Brain Periphery Research Lab

Sonia Villapol, PhD
Assistant Member, Research Institute
Center for Neuroregeneration
Department of Neurosurgery
Neurological Institute
Houston Methodist

The Brain-Periphery lab is focus on the pursuit of novel neurorestorative treatments for debilitating brain injuries to open the door to alternative therapies that repair and recovery in the damaged brain through the periphery. Our research interests are mainly focused on the elucidating of mechanisms of cell death, gliosis, inflammation, and neurogenesis via models of brain damage (ischemia and trauma), and how inflammatory mediators connect the brain with the periphery. We have been dedicated towards the development of novel therapeutics to repair the brain after damage, focusing on endogenous inhibitors of apoptosis, nitric oxide, melatonin or angiotensin II receptor inhibitors and exploiting their protective roles in the brain. Our passion is the pursuit of novel neurorestorative treatments for debilitating brain injuries and to open the door to alternative systemic therapies that may potentially provide repair and recovery in the damaged brain has driven us to our overall goal is to identify new treatments to restore the injured brain. 

 

Research Interests:

  • Cerebral ischemia and traumatic brain injury
  • Neuroinflammation and neurodegeneration
  • Sex and gender differences in response to brain damage
  • Brain-Liver axis ~ Brain-gut-microbiome axis ~ Brain-Periphery axis
  • Glia activation
  • Neuroprotection and Neurorestoration

     

    Research Methods:

  • Animal models of brain injury
  • Immunohistochemistry and microscopy analysis
  • Protein analysis
  • DNA and RNA purification
  • Sequence analysis

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