Nanomedicine Research

At Houston Methodist, our goal is to bring nanotechnologies to the clinic. By using interdisciplinary methods to combine nanoengineering, mathematical modeling and biomedical sciences, we develop nanotechnology-enabled therapeutic and diagnostic platforms to combat diseases including cancer, diabetes, cardiovascular and infectious diseases. Our main strategies are to make it possible for clinicians to detect disease early from blood proteomic signatures through the use of nanochips, to produce injectable nanovectors for targeted therapies and to design and create intelligent implants that allow controlled, time-released doses of substances. We have also created nanoscale scaffolding to aid in bone tissue engineering. Through our research, we are also attempting to understand the physics of mass transport within a cancer lesion and mass exchanges between cancer and surrounding host biology in order to create better nanomedicine treatments for cancer. We use several core facilities to advance our research goals; Molecular Diagnostics, Nanoengineering and Peptidomics-Nanoengineering to name just a few.

INJECTABLE NANOPARTICLE GENERATOR FOR METASTATIC BREAST CANCER TREATMENT

Researchers from the Houston Methodist Research Institute have developed the first drug delivery system to successfully eliminate lung metastases in mice models with triple negative breast cancer. Results were published in Nature BiotechnologyLearn more.

$9 MILLION NCI GRANT TO ESTABLISH CENTER FOR IMMUNOTHERAPEUTIC TRANSPORT ONCOPHYSICS

Houston Methodist received $9 million from the National Cancer Institute to establish a center focused on the physics of cancer immunotherapy. Mauro Ferrari, PhD, president and CEO of the Houston Methodist Research Institute, is leading this effort. Learn more.

REMOTE-CONTROLLED DEVICE DELIVERS HIV PREVENTION DRUG

Houston Methodist research team receives nearly $4 million to test a transcutaneously refillable implant that administers pre-exposure prophylaxis drugs to subjects at risk of HIV-exposure. Learn more. 

Pocket test measures 50 things in a drop of blood

V-chip - device about the size of a business card can test for insulin, cholesterol, blood proteins, and even signs of viral or bacterial infection at the same time—with one drop of blood. Preliminary results were published by Nature Communications. Learn More.