Drug and RNAi Library Information
- The Johns Hopkins Clinical Compound Screening Initiative (3,500 drugs, of which we received 1,503 compounds, many FDA approved and off patent with known pharmacologic properties and side effects)
- Prestwick Chemical Library (1,200 mainly off-patent compounds)
- Greenpharma Natural Compound Library (240 compounds)
- Prestwick Rare Phytochemicals Library (320 compounds)
- Sigma LOPAC Compound Library (1280 compounds)
- Tocriscreen Compound Library (1120 compounds)
- MicroSource Spectrum Library (2000 compounds)
- Asinex Library (72,500 compounds)
- ON-TARGET plus SMARTPOOL siRNA Library (Dharmacon)
- Chemical Library (40,000 compounds) (Life Chemicals)
In the Department of System Medicine and Bioengineering at Houston Methodist, a computing and storage environment has been established and continues to be upgraded. Two computing clusters, a 242-core Linux-based and a 64-core Windows-based, are online for intense computations required in our biomedical research.
- The Linux cluster — HP BL460c (8-core per node, with 8GB or 32GB memory) blade system and Thinkmat superBlade Module SBA 7142G (48-core or 64-core per node with 128GB or 512GB memory).
- The Windows cluster — HP BL460c (8-core per node, with 32GB memory) blade system with 4 storage servers (HP AIO1200, HP GL185 G5 and 2 of Dell PowerEdgeR 510) with a total capacity of 66 TB, which provide network storage and data backup. Furthermore, a GPU-based computing server (Dell PowerEdge C1100 with 4 NVidia Tesla M2070 GPU units) has been installed.
Externally, we have access to the BlueBioU IBM supercomputer located at Rice University and Supercomputing Linux clusters at Texas Advanced Computing Center (TACC).
- BlueBioU is an IBM POWER7 computer cluster at Rice. The system contains 47 IBM P750 compute nodes. Each node has four eight-core IBM POWER7 processors running at 3.8GHz. Each core is capable of running four threads resulting in 128 threads per node with a cluster-wide total of 6016 threads and 1504 cores. Each node contains 256GB of RAM.
- Ranger and Lonestar are two Linux-based clusters at TACC with 62976 and 22656 CPU cores, respectively. The extremely intense simulations in our research can be carried out on these supercomputing facilities.
- Related software is also available.