name- FTY720) on the background of standard immunosuppression will prevent e... Read more >

    A Phase 3, Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial of Selinexor in Maintenance Therapy After Systemic Therapy for Patients with P53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

    Status: Enrolling

    Investigator: Pedro Ramirez

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    The purpose of this study is to evaluate the efficacy and safety of selinexor as a maintenance treatment in patients with p53 wt endometrial carcinoma (EC), who have achieved a partial response (PR) or complete response (CR) (per Response Evaluation ... Read more >

    A Phase II Trial of Ribociclib (LEE011) Plus Letrozole in Women With Recurrent Low-Grade Serous Carcinoma of the Ovary, Fallopian Tube or Peritoneum (GOG-3026)

    Status: Open Not Enrolling

    Investigator: Aparna Kamat

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    The study evaluates the response to treatment with Ribociclib and Letrozole in patients with recurrent low grade serous cancer of the ovary, fallopian tube or peritoneum.... Read more >

    A Phase III Randomised Clinical Trial Comparing Sentinel Node Biopsy With No Retroperitoneal Node Dissection in Apparent Early-Stage Endometrial Cancer

    Status: Enrolling

    Investigator: Behrouz Zand

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    Endometrial cancer (EC) is the most common gynaecological cancer. Current treatment of EC typically includes removal of the uterus and to determine the extent of the disease (removal of fallopian tubes, ovaries & if required a lymph node dissection (... Read more >

    A phase III Randomized Trial to Evaluate the Influence of BCG Strain Differences and T Cell Priming with Intradermal BCG Before Intravesical Therapy for BCG-Naive, High Grade Non-Muscle Invasive Bladder Cancer.

    Status: Open Not Enrolling

    Investigator: Raj Satkunasivam

    Study Coordinator: Taliah Muhammad

    Phone: 346.238.4523

    This randomized phase III trial studies Tokyo-172 strain bacillus Calmette-Guerin (BCG) solution with or without a vaccination using Tokyo-172 strain BCG to see how well it works compared with TICE BCG solution in treating patients with bladder cance... Read more >

    A Phase III Trial of One vs. Two Years of Maintenance Olaparib, With or Without Bevacizumab, in Patients With BRCA1/2 Mutated or Homologous Recombination Deficient (HRD+) Ovarian Cancer Following Response to First Line Platinum-Based Chemotherapy

    Status: Enrolling

    Investigator: Karolina Kilowski

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    This phase III trial compares the effect of olaparib for one year versus two years, with or without bevacizumab, for the treatment of BRCA 1/2 mutated or homologous recombination deficient stage III or IV ovarian cancer. Olaparib is a polyadenosine 5... Read more >

    A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer (RAMP 301)

    Status: Enrolling

    Investigator: Aparna Kamat

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    This study will assess the safety and efficacy of avutometinib (VS-6766) in combination with defactinib versus Investigator's choice of treatments (ICT) in subjects with recurrent LGSOC who have progressed on a prior platinum-based therapy.... Read more >

    A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/?TroFuse-020/?Gog-3101/?ENGOT-cx20)

    Status: Enrolling

    Investigator: Pedro Ramirez

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    This study will have two phases: a sacituzumab tirumotecan safety run-in and a Phase 3 portion. The safety run-in phase will be used to evaluate the efficacy and safety of sacituzumab tirumotecan at the dose for evaluation in the Phase 3 portion. The... Read more >

    An Open-Label, Controlled, Randomized Phase 3 Trial Evaluating 12-Month Kidney Function in Highly Sensitized (cPRA =99.9%) Kidney Transplant Patients with Positive Crossmatch Against a Deceased Donor, Using Imlifidase with Standard of Care

    Status: Open Not Enrolling

    Investigator: Ahmed Gaber

    Study Coordinator: Beatriz Efron

    Phone: 713.363.8890

    An open-label, controlled, randomized Phase 3 trial evaluating 12-month kidney function in highly sensitized (cPRA =99.9%) kidney transplant patients with positive crossmatch against a deceased donor, comparing desensitization using imlifidase with s... Read more >

    Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

    Status: Enrolling

    Investigator: Pedro Ramirez

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    This phase III trial compares minimally invasive surgery (MIS) to laparotomy in treating patients with stage IIIC-IV ovarian, primary peritoneal, or fallopian tube cancer who are receiving chemotherapy before and after surgery (neoadjuvant chemothera... Read more >

    MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005)

    Status: Open Not Enrolling

    Investigator: Aparna Kamat

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    The purpose of this study is to determine the safety, tolerability, and preliminary efficacy of pembrolizumab/vibostolimab co-formulation (MK-7684A) with or without other anticancer therapies in participants with selected advanced solid tumors. The p... Read more >

    Open-label study of Androgen Receptor Inhibition with dArolutamide plus Androgen Deprivation Therapy (ADT) Versus ADT in men with Metastatic Hormone-Sensitive Prostate Cancer Using an External Control Arm (ARASEC)

