Study of KRN23 in Adults With X-linked Hypophosphatemia (XLH)

Investigator: Mary Ruppe, MD

Study Coordinator: Romeo Parada

Status: Open Not Enrolling

ClinicalTrials.gov Number: NCT02526160

Phone: 713.443.7005

IRB Number: Pro00013130

Description

UX023-CL303 is a phase 3 multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of KRN23 in adult subjects with XLH. Approximately 120 subjects with a diagnosis of XLH supported by clinical and biochemical features consistent with XLH and/or a confirmed PHEX mutation (self or family member consistent with X-linked inheritance) and with bone or joint pain at baseline will be enrolled. Subjects not receiving supplementation therapy with oral phosphate and active vitamin D metabolites or those willing to discontinue supplementation therapy are eligible.
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