    Status: Open Not Enrolling

    Investigator: Eleni Efstathiou

    Study Coordinator:

    Phone:

    This is a phase 2 open label single arm study using an external control arm, to assess if the addition of darolutamide to ADT provides superior efficacy in terms of progression-free survival (PFS), as compared to ADT alone for men diagnosed with meta... Read more >

    Palbociclib and Binimetinib in RAS-Mutant Cancers: A ComboMATCH Treatment Trial

    Status: Enrolling

    Investigator: Monisha Singh

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    This phase II ComboMATCH treatment trial evaluates the effectiveness of palbociclib and binimetinib in treating patients with RAS-mutated cancers. Palbociclib and binimetinib are both in a class of medications called kinase inhibitors. They work by b... Read more >

    Phase 3, Prospective, Randomized, Open-label Study for Intraoperative Ureter(s) Visualization When Using ASP5354 With Near-infrared Fluorescence (NIR-F) Imaging in Adult Participants Undergoing Minimally Invasive and Open Abdominopelvic Surgeries

    Status: Enrolling

    Investigator: Aparna Kamat

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    he ureter is the tube that carries urine from the kidneys to the bladder. It is difficult for surgeons to see the ureter during abdominal surgery. This could lead to injuring the ureter which, although rare, could be serious. This study is about a... Read more >

    Phase II Open Label, Study of IMMU-132 in Metastatic Urothelial Cancer After Failure of Platinum-Based Regimen or Anti-PD-1/ PD-L1 Based Immunotherapy

    Status: Open Not Enrolling

    Investigator: Eleni Efstathiou

    Study Coordinator:

    Phone:

    This is an international, multi-center, open-label, phase II study in patients with metastatic urothelial cancer after failure of platinum-based regimen or anti-PD-1 /PD-L1 based immunotherapy. At least 140 patients are anticipated to be enrolled acr... Read more >

    Phase III Trial of Docetaxel vs. Docetaxel and Radium-223 for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

    Status: Open Not Enrolling

    Investigator: Eleni Efstathiou

    Study Coordinator:

    Phone:

    The purpose of this study is to compare any good and bad effects of using radium-223 along with docetaxel chemotherapy treatment versus using docetaxel alone.... Read more >

    PROspective ACcrual To Investigate reprOductive Cancers in womeN

    Status: Enrolling

    Investigator: Pedro Ramirez

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    The goal of this study is to create a non-invasive diagnostic test to rule out gynecological cancer in females aged 45 and older with abnormal uterine or postmenopausal bleeding.... Read more >

    Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005) (TroFuse-005)

    Status: Enrolling

    Investigator: Pedro Ramirez

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    Researchers are looking for new ways to treat people with endometrial cancer (EC) who have previously received treatment with platinum based therapy (a type of chemotherapy) and immunotherapy. Immunotherapy is a treatment that helps the immune system... Read more >

    Study of AZD5305 When Given in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer (PETRANHA)

    Status: Enrolling

    Investigator: Eleni Efstathiou

    Study Coordinator: Monisha Singh

    Phone: 713.441.9948

    This study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of AZD5305 when given in combination with new hormonal agents (NHAs) in patients with Metastatic Prostate Cancer.... Read more >

    Study of Sasanlimab (PF-06801591) in Combination With Bacillus Calmette-Guerin (BCG) in Participants With High-Risk Non-Muscle Invasive Bladder Cancer (CREST)

    Status: Open Not Enrolling

    Investigator: Raj Satkunasivam

    Study Coordinator: Taliah Muhammad

    Phone: 346.238.4523

    Primary Purpose: Treatment... Read more >

    Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer (STRIKE)

    Status: Enrolling

    Investigator: Patrick Prath

    Study Coordinator: Syeda Sarwat

    Phone: 832.358.4365

    This phase III trial compares the effect of adding tivozanib to standard therapy pembrolizumab versus pembrolizumab alone for the treatment of patients with high-risk renal cell carcinoma (RCC). Immunotherapy with monoclonal antibodies, such as pembr... Read more >

    Testing the Addition of Trastuzumab or Trastuzumab/?Pertuzumab to the Usual Chemotherapy for HER2 Positive Endometrial Cancer

    Status: Enrolling

    Investigator: Aparna Kamat

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    This phase II/III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin Hylecta [TM]) or pertuzumab, trastuzumab and hyaluronidase-zzxf (Phesgo [TM]) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink tumors in ... Read more >

    The Impact of Vitamin D Supplementation on Preterm Labor

    Status: Enrolling

    Investigator: Barbara Held

    Study Coordinator: Jaya Kamath

    Phone: 713.441.6616

    The primary goal of this study is to assess if vitamin D supplementation decreases the incidence of preterm labor, and the secondary goal of this study is to assess if vitamin D supplementation decreases the incidence of gestational hypertension or p... Read more